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| 1 | Interleukin-6 and its soluble receptor in patients with liver cirrhosis and hepatocellular carcinoma显示文摘瞄准:为了评估免疫, interleukin-6 ( IL-6 )和从有肝细胞癌( HCC )和浆液的病人的肿瘤组织标本上的 IL-6 受体( IL-6R )的组织化学的本地化与 HCC 以及肝肝硬化( LC )在一组病人 IL-6 和 sIL-6R 铺平在一组有独自一个的 LC 并且在一个控制组的病人。方法:三组题目被学习:组我(n = 83 ) 受不了 HCC 和 LC,组 II (n = 72 ) 受不了独自一个的 LC 和组 III (n = 42 ) 同样健康的控制。所有病人有丙肝病毒感染。浆液 IL-6 和 IL-6R 层次用一个商业地可得到的 ELISA 工具包被决定。Immunohistochemistry 对 IL-6 和 IL-6R 用 streptavidin-biotin 建筑群和兔子 polyclonal 抗体被执行。结果:Immunohistochemistry 分析显示出媒介到强壮细胞质并且为 IL-6 和 IL-6R 的膜反应分别地在 HCC 的至少 40% 盒子,而肝肝硬化病人和控制为 IL-6 是否定的或为 IL-6R 显示出很温和、焦点的像点的细胞质的反应。在 HCC 组的浆液 IL-6 层次比在 LC 和控制组的那些显著地高(P <
0.0001 ) 。在在 3 个组之中的 sIL-6R 集中没有有效差量。当有 HCC 的病人根据 Okuda 的分类被划分成组时, IL-6 和 sIL-6R 水平的重要浆液增加从舞台被观察我上演 III (P <
0.02, P <
0.0005 ) 。当 HCC 和 LC 病人根据孩子呸被划分成肝硬化严厉的 3 个班时,在 HCC 病人的价值比在为各相应的班的 LC 病人的那些显著地高(P <
0.01 ).CONCLUSION:在 HCC 病人的 IL-6 浆液层次比在 LC 病人和控制的那些高,建议由肿瘤的房间的这 cytokine 的增加的生产。sIL-6R 价值在所有组是类似的,仅仅在阶段 III HCC 病人增加。这些数据建议他们与肿瘤的团而非与剩余的工作有一种更靠近的关系肝的质量。 | Soresi Maurizio Giannitrapani Lydia D'Antona Fabio Florena Ada Maria La Spada Emanuele Terranova Angela Cervello Melchiorre D'Alessandro Natale Montalto Giuseppe | 2006 | World Journal of Gastroenterology2006，12，16： | 25 |
| 2 | Hypocholesterolemia and risk of death in the critically ill surgical patient 显示文摘 | Gui D Spada PL De Gaetano A Pacelli F | 1996 | Intensive Care Med1996，22，8： | 1 |
| 3 | Antioxidant activity of the flavonoid hesperidin in chemical and biological systems显示文摘 | WILMSEN P K SPADA D S SALVADOR M | 2005 | Agric Food Chem2005，53，12： | 1 |
| 4 | Selectively-infective phage (SIP):a mechanistic dissection of a novel in vivo selection for protein-ligand interations显示文摘 | Krebber C Spada S Desplancq D | 1997 | J Mol Bio11997，268，： | 1 |
| 5 | Structure and phase transformation of ferromagnetic shape memory alloy Ni49Mn30Ga21 fine particles prepared by spark erosion显示文摘 | TANG Y J SMITH D J HU H SPADA F E HARPER H BERKOWITZ A E | 2003 | IEEE Trans Magn2003，39，： | 1 |
| 6 | Selectively-infective phage (SIP): A mechanistic dissection of a novel in vivo selection for protein-ligand interactions 显示文摘 | Krebber C Spada S Desplancq D | 1997 | J Mol Biol1997，268，3： | 1 |
| 7 | Antioxidant activity of theflavonoid hesperidin in chemical and biological systems显示文摘 | Wilmsen P K Spada D S Salvador M | 2005 | Journal of Agricultural and Food Chemistry2005，53，12： | 1 |
| 8 | Clinical biochemical and morphological correlates in patients bearing growth hormone--secreting pituitary tumora with or without constituitively active adenylyl cyclase显示文摘 | Spada A Arosio M Bochicchio D | 1990 | J Clin Endocrinol Metab1990，71，： | 1 |
| 9 | Hypocholesterolemia and risk of death in the critically ill surgical patient显示文摘 | Gui D Spada PL De Gaetano A | 1996 | Intensive Care Med1996，22，8： | 1 |
| 10 | A nucleotide binding site in caspase-9 regulates apoptosome activation 显示文摘 | Chereau D Zou H Spada AP | 2005 | Biochemistry2005，44，13： | 1 |
| 11 | Genetic mark- ers between Biomphalaria glabrata snails susceptible and resist ant to Sckistosoma mansoni infection显示文摘 | Spada RG da Silva D Abdel Hamid AZ | 2002 | Mem Inst Oswaldo Cruz2002，97，1： | 1 |
| 12 | Prevalence of faecal-borne parasites in colony stray cats in Northern Italy显示文摘 | Spada E Proverbio D Della Pepa A | 2013 | J Feline Med Surg2013，15，8： | 1 |
| 13 | Antioxidant activity of the flavonoid hesperidin in chemical and biological systems显示文摘 | Wilmsen P K Spada D S Salvador M | 2005 | Agric Food Chem2005，53，12： | 1 |
| 14 | Antioxidant activity of the flavonoid hesperidin in chemical and biological systems显示文摘 | Wilmsen P K Spada D S Salvador M | 2005 | Journal of Agricultural and Food Chemistry2005，53，12： | 1 |
| 15 | Polymorphism of CAG motif of SK3 gene is associated with acute oxaliplatin neurotoxicity显示文摘 | Basso M Modoni A Spada D | 2011 | Cancer Chemother Pharmacol2011，67，5： | 1 |
| 16 | Andro- gen receptor gene mutations in X-linked spinal and bulbar muscular atrophy 显示文摘 | La Spada A R Wilson E M Lubahn D B | 1991 | Nature1991，352，6330： | 1 |
| 17 | Antioxidant activity of the flavonoid hesperidin in chemical and biological systems显示文摘 | Wilmsen P K Spada D S Salvador M | 2005 | J Agric Food Chem2005，53，12： | 1 |
| 18 | and the ESGE Clinical Guidelines Committee, European Society of Gas- trointestinal Endoscopy (ESGE): Recommendations (2009) on clinical use of video capsule endoscopy to investigate small-bowel, esophageal and colonic diseases显示文摘 | Ladas S D Triantafyllou K Spada C | 2010 | Endoscopy2010，42，3： | 1 |
| 19 | Intra abdomi hal vacuum-assisted closure (VAC) after necrosectomy for acute necrotising pancreatitis: preliminary experience 显示文摘 | Sermoneta D Di Mugno M Spada PL | 2010 | Int Wound J2010，7，6： | 1 |
| 20 | A nucleotide binding site in caspase-9 regulates apoptosome activation显示文摘 | Chereau D Zou H Spada AP | 2005 | Biochemistry2005，44，13： | 1 |
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