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| 1 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 2 | Chronic kidney disease after nephrectomy in patients with renal cortical tumours: a retrospective cohort study显示文摘 | William C Huang Andrew S Levey Angel M Serio Mark Snyder Andrew J Vickers Ganesh V Raj Peter T Scardino Paul Russo | 2006 | Lancet Oncology2006，，9： | 4 |
| 3 | Haploid Induction via In vitro Gynogenesis in Tomato(Solanum lycopersicum L.)显示文摘In order to determine the potential for haploid induction via in vitro gynogenesis in tomato, the ovules and protoplasts of embryo sacs from the hybrids Zhongza 101 and Zhongza 105 were cultured. An efficient method of ovule isolation was established in this study. Using this method, 100-150 ovules could be isolated from one ovary. Isolated ovules were cultured on three induction media to induce gynogenesis in vitro. During culture, ovules were enlarged markedly, with opaque white color. When observed microscopically, there were cell divisions and cell clumps in embryo sacs. Subsequently, the cell clumps in embryo sacs ceased growth, likely because the integument grew faster than embryo sacs did and hindered the further development of embryo sacs. Therefore, subsequent callus morphogenesis might be originated from the integument. Thousands of calli from the two tomato varieties were obtained. Five diploid plants were regenerated after 15 months of subculturing. To eliminate the hindering effect of integument on embryo sac cells, the protoplasts of embryo sacs were prepared and cultured. After 48 hours of culture, the protoplasts of embryo sacs doubled in size and gradually formed clusters of cells. These results suggested that gynogenesis might be a potential way for haploid induction in tomato. | ZHAO He WANG Xiao-xuan DU Yong-chen ZHU De-wei GUO Yan-mei GAO Jian-chang LI Fei John C Snyder | 2014 | Journal of Integrative Agriculture2014，13，10： | 3 |
| 4 | Very early pregnancy detection with endovaginal ultrasound显示文摘 | Snyder JR Watson C | 1988 | Obstet Gynecol1988，72，： | 1 |
| 5 | The burden of illness of cancer:economic cost and quality of life显示文摘 | Brown M L Lipscomb J Snyder C | 2001 | Annu Rev Public Health2001，22，： | 1 |
| 6 | The design of systems to control actively periodic sound transmission into enclosed spaces, Part II: Mechanisms and trends显示文摘 | Snyder S D Hansen C H | 1994 | J Sound and Vibration1994，170，4： | 1 |
| 7 | Multipotential neural precursors can differentiate toward replacement of neurons undergoing targeted apoptotic degeneration in adult mouse neocortex显示文摘 | Snyder EY Yoon C Flax JD | 1997 | PNAS1997，94，11： | 1 |
| 8 | Research management team(RMT) : A model for research support -services at Duke Univelity显示文摘 | Snyder D C Epps S Berestbrd H F el al | 2012 | Clinical and Translational Science2012，5，6： | 1 |
| 9 | Tribology of water and oil repellent sol-gel coatings for optical applications显示文摘 | KESSMAN A HUCKABY D SNYDER C | 2009 | Wear2009，267，1： | 1 |
| 10 | Species identity dominates the relationship between predator biodiversity and herbivore suppression显示文摘 | Straub C S Snyder W E | 2006 | Ecology2006，87，2： | 1 |
| 11 | Physiological changes in male competitive cyclists after two weeks of intensified training显示文摘 | JEUKENDRUP A E HESSELINK MKC SNYDER A C | 1992 | Int J Sports Med1992，13，： | 1 |
| 12 | Thermoelectric microdevice fabricated by a MEMS-like electrochemical process 显示文摘 | Snyder G J Lira J R Huang C K | 2003 | Nature Materials & Design2003，2，5： | 1 |
| 13 | Toxicity and Repellency of Hot Pepper Extracts to Spider Mite显示文摘 | ANTONIOUS G F MEYER J E SNYDER J C | 2006 | Journal of Environmental Science and Health-part B Pesticides Food Contaminants and Agricultural Wastes2006，41，8： | 1 |
| 14 | Potential errors in measuring nitrogen content of soils low in nitrogen显示文摘 | Wang D Snyder M C Bormann F H | 1993 | Soil Science Society of America Journal1993，57，6： | 1 |
| 15 | Broadband receiver response from dual-streamer data and applications in deep reflection seismology显示文摘 | Singh S C Hobbs R W Snyder D B | | 0，，01： | 1 |
| 16 | Excuses:their effective role in the negotiation of reality显示文摘 | Snyder C R Higgins R L | | 0，，01： | 1 |
| 17 | Dispositional forgiveness of self, others, and situations 显示文摘 | Thompson L Y Snyder C Hoffman L | 2005 | Journal of Personality2005，73，2： | 1 |
| 18 | Hole of Bcl - 2 family members inanoxia induced cell death 显示文摘 | ShroffEH Snyder C ChandelNS | 2007 | CellCycle2007，6，7： | 1 |
| 19 | Hopeful choices: A school counselorg guide to hope theory显示文摘 | Snyder C R Feldman D Shorey H Rand K | 2002 | Journal of Personality2002，5，5： | 1 |
| 20 | Assimilation of simulated Doppler radar obser-ations with an ensemble Kalman filter显示文摘 | Snyder C F Zhang | 2003 | Mon Wea Rev2003，131，： | 1 |
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