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| 1 | Arthroscopic treatment options for irreparable rotator cuff tears of the shoulder显示文摘The management of patients with irreparable rotator cuff tears remains a challenge for orthopaedic surgeons with the final treatment option in many algorithms being either a reverse shoulder arthroplasty or a tendon transfer. The long term results of these procedures are however still widely debated, especially in younger patients. A variety of arthroscopic treatment options have been proposed for patients with an irreparable rotator cuff tear without the presence of arthritis of the glenohumeral joint. These include a simple debridement with or without a biceps tenotomy, partial rotator cuff repair with or without an interval slide, tuberplasty, graft interposition of the rotator cuff, suprascapular nerve ablation, superior capsule reconstruction and insertion of a biodegradable spacer(Inspace) to depress the humeral head. These options should be considered as part of the treatment algorithm in patients with an irreparable rotator cuff and could be used as either as an interim procedure, delaying the need for more invasive surgery in the physiologically young and active, or as potential definitive procedures in the medically unfit.The aim of this review is to highlight and summarise arthroscopic procedures and the results thereof currently utilised in the management of these challenging patients. | Cameron M Anley Samuel KL Chan Martyn Snow | 2014 | World Journal of Orthopedics2014，5，5： | 8 |
| 2 | Three-dimensional perfused human in vitro model of nonalcoholic fatty liver disease显示文摘AIM To develop a human in vitro model of non-alcoholic fatty liver disease(NAFLD), utilising primary hepatocytes cultured in a three-dimensional(3D) perfused platform. METHODS Fat and lean culture media were developed to directly investigate the effects of fat loading on primary hepatocytes cultured in a 3D perfused culture system. Oil Red O staining was used to measure fat loading in the hepatocytes and the consumption of free fatty acids(FFA) from culture medium was monitored. Hepatic functions, gene expression profiles and adipokine release were compared for cells cultured in fat and lean conditions. To determine if fat loading in the system could be modulated hepatocytes were treated with known anti-steatotic compounds. RESULTS Hepatocytes cultured in fat medium were found to accumulate three times more fat than lean cells and fat uptake was continuous over a 14-d culture. Fat loading of hepatocytes did not cause any hepatotoxicity and significantly increased albumin production. Numerous adipokines were expressed by fatty cells and genes associated with NAFLD and liver disease were upregulated including: Insulin-like growth factorbinding protein 1, fatty acid-binding protein 3 and CYP7A1. The metabolic activity of hepatocytes cultured in fatty conditions was found to be impaired and the activities of CYP3A4 and CYP2C9 were significantlyreduced, similar to observations made in NAFLD patients. The utility of the model for drug screening was demonstrated by measuring the effects of known antisteatotic compounds. Hepatocytes, cultured under fatty conditions and treated with metformin, had a reduced cellular fat content compared to untreated controls and consumed less FFA from cell culture medium.CONCLUSION The 3D in vitro NAFLD model recapitulates many features of clinical NAFLD and is an ideal tool for analysing the efficacy of anti-steatotic compounds. | Tomasz Kostrzewski Terri Cornforth Sophie A Snow Larissa Ouro-Gnao Cliff Rowe Emma M Large David J Hughes | 2017 | World Journal of Gastroenterology2017，23，2： | 6 |
| 3 | Pharmacologic management of acute attacks of migraine and prevention of migraine headache显示文摘 | Vincenza Snow Kevin Weiss eric M Wall | 2002 | Ann Intern Med2002，137，： | 1 |
| 4 | Nanofabrication with proximal probes显示文摘 | Campbell Paul M Perkins F Keith | 1997 | Proceedings of the IEEE1997，85，4： | 1 |
| 5 | Commercialization of transgenic plants potential ecological risks显示文摘 | SNOW A A PEDRO M P | 1997 | Bioscience1997，47，： | 1 |
| 6 | Tetraploid mouse embryos produced by cytochalasin B during cleavage 显示文摘 | SNOW M H L | 1973 | Nature1973，244，： | 1 |
| 7 | Phytase effects on amino acid digestibility in molted laying hens显示文摘 | Snow J L M W Douglas | 2003 | Poult Sci2003，82，： | 1 |
| 8 | Phytase, Citric Acid and 1α- Hydroxycholecalciferol Improve Phytate Phosphorus Utilization in Chicks Feed Corn-soybean Meal Diet 显示文摘 | Snow J Baker D H Parsons C M | 2004 | Pouh Sci2004，83，： | 1 |
| 9 | Moderate exercise during growth in prepuber-tal boys:changes in bone mass, size volumetric density and bone strength:a controlled prospective study显示文摘 | Fuchs RK Snow CM Bradney M et al | 1998 | Bone Miner Res1998，13，： | 1 |
| 10 | The size of lymph nodes in the neck on sonograms as a radiologic cri- terion for metastasis: how reliable is it? 显示文摘 | van den Brekel M Castelijns JA Snow GB | 1998 | AJNR Am J Neuroradiol1998，19，4： | 1 |
| 11 | Experiments on phyllotaxis I:the effect of isolating a primordium显示文摘 | Snow M Snow R | 1931 | Philosophical Transactions of the Royal Society London1931，221，： | 1 |
| 12 | Arsenic and heavy metal contamination of vegetables grown in Samta village,Bangladesh显示文摘 | Alam M G Snow E T Tanaka A | 2003 | Science of the Total Environment2003，308，13： | 1 |
| 13 | Long-term persistence of crop alleles in weedy populations of wild radish (Raphanus raphanistrum) 显示文摘 | Snow AA Culley TM Campbell LGP Sweeney M Hegde SG Ellstrand NC | 2010 | New Phytol2010，186，： | 1 |
| 14 | Expression Kinetics of interferon and interferon-induced genes in Atlan- tic salmon ( Salmo salar ) following infection with infectious pancreatic necrosis virus and infectious salmon anaemia vi- rus 显示文摘 | Mc Beath A J Snow M Secombes C J | 2007 | Fish Shellfish Immunol2007，22，3： | 1 |
| 15 | Toxicity and carcinogenicity of nickel compounds显示文摘 | Coogan T P Latta D M Snow E T | 1989 | CRC Critical Rev Toxicaol1989，19，4： | 1 |
| 16 | Single-wall carbon nanotube atomic force microscope probes显示文摘 | SNOW E S CAMPBELL P M NOVAK J P | 2002 | Appl Phy Lett2002，80，11： | 1 |
| 17 | A new method for building protein conformations from sequence alignments with homologues of known structure显示文摘 | HAVEL T F SNOW M E | 1991 | J Mol Biol1991，217，： | 1 |
| 18 | Posterior arthroscopic capsular release in frozen shoulder显示文摘 | Snow M Boutros I Funk L | 2009 | Arthroscopy2009，25，1： | 1 |
| 19 | Lipid control in the management of type 2 diabetes mellitus: a clinical practice guideline from the American College of Physicians显示文摘 | Snow V Weiss KB LeFevre M | 2004 | Ann Intern Med2004，140，8： | 1 |
| 20 | The kinetics and mechanism of scanned probe oxidation of Si显示文摘 | SNOW E S JERNIGAH G G CAMPBELL P M | 2000 | Appl Phys Lett2000，76，13： | 1 |
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