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| 1 | 扁桃体鳞癌中HPV感染与EGFR、VEGF表达的相关性研究显示文摘目的:研究扁桃体鳞癌(squamous cell carcinomas of the tonsil tonsillar,SCCs)中人乳头瘤病毒(human papillomavirus,HPV)感染与血管内皮生长因子(vascular endothelial growth factor,VEGF)和表皮生长因子受体(epidermal growth factor,EGFR)表达的关系,探讨HPV与EGFR和VEGF在扁桃体鳞癌发生中的交互效应。方法:采用多重实时荧光定量聚合酶链反应(multiplex real-time polymerase chain reaction,MT-PCR)检测85例扁桃体鳞癌HPV DNA及型别,通过HPV DNA分析进行HPV感染状况的测定;同时采用半定量免疫组化检测HPV(+)组和HPV(-)组中VEGF、EGFR蛋白表达情况。结果:扁桃体鳞癌中HPV感染率为49.4%(42/85),HPV-16型占所有感染者的比例为90.5%(38/42),明显高于其他型别;HPV(+)组EGFR蛋白表达明显低于HPV(-)组(P值均<0.01);HPV(+)组与HPV(-)组VEGF蛋白表达无明显差异;此外,VEGF表达与EGFR、患者的年龄、性别、TNM分期、组织学分级均无明显相关性。结论:HPV感染与扁桃体鳞癌的发生存在相关性,HPV相关的扁桃体鳞癌中,HPV基因可能通过改变EGFR表达致癌,为HPV致癌机理进一步研究提供一个新的视角,具有重要的理论意义。 | 费继敏 Timothy A Dobbins Deanna Jones C Soon Lee Christine Loo Jonathan Clark Barbara Rose | 2015 | 现代肿瘤医学2015，23，4： | 3 |
| 2 | Antioxidant activity and free radical scavenging capacity between Korean medicinal plants and flavonoids by assay-guided comparison 显示文摘 | Sei C K Soon S | 2002 | Plant Science2002，163，： | 1 |
| 3 | Laparoscopie versus open simple prosta tectomy an evaluation of morbidity显示文摘 | McCullough T C Heldwein F L Soon S J Galiano M Barret E Cathelineau X | 2009 | J Endourol2009，23，： | 1 |
| 4 | The Z-phase in 9-12%Cr ferritic steels:a phase stability analysis 显示文摘 | Kocer C Abe T Soon A | 2009 | Materials Science and Engineering2009，505，12： | 1 |
| 5 | Noisy speech enhancement using discrete cosine transform显示文摘 | SOON I Y KOH S N YEO C K | 1998 | Speech Commun1998，24，3： | 1 |
| 6 | Characterization of materials behavior in microwave joining of ceramics 显示文摘 | Yarlagadda P K D V Soon R C T | 1998 | Journal of Materials Processing Technology1998，84，13： | 1 |
| 7 | A machine learning approach to coreference resolution of noun phrases显示文摘 | Soon W M Ng H T Lim D C Y | 2001 | Computational Linguistics2001，27，4： | 1 |
| 8 | New set of intravascular ultra- sound-derived anatomic criteria for defining functionally significant stenoses in small coronary arteries (results from Intravascular Ultra- sound Diagnostic Evaluation of Athcrosclerosis in Singapore study) 显示文摘 | Lee C H Tai B C Soon C Y | 2010 | Am J Cardiol2010，105，10： | 1 |
| 9 | Evaluation of sodium lactate as a replacement for conventional chemical preservatives in comminuted sausages inoculated with Listeria mono-cytogeneses 显示文摘 | Soon H C Koo B C | 2003 | Meat Science2003，65，1： | 1 |
| 10 | Google Earth as a Tool in2D Hydrodynamic Modeling 显示文摘 | Nguyen Q C Soon K T | 2011 | Computers & Ge-osciences2011，37，1： | 1 |
| 11 | Structural steel boundary elements for ductile concrete walls 显示文摘 | Soon H C Bryce T William D C | 2004 | Journal of Structural Engineering ASCE2004，130，5： | 1 |
| 12 | Genetic variation and population structure in Korean populations of Eurya japonica (Theaceae)显示文摘 | Myong G C Soon S K | 1994 | Am J Bot1994，81，8： | 1 |
| 13 | Genetic algorithm for text clustering based on latent semantic indexing 显示文摘 | SONG Wei SOON C P | 2009 | Computers& Mathematics with Applications2009，57，1112： | 1 |
| 14 | Indeterminacy and identifiability of blind identification 显示文摘 | Lang Tong Ruey-wen Liu Victor C Soon Yih-Fang Huang | 1991 | IEEE Transactions on Circuits and Systems (S0098-4094)1991，38，5： | 1 |
| 15 | Thermal power estimation by fouling phenomena compensation using wavelet and principal component analysis显示文摘 | GYUNYOUNG H SEONG S C SOON H C | 2000 | Nuclear Engineeing and Design2000，，2： | 1 |
| 16 | Production of nanocrystalline Y2O3:Eu powder by microwave plasma-torch and its characterization 显示文摘 | SOON C C HANS U CHAN U B | 2009 | Thin Solid Films2009，517，14： | 1 |
| 17 | Proton therapy for pancreatic cancer显示文摘Radiotherapy is commonly offered to patients with pancreatic malignancies although its ultimate utility is compromised since the pancreas is surrounded by exquisitely radiosensitive normal tissues, such as the duodenum, stomach, jejunum, liver, and kidneys. Proton radiotherapy can be used to create dose distributions that conform to tumor targets with significant normal tissue sparing. Because of this, protons appear to represent a superior modality for radiotherapy delivery to patients with unresectable tumors and those receiving postoperative radiotherapy. A particularly exciting opportunity for protons also exists for patients with resectable and marginally resectable disease. In this paper, we review the current literature on proton therapy for pancreatic cancer and discuss scenarios wherein the improvement in the therapeutic index with protons may have the potential to change the management paradigm for this malignancy. | Romaine C Nichols Soon Huh Zuofeng Li Michael Rutenberg | 2015 | World Journal of Gastrointestinal Oncology2015，7，9： | 1 |
| 18 | A machine learning approach to co reference resolution of nounphrase 显示文摘 | SOON W M NG H T LIM C Y | 2001 | Computational Linguistics2001，27，4： | 1 |
| 19 | Studies on the stubilitiesof red pepper oleoresin 显示文摘 | SOON K C HEE L G SENL B J | 1987 | Pharm Sci1987，16，3： | 1 |
| 20 | Antioxidant activity and free radical scavenging capacity between Korean medicine plants and flavonoids by assay-guided comparison显示文摘 | CHANG W C SEI C K SOON S H | 2002 | Plant Scie2002，163，6： | 1 |
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