|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Expression of matrix metalloproteinases 2 and 9 in human gastric cancer and superficial gastritis显示文摘AIM:To assess expression of matrix metalloproteinases 2(MMP2)and MMP9 in gastric cancer,superficial gastritis and normal mucosa,and to measure metalloproteinase activity.METHODS:MMP2 and MMP9 mRNA expression was determined by quantitative real-time polymerase chain reaction.Normalization was carried out using three different factors.Proteins were analyzed by quantitative gelatin zymography(qGZ).RESULTS:18S ribosomal RNA(18SRNA)was very highly expressed,while hypoxanthine ribosyltransferase-1(HPRT-1)was moderately expressed.MMP2 was highly expressed,while MMP9 was not detected or lowly expressed in normal tissues,moderately or highly expressed in gastritis and highly expressed in cancer.Relative expression of 18SRNA and HPRT-1 showed no significant differences.Significant differences in MMP2 and MMP9 were found between cancer and normal tissue,but not between gastritis and normal tissue.Absolute quantification of MMP9 echoed this pattern,but differential expression of MMP2 proved conflictive.Analysis by qGZ indicated significant differences between cancer and normal tissue in MMP-2,total MMP-9,250 and 110 kDa bands.CONCLUSION:MMP9 expression is enhanced in gastric cancer compared to normal mucosa;interpretation of differential expression of MMP2 is difficult to establish. | Clara Luz Sampieri Sol de la Pea Mariana Ochoa-Lara Roberto Zenteno-Cuevas Kenneth León-Córdoba | 2010 | World Journal of Gastroenterology2010，16，12： | 46 |
| 2 | Predictors of dehydration and acute renal failure in patients with diverting loop ileostomy creation after colorectal surgery显示文摘BACKGROUND Despite the potential benefits of fecal diversion after low pelvic anastomosis in colorectal surgery, diverting loop ileostomy construction is related to significant rates of complications. AIM To determine potential predictors of high output related complications in patients with diverting loop ileostomy creation after colorectal surgery. METHODS Patients who underwent open and laparoscopic colorectal surgery requiring a diverting loop ileostomy from January 2010 to March 2018 were retrospectively analyzed. We included patients older than 18 years, who underwent colorectal surgery with primary low pelvic anastomosis, and with the creation of a diverting loop ileostomy, at elective or emergency settings for the treatment of benign or malignant conditions. Univariate and multivariate logistic regression analysis was used to determine the effect of the potential predictors on the rate of high output related complications. The high output related complications were dehydration and acute renal failure that required visits to the emergency department and hospitalizations. RESULTS Of the 102 patients included in the study, 23.5%(n = 24) suffered high output related complications. In this group of patients at least one visit to the emergency department (mean 1.6), and at least one readmission to the hospital was needed. The factors associated with high-output ileostomy, in the univariate analysis, were: urgent surgical intervention (OR = 2.6;P = 0.047), the development of postoperative complications (OR = 3;P = 0.024), have ulcerative colitis (OR = 4.8;P = 0.017), use of steroids (OR = 4.3;P = 0.010), mean output at discharge greater than 1000 mL/24 h (OR = 3.2;P = 0.016), and use of loperamide at discharge (OR = 2.8;P = 0.032). Multivariate logistic regression analysis identified two independent risk factors for high output related complications: ulcerative colitis [OR = 7.6 (95%CI: 1.81-31.95);P = 0.006], and ileostomy output at discharge ≥ 1000 mL/24 h [OR = 3.3 (1.18-9.37);P = 0.023]. CONCLUSION In our study, patients with ulcerative colitis and those with an ileostomy output above 1000 mL/24 h at discharge, were at increased risk of high output related complications. | Omar Vergara-Fernández Mario Trejo-Avila Oscar Santes Danilo Solórzano-Vicu?a Noel Salgado-Nesme | 2019 | World Journal of Clinical Cases2019，7，14： | 2 |
| 3 | Catalysts for electrochemical ammonia oxidation:Trend,challenge,and promise显示文摘Developing sustainable and clean energy technology is critial to address the current energy and environmental crisis.As an energy carrier,hydrogen has been getting attention due to its abundance,high energy density,and zero carbon emission.Due to the difficulty of hydrogen storage and transport,the electro-oxidation of ammonia shows great potential for renewable energy since it satisfies both energy supply and environmental protection as a carbon-free fuel with high hydrogen content.However,ammonia electro-oxidation is a sluggish reaction and shows low durability.Understanding the complicated mechanism and intermediates is conducive to developing efficient electrocatalysts with high catalytic activity and durability.This review begins with the ammonia oxidation technologies and their principles.The two typical mechanisms for ammonia electro-oxidation,Oswin-Salomon mechanism and Gerischer-Mauerer mechanism,are discussed,and attention to the poisoning species is included.Then,the electrocatalysts for ammonia reaction are classified into Pt-based catalysts and non-noble metal-based catalysts,and their performances are reviewed with various strategies.Based on the progress on the electrochemical ammonia oxidation catalysts,the challenges and future insight on ammonia oxidation reaction are discussed and proposed. | Sol A Lee Mi Gyoung Lee Ho Won Jang | 2022 | Science China Materials2022，65，12： | 2 |
| 4 | Embryo- growth rate and duration in sunflower as affected by tem- perature显示文摘 | CHIMENTI C A Hall A J SOL LOAPEZ M | 2001 | Field Crops Research2001，69，： | 1 |
| 5 | Fungal infections after lung transplantation显示文摘 | Solé A Salavert M | | 0，，： | 1 |
| 6 | C677T polymorphism of the methylentetrahydrofolate reductase gene in mothers of children affected with neural tube defects显示文摘 | Morales M A Méndez K Solís E | 2015 | Investigacion clinica2015，56，3： | 1 |
| 7 | Laparoscopic cholecystectomy for acute cholecystitis显示文摘 | Cirocchi R Del Sol A Morelli U | 2008 | G Chir2008，29，67： | 1 |
| 8 | Risk factors for progression of atheroscleresis measml at multiple sites in the arterial tree: the Rotterdam Study 显示文摘 | Van der Meer IM Iglesias del Sol A Hak AE | 2003 | Stroke2003，34，： | 1 |
| 9 | Heavy metal accumulation in plants and soil irrigated with wastewater from mexico city显示文摘 | MIRELES A SOLS C ANDRADE E | 2004 | Nuclear Instruments and Methods in Physics Research2004，，6： | 1 |
| 10 | Effects of chronic acarbose treatment on adipocyte insulin responsiveness, serum levels of leptin and adiponectin and hypothalamic NPY expression in obese diabetic Wistar rats显示文摘 | Perez C Fern a ndez-Agull o T De Sol i s AJ | 2008 | Clin Exp Pharmacol Physiol2008，35，3： | 1 |
| 11 | Transcriptome responses toRalstonia solanacearuminfection in the roots of the wild potato Solanumcom-mersonii显示文摘 | ZULUAGA A P SOLM LU H B | 2015 | BMC Genomics2015，，16： | 1 |
| 12 | Multiplexed Biosensing Diagnostic Platforms Detecting Autoantibodies to Tumor-Associated Antigens from Exosomes Released by CRC Cells and Tissue Samples Showed High Diagnostic Ability for Colorectal Cancer显示文摘Colorectal cancer(CRC)is the second leading cause of cancer-related death worldwide.The five-year survival rate of CRC patients depends on the stage at diagnosis,being higher than 80%when CRC is diagnosed in the early stages but lower than 10%when CRC is diagnosed in advanced stages.Autoantibodies against specific CRC autoantigens(tumor-associated antigens(TAAs))in the sera of patients have been widely demonstrated to aid in early diagnosis.Thus,we herein aim to identify autoantigens target of autoantibodies specific to CRC that possess a significant ability to discriminate between CRC patients and healthy individuals by means of liquid biopsy.To that end,we examined the protein content of the exosomes released by five CRC cell lines and tissue samples from CRC patients by means of immunoprecipitation coupled with mass spectrometry analysis.A total of 103 proteins were identified as potential autoantigens specific to CRC.After bioinformatics and meta-analysis,we selected 15 proteins that are more likely to be actual CRC autoantigens in order to evaluate their role in CRC prognosis by Western blot(WB)and immunohistochemistry(IHC).We found dysregulation at the protein level for 11 of these proteins in both tissue and plasma exosome samples from patients,along with an association of nine of these proteins with CRC prognosis.After validation,all but one showed a statistically significant high diagnostic ability to distinguish CRC patients and individuals with premalignant lesions from healthy individuals,either by luminescence Halotag-based beads,or by a multiplexed biosensing platform involving the use of magnetic microcarriers as solid support modified with covalently immobilized Halotag fusion proteins constructed for CRC detection.Taken together,our results highlight the usefulness of the approach defined here to identify the TAAs specific to chronic diseases;they also demonstrate that the measurement of autoantibody levels in plasma against the TAAs identified here could be integrated into a point-of-care(POC)device for CRC detection with high diagnostic ability. | Ana Montero-Calle Itziar Aranguren-Abeigon María Garranzo-Asensio Carmen Poves María Jesús Fernández-Aceñero Javier Martínez-Useros Rodrigo Sanz Jana Dziaková Javier Rodriguez-Cobos Guillermo Solís-Fernández Eloy Povedano Maria Gamella Rebeca Magnolia Torrente-Rodríguez Miren Alonso-Navarro Vivian de los Ríos J.Ignacio Casal Gemma Domínguez Ana Guzman-Aranguez Alberto Peláez-García JoséManuel Pingarrón Susana Campuzano Rodrigo Barderas | 2021 | Engineering2021，7，10： | 1 |
| 13 | Rapid and simple method for purification of nucleic acids显示文摘 | Boom R C J A Sol M M M Salimans | 1990 | Journal of Clinical Microbiology1990，28，： | 1 |
| 14 | Carotid plaques in crease the risk of stroke and subtypes of cerebral infarction in a symptomatic elderly: the Rotterdam study 显示文摘 | Hollander M Bots ML Del Sol A 1 | 2002 | Circulation2002，105，24： | 1 |
| 15 | Microbial decolouration of azo dyes:A review显示文摘 | Solís M Solís A Perez H I | 2012 | Process Biochemistry2012，47，： | 1 |
| 16 | Substrate specificity of brain hexokinase显示文摘 | Sols A Crane RK | | 0，，02： | 1 |
| 17 | Successful Treatment of Severe Gastrointestinal Bleeding Secondary to Crohn Disease with Recombinant Factor VIIa显示文摘 | Eva Girona Joaquín Borrás-Blasco Venancio Conesa-García Andrés Navarro-Ruiz Javier Solís Mariana Fe García-Sepulcre Israel Oliver-García | 2007 | Southern Medical Journal2007，，6： | 1 |
| 18 | Rapid and simple methods for purification ofnucleic acid 显示文摘 | Boom R Sol C J A Salimans M M M | 1990 | J Clin Microbiol1990，28，： | 1 |
| 19 | Topology of small-world networks of protein-protein complex structures显示文摘 | del Sol A Fujihashi H O'Meara P | 2005 | Bioinformatics2005，21，8： | 1 |
| 20 | Bronchus-associated lym-phoid tissue lymphoma and mycobacterium tuberculosis infec-tion:an Unusual Case and a Review of the Literature显示文摘 | Klein T O Sol B A Issel B F | | 0，，06： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员