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| 1 | OTOTOXIC EFFECTS OF CARBOPLATIN IN ORGANOTYPIC CULTURES IN CHINCHILLAS AND RATS | DING Dalian JIANG Haiyan FU Yong Richard SALVI Shinichi SOMEYA Masaru TANOKURA | 2012 | Journal of Otology2012，7，2： | 14 |
| 2 | Detection of apoptosis by RT-PCR array in mefloquine-induced cochlear damage显示文摘Objective To investigate the occurrence and possible mechanisms of apoptosis in cochlear epithelium and spiral ganglion neurons after mefloquine treatment. Methods We used quantitative RT-PCR apoptosis-focused gene arrays (96-well, 84 apoptosis related genes) to assess changes of gene expression in the cochlear basilar membrane (hair cells-supporting cells) and spiral ganglion neurons of rat cochlear organotypic cultures treated with 100 μM mefloquine for 3 h. Results Significant up-or down-regulation in gene expression was detected in 23 genes in the cochlear basilar membrane, and in 32 genes in the spiral ganglion neurons compared with time-matched controls. The responding genes could be classified as pro-or anti-apoptotic, and were mainly implicated in the Bcl-2, Caspase, Card, IAP, TNF ligand/TNF receptor, Death domain/Death effector domain, DNA damage/p53, and NF-kappa B families. Synthetic analysis suggested that these families could be revised to two major pathways mainly involved in the death receptor-mediated signaling pathway and apoptotic mitochondrial pathway. In addition, it was found that numerous anti-apoptotic genes such as Bcl2a1, Birc1b, Birc3, Birc4, Bnip1, Cflar, Il10, Lhx4, Mcl1, Nfkb1, Prlr, Prok2, and TNF were greatly up-regulated in the cochlear tissue, which might imply the co-existence of protective response in the cells at the early stage of mefloquine-induced damage. | DING Da-lian Someya Shinichi JIANG Hai-yan QI Wei-dong YU Dong-zhen | 2011 | Journal of Otology2011，6，1： | 9 |
| 3 | OTOTOXIC MODEL OF OXALIPLATIN AND PROTECTION FROM NICOTINAMIDE ADENINE DINUCLEOTIDE显示文摘Oxaliplatin,an anticancer drug commonly used to treat colorectal cancer and other tumors,has a number of serious side effects,most notably neuropathy and ototoxicity.To gain insights into its ototoxic profile,oxaliplatin was applied to rat cochlear organ cultures.Consistent with it neurotoxic propensity,oxaliplatin selectively damaged nerve fibers at a very low dose 1μM.In contrast,the dose required to damage hair cells and spiral ganglion neurons was 50 fold higher(50μM).Oxailiplatin-induced cochlear lesions initially increased with dose,but unexpectedly decreased at very high doses.This non-linear dose response could be related to depressed oxaliplatin uptake via active transport mechanisms.Previous studies have demonstrated that axonal degeneration involves biologically active processes which can be greatly attenuated by nicotinamide adenine dinucleotide(NAD+).To determine if NAD+would protect spiral ganglion axons and the hair cells from oxaliplatin damage,cochlear cultures were treated with oxaliplatin alone at doses of 10μM or 50μM respectively as controls or combined with 20 mM NAD+.Treatment with 10μM oxaliplatin for 48 hours resulted in minor damage to auditory nerve fibers,but spared cochlear hair cells.However,when cochlear cultures were treated with 10μM oxaliplatin plus 20 mM NAD+,most auditory nerve fibers were intact.50μM oxaliplatin destroyed most of spiral ganglion neurons and cochlear hair cells with apoptotic characteristics of cell fragmentations.However,50μM oxaliplatin plus 20 mM NAD+treatment greatly reduced neuronal degenerations and hair cell missing.The results suggested that NAD+provides significant protection against oxaliplatin-induced neurotoxicity and ototoxicity,which may be due to its actions of antioxidant,antiapoptosis,and energy supply. | DING Dalian JIANG Haiyan FU Yong LI Yongqi Richard Salvi Shinichi Someya Masaru Tanokura | 2013 | Journal of Otology2013，8，1： | 9 |
| 4 | Identification of advanced spin-driven thermoelectric materials via interpretable machine learning显示文摘Machine learning is becoming a valuable tool for scientific discovery.Particularly attractive is the application of machine learning methods to the field of materials development,which enables innovations by discovering new and better functional materials.To apply machine learning to actual materials development,close collaboration between scientists and machine learning tools is necessary.However,such collaboration has been so far impeded by the black box nature of many machine learning algorithms.It is often difficult for scientists to interpret the data-driven models from the viewpoint of material science and physics.Here,we demonstrate the development of spin-driven thermoelectric materials with anomalous Nernst effect by using an interpretable machine learning method called factorized asymptotic Bayesian inference hierarchical mixture of experts(FAB/HMEs).Based on prior knowledge of material science and physics,we were able to extract from the interpretable machine learning some surprising correlations and new knowledge about spin-driven thermoelectric materials.Guided by this,we carried out an actual material synthesis that led to the identification of a novel spin-driven thermoelectric material.This material shows the largest thermopower to date. | Yuma Iwasaki Ryohto Sawada Valentin Stanev Masahiko Ishida Akihiro Kirihara Yasutomo Omori Hiroko Someya Ichiro Takeuchi Eiji Saitoh Shinichi Yorozu | 2019 | npj Computational Materials2019，，1： | 7 |
| 5 | Survival of pathogenic bacteria in compost with special reference to Escherichia coli显示文摘Application of compost in agricultural practice could potentially cause contamination of foodstuffs with pathogenic bacteria such as Escherichia coli O157: H7 ( E. Coli O157). We investigated pathogenic bacteria in compost collected from the compost facilities, and evaluated the survival of E. coli K12 and O157 in laboratory experiments. Out of 19 compost product samples, coliform bacteria and salmonella were detected in 7 and 3 samples respectively. The number of coliform bacteria was 1.8 × 102 to 2.5 × 106 CFU/g dw and that of salmonella was 4.2 × 101 to 6.0 × 103 CFU/g dw. Moreover, coliform bacteria, fecal coliform, E. coli and salmonella were detected during composting at 54℃ to 67℃. The results indicated that moisture content was a very important factor to the heat sensitivity of pathogenic bacteria in compost, E. coli in compost of high moisture content was more sensitive than that in compost of low moisture content, cells harvested in logarithmic phase was more sensitive than these in stationary phase, and E. coli K12 was more sensitive than E. coli O157. Based on the D values, the lethal time of E. coli K12 and O157 from 108 to 100 CFU/g dw were 16.3 and 28.8 min, respectively, at 60℃ in compost with 40% moisture content. However, some E. coli cells survived in composting process at 54℃ to 67℃. Water potential (low moisture content) and physiological aspects of bacteria (stationary phase) could explain only in part of the prolonged survival of E. coli in compost, and there should be some other factors that are conducive to bacterial survival in compost. | GONG Chun-ming Koichi Inoue Shunji Inanaga Takashi Someya | 2005 | Journal of Environmental Sciences2005，17，5： | 7 |
| 6 | Occurrence of emerging flame retardants from e-waste recycling activities in the northern part of Vietnam显示文摘This study investigated the contamination status of 21 emerging flame retardants(FRs)in soils(n=32)and river sediments(n=8)from an e-waste recycling(EWR)site in the northern part of Vietnam.Among analyzed FRs,higher levels of decabromodiphenyl ethane(DBDPE)(NDe4200 ng/g dw),1,2-bis-(2,4,6-tribromophenoxy)ethane(BTBPE)(NDe350 ng/g dw)and Dechlorane Plus isomers(DPs)(NDe65 ng/g dw)were found in soils near EWR workshops and open burning places.The highest concentrations of DBDPE(20 ng/g dw),BTBPE(5.7 ng/g dw)and DPs(6.7 ng/g dw)were also detected in sediments collected from the middle of the EWR site.The levels decreased concomitantly with increasing distance from the EWR site.These results indicate that these FRs were released to the surrounding environment from improper recycling activities,such as manual dismantling of devices and open burning of e-wastes.Moreover,the estimated daily intakes of those FRs via soil ingestion were approximately ten times higher for children than adults.To our knowledge,this is a first comprehensive study on characterization of soil and sediment contamination by a series of emerging FRs at an EWR site in Vietnam. | Masayuki Someya Go Suzuki Alin C.Ionas Nguyen Minh Tue Fuchao Xu Hidenori Matsukami Adrian Covaci Le Huu Tuyen Pham Hung Viet Shin Takahashi Shinsuke Tanabe Hidetaka Takigami | 2016 | Emerging Contaminants2016，2，2： | 5 |
| 7 | Current concepts in age-related hearing loss: Epidemiology and mechanistic pathways显示文摘 | Tatsuya Yamasoba Frank R. Lin Shinichi Someya Akinori Kashio Takashi Sakamoto Kenji Kondo | 2013 | Hearing Research2013，，： | 2 |
| 8 | Com- parative study of catching compositions in five Japanese persimmons (Diospyroskaki) 显示文摘 | Takuya Suzuki Shinichi Someya Fangyu Hu etal | 2005 | Food Chemistry2005，93，： | 1 |
| 9 | Evaluation of the effects of peptide antibiotics human 显示文摘 | Niyonsaba F Someya A Hirata M | 2001 | Eur J Immunol2001，31，4： | 1 |
| 10 | Mitochondrial oxidative damage andapoptosis in age - related hearing loss 显示文摘 | Someya S Prolla TA | 2010 | Mech AgeingDev2010，131，： | 1 |
| 11 | Brain-derived neurotrophic factor suppresses anoikis-indueed death of Schwaan cells显示文摘 | Koda M Someya Y Nishio Y | 2008 | Neu- rosci Lett2008，444，2： | 1 |
| 12 | Influence of bacteria i- solated from rice plants and rhizospheres on antibiotic production by the antagonistic bacterium Serratia marcescens strain B2显示文摘 | Someya N Nakajima M Watanabe K | 2003 | J Gen Plant Pathol2003，69，5： | 1 |
| 13 | Synergistic antifun?gal activity of chitina-lytic enzymes and prodigiosin produced by biocontrol bacterium, Serratia marcescens strain B2 against gray mold pathogen, Botrytis cinerea显示文摘 | Someya N Nakajima M Hirayae K | 2001 | Journal of General Plant Pathology2001，67，4： | 1 |
| 14 | Ability to repair DNA double-strand breaks related to cancer susceptibility and radiosensitivity显示文摘 | Sakata K Someya M Matsumoto Y | 2007 | Radiat Med2007，25，9： | 1 |
| 15 | Phase relationships and equations of state for FeS at high pressures and temperatures and implications for the internal structure of mars 显示文摘 | Urakawa S Someya K Terasak H | 2004 | Physics of the Earth and Planetary Interiors2004，143，15： | 1 |
| 16 | Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis 显示文摘 | Someya S Xu J Kondo K | 2009 | Proc Natl Acad Sci U S A2009，106，19： | 1 |
| 17 | Thymosin beta 4is associated with RUNX2expression through the Smad and Akt signaling pathways in mouse dental epithelial cells显示文摘 | Someya H Fujiwara H Nagata K | 2015 | Int J Mol Med2015，35，5： | 1 |
| 18 | The effects of a 5-hydroxytryptamine 1A receptor gene polymorphism on the clinical response to fluvoxamine in depressed patients显示文摘 | Suzuki Y Sawamura K Someya T | 2004 | Pharmacogenomics J2004，4，： | 1 |
| 19 | Randomized, controlled trial of natural interferon-α therapy for e-antigen-positive chronic hepatitis B patients显示文摘 | Yasuji Arase Akihito Tsubota Satoshi Saitoh Yoshiyuki Suzuki Masahiro Kobayashi Fumitaka Suzuki Takashi Someya Norio Akuta Kenji Ikeda Mariko Kobayashi Hiromitsu Kumada | 2002 | Hepatology Research2002，，2： | 1 |
| 20 | Application of millimeter waves to measure blood sugar level显示文摘 | Nikawa Y Someya D | 2001 | P~ of APM2001，3，3： | 1 |
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