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| 1 | Effects of alkaline-electrolyzed and hydrogen-rich water,in a high-fat-diet nonalcoholic fatty liver disease mouse model显示文摘AIM To identify the effect of hydrogen-rich water(HRW) and electrolyzed-alkaline water(EAW) on high-fat-induced non-alcoholic fatty acid disease in mice.METHODS Mice were divided into four groups:(1) Regular diet(RD)/regular water(RW);(2) high-fat diet(HFD)/RW;(3) RD/EAW; and(4) HFD/EAW. Weight and body composition were measured. After twelve weeks, animals were sacrificed, and livers were processed for histology and reverse-transcriptase polymerase chain reaction. A similar experiment was performed using HRW to determine the influence and importance of molecular hydrogen(H2) in EAW. Finally, we compared the response of hepatocytes isolated from mice drinking HRW or RW to palmitate overload.RESULTS EAW had several properties important to the study:(1) pH = 11;(2) oxidation-reduction potential of-495 mV; and(3) H2 = 0.2 mg/L. However, in contrast to other studies, there were no differences between the groups drinking EAW or RW in either the RD or HFD groups. We hypothesized that the null result was due to low H2 concentrations. Therefore, we evaluated the effects of RW and low and high HRW concentrations(L-HRW = 0.3 mg H2/L and H-HRW = 0.8 mg H2/L, respectively) in mice fed an HFD. Compared to RW and L-HRW, H-HRW resulted in a lower increase in fat mass(46% vs 61%), an increase in lean body mass(42% vs 28%), and a decrease in hepatic lipid accumulation(P < 0.01). Lastly, exposure of hepatocytes isolated from mice drinking H-HRW to palmitate overload demonstrated a protective effect from H2 by reducing hepatocyte lipid accumulation in comparison to mice drinking regular water.CONCLUSION H2 is the therapeutic agent in electrolyzed-alkaline water and attenuates HFD-induced nonalcoholic fatty liver disease in mice. | Karen Jackson Noa Dressler Rotem S Ben-Shushan Ari Meerson Tyler W LeBaron Snait Tamir | 2018 | World Journal of Gastroenterology2018，24，45： | 9 |
| 2 | Estrogen-like Activity ot Glabrene and other Constituents Isolated from Llicorice Roots显示文摘 | Snait Tamira Mark Eizenberg | 2001 | Journal of Steroid Biochemistry & Molecular Biology2001，7，： | 1 |
| 3 | Chalcones as potent tyrosinase inhibitors: the importance of a 2,4-substituted resorcinol moiety显示文摘 | Soliman Khatib Ohad Nerya Ramadan Musa Maayan Shmuel Snait Tamir Jacob Vaya | 2004 | Bioorganic & Medicinal Chemistry2004，，2： | 1 |
| 4 | Estrogen- like Activity of Glabene and other Constituents Isolated from Llicoricc Root显示文摘 | Snait Tatnira Mark Eizcnberg | 2001 | Journal of Steroid Biochemistry & Molecular Biology2001，78，： | 1 |
| 5 | Endothelial Dysfunction Is Reversible in Helicobacter Pylori -Positive Subjects显示文摘 | Arnon Blum Snait Tamir Keren Mualem Rotem Shelly Ben-Shushan Lital Keinan-Boker Maya Paritsky | 2011 | The American Journal of Medicine2011，，12： | 1 |
| 6 | Inhibition of serotonin re-uptake by licorice constituents显示文摘 | Rivka O Snait T Soliman K | 2003 | J Mol Neurosci2003，20，： | 1 |
| 7 | Estrogenic and antiproliferative properties of glabridin from licorice in human breast cancer cells显示文摘 | Snait T Mark E Dalia S | 2000 | Cancer Res2000，60，20： | 1 |
| 8 | Estrogen-like activity of glabrene and other constituents isolated from locrice root 显示文摘 | SNAIT TAMIRA MARK EIZENBERG | 2001 | Journal of Steroid Biochemistry & molecular Biology2001，18，： | 1 |
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