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| 1 | 抗表皮生长因子受体和抗血管内皮生长因子药物在非小细胞肺癌治疗中的作用显示文摘采用以铂类药物为基础联合细胞毒性药物作为非小细胞肺癌(non-small-cell lung cancer,NSCLC)的标准化一线治疗的疗效已达到相应的平台。作用于特定通路的新型分子靶向药物逐渐成为治疗NSCLC的有效药物;某些药物的III期试验已取得阳性结果。值得注意的是,有研究证实,采用抗血管内皮生长因子(vascular endothelial growth factor,VEGF)抗体贝伐珠单抗抑制VEGF通路,以及采用表皮生长因子受体(epidermal growth factor receptor,EGFR)的小分子酪氨酸激酶抑制剂厄洛替尼或单克隆抗体(西妥昔单抗)靶向作用于EGFR通路作为一线或二线治疗方案,均可延长晚期肺癌患者的生存期。可导致肿瘤细胞存活和增殖的信号处理过程不同,为靶向作用于多种信号通路为有效的抗癌治疗策略提供了依据。因此,分子靶向药物的合理联用可能达到更好的临床疗效,并可成为对标准化疗耐药或不能耐受标准化疗的患者的可替代的治疗选择。目前的挑战在于明确应探寻哪些分子实体,以及它们的最佳联合方案。本综述旨在探讨贝伐珠单抗联合厄洛替尼抑制血管生成和EGFR信号作为治疗NSCLC的有效的非化疗方案的潜在临床疗效。其它可阻滞EGFR和血管生成通路以及互补信号通路的新型药物的联合具有独特的作用机制和较轻的毒副作用,有可能为晚期NSCLC患者的个体化治疗选择提供更多的治疗方案。 | Corey LANGER Jean-Charles SORIA 南娟(翻译) 丁燕(校对) | 2010 | 中国肺癌杂志2010，13，9： | 16 |
| 2 | Aquaporins:Their role in cholestatic liver disease显示文摘This review focuses on current knowledge on hepato-cyte aquaporins(AQPs)and their significance in bile formation and cholestasis.Canalicular bile secretion results from a combined interaction of several solute transporters and AQP water channels that facilitate water flow in response to the osmotic gradients created. During choleresis,hepatocytes rapidly increase their canalicular membrane water permeability by modulating the abundance of AQP8.The question was raised as to whether the opposite process,i.e.a decreased canalicular AQP8 expression would contribute to the development of cholestasis.Studies in several experimental models of cholestasis,such as extrahepatic obstructive cholestasis,estrogen-induced cholestasis, and sepsis-induced cholestasis demonstrated that the protein expression of hepatocyte AQP8 was impaired. In addition,biophysical studies in canalicular plasma membranes revealed decreased water permeability associated with AQP8 protein downregulation.The combined alteration in hepatocyte solute transporters and AQP8 would hamper the efficient coupling of osmotic gradients and canalicular water flow.Thus cholestasis may result from a mutual occurrence of impaired solute transport and decreased water permeability. | Guillermo L Lehmann Maria C Larocca Leandro R Soria Raúl A Marinelli | 2008 | World Journal of Gastroenterology2008，14，46： | 8 |
| 3 | Clinical impact of confocal laser endomicroscopy in the management of gastrointestinal lesions with an uncertain diagnosis显示文摘AIM To evaluate the clinical impact of confocal laser endomicroscopy(CLE) in the diagnosis and management of patients with an uncertain diagnosis.METHODS A retrospective chart review was performed.Patients who underwent CLE between November 2013 and October 2015 and exhibited a poor correlation between endoscopic and histological findings were included.Baseline characteristics,indications,previous diagnostic studies,findings at the time of CLE,clinical management and histological results were analyzed.Interventions based on CLE findings were also analyzed.We compared the diagnostic accuracy of CLE and target biopsies of surgical specimens.RESULTS A total of 144 patients were included.Of these,51%(74/144) were female.The mean age was 51 years old.In all,41/144(28.4%) lesions were neoplastic(13 bile duct,10 gastric,8 esophageal,6 colonic,1 duodenal,1 rectal,1 ampulloma and 1 pancreatic).The sensitivity,specificity,positive predictive value,negative predictive value,and observed agreement when CLE was used to detect N-lesions were 85.37%,87.38%,72.92%,93.75% and 86.81%,respectively.Cohen's Kappa was 69.20%,thus indicating good agreement.Changes in management were observed in 54% of the cases.CONCLUSION CLE is a new diagnostic tool that has a significant clinical impact on the diagnosis and treatment of patients with uncertain diagnosis. | Carlos Robles-Medranda Maria Vargas Jesenia Ospina Miguel Puga-Tejada Manuel Valero Miguel Soria Gladys Bravo Carlos Robles-Jara Hannah Pitanga Lukashok | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，8： | 6 |
| 4 | Sustained Type I interferon signaling as a mechanism of resistance to PD-1 blockade显示文摘PD-1 blockade represents a major therapeutic avenue in anticancer immunotherapy.Delineating mechanisms of secondary resistance to this strategy is increasingly important.Here,we identified the deleterious role of signaling via the type I interferon(IFN)receptor in tumor and antigen presenting cells,that induced the expression of nitric oxide synthase 2(N0S2),associated with intratumor accumulation of regulatory T cells(Treg)and myeloid cells and acquired resistance to anti-PD-1 monoclonal antibody(mAb).Sustained IFNP transcription was observed in resistant tumors,in turn inducing PD-L1 and N0S2 expression in both tumor and dendritic cells(DC).Whereas PD-L1 was not involved in secondary resistance to anti-PD-1 mAb,pharmacological or genetic inhibition of N0S2 maintained long-term control of tumors by PD-1 blockade,through reduction of Treg and DC activation.Resistance to immunotherapies,including anti-PD-1 mAb in melanoma patients,was also correlated with the induction of a type I IFN signature.Hence,the role of type I IFN in response to PD-1 blockade should be revisited as sustained type I IFN signaling may contribute to resistance to therapy. | Nicolas Jacquelot Takahiro Yamazaki Maria PRoberti Connie PMDuong Miles CAndrews Loic Verlingue Gladys Ferrere Sonia Becharef Marie Vetizou Romain Daillere Meriem Messaoudene David PEnot Gautier Stoll Stefano Ugel Maria Marigo Shin Foong Ngiow Aurelien Marabelle Armelle Prevost-Blondel Pierre-Olivier Gaudreau Vancheswaran Gopalakrishnan Alexander MEggermont Paule Opolon Christophe Klein Gabriele Madonna Paolo AAscierto Antje Sucker Dirk Schadendorf Mark JSm yth Jean-Charles Soria Guido Kroemer Vincenzo Bronte Jennifer Wargo and Laurence Zitvogel | 2019 | Cell Research2019，29，10： | 6 |
| 5 | 酞咪哌啶酮对多发性骨髓瘤细胞系血管新生抑制作用的研究显示文摘目的 研究多发性骨髓瘤 (MM)细胞系培养上清液对人骨髓来源的内皮细胞系(HBMEC)的增殖、迁移、血管新生的促进作用及酞咪哌啶酮对其抑制作用。方法 用MM细胞系 (IM9、XG1、U2 6 6和MOLP 5 )培养上清液培养HBMEC ,检测其对HBMEC的增殖、迁移作用。在纤维蛋白胶及基质胶 (matrigel)中观察此上清液对血管新生的影响 ,并研究酞咪哌啶酮对这些作用的抑制。用酶联免疫吸附实验 (ELISA)测定此上清液中血管内皮生长因子 (VEGF)含量。结果 MM培养上清液明显促进HBMEC的增殖及迁移。在纤维蛋白胶及基质胶 (matrigel)中 ,促进微血管的生长。这些作用均可被酞咪哌啶酮抑制。所有这些作用与MM细胞系产生的VEGF无相关性。结论 MM细胞系通过分泌VEGF或其他某些细胞因子促进HBMEC的增殖、迁移及微血管形成 ;酞咪哌啶酮可抑制这些作用 。 | 陈文明 朱嘉芷 F Mirshahi J Soria M Mirshahi C Soria | 2002 | 中华血液学杂志2002，23，10： | 5 |
| 6 | 多发性骨髓瘤血管新生的体外研究显示文摘探讨多发性骨髓瘤细胞系培养上清液对人骨髓来源内皮细胞系(HBMEC)的增殖、迁移及血管新生的作用。用含2%胎牛血清(FBS)的RPMI 1640培养液培养骨髓瘤细胞系获得上清液,将此培养液培养HBMEC,研究其时HBMEC的增殖及迁移的影响,并将此液放入含有携带HBMEC微珠的三维纤维蛋白中,研究其对血管新生的影响。结果表明,与含2%FBS的RPMI 1640培养液比较,骨髓瘤细胞系培养液对HBMEC的增殖有明显促进作用(P<0.001),并促进HBMEC的迁移,诱导毛细血管管腔的形成(长度及宽度)(P<0.001)。结论:骨髓瘤细胞系可能通过分泌某些细胞因子促进HBMEC增殖、迁移及血管新生。 | 陈文明 吴垠 朱嘉芷 Jeannette Soria Massoud Mirshahi | 2002 | 中国实验血液学杂志2002，10，4： | 4 |
| 7 | 在与心肌的梗塞介绍的就医的病人的心率的预示的意义显示文摘 AIM: To investigate the prognostic significance of resting heart rate in patients with acute coronary syndrome (ACS), independent of other known factors. METHODS: Patients 40 years of age or older who had been admitted with acute coronary syndrome (ACS) to one of the 94 hospitals participating in the Prevalence of Peripheral Arterial Disease in Patients with Acute Coronary Syndrome (PAMISCA) study were included. Patients were divided into two groups based on their resting heart rate (HR ≥ or < 70 bpm). Complications were recording during a follow-up period of 1 year. RESULTS: There were 1054 ACS patients analyzed (43.5% with ST segment elevation and 56.5% without elevation). Mean age was 66.6 ± 11.7 years, 70.6% were male and 29.4% of subjects were female. During follow-up, more patients in the HR ≥ 70 bpm group were hospitalized for heart failure and they also had a higher mortality rate. In the multivariate analysis, a heart rate of ≥ 70 bpm was independently related to overall mortality during the follow-up period (hazard ratio 2.5; 95% confidence interval, 1.26-4.97, P = 0.009). CONCLUSION: A resting heart rate ≥ 70 bpm in patients who survive an ACS is an indicator of a high risk of suffering cardiovascular events during follow-up. | Lorenzo Fácila Pedro Morillas Juan Quiles Federico Soria Alberto Cordero Pilar Mazón Manuel Anguita Cándido Martín-Luengo Jose Ramón Gonzalez-Juanatey Vicente Bertomeu | 2012 | World Journal of Cardiology2012，4，1： | 3 |
| 8 | Heuristics of node selection criteria to assess robustness of world airport network显示文摘The world airport network(WAN) is one of the networked infrastructures that shape today's economic and social activity, so its resilience against incidents affecting the WAN is an important problem. In this paper, the robustness of air route networks is extended by defining and testing several heuristics to define selection criteria to detect the critical nodes of the WAN.In addition to heuristics based on genetic algorithms and simulated annealing, custom heuristics based on node damage and node betweenness are defined. The most effective heuristic is a multiattack heuristic combining both custom heuristics. Results obtained are of importance not only for advance in the understanding of the structure of complex networks, but also for critical node detection. | Manel SORIA Oriol LORDAN JosMaría SALLAN | 2017 | Chinese Journal of Aeronautics2017，30，4： | 3 |
| 9 | Antifeedant effects and chemical composition of essential oils from different populations of Lavandula luisieri L.显示文摘 | Azucena González-Coloma Darío Martín-Benito Nagla Mohamed M a Concepción García-Vallejo Ana Cristina Soria | 2006 | Biochemical Systematics and Ecology2006，，8： | 2 |
| 10 | Tomato plant-water uptake and plant-water relationships under saline growth conditions显示文摘 | R Romero-Aranda T Soria J Cuartero | 2001 | Plant Science2001，，2： | 2 |
| 11 | Regulation of mitochondrial function and endoplasmic reticulum stress by nitric oxide in pluripotent stem cells显示文摘Mitochondrial dysfunction and endoplasmic reticulum stress(ERS) are global processes that are interrelated and regulated by several stress factors. Nitric oxide(NO) is a multifunctional biomolecule with many varieties of physiological and pathological functions, such as the regulation of cytochrome c inhibition and activation of the immune response, ERS and DNA damage; these actions are dose-dependent. It has been reported that in embryonic stem cells, NO has a dual role, controlling differentiation, survival and pluripotency, but the molecular mechanisms by which it modulates these functions are not yet known. Low levels of NO maintain pluripotency and induce mitochondrial biogenesis. It is well established that NO disrupts the mitochondrial respiratory chain and causes changes in mitochondrial Ca^(2+) flux that induce ERS. Thus, at high concentrations, NO becomes a potential differentiation agent due to the relationship between ERS and the unfolded protein response in many differentiated cell lines. Nevertheless, many studies have demonstratedthe need for physiological levels of NO for a proper ERS response. In this review, we stress the importance of the relationships between NO levels, ERS and mitochondrial dysfunction that control stem cell fate as a new approach to possible cell therapy strategies. | Estefania Caballano-Infantes José Terron-Bautista Amparo Beltrán-Povea Gladys M Cahuana Bernat Soria Hajji Nabil Francisco J Bedoya Juan R Tejedo | 2017 | World Journal of Stem Cells2017，9，2： | 2 |
| 12 | Study of photodegradation of the pefticide ethiofencarb in aqueous and non - aqueous media, by gas chromatograghy - mass spectrometry 显示文摘 | J Sanze - Asensio M Plaza - Medina M T Martinez - Soria M Perez -Clavijo | 1999 | Journal of Chromatograghy A1999，84，： | 2 |
| 13 | 猪圆环病毒2型相关疾病的临床诊断和控制新知显示文摘圆环病毒2型及相关疾病主要影响断奶仔猪和生长肥育阶段的猪只,导致其增重下降;该病也可造成猪只的繁殖疾病,严重影响养猪的经济效益。本文介绍了猪圆环病毒2型相关疾病的临床诊断及其控制措施。 | Sergio López Soria Joaquim Segalés 唐万勇 | 2015 | 中国猪业2015，10，5： | 2 |
| 14 | “猪Ⅱ型圆环病毒”专栏二:由猪圆环病毒引起的病毒血症对生产性能的影响显示文摘自1998年病毒血症与猪圆环病,现在也称作由PCV2引起的系统疾病(Systemic Disease due toPCV2,PCV2-SD)与联系起来后,与PCV2有关的病理学及其造成的养猪生产损失已成为研究的目标。自那时起, | 陶莉 Sergio Lopez Soria Joaquim Segales | 2013 | 国外畜牧学(猪与禽)2013，，5： | 2 |
| 15 | Clinical significance of cyclinB1 protein expression in squamous cell carcinoma of the tongue 显示文摘 | Hassan K A Elnaggar A K Soria J C | 2001 | Clin Cancer Res2001，7，8： | 1 |
| 16 | Prevalence and clinical relevance of autoimmune neutropenia in patients with primary Sjogren's syndrome 显示文摘 | Brito Zeron P Soria N Munoz S | 2009 | Semin Arthritis Rheum2009，38，5： | 1 |
| 17 | Regulation of fibrinogen biosynthesis by cytokines, conse- quences on the vascular risk 显示文摘 | VASSE M PAYSANT J SORIA J COLLET JP VANNIER JP SO- RIA C | 1996 | Haemostasis1996，26，： | 1 |
| 18 | Ureteral double-J wire stent effectiveness after endopyelotomy:an animal model study显示文摘 | Soria F Delgado MI Rioja L | 2010 | Urol Int2010，85，3： | 1 |
| 19 | Immunohistochemical stain-ing of the excision repair cross-complementing 1(ERCC1)protein aspredictor for benefit of adjuvant chemotherapy(CT)in the internation-al lung cancer trial(IALT)显示文摘 | Soria J Haddad V Olaussen K A | 2006 | JCO2006，24，18： | 1 |
| 20 | Val66Met BDNFGenotypes in melancholic depression: effects on brain struc-ture and treatment outcome显示文摘 | Cardoner N Soria V Gratacos M | 2013 | Depress Anxiety2013，30，3： | 1 |
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