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| 1 | Radiofrequency ablation for early oesophageal squamous neoplasia:Outcomes form United Kingdom registry显示文摘AIM:To report outcomes on patients undergoing radiofrequency ablation(RFA)for early oesophageal squamous neoplasia from a National Registry.METHODS:A Prospective cohort study from 8 tertiary referral centres in the United Kingdom.Patients with squamous high grade dysplasia(HGD)and early squamous cell carcinoma(ESCC)confined to the mucosa were treated.Visible lesions were removed by endoscopic mucosal resection(EMR)before RFA.Following initial RFA treatment,patients were followed up 3monthly.Residual flat dysplasia was treated with RFA until complete reversal dysplasia(CR-D)was achieved or progression to invasive Squamous cell cancer defined as infiltration into the submucosa layer or beyond.The main outcome measures were CR-D at 12 mo from start of treatment,long term durability,progression to cancer and adverse events.RESULTS:Twenty patients with squamous HGD/ESCC completed treatment protocol.Five patients(25%)had EMR before starting RFA treatment.CR-D was 50%at12 mo with a median of 1 RFA treatment,mean 1.5(range 1-3).Two further patients achieved CR-D with repeat RFA after this time.Eighty per cent with CR-D remain dysplasia free at latest biopsy,with median follow up 24 mo(IQR 17-54).Six of 20 patients(30%)progressed to invasive cancer at 1 year.Four patients(20%)required endoscopic dilatations for symptomatic structuring after treatment.Two of these patients have required serial dilatations thereafter for symptomatic dysphagia with a median of 4 dilatations per patient.The other 2 patients required only a single dilatation to achieve an adequate symptomatic response.One patient developed cancer during follow up after end of treatment protocol.CONCLUSION:The role of RFA in these patients re-mains unclear.In our series 50%patients responded at12 mo.These figures are lower than limited published data. | Rehan J Haidry Mohammed A Butt Jason Dunn Matthew Banks Abhinav Gupta Howard Smart Pradeep Bhandari Lesley Ann Smith Robert Willert Grant Fullarton Morris John Massimo Di Pietro Ian Penman Marco Novelli Laurence B Lovat | 2013 | World Journal of Gastroenterology2013，19，36： | 7 |
| 2 | GDF11 modulates NGN3+ islet progenitor cell number and promotes beta-cell differentiation in pancreas development显示文摘 | Harmon E B Apelqvist A A Smart N G | 2004 | Development2004，131，24： | 1 |
| 3 | Stress sensitivity of low-permeability sandstones from the rotliegendes sandstone显示文摘 | Farquhar R A Smart B G D and Todd A C | 1993 | SPE265011993，，： | 1 |
| 4 | How single-sensor seismic improved image of Kuwait's Minagish Field显示文摘 | Shabrawi A Smart A Anderson B | 2005 | First Break2005，23，1： | 1 |
| 5 | A Critical Evaluation of Ontology Languages for Geographical Information Retrieval on the Internet显示文摘 | Alia I A Smart P D Jones C B | 2005 | Journal of Visual Languages and Computing2005，16，： | 1 |
| 6 | Electrochemical behavior of layered sol- id solution Li2MnO3-LiMO2 ( M = Ni, Mn, Co) Li-ion cathode with and without alumina coatings 显示文摘 | West W C Soler J Smart M C Ratnakumar B V Fir- dosy S Ravi V Anderson M S Hrbacek J Lee E S Manthiram A | 2011 | Journal of the Electrochemical Society2011，158，8： | 1 |
| 7 | Gel polymer electrolyte lithium-ion cells with improved low temperature performance显示文摘 | Smart M C Ratnakumar B V Behar A | 2007 | Journal of Power Sources2007，165，2： | 1 |
| 8 | Predicting within-family variability in juvenile height growth of Salix based upon similarity among parental AFLP fingerprints 显示文摘 | Kopp R F Smart L B Maynard C A | 2002 | Theor Appl Genet2002，105，： | 1 |
| 9 | The effectof acid digestion technique on the performance of neb-ulisation systems used in inductively coupled plasmaspectrometry 显示文摘 | Zarcinas B A McLaughlin M J Smart M K | 1996 | Communications in Soil Science andPlant Analysis1996，27，58： | 1 |
| 10 | Increased accumulation of cuticular wax and expression of lipid transfer protein in response to periodic drying events in leaves of tree to- bacco显示文摘 | CAMERON K D TEECE M A SMART L B | 2006 | Plant Physiol2006，140，1： | 1 |
| 11 | Predicting within-family variability in juvenile height growth of Salix based upon similarity among parental AFLP fingerprint显示文摘 | Kopp R F Smart L B Maynard C A | 2002 | Theor Appl Genet2002，105，： | 1 |
| 12 | Gel polymer electrolyte lithium-ion cells with improved low temperature performance 显示文摘 | SMART M C RATNAKUMAR B V BEHAR A WHITCANACK L D YU J S ALAGIR M | 2007 | Journal of Power Sources2007，165，： | 1 |
| 13 | The pore dimensions of gramicidin A显示文摘 | SMART O S C OODFELLOW J M WALLACE B A | 1993 | Biophys J1993，65，： | 1 |
| 14 | Two dimensional electron gases induced by spontaneous and piezoelectric polarization in undoped and doped A1GaN/GaN hetero-structures显示文摘 | Ambacher O Foutz B Smart J Shealy J R Weimann N G Chu K Murphy M Sierakowski A J SchaffW J Eastman L F Dimitrov R Mitchell A Stutzmann M | | 0，，01： | 1 |
| 15 | Lithiumbatteries for aerospace applications:2003 Mars ExplorationRover显示文摘 | Ratnakumar B V Smart M C Kindler A | 2003 | J Power Sources2003，，： | 1 |
| 16 | Electrophilic reac- tions of fluorocarbons under the action of aluminum chlo- rofluoride, a potent Lewis acid 显示文摘 | Petrov V A Krespan C G Smart B E | 1996 | Journal of Fluorine Chemistry1996，77，： | 1 |
| 17 | Gel polymer electrolyte lithium-ion cells with improved low temperature performance显示文摘 | SMART M C RATNAKUMAR B V BEHAR A | | 0，，： | 1 |
| 18 | The mycobacte- ricidal efficacy of ortho-phthalaldehyde and the comparative resistances of Mycobacterium bovis, Mycobacterium terrae, and Mycobacterium chelo-nae显示文摘 | GREGORY A W SCHAALJE G B SMART J D | 1999 | Infect Cont Hosp Epidemiol1999，20，5： | 1 |
| 19 | Nasal and sinus endoscopy for medical management of resistant rhinosinusitis, including postsurgical patients 显示文摘 | Tichenor WS Adinoff A Smart B | 2008 | J Allergy Clin Immunol2008，121，4： | 1 |
| 20 | Gel polymer electrolyte lithium-ion cells with improved low temperature performance 显示文摘 | SMART M C RATNAKUMAR B V BEHAR A | 2007 | J Power Sources2007，165，2： | 1 |
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