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| 1 | Success of photodynamic therapy in palliating patients with nonresectable cholangiocarcinoma: A systematic review and meta-analysis显示文摘AIM To perform a systematic review and meta-analysis on clinical outcomes of photodynamic therapy(PDT) in non-resectable cholangiocarcinoma. METHODS Included studies compared outcomes with photodynamic therapy and biliary stenting(PDT group) vs biliary stenting only(BS group) in palliation of non-resectable cholangiocarcinoma. Articles were searched in MEDLINE, PubM ed, and EMBASE. Pooled proportions were calculated using fixed and random effects model. Heterogeneity among studies was assessed using the I2 statistic.RESULTS Ten studies(n = 402) that met inclusion criteria were included in this analysis. The P for χ2 heterogeneity for all the pooled accuracy estimates was > 0.10. Pooled odds ratio for successful biliary drainage(decrease in bilirubin level > 50% within 7days after stenting)in PDT vs BS group was 4.39(95%CI: 2.35-8.19).Survival period in PDT and BS groups were 413.04d(95%CI: 349.54-476.54) and 183.41(95%CI:136.81-230.02) respectively. The change in Karnofsky performance scores after intervention in PDT and BS groups were +6.99(95%CI: 4.15-9.82) and-3.93(95%CI:-8.63-0.77) respectively. Odds ratio for postintervention cholangitis in PDT vs BS group was 0.57(95%CI: 0.35-0.94). In PDT group, 10.51%(95%CI:6.94-14.72) had photosensitivity reactions that were self-limiting. Subgroup analysis of prospective studies showed similar results, except the incidence of cholangitis was comparable in both groups. CONCLUSION In palliation of unresectable cholangiocarcinoma, PDT seems to be significantly superior to BS alone. PDT should be used as an adjunct to biliary stenting in these patients. | Harsha Moole Harsha Tathireddy Sirish Dharmapuri Vishnu Moole Raghuveer Boddireddy Pratyusha Yedama Sowmya Dharmapuri Achuta Uppu Naveen Bondalapati Abhiram Duvvuri | 2017 | World Journal of Gastroenterology2017，23，7： | 38 |
| 2 | Kalman filters in non-uniformly sampled multirate systems: For FDI and beyond显示文摘 | Weihua Li Sirish L. Shah Deyun Xiao | 2007 | Automatica2007，，1： | 2 |
| 3 | Analysis of Gene Expression in the Tumor-Associated Macrophage显示文摘 | Michael D. Duff Juan Mestre Sirish Maddali Zhao Ping Yan Philip Stapleton John M. Daly | 2007 | Journal of Surgical Research2007，，1： | 1 |
| 4 | Porphyrin-based Peptide Receptors: Syntheses and NMR Analysis 显示文摘 | Sirish M Chertkov V A Schneider H J | 2002 | Chemistry2002，8，5： | 1 |
| 5 | Porphyrin derivatives as water-soluble receptors for peptides显示文摘 | SIRISH M SCHEIDER H J | 1999 | Ghem Commun1999，10，： | 1 |
| 6 | Identification from step responses with transient initial conditions 显示文摘 | Salim Ahmed Biao Huang Sirish L Shah | 2008 | Journal of Process Control (S0959-1524)2008，18，2： | 1 |
| 7 | MieroRNA profiling predicts a variance in the proliferative potential of cardiac progenitor cells derived from neonatal and adult murine hearts显示文摘 | Sirish P Lopez JE Li N | 2012 | J Mol Cell Cardiol2012，52，1： | 1 |
| 8 | On-line outlier detec- tion and data cleaning 显示文摘 | LIU H C SIRISH S JIANG W | 2004 | Computers & chemical engi- neering2004，28，： | 1 |
| 9 | Novel identification method from step response 显示文摘 | Salim Ahmed Biao Huang Sirish L Shah | 2007 | Control Engineering Practice (S0967-0661)2007，15，5： | 1 |
| 10 | Porphyrin derivatives as water-soluble receptors for peptides显示文摘 | Sirish M Hans-Jorg S | 1999 | Chem Commun1999，，： | 1 |
| 11 | Thiol-ene photopolymerization of polymer-derived ceramic precursors显示文摘 | Neil B Cramer Sirish K Reddy Hui Lu | 2004 | J Polym Sci Part A: Polym Chem2004，42，： | 1 |
| 12 | Diagnosis of poor control-loop performance using higher-order statistics 显示文摘 | Shoukat Choudhury M A A Sirish L Shah Nina F Thornhill | 2004 | Automatica2004，40，： | 1 |
| 13 | Detection and diagnosis of plant-wide oscillations from industrial data using the spectral envelope method 显示文摘 | Hailei Jiang Shoukat Choudhury M A A Sirish L Shah | 2007 | Journal of Process Control2007，17，2： | 1 |
| 14 | A prospective assessment of sedation-re-lated adverse events and patient and endoscopist satisfaction in ERCP with anesthesiologistadministered sedation显示文摘 | Tyler M Sirish S Sheila R | 2011 | Gastrointestinal Endosco-py2011，73，4： | 1 |
| 15 | Determination of the quaternary ammonium compound trospium in human plasma by LC -MS/MS : Application to a pharmacokinetic study 显示文摘 | Hotha K K Vijaya Bharathi D Sanagapati Sirish Kumar | 2010 | J Chromatogr B2010，878，： | 1 |
| 16 | Optimal H∞ filtering in networked control systems with multiple packet dropout显示文摘 | Mehrdad S Chen T W Sirish L S | 2003 | IEEE Trans on Automatic Control2003，52，8： | 1 |
| 17 | Kalman filters in non-uniformly sampled multirate systems: For FDI and beyond显示文摘 | Li Wei-hua Sirish L Shah Xiao De-yun | 2008 | Automatica2008，44，1： | 1 |
| 18 | A PCA based fault detection scheme for an industrial high pressure polyethylene reactor 显示文摘 | RUMANA S SIRISH L S UTYANDARAMAN S | 2008 | Macromolecular Reaction Engineering2008，2，1： | 1 |
| 19 | Silica Induced Early Fibrogenic Reaction in Lung of Mice Ameliorated by Nyctanthes arbortristis Extract显示文摘Objective To investigate the pharmacological effect of Nyctanthes arbortristis (NAT) leaf extract in the prevention of lung injury induced by silica particles. Method Lung injury was induced in Swiss mice through inhalation exposure to silica particles (<5m) using a Flow Past Nose Only Inhalation Chamber at the rate of -10 mg/m3 respirable mass for 5 h. Lung bronchoalveolar lavage (BAL) fluid collected between 48 and 72 h was subjected to protein profiling by electrophoresis and cytokine evaluation by solid phase sandwich ELISA. Lung histopathology was performed to evaluate lung injury. Results Inhalation of silica increased the level of tumor necrosis factor-a (TNF-a), and of the 66 and 63 kDa peptides in the BAL fluid in comparison to sham-treated control. Pre-treatment of silica exposed mice with NAT leaf extract significantly prevented the accumulation of TNF-a in the BAL fluid, but the 66 and 63 kDa peptides remained unchanged. The extract was also effective in the prevention of silica-induced early fibrogenic reactions like congestion, edema and infiltration of nucleated cells in the interstitial alveolar spaces, and thickening of alveolar septa in mouse lung. Conclusion NAT leaf extract helps in bypassing silica induced initial lung injury in mice. | BHOLA NATH PAUL*,1, ANAND PRAKASH*, SIRISH KUMAR*, AJAY K. YADAV*, U. MANI+, ASHOK K. SAXENA*, ANAND PRAKASH SAHU#, KEWAL LAL+, AND KALYAN K. DUTTA+ *Immunobiology Laboratory +Inhalation Toxicology Laboratory #Preventive Toxicology Laboratory Industrial Toxicology Research Centre, M.G.Marg, Lucknow 226001, U.P. India | 2002 | Biomedical and Environmental Sciences2002，15，3： | 1 |
| 20 | Stiction – definition, modelling, detection and quantification显示文摘 | M.A.A. Shoukat Choudhury Mridul Jain Sirish L. Shah | 2007 | Journal of Process Control2007，，3： | 1 |
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