|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Increased frequency of bacterial vaginosis and Chlamydia traehomatis in preg- nant women with human papillomavirus infection 显示文摘 | da Silva CS Adad SJ Hazarabedian de Souza MA | 2004 | Gynecologic and Obstetric Investigation2004，58，4： | 1 |
| 3 | Increased frequency of bacterial vaginosis and Chlamydia trachomatis in pregnabt women with human papillomavirus infection显示文摘 | da Silva CS Adad SJ Hazarabedian de Souza MA | 2004 | Gynecol Obstet Invest2004，58，4： | 1 |
| 4 | NR3C1 polymor- phisms in Brazilians of Caucasian, African, and Asian ancestry: glucocorticoid sensitivity and genotype association显示文摘 | Souza MC Martins CS Silva -Junior IM | 2014 | Arq Bras En- docrinol Metabol2014，58，： | 1 |
| 5 | Carbon sources influence the nitrate removal activity,community structure and biofilm architecture显示文摘 | Srinandan CS D'souza G Srivastava N Nayak BB Nerurkar AS | | 0，，： | 1 |
| 6 | Semiotic approaches to user interface design显示文摘 | de Souza CS | 2001 | Knowledge-Based Systems2001，14，： | 1 |
| 7 | Hyperkalaemia incongestive heart failure patients using ACE inhibitors andspironolactone显示文摘 | Cruz CS Cruz AA Marcilio de Souza CA | 2003 | Nephrology dialysis transplantation2003，18，9： | 1 |
| 8 | A novel system using the Forced Oscillations Technique for the biomechanical analy- sis of swallowing显示文摘 | Souza CS Jfinior JA Melo PL | 2008 | Technol Health Care2008，16，5： | 1 |
| 9 | An interactive key(Lucid) for the identifying of the genera of seed plants from the Ducke Reserve,Manaus,AM,Brazil显示文摘 | Bittrich V Souza CS Coelho R | 2012 | Rodriguésia2012，63，1： | 1 |
| 10 | Wegener's granulomatosis: experience from a Brazilian tertiary center显示文摘 | De Souza FH Radu-Halpem AS Valente-Barbas CS | 2010 | Clin Rheumatol2010，29，： | 1 |
| 11 | The influence of surface carbohydrates during in vitro infection of mammalian cells by the dermatophyte Trichophyton rubrum显示文摘 | Esquenazi D Alviano CS de Souza W | 2004 | Res Microbiol2004，155，3： | 1 |
| 12 | Herpetomonas samuelpessoai:Dimethylsulfoxide-Induced Differentiation Is Influenced by Proteinase Expression显示文摘 | Rodrigues ML Alviano CS | 2003 | Curr Microbiol2003，46，： | 1 |
| 13 | Cord blood cytokine levels in focal early-onset neonatal infection after preterm premature rupture of membranes显示文摘 | Kurokawa CS Hashimoto M de Souza Rugolo LM | 2013 | Turk J Pediatr2013，55，6： | 1 |
| 14 | Increased frequency of bacterial vaginosis and Chlamydia trachomatis in pregnant women with human papillomavirus infection 显示文摘 | da Silva CS Adad SJ Hazarabedian de Souza MA | 2004 | Gynecol Obstet Invest2004，58，4： | 1 |
| 15 | E-learning program for medical students in dermatology 显示文摘 | Silva CS Souza MB Silva RS | 2011 | Clinics2011，66，4： | 1 |
| 16 | Increased frequency of bacterial vaginosis and Chlamydia trachomatis in p regnant women with human papillomavirus infection显示文摘 | Adad SJ Hazarabedian de Souza MA | 2004 | Gynecol Obstet Invest2004，58，4： | 1 |
| 17 | Increased frequency of bacterial vaginosis and Chlamydia trachomatis in pregnant women with human papillomavirus infection 显示文摘 | da Silva CS Adad SJ Hazarabedian de Souza MA | 2004 | Gynecol Obstet Invest2004，58，4： | 1 |
| 18 | Long-term follow-up of topical 5-aminolaevulinic acid photodynamic therapy diode laser single session for non-melanoma skin cancer显示文摘 | Souza CS Felicio LBA Ferreira J | | 0，，3： | 1 |
| 19 | Wegener's granulomatosis:experience from a Brazilian tertiary center显示文摘 | De Souza FH Radu-halpern AS Valente-Barbas CS | 2010 | Clin Rheumatol2010，29，： | 1 |
| 20 | Severe hypoxaemia can predict unfavourable clinical outcomes in individuals with pulmonary embolism aged over 40 years 显示文摘 | Souza CS Resende FS Rodrigues MP | 2014 | Singapore Med J2014，55，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员