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| 1 | Cancer stem cells in Helicobacter pylori infection and aging: Implications for gastric carcinogenesis显示文摘AIM: To demonstrated the combined effects of aging and carcinogen treatment on cancer stem/stem-like cells(CSCs) of gastric mucosa in an animal model. METHODS: In this study we investigated the effects of aging and Helicobacter pylori(H. pylori) inflammation as a model for inflammation induced carcinogenesis in human and rat gastric mucosa samples. In aging studies, we compared 4-mo old(young) with 22 mo(aged) old Fischer-344 rats. For human studies, gastric biop-sies and resection specimens representing normal mucosa or different stages of H. pylori gastritis and gastric adenocarcinomas were used for determining the expression of stem cell markers CD166, ALDH1 and LGR5. In addition we performed immunofluorescent double labeling for B-catenin and Lgr5 in both rat and human gastric tissues to examine the status of Wnt signaling in these cells. RESULTS: CSC markers ALDH1, LGR5, and CD166 were expressed in very low levels in normal human gastric mucosa or young rat gastric mucosa. In contrast, level of expression for all three markers significantly increased in H. pylori gastritis and gastric adenocarcinomas as well as in normal gastric mucosa in aged rats. We also observed cytoplasmic B-catenin staining in both aged rat and human H. pylori inflamed gastric mucosa, which were found to be colocalized with Lgr5 immunoreactive cells. The increased number of ALDH1, CD166 and LGR5 positive cells in H. pylori gastritis indicates that increased number of stem-like cells in gastric mucosa is an early event, and may constitute an important step in the progression to neoplasia. CONCLUSION: Our observation of the age-related increase in cancer stem/stem-like cells in the gastric mucosa may explain the increased incidence of gastric cancer during aging. Combination of aging and H. pylori infection may have additive effects in progression to neoplasia. | Edi Levi Paula Sochacki Nabiha Khoury Bhaumik B Patel Adhip PN Majumdar | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，3： | 5 |
| 2 | Nonunion of distal femoral fractures : a systematic review 显示文摘 | Ebraheim NA Martin A Sochacki KR | 2013 | Orthop Surg2013，5，1： | 1 |
| 3 | Absorbing boundary conditions and surface waves显示文摘 | Sochacki J Kubichek R George J | 1987 | Geophys ics1987，52，1： | 1 |
| 4 | Nonunion of distal femoral fractures: a systematic review显示文摘 | Ebraheim NA Martin A Sochacki KR | 2013 | Orthop Surg2013，5，1： | 1 |
| 5 | Factors influencing micropropagatJon of Narcissus显示文摘 | Sochacki D e] al | 2005 | Acta Hort(ISHS)2005，673，： | 1 |
| 6 | Absorbing boundary conditions and surface waveg显示文摘 | Sochacki J Kubichek R George J | 1987 | Geophysics1987，52，1： | 1 |
| 7 | Gronwall' s inequality and the Henstock integral 显示文摘 | OSTASZEWSKI K SOCHACKI J | 1987 | Journal of Mathematical Analysis and Applications1987，128，2： | 1 |
| 8 | The obtaining of narcissus plants free from potyviruses via adventitious shoot regeneration in vitro from infected bulbs显示文摘 | Sochacki D Orlikowska T | 2005 | Scientia horticulturae2005，103，2： | 1 |
| 9 | Detection of Narcissus latent virus isolates using one - tep RT - PCR Assay 显示文摘 | Berniak H Komorowska B Sochacki D | 2013 | Journal of Horticul- tural Research2013，21，1： | 1 |
| 10 | Measurement and prediction of biomass and carbon content of Pinus pinaster trees in farm forestry plantations,south-western Australia显示文摘 | Ritson P Sochacki S | 2003 | Forest Ecology and Managemere2003，175，： | 1 |
| 11 | The obtaining of narcissus plants free from potyviruses via adventitious shoot regeneration in vitro from infected bulbs显示文摘 | Sochacki D Orlikowska T | 2005 | Scientia Horticulturae2005，103，2： | 1 |
| 12 | Factors Influencing Micropmpagation of Narcissus显示文摘 | Sochacki D Orlikowska T | 2005 | Acts Hort2005，673，： | 1 |
| 13 | Locking Plate Fixation of Periprosthetic Femur Fractures with and without Cerclage Wires显示文摘 | Nabil A Ebraheim Kyle R Sochacki Xiaochen Liu Adam G Hirschfeld Jiayong Liu | 2013 | Orthopaedic Surgery2013，，3： | 1 |
| 14 | Effects of hypoxia on differentiation from human placenta-derived mesenchymal stem cells to nucleus pulposus-like cells 显示文摘 | NI L L SOCHACKI K R | 2014 | Spine J2014，14，10： | 1 |
| 15 | Annular-aperture logarithmic axicon显示文摘 | Sochacki J Jaroszewicz Z Staronski L | 1993 | J Opt Soc Am A1993，10，8： | 1 |
| 16 | Apodized Annular-aperture Logarithmic Axicon: Smoothness and Uniformity of Intensity Distributions 显示文摘 | JAROSZEWICZ Z SOCHACKI J KOLODZIEJCZYK A | 1993 | Opt Lett1993，18，： | 1 |
| 17 | Absorbing boundary conditions and surface waves显示文摘 | Sochacki J Kubichek R George J | 1987 | Geophysics1987，52，1： | 1 |
| 18 | Influence of annealing on reverse current of 4H-SiC Schottky diodes显示文摘 | SOCHACKI M SZMIDT J BAKOWSKI M | 2002 | Diamond and Related Materials2002，11，36： | 1 |
| 19 | Nonunion of distal femoral fractures:a systematic review显示文摘 | Ebraheim NA Martin A Sochacki KR | 2013 | Orthop Surg2013，5，1： | 1 |
| 20 | Polishing of synthetic electroplating wastewater in microcosm upflow constructed wetlands : effect of operating conditions 显示文摘 | Sochacki A Surmacz-G6rska J Faure O | 2014 | Chemical Engineering Journal2014，237，： | 1 |
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