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| 1 | Cardiovascular efficacy and safety of dipeptidyl peptidase-4 inhibitors:A meta-analysis of cardiovascular outcome trials显示文摘BACKGROUND Dipeptidyl peptidase-4(DPP-4)inhibitors are a generally safe and well tolerated antidiabetic drug class with proven efficacy in type 2 diabetes mellitus(T2DM).Recently,a series of large,randomized controlled trials(RCTs)addressing cardiovascular outcomes with DPP-4 inhibitors have been published.AIM To pool data from the aforementioned trials concerning the impact of DPP-4 inhibitors on surrogate cardiovascular efficacy outcomes and on major cardiac arrhythmias.METHODS We searched PubMed and grey literature sources for all published RCTs assessing cardiovascular outcomes with DPP-4 inhibitors compared to placebo until October 2020.We extracted data concerning the following“hard”efficacy outcomes:fatal and non-fatal myocardial infarction,fatal and non-fatal stroke,hospitalization for heart failure,hospitalization for unstable angina,hospitalization for coronary revascularization and cardiovascular death.We also extracted data regarding the risk for major cardiac arrhythmias,such as atrial fibrillation,atrial flutter,ventricular fibrillation and ventricular tachycardia.RESULTS We pooled data from 6 trials in a total of 52520 patients with T2DM assigned either to DPP-4 inhibitor or placebo.DPP-4 inhibitors compared to placebo led to a non-significant increase in the risk for fatal and non-fatal myocardial infarction[risk ratio(RR)=1.02,95%CI:0.94-1.11,I2=0%],hospitalization for heart failure(RR=1.09,95%CI:0.92-1.29,I2=65%)and cardiovascular death(RR=1.02,95%CI:0.93-1.11,I2=0%).DPP-4 inhibitors resulted in a non-significant decrease in the risk for fatal and non-fatal stroke(RR=0.96,95%CI:0.85-1.08,I2=0%)and coronary revascularization(RR=0.99,95%CI:0.90-1.09,I2=0%),Finally,DPP-4 inhibitors demonstrated a neutral effect on the risk for hospitalization due to unstable angina(RR=1.00,95%CI:0.85-1.18,I2=0%).As far as cardiac arrhythmias are concerned,DPP-4 inhibitors did not significantly affect the risk for atrial fibrillation(RR=0.95,95%CI:0.78-1.17,I2=0%),while they were associated with a significant increase in the risk for atrial flutter,equal to 52%(RR=1.52,95%CI:1.03-2.24,I2=0%).DPP-4 inhibitors did not have a significant impact on the risk for any of the rest assessed cardiac arrhythmias.CONCLUSION DPP-4 inhibitors do not seem to confer any significant cardiovascular benefit for patients with T2DM,while they do not seem to be associated with a significant risk for any major cardiac arrhythmias,except for atrial flutter.Therefore,this drug class should not be the treatment of choice for patients with established cardiovascular disease or multiple risk factors,except for those cases when newer antidiabetics(glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter-2 inhibitors)are not tolerated,contraindicated or not affordable for the patient. | Dimitrios Ioannis Patoulias Aristi Boulmpou Eleftherios Teperikidis Alexandra Katsimardou Fotios Siskos Michael Doumas Christodoulos E Papadopoulos Vassilios Vassilikos | 2021 | World Journal of Cardiology2021，13，10： | 2 |
| 2 | Addition of grignard and organolithiurn reagents to N - sulfonyl aldimines generated in situ from aldehydes and N-sulfinyl sulfonamides显示文摘 | SISKO J WEINREB S M | 1990 | J Org Chem1990，55，： | 2 |
| 3 | Preference disaggregation :20 years of MCDA experience显示文摘 | Jacquet-Lagreze E Siskos Y | 2001 | European Journal of Operations Researchs2001，130，： | 1 |
| 4 | Apexification with the use of calcium hydroxide:a clincal study显示文摘 | Morifis AS Siskos G | 1991 | Clin Padiatra Dent1991，16，1： | 1 |
| 5 | A survey of customer satisfaction barormeters : Some results from the transportation - communications sector显示文摘 | Grigoroudis E Siskos Y | 2003 | European Journal of Operational Research2003，152，： | 1 |
| 6 | 查看详情显示文摘 | (f)Kasparec J Adams J L Sisko J Silva D J | | 0，，： | 1 |
| 7 | Distribution of polybrominated diphenyl ethers (PBDEs) and other persistent organic pollutants in human serum from Greece显示文摘 | Olga I. Kalantzi Tinne Geens Adrian Covaci Panayiotis A. Siskos | 2010 | Environment International2010，，2： | 1 |
| 8 | Protein-calorie malnutrition:A host determinant for pneumocystis carinii infection显示文摘 | Hughes W T Price R A Sisko F | 1974 | Am J Dis Child1974，128，： | 1 |
| 9 | Customer satisfaction measurement in the private bank sector显示文摘 | Mihelis G Grigoroudis E Siskos Y Politis Y Malandrakis Y | 2001 | European Journal of Operational Research2001，2，130： | 1 |
| 10 | National health spending projections: the estimated impact of reform through 2019显示文摘 | Sisko AM Truffer CJ Keehan SP | 2010 | Health Aft (Millwood)2010，29，10： | 1 |
| 11 | Genome size znalysis in genus Cucubita and its use for determination of interspecific hybrids obtained using the embryo rescue technique显示文摘 | Sisko m a Ivancic B Bohance | 2003 | Plant Science2003，165，2： | 1 |
| 12 | Preference disaggregation:20 years of MCDA experience显示文摘 | Jacquet-Lagreze E Siskos Y | 2001 | European Journal of Operational Research2001，130，2： | 1 |
| 13 | Assessing a set of additive utility functions for multicriteria decision making: the UTA method显示文摘 | Jacquet-Lagreze E Siskos Y | 1982 | EuropeanJournal of Operational Research1982，10，： | 1 |
| 14 | Effects of organic side group structures on the properties of poly(organophosphazenes) 显示文摘 | Harry R Allcock Mark S Connolly John T Sisko Saman AI-Shall | 1988 | Maeromoleeules1988，21，2： | 1 |
| 15 | Tracking changes of e-customer preferences using multicriteria analysis显示文摘 | Evangelos Grigoroudis Panagiotis Kyriazopoulos Yannis Siskos Athanasios Spyridakos Denis Yannacopoulos | 2007 | Managing Service Quality2007，，5： | 1 |
| 16 | Preference disaggregation for measuring and analysing customer satisfaction: The MUSA method显示文摘 | E. Grigoroudis Y. Siskos | 2002 | European Journal of Operational Research2002，，1： | 1 |
| 17 | Muhicriteria job evaluation for large organizations显示文摘 | SPYRIDAKOS A SISKOS Y YANNACOPOULOS D | 2001 | European Journal of Operational Research2001，130，2： | 1 |
| 18 | Assessment of source apportionment by Positive Matrix Factorization analy- sis on fine and coarse urban aerosol size fractions显示文摘 | Karanasiou A A Siskos P A Eleftheriadis K | 2009 | Atmos pheric Environment2009，43，21： | 1 |
| 19 | Measuring Customer Satisfaction Using a Collective Preference Disaggregation Model显示文摘 | Y. Siskos E. Grigoroudis C. Zopounidis O. Saurais | 1998 | Journal of Global Optimization1998，，2： | 1 |
| 20 | Gas/particle partitioning of seven volatile polycyclic aromatic hydrocarbons in a heavy traffic urban area 显示文摘 | Sitars I E Bakeas E B Siskos P A | 2004 | Sci Total Environ2004，327，13： | 1 |
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