|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Propolis from Thailand:antimicrobial,antiproliferative and cytotoxic activities显示文摘 | Supawadee U Songchan P Chanpen C | 2005 | The American Journal of Chinese Medicine2005，37，9： | 1 |
| 2 | Glocalization pursuit support vector machine 显示文摘 | XUE Hui CIIEN Songchan | | Neural computing and applications0，20，7： | 1 |
| 3 | Effect of hysterectomy on conserved ovarian function 显示文摘 | Ahn Eun Hee BaiSangWook SongChan Ho | 2002 | Yonsei Med J2002，43，1： | 1 |
| 4 | Structure and evolution of the Himalaya-Tibet orogenic belt 显示文摘 | Allegre C J Courtillot V Tapponnier L Him A Mattauer M Coulon C Jaeger J J Achache J Scharer U Marcoux J Burg J L Girardeau J Armijo R Gariepy C Gopel C Li Tindong Xiao Xuchang Chang Chenfa Li Guangqin Lin Baoyu Teng Jiwen Wang Naiwen Chert Guoming Hart Tonglin Wang Xibin Den Wanming Sheng Huaibin Cao Yougong Zhou Ji Qiu Hongrong Bao Peisheng Wang Songchan Wang Bixiang Zhou Yaoxiu RonghuaXu | 1984 | Nature1984，307，5946： | 1 |
| 5 | In vitro cytotoxicity of Indonesian stingless bee products against human cancer cell lines显示文摘Objective:To screen crude extracts of propolis,bee pollen and honey from four stingless bee species[Trigona incisa(T.incisa)],Timia apicalis,Trigona fuso-baltata and Trigona filscibasis)native to East Kalimantan.Indonesia for cytotoxic activity against five human cancer cell lines(HepG2,SW620,ChaGo-1,KATO-Ⅲand BT474).Methods:All samples were extracted with methanol,and then subpartitioned with n-hexane and ethyl acetate.Each crude extract was screened at 20μg/mL for in vitro cytotoxicity against the cell lines using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay.Tn addition,four previously shown bioactive components from propolis(apigenin,cafieic acid phenyl ester,kaempferol and naringenin)and two chemotherapeutic drugs(doxorubicin and 5-fluorouracil)were used to evaluate the sensitivity of the cell lines.Results:Overall,crude extracts from propolis and honey had higher cytotoxic activities than bee pollen,but the activity was dependent upon the extraction solvent,bee species and cell line.Propolis extracts from T.incisa and Tarda apicalis showed the highest and lowest cytotoxic activity,respectively.Only the HepG2 cell line was broadly sensitive to the honey extracts.For pure compounds,doxorubicin was the most cytotoxic,the four propolis compounds the least,but the ChaGo-I cell line was sensitive to kaempferol at 10μg/mL and KATO-Ⅲwas sensitive to kaempferol and apigenin at 10μg/mL,.All pure compounds were effective against the BT474 cell line.Conclusions:Propolis from f,incisa and Trigona fusco-balteata contain an in vitro cytotoxic activity against human cancer cell lines.Further study is required,including the isolation and characterization of the active antiproliferative agent(s). | Paula M.Kustiawan Songchan Puthong Enos T.Arung Chanpen Chanchao | 2014 | Asian Pacific Journal of Tropical Biomedicine2014，4，7： | 1 |
| 6 | Development of a monocional antibody-based enzyme-linked immunosorbent assay for detection of the furaltadone metabolite,AMOZ,in fortified shrimp samples 显示文摘 | Umaporn Pimpitak Songchan Putong Kittinan Komolpis | 2009 | J Food Chemistry2009，116，3： | 1 |
| 7 | Development of a monoclonal antibody-based enzyme-linked immunosorbent assay for detection of the furaltadone metabolite,AMOZ,in fortified shrimp samples显示文摘 | Umaporn P Songchan P Kittinan K | | 0，，： | 1 |
| 8 | α-Mangostin and apigenin induced the necrotic death of BT474 breast cancer cells with autophagy and inflammation显示文摘Objective: To find new compounds in order to overcome the mainstay of metastatic breast cancer due to the adverse side effects from, and increasing resistance to, current chemotherapeutic agents. Methods: 毩-Mangostin and apigenin were reported in comparison to doxorubicin, a chemotherapeutic drug. Ductal carcinoma(BT474) cell line and nontumorigenic epithelial tissue from mammary gland(MCF-10 A) were used. Cell viability assessment was calculated by the standard 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide method. Cell morphology was investigated by light microscopy. By flow cytometry analysis, programmed cell death was observed using annexin observed using propidium iodide st桋 and propidium iodide staining while cell-cycle arrest wasaining. Change in transcriptional expression was evaluated by real-time quantitative reverse transcription PCR. Results: In 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, the result revealed and apigenin were more cytotoxic to BT474 cells. Longer exposure times to 毩-mangostin enin caused more floating cells and a lower density of adhered cells wi毩-mangostin and apigth more vacuoles present in the colonies in BT474 only. 毩-Mangostin and apigenin caused necrosis in BT474 cells in a 24 h exposure, but a small amount of early apoptotic cells could also be detected at 24, 48 and 72 h exposure, whereas doxorubicin caused early apoptosis to BT474 cells at 24 h. Transcript expression and activity analysis supported caspase-3 was involved in the death of BT474 cells treated by all compounds. Moreover, 毩-mangostin and apigenin arrested the cellcycle at the G1-phase, but at the G2/M-phase by doxorubicin. All three compounds induced a change in transcript expression levels of inflammation-associated, proto-oncogene, autophagyassociated and apoptosis-associated genes. Conclusions: ntial new sources of chemotherapeuti毩-Mangostin and apigenin are worth investigating as potec agents for breast cancer treatment. | Teeranai Ittiudomrak Songchan Puthong Tanapat Palaga Sittiruk Roytrakul Chanpen Chanchao | 2018 | Asian Pacific Journal of Tropical Biomedicine2018，8，11： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员