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| 1 | Handgrip strength and health outcomes: Umbrella review of systematic reviews with meta-analyses of observational studies显示文摘Purpose:The aim of the present study was to assess both the credibility and strength of evidence arising from systematic reviews with meta-analyses of observational studies on handgrip strength and health outcomes.Methods:An umbrella review of systematic reviews with meta-analyses of observational studies was conducted.We assessed meta-analyses of observational studies based on random-effect summary effect sizes and their p values,95%prediction intervals,heterogeneity,small-study effects,and excess significance.We graded the evidence from convincing(Class I)to weak(Class IV).Results:From 504 articles returned in a search of the literature,8 systematic reviews were included in our review,with a total of 11 outcomes.Overall,nine of the 11 of the outcomes reported nominally significant summary results(p<0.05),with 4 associations surviving the application of the more stringent p value(p<106).No outcome presented convincing evidence.Three associations showed Class II evidence(i.e.,highly suggestive):(1)higher handgrip values at baseline were associated with a minor reduction in mortality risk in the general population(n=34 studies;sample size=1,855,817;relative risk=0.72,95%confidence interval(95%CI):0.670.78),(2)cardiovascular death risk in mixed populations(n=15 studies;relative risk=0.84,95%CI:0.780.91),and(3)incidence of disability(n=7 studies;relative risk=0.76,95%CI:0.660.87).Conclusion:The present results show that handgrip strength is a useful indicator for general health status and specifically for early all-cause and cardiovascular mortality,as well as disability.To further inform intervention strategies,future research is now required to fully understand mechanisms linking handgrip strength scores to these health outcomes. | Pinar Soysal Christopher Hurst Jacopo Demurtas Joseph Firth Reuben Howden Lin Yang Mark A.Tully Ai Koyanagi Petre Cristian Ilie Guillermo F.Lopez-Sanchez Lukas Schwingshackl Nicola Veronese Lee Smith | 2021 | Journal of Sport and Health Science2021，10，3： | 5 |
| 2 | An initial evaluation of gellangum as a material for tissue engineering applications 显示文摘 | Smith AM Shelton RM Perrie Y ’ et ai | 2007 | Journal of Bio-materials Applications2007，22，： | 1 |
| 3 | Resveratrol and neurodegen?erative diseases: activation of SIRTI as the potential pathway towards neuroprotection显示文摘 | Pallas M Casadesas G Smith MA et aI | 2009 | Curr Neurovasc Res2009，6，： | 1 |
| 4 | Identification of the 49-kDa autoantigen associated with lymphocytic hypophysitis as alpha-enolase显示文摘 | O′dwyer DT Smith AI Matthew ML | 2002 | J Clin Endocrinol Metab2002，87，2： | 1 |
| 5 | Degradation of cyanobacteria toxin by advanced oxidation processes显示文摘 | AI Momani F Smith D W Gamal El-Din M | 2008 | Journal of Hazardous Materials2008，150，2： | 1 |
| 6 | Comparison of thyrotropin-releasing hormone(TRH),naloxone,and dexamethasone treatments in experimental spinal cord injury显示文摘 | Jacobs TP Smith MT | 1983 | Neurology1983，33，3： | 1 |
| 7 | ACC/AHA/SCA 2005 guideline update for percutaneous coronary intervention;a report of the American College of Cardiology/American Heart Association Task Force on Practice Guideline(ACC/AHA/SCA I Writing Committee to Update the 2001 Guideline for Percutaneous Coronary lntervention)显示文摘 | Sidney C Smith SC Jr Ted E el aI | 2006 | J Am CoU Cardiol2006，47，： | 1 |
| 8 | PTEN inhibits insulinstimulated MEK/MAPK activation and cell growth by blocking in human breast ancer显示文摘 | Weng LP Smith WM Brown JL et aI | 2002 | Oncogene2002，39，12： | 1 |
| 9 | Isoflurane minimum alvelor concentration reduction by fentanyl 显示文摘 | McEwan AI Amaes FC Smith C | 1993 | Anesthesiology1993，78，5： | 1 |
| 10 | Impact of oestradiol and inhibin A concentrations on pregnancy rate in in-vitro oocyte maturation显示文摘 | Mikkelson AI Smith S Lindenberg S | 2000 | Hum Reprod2000，15，： | 1 |
| 11 | The interaction of fentanyl on the CP50 of propofol for loss of consciousness and skin incision显示文摘 | Smith C McEwan AI Jhareri R | 1994 | Anesthesiology1994，81，： | 1 |
| 12 | Palliative use of aminocaproic acid to control upper gastrointestinal bleeding显示文摘 | Roberts SB Ooyne PJ Smith TJ et aI | 2010 | J Pain Symptom Manage2010，40，3： | 1 |
| 13 | Definitive neuroradio- logical diagnostic feature of tuberculous meningitis in children 显示文摘 | Andronikon S Smith B Hatherhill M et ai | 2004 | Pediatr Radio12004，34，11： | 1 |
| 14 | The interaction of fentanyl on the Cp50 of propofol for loss of consciousness and skin incision显示文摘 | Smith C McEwan AI Jhaveri R | 1994 | Anesthesiology1994，81，： | 1 |
| 15 | The potential distribution of bioenergy crops in Europe under present and future climate显示文摘 | Tuck G Glendining M J Smith P et aI | 2006 | Biomass and Bioenergy2006，，： | 1 |
| 16 | The ever-t evolving role of mTOH in translation显示文摘 | Fonseca BD Smith EM Yelle N et ai | 2014 | Semin Cell Dev Biol2014，36，： | 1 |
| 17 | The interaction of fentanyl on the Cp50 of propofol for loss of consciousness and skin incision显示文摘 | Smith C McEwan AI Jhaveri R | 1994 | Anesthesiology1994，81，： | 1 |
| 18 | The fate of virulent and attenuated Mycobacteria in Guinea pigs infected by the respiratoryroute 显示文摘 | Alsaadi AI Smith DW | 1973 | Am Rev Respir Dis1973，107，6： | 1 |
| 19 | Circulating adiponectin levels are reduced in nonobese but insulin-resistant first-degree relatives of type 2 diabetic patients显示文摘 | PellmeF Smith U Funahashi T et aI | 2003 | Diabetes2003，52，5： | 1 |
| 20 | Development of a scanning near-field optical probe for localised Raman显示文摘 | D Smith S Webster M Ayed | 1995 | Ultramicroscopy1995，61，： | 1 |
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