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| 1 | 儿童心脏移植后的体外膜肺氧合支持:单中心队列研究显示文摘目的体外膜肺氧合(extracorporeal membrane oxygenation,ECMO)用于心脏切开术后低心排患儿,但较少用于心脏移植后。本文总结了心脏移植后接受ECMO支持患儿的预后特点。设计单中心回顾性研究。场所大型儿童心脏转诊中心。对象1995至2016年所有接受心脏移植且插管行ECMO支持的患儿。干预措施主要预后指标为ECMO后12个月的病死率。根据早期移植失败(心脏移植后ECMO≤7 d)和晚期移植失败,分析患儿的特点及与预后的相关性。测量方法和主要结果研究期间共进行了246例心脏移植手术,其中44例患儿进行了50次ECMO。心脏移植至ECMO的中位时间为1 d(0 d~11.7年),其中28例患儿早期移植失败[1(0~2)d],20例晚期移植失败患儿共行22次ECMO[中位时间0.8年(8 d~11.7年)],其中4例患儿之前因早期移植失败亦接受过ECMO支持。26例(59%)患儿存活至出院,24例(55%)患儿ECMO后12个月仍存活,晚期移植失败患儿的存活率较低(40%比67%,P=0.02)。12个月病死率的独立危险因素包括先天性心脏病、较高的肺血管阻力指数别体表面积值(>2.2 Woods U/m^(2))和较高的肌酐值。高群体反应性抗体水平仅与晚期移植失败组12个月病死率有关。结论ECMO可有效地用于抢救心脏移植后移植功能障碍的患儿,但其早期病死率较高。与12个月内病死率相关的因素包括先天性心脏病、肾功能不全、肺血管阻力指数别体表面积值升高;在心脏移植后晚期ECMO支持患儿还包括高HLA致敏性。 | Nair AG Sleeper LA Smoot LB 方伯梁(译) 钱素云(校) | 2021 | 中国小儿急救医学2021，28，2： | 2 |
| 2 | One-year survival fol- lowing early revascularization for cardiogenic shock显示文摘 | Hochman JS Sleeper LA White HD | 2001 | J Am Med Associ2001，285，2： | 1 |
| 3 | Early revascularization inaeute myocardial infarction complicated by cardiogenic shock 显示文摘 | Hoch man JS Sleeper LA Webb JG | 1999 | N Engl J Med1999，341，9： | 1 |
| 4 | Early revascularization in acute myocardial infarction complicated by cardiogeeic shock,SHOCK Investigation,Shoud We Emergently Revascularize Occluded Coronaries for Cardiogenic Shock显示文摘 | Hochman JS Sleeper LA Webb JG | | 0，，09： | 1 |
| 5 | One year surviral following early revascularization for cardiogenic shock 显示文摘 | Hochman JS Sleeper LA White HD | 2001 | JAMA2001，285，： | 1 |
| 6 | Recovery of eehocardio- graphic function in children with idiopathic dilated eardiomyo- pathy;results from the pediatric cardiomyopathy registry显示文摘 | Everitt MD Sleeper LA Lu M | 2014 | J Am Coil Cardiol2014，63，14： | 1 |
| 7 | Evaluation of Kawasaki disease risk-scoring systems for intravenous immunoglobulin resistance 显示文摘 | Sleeper LA Minich LL McCrindle BM | 2011 | J Pediatr2011，158，5： | 1 |
| 8 | The incidence of pediatric cardiomyopathy in two region of the US 显示文摘 | Lipshultz SE Sleeper LA Towbin JA et ol | 2003 | New Engl J M2003，348，： | 1 |
| 9 | Percutaneous coronary intervention for cardiogenic shock in the SHOCK trial registry 显示文摘 | Webb JG Sanborn TA Sleeper LA | 2001 | Am Heart J2001，141，6： | 1 |
| 10 | Challenges in echocardiographic assessment of mitral regurgitation in children after repair of atrioventricular septal defect显示文摘 | Prakash A Lacro RV Sleeper LA | | 0，，02： | 1 |
| 11 | Randomized trial of pulsed corticosteroid therapy for primary treatment of Kawasaki disease显示文摘 | Newburger JW Sleeper LA McCrindle BW | 2007 | N Engl J Med2007，356，7： | 1 |
| 12 | Correlates of one-year survival in patients with cardiogenic shock complicating acute myocardial infarction: angiographic findings from the Shock trial 显示文摘 | Sanborn TA Sleeper LA Webb JG | 2003 | J Am Coil Cardiol2003，42，： | 1 |
| 13 | Trends in cardiogenic shock ; report from the SHOCK study显示文摘 | Canendran L Abboud R Sleeper LA etal | 2001 | Eur Heart J2001，22，： | 1 |
| 14 | Intermediate-termmortality and cardiac transplantation in infants with single-ventricle lesions:risk factors and their interaction with shunttype显示文摘 | Tweddell JS Sleeper LA Ohye RG | 2012 | J Thorac Cardiovasc Surg2012，144，： | 1 |
| 15 | The pediatric cardiomyo- pathy registry :1995 - 2007 显示文摘 | Wilkinson JD Sleeper LA Alvarez JA | 2008 | Prog Pediatr Cardiol2008，25，1： | 1 |
| 16 | Trends in cardiogenic shock; report from the SHOCK study显示文摘 | Carnedran L Abboud R Sleeper LA | 2001 | Eur Heart J2001，22，6： | 1 |
| 17 | Early revas-cularization and long-term survival in cardiogenic shock complicating acute myocardial infarction显示文摘 | Hochman JS Sleeper LA Webb JG | 2006 | JAMA2006，295，21： | 1 |
| 18 | Early revascularization and long-term survival in cardiogenic shock complicating acute myocardial infarction显示文摘 | Hochman JS Sleeper LA webb JG | 2006 | JAMA2006，295，： | 1 |
| 19 | Early revascularization in acute myocardial infaction complicated by cardiogenic shock显示文摘 | Hochman JS Sleeper LA Webb JG etal | 1999 | N Engl Jmed1999，341，9： | 1 |
| 20 | Should we emergently revascularize occluded coronaries for cardiogenie shock:an international randomized trial of emergency PTCA/CABG-trial design 显示文摘 | Hochman JS Sleeper LA Godfrey E | 1999 | Am Heart J1999，137，8： | 1 |
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