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| 1 | Novel epigenetic-based therapies useful in cardiovascular medicine显示文摘Epigenetic modifications include DNA methylation, his-tone modifications, and micro RNA. Gene alterations have been found to be associated with cardiovascular diseases, and epigenetic mechanisms are continuously being studied to find new useful strategies for the clinical management of afflicted patients. Numerous cardiovascular disorders are characterized by the abnormal methylation of Cp G islands and so specific drugs that could inhibit DNA methyltransferase directly or by reducing its gene expression(e.g., hydralazine and procainamide) are currently under investigation. The anti-proliferative and anti-inflammatory properties of histone deacetylase inhibitors and their cardio-protective effects have been confirmed in preclinical studies. Furthermore, the regulation of the expression of micro RNA targets through pharmacological tools is still under development. Indeed, large controlled trials are required to establish whether current possible candidate antisense micro RNAs could offer better therapeutic benefits in clinical practice. Here, we updated therapeutic properties, side effects, and feasibility of eme-rging epigenetic-based strategies in cardiovascular diseases by highlighting specific problematic issues that still affect the development of large scale novel therapeutic protocols. | Claudio Napoli Vincenzo Grimaldi Maria Rosaria De Pascale Linda Sommese Teresa Infante Andrea Soricelli | 2016 | World Journal of Cardiology2016，8，2： | 5 |
| 2 | 脾对比增强复合谐波超声检查对于提高霍奇金淋巴瘤病人的分期准确性:前瞻性研究显示文摘目的前瞻性比较对比增强复合谐波超声(US)、CT、18-氟脱氧葡萄糖正电子发射断层显像(FDG—PET)对初诊霍奇金淋巴瘤病人脾结节样浸润的检出效果。方法经机构审查委员会批准,病人知情同意后,在对连续100例霍奇金淋巴瘤病人进行治疗前分期,探查脾是否受累时,前瞻性比较复合谐波超声(33例病人静脉注射微泡对比剂)与CT、FDG—PET的检查结果。以上影像学手段发现恶性结节的提示征象时认为是淋巴瘤浸润;对于存在争议的病灶, | M. Picardi A. Soricelli F. Pane P. Zeppa E. Nicolai M. De Laurentiis 李瑞利(译) 沈文(校) | 2009 | 国际医学放射学杂志2009，32，4： | 5 |
| 3 | Long-term results of hiatal hernia mesh repair and antireflux laparoscopic surgery 显示文摘 | Soricelli E Basso N Genco A | 2009 | Surg Endosc2009，23，11： | 1 |
| 4 | Enhanced detection of viable myocardium by 99m Tc-MIBI imaging after nitrate administration in chronic coronary arterydisease显示文摘 | Maurea S Cuocolo A Soricelli A | 1995 | J Nucl Med1995，36，11： | 1 |
| 5 | Enhanced detection of viable myocardium by 99 m Tc-MIBI imaging afternitrate administration in chronic coronary artery disease显示文摘 | Maurea S Cuocolo A Soricelli A etal | 1995 | J NuclMed1995，36，11： | 1 |
| 6 | Congenital fistulas of the lower lip 显示文摘 | Soricelli DA Bell L Alexander WA | 1966 | Oral Surg Oral Med Oral Pathol1966，，4： | 1 |
| 7 | Long-term results of hiatal hernia mesh repair and antireflux laparoscopic surgery显示文摘 | Soricelli E Basso N Genco A | 2009 | Surg Endosc2009，23，11： | 1 |
| 8 | Technetium-99m-sestamibi Uptake in BrainTumors by SPECT: Comparison With Thallium-201 Imaging显示文摘 | Soricelli A Cuocolo A Varrone A | 1998 | J Nucl Med1998，39，： | 1 |
| 9 | Long-term results of hiatalhernia mesh repair and antireflux laparoscopic surgery显示文摘 | Soricelli E Basso N Genco A | 2009 | Surg Endosc2009，23，： | 1 |
| 10 | Technetium-99m- sestamibi Uptake in Brain Tumors by SPECT: Comparison with Thallium-201 Imaging 显示文摘 | Soricelli A Cuocolo A Varrone A | 1998 | J Nucl Med1998，39，2： | 1 |
| 11 | Long-term results of hiatal hernia mesh repair and antireflux laparoscopic surgery显示文摘 | Soricelli E Basso N Gertco A | 2009 | Surg Endosc2009，23，11： | 1 |
| 12 | Technetium-99m sestamibi uptake in brain tumors by SPECT:eomparison with thallium-201 imaging显示文摘 | Soricelli A Cuocolo A Varrone A | 1998 | J Nuel Med1998，39，： | 1 |
| 13 | Long-term results of hiatal hernia mesh repair and antireflux laparoscopic surgery显示文摘 | Soricelli E Basso N Genco A | 2009 | Surg Endosc2009，23，11： | 1 |
| 14 | Long-term results of hiatal hernia mesh repair and antireflux laparoscopic surgery显示文摘 | Soricelli E Basso N Genco A | 2009 | Surg Endosc2009，23，11： | 1 |
| 15 | Adenosine techne- tium -99m - methoxy isobutyl isonitrile myocardial tomography in patients with coronary artery disease: comparison with exercise 显示文摘 | CUOCOLO A SORICELLI A PACE L | 1994 | J Nucl Med1994，35，7： | 1 |
| 16 | Primary prevention of atherosclerosis A clinical challenge for the reversal of epigenetic mechanisms显示文摘 | Napoli C Crudele V Soricelli A | | 0，，： | 1 |
| 17 | Enhanced detection of viable myocardium by 99mTc - MIBI imaging after nitrate administration in chronic coronary artery disease显示文摘 | Maurea S Cuocolo A Soricelli A | 1995 | J Nucl Med1995，36，： | 1 |
| 18 | Evaluation of brain tumors with technetium-99m tetrofosmin and thallium-201:A preliminary report(abstact)显示文摘 | SORICELLI A CUOCOLO A TEDESCHI E | 1994 | Eur J Nucl Med1994，，： | 1 |
| 19 | Effect of Adenosine on Cerebral Blood Flow as Evaluated by SinglePhoton Emission Computed Tomography in Normal Subjects and in Patients With Occlusive Carotid Disease A Comparison With Acetazolamide显示文摘 | Alfredo Postiglione Alberto Cuocolo | 1995 | Stroke1995，26，： | 1 |
| 20 | Primary prevention of atherosclerosis: A clinical challenge for the reversal of epigenetic mechanisms 显示文摘 | Napoli C Crudele V Soricelli A | 2012 | Circulation2012，125，19： | 1 |
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