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| 1 | Hematopoietic stem cell-derived adipocytes and fibroblasts in the tumor microenvironment显示文摘The tumor microenvironment(TME) is complex and constantly evolving. This is due, in part, to the crosstalk between tumor cells and the multiple cell types that comprise the TME, which results in a heterogeneous population of tumor cells and TME cells. This review will focus on two stromal cell types, the cancerassociated adipocyte(CAA) and the cancer-associated fibroblast(CAF). In the clinic, the presence of CAAs and CAFs in the TME translates to poor prognosis in multiple tumor types. CAAs and CAFs have an activated phenotype and produce growth factors, inflammatory factors, cytokines, chemokines, extracellular matrix components, and proteases in an accelerated and aberrant fashion. Through this activated state, CAAs and CAFs remodel the TME, thereby driving all aspects of tumor progression, including tumor growth and survival, chemoresistance, tumor vascularization, tumor invasion, and tumor cell metastasis. Similarities in the tumorpromoting functions of CAAs and CAFs suggest that a multipronged therapeutic approach may be necessary to achieve maximal impact on disease. While CAAs and CAFs are thought to arise from tissues adjacent to the tumor, multiple alternative origins for CAAs and CAFs have recently been identified. Recent studies from our lab and others suggest that the hematopoietic stem cell, through the myeloid lineage, may serve as a progenitor for CAAs and CAFs. We hypothesize that the multiple origins of CAAs and CAFs may contribute to the heterogeneity seen in the TME. Thus, a better understanding of the origin of CAAs and CAFs, how this origin impacts their functions in the TME, and thetemporal participation of uniquely originating TME cells may lead to novel or improved anti-tumor therapeutics. | Ying Xiong Lindsay T Mc Donald Dayvia L Russell Ryan R Kelly Katie R Wilson Meenal Mehrotra Adam C Soloff Amanda C LaRue | 2015 | World Journal of Stem Cells2015，7，2： | 6 |
| 2 | Enemy at the gates: dendritic cells and immunity to mucosal pathogens显示文摘树枝状的房间(DC ) 是用作在天生、适应的免疫之间的一座必要的桥的多样、专业化的造血的房间。DC 在淋巴的所有和 nonlymphoid 机关存在并且在到在包括 mucosal 纸巾的上皮的表面的感染的第一个应答者之中。肺,内脏,和阴道 mucosa 显示的 DC 反映各独特的织物的不同显型和功能并且与他们在怒气和淋巴节点的对应物相对照,常常暴露于他们的环境的有害、良性的因素。Mucosal DC 认出并且通过模式识别的约会回答受体,和激活的 DC 移居到排干淋巴节点导致适应有免疫力的回答到病原体。DC 的专业化函数在 mucosa 帮助免疫和病原体控制的正式就职。如此的专门化包括有势力到病毒的 nucleic 酸,到在内脏腔的俘获有机体的 mucosal DC 的能力,到从另外的感染的房间的跨礼品的抗原的 DC 的能力,和开始 IgA 班在 B 房间切换的 mucosal DC 的能力的 plasmacytoid DC 的抗病毒的干扰素反应。DC 粘性在对 mucosal 病原体的有免疫力的反应也是批评的,当 DC 能对微型环境作出回应并且在附近的上皮的房间察觉到导致病原体的应力。最后, DC 通过串音与对方一起交往支持抗原表示和 T 房间免疫。一起,为对病原体的定制的有免疫力的回答的正式就职的这些过程条件 mucosal DC。 | Adam C Soloff | 2010 | Cell Research2010，20，8： | 4 |
| 3 | Protection of mice and poultry from lethal H5N1 avian influenza virus through adenovirus-based immunization显示文摘 | Gao W Soloff AC Lu X | | 0，，4： | 2 |
| 4 | Protection of mice and poultry from lethal H5N1 avian influenza virus through adenovirus-based immunization 显示文摘 | Gao Wen-tao Soloff A Lu Xiu-hua | 2006 | Virology2006，80，： | 1 |
| 5 | Proliferation of DUI45 prostate cancer cells is inhibited by suppressing IGFBP-2 显示文摘 | Chatterjee S Park ES Soloff MS | 2004 | Int J Urol2004，11，10： | 1 |
| 6 | Stress and hippocampal abnormalities in psychiatric disorder显示文摘 | Sala M Perez J Soloff P | | 0，，5： | 1 |
| 7 | Cultured Chi- nese hamster cells undergo apoptosis after exposure to cold but nonfreezing temperatures显示文摘 | NAGLE W A SOLOFF B L MOSS AJ | 1990 | Cryobiology1990，27，4： | 1 |
| 8 | Incidence of significant coronary artery disease in rheumatic valvular heart disease显示文摘 | Coleman EH Soloff LA | 1970 | The American Journal of Cardiology1970，25，4： | 1 |
| 9 | Stress and hippocampal abnormali? ties in psychiatric disorders显示文摘 | SALA M PEREZ J SOLOFF P | 2004 | Eur Neuropsycho- pharmacol2004，14，5： | 1 |
| 10 | Protection of mice and poultry from lethal HSNI avian influenza virus through adenovirus-based immunization 显示文摘 | Gao W Soloff AC Lu X | 2006 | J Virol2006，80，4： | 1 |
| 11 | Stress and hippocampal abnormalities in psychiatric disorders显示文摘 | M. Sala J. Perez P. Soloff S. Ucelli di Nemi E. Caverzasi J.C. Soares P. Brambilla | 2004 | European Neuropsychopharmacology2004，，5： | 1 |
| 12 | Stress and hippocampal abnormalities in psychiatric disorders 显示文摘 | Sala M Perez J Soloff P | 2004 | Eur Neuropsychopharmacol2004，14，： | 1 |
| 13 | Effects of a SARS-associated coronavirus vaccine in monkeys显示文摘 | Gao W Tamin A Soloff A | 2003 | Lancet2003，362，9399： | 1 |
| 14 | Effect of a SARS-associated coronavirus vaccine in monkeys显示文摘 | Gao W Tamin A Soloff A | 2003 | Lancet2003，362，9399： | 1 |
| 15 | Effects of a SARS-associated coronavirus vaccine in monkeys 显示文摘 | Gao W Tamin A Soloff A | 2003 | Lancet2003，362，9399： | 1 |
| 16 | Stress and hippocampal ab-norm alities in psychiatric disorders 显示文摘 | Sala M Perez J Soloff P | 2004 | Eur Neuropsy- chopharm a-co 12004，14，5： | 1 |
| 17 | Effect of a SARS-associated coronavirus vaccine in monkeys显示文摘 | Gao WT Tamin A Soloff A | 2003 | Lancet2003，362，： | 1 |
| 18 | Effects of a SARS - associated coronavirus vaccine in monkeys 显示文摘 | GAO W TAMIN A SOLOFF A | 2003 | Lancet2003，362，9399： | 1 |
| 19 | Oxytocin receptors:triggers for parturition and lactation-显示文摘 | Soloff MS Alexandrova M Fernstrom MJ | 1979 | Science1979，204，4399： | 1 |
| 20 | Perspectives on Epidermal Growth Factor Receptor Regulation in Triple-Negative Breast Cancer:Ligand-Mediated Mechanisms of Receptor Regulation and Potential for Clinical Targeting显示文摘 | Williams CB Soloff AC Ethier SP | 2015 | Adv Cancer Res2015，127，： | 1 |
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