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| 1 | NAFLD fibrosis score:A prognostic predictor for mortality and liver complications among NAFLD patients显示文摘AIM:To study whether the severity of liver fibrosis estimated by the nonalcoholic fatty liver disease(NAFLD) fibrosis score can predict all-cause mortality,cardiac complications,and/or liver complications of patients with NAFLD over long-term follow-up.METHODS:A cohort of well-characterized patients with NAFLD diagnosed during the period of 1980-2000 was identified through the Rochester Epidemiology Project.The NAFLD fibrosis score(NFS) was used to separate NAFLD patients with and without advanced liver fibrosis.We used the NFS score to classify the probability of fibrosis as <-1.5 for low probability,>-1.5 to < 0.67 for intermediate probability,and > 0.67 for high probability.Primary endpoints included allcause death and cardiovascular-and/or liver-related mortality.From the 479 patients with NAFLD assessed,302 patients(63%) greater than 18 years old were included.All patients were followed,and medical charts were reviewed until August 31,2009 or the date when the first primary endpoint occurred.By using a standardized case record form,we recorded a detailed history and physical examination and the use of statins and metformin during the follow-up period.RESULTS:A total of 302/479(63%) NAFLD patients(mean age:47 ± 13 year) were included with a followup period of 12.0 ± 3.9 year.A low probability of advanced fibrosis(NFS <-1.5 at baseline) was found in 181 patients(60%),while an intermediate or high probability of advanced fibrosis(NSF >-1.5) was found in 121 patients(40%).At the end of the follow-up period,55 patients(18%) developed primary endpoints.A total of 39 patients(13%) died during the follow-up.The leading causes of death were non-hepatic malignancy(n = 13/39;33.3%),coronary heart disease(CHD)(n = 8/39;20.5%),and liver-related mortality(n = 5/39;12.8%).Thirty patients had new-onset CHD,whereas 8 of 30 patients(27%) died from CHD-related causes during the follow-up.In a multivariate analysis,a higher NFS at baseline and the presence of new-onset CHD were significantly predictive of death(OR = 2.6 and 9.2,respectively;P < 0.0001).Our study showed a significant,graded relationship between the NFS,as classified into 3 subgroups(low,intermediate and high probability of liver fibrosis),and the occurrence of primary endpoints.The use of metformin or simvastatin for at least 3 mo during the follow-up was associated with fewer deaths in patients with NAFLD(OR = 0.2 and 0.03,respectively;P < 0.05).Additionally,the rate of annual NFS change in patients with an intermediate or high probability of advanced liver fibrosis was significantly lower than those patients with a low probability of advanced liver fibrosis(0.06 vs 0.09,P = 0.004).The annual NFS change in patients who died was significantly higher than those in patients who survived(0.14 vs 0.07,P = 0.03).At the end of the follow-up,we classified the patients into 3 subgroups according to the progression pattern of liver fibrosis by comparing the NFS at baseline to the NFS at the end of the followup period.Most patients were in the stable-fibrosis(60%) and progressive-fibrosis(37%) groups,whereas only 3% were in the regressive fibrosis.CONCLUSION:A higher NAFLD fibrosis score at baseline and a new onset of CHD were significantly predictive of death in patients with NAFLD. | Sombat Treeprasertsuk Einar Bjrnsson Felicity Enders Sompongse Suwanwalaikorn Keith D Lindor | 2013 | World Journal of Gastroenterology2013，19，8： | 13 |
| 2 | Effect of cryoprotectants and reducing reagent on the stability of actomyosin during ice storage显示文摘 | SOMPONGSE E ITOH Y OBATAKE A | 1996 | Fish Sci1996，62，： | 1 |
| 3 | Effect of cryoprotectants and a reducing reagent on the stability of actomyosin during iced storage显示文摘 | Sompongse W Itoh Y Obatake A | 1996 | Fishes Science1996，62，1： | 1 |
| 4 | Multi-country study on the prevalence and clinical features of peripheral arterial disease in asian type 2 diabetes patients at high risk of atherosclerosis显示文摘 | Sang Youl Rhee Heng Guan Zhi Min Liu Stephen Wing-Keung Cheng Sarwono Waspadji Patricio Palmes Tong Yuan Tai Sompongse Suwanwalaikorn Young Seol Kim | 2006 | Diabetes Research and Clinical Practice2006，，： | 1 |
| 5 | Effect of cryoprotectants and a reducing reagent on the stability of actomyosin during ice storage显示文摘 | Sompongse W Itoh Y Obatake A | 1996 | Fisheries Science1996，62，1： | 1 |
| 6 | Effect of cryoprotectants and reducing reagent the stability of actomyesin during ice storage显示文摘 | SOMPONGSE E ITOH Y OBATAKE A | 1996 | Fisheries Science1996，62，： | 1 |
| 7 | Effect of cryoprotectants and a reducing reagent on the stability of actomyosin during ice storage显示文摘 | Sompongse W hob Y Obatake A | 1996 | Fisheries Science1996，62，1： | 1 |
| 8 | Effect of cryoprotectants and a reducing reagent on the stability of actomyosin during ice storage显示文摘 | Sompongse W hoh Y Obatake A | 1996 | Fisheries Science1996，62，1： | 1 |
| 9 | Effect of cryoprotectants and a reducing reagent on the stability of actomyosin during ice storage显示文摘 | Sompongse W Itoh Y Obatake A | 1996 | Fisheries Science1996，62，1： | 1 |
| 10 | Effect of cryoprotectant anda reducing reagent on the stability of actomyosin during ice storage显示文摘 | SOMPONGSE W ITOH Y OBATAKE A | 1996 | Fisheries Science1996，62，1： | 1 |
| 11 | Vitamin D inadequacy in postmenopausal women in Eastern Asia 显示文摘 | Lim SK Kung AW Sompongse S | 2008 | Curr Med Res Opin2008，24，1： | 1 |
| 12 | Effect of cryoprotectants and a reducing reagent on the stability of actomyosin during ice storage显示文摘 | SOMPONGSE W ITOH Y OBATAKE A | 1996 | Fisheries Science1996，62，1： | 1 |
| 13 | Effect of cryoprotectants and a reducing reagent on the stability of actomyosin during ice storage 显示文摘 | Sompongse W Itoh Y Obatake A | 1996 | Fisheries Science1996，62，1： | 1 |
| 14 | Effect of cryoprotectants and a reducing reagent on the stability of actomyosin during ice storage 显示文摘 | Sompongse W Itoh Y Obatake A | 1996 | Fisheries Science1996，62，1： | 1 |
| 15 | Effect of cryoprotectants and a reducing reagent on the stability of actomyosin during iced storage显示文摘 | Sompongse W Itoh Y Ohatake A | 1996 | Fisheries Science1996，62，1： | 1 |
| 16 | Effect of cryoprotectants and a reducing reagent on the stability of actomyosin during ice storage显示文摘 | Sompongse W | 1996 | Fisheries Science1996，62，1： | 1 |
| 17 | Effect of cryolarotectants and a reducing reagent on the stability of actomyosin during ice storage 显示文摘 | Sompongse W | 1996 | Fisheries Science1996，62，1： | 1 |
| 18 | Effect of cryoprotectants anda reducing reagent on the stability of actomyosin during ice storage显示文摘 | SOMPONGSE W ITOH Y OBATAKE A | 1996 | Fisheries Science1996，62，1： | 1 |
| 19 | Effect of cryoprotectants and a reducing reagent on the stability of actomyosin during ice storage显示文摘 | Sompongse W Itoh Y Obatake A | 1996 | Fisheries Science1996，62，1： | 1 |
| 20 | Effect of cryoprotectants and a reducing reagent on the stability of actomyosin during ice storage 显示文摘 | Sompongse W Itoh Y Obatake A | 1996 | Fishes Science1996，62，1： | 1 |
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