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| 1 | 内皮细胞和平滑肌细胞氧化应激时Nrf2/ARE信号通路对抗氧化基因表达的调控:与动脉粥样硬化和先兆子痫的关系显示文摘动脉粥样硬化、糖尿病、慢性肾功能衰竭和先兆子痫等血管疾病时活性氧(reactive oxygen species,ROS)生成增加,容易导致内皮依赖性血管舒张功能的损害和血管损伤,而细胞可以诱导多种编码Ⅱ相解毒酶和抗氧化蛋白的基因表达,从而减轻ROS和亲电子物质介导的细胞损伤。一个被称为抗氧化反应元件(antioxidant response element,ARE)或亲电子反应元件(electrophile response element,EpRE)的顺式转录调控元件,可以介导诸如亚铁血红素加氧酶1、γ-谷氨酰半胱氨酸合成酶、硫氧还蛋白还原酶、谷胱甘肽-S转移酶和NAD(P)H:苯醌氧化还原酶等基因的转录。其他抗氧化酶,如超氧化物歧化酶、过氧化氢酶和非酶清除剂(如谷胱甘肽)等也参与ROS的清除。转录因子NF-E2相关因子2(nuclear factor-erythroid 2-related factor 2, Nrf2)是属于Cap‘n’Collar家族的转录因子,具有碱性亮氨酸拉链(basic region-leucine zipper,bZIP),它在ARE介导的抗氧化基因表达中起重要的作用。在正常情况下,Kelch样环氧氯丙烷相关蛋白-1(Kelch-like ECH-associated protein-1,Keapl)与Nrf2耦联,并与肌动蛋白细胞骨架结合被锚定于胞浆,但是在半胱氨酸残基发生氧化的情况下,Nrf2和Keapl解耦联,进入细胞核并与ARE结合,从而激活多种抗氧化基因和Ⅱ相解毒酶基因的转录。蛋白激酶C、丝裂原活化蛋白激酶和磷脂酰肌醇-3激酶参与Nrf2/ARE信号转导的调控。本文综述了有关Nrf2/ARE信号转导通路在血管稳态和动脉硬化、先兆子痫等疾病情况下内皮及平滑肌细胞对抗持续性氧化应激中起的作用。 | Giovanni E. Mann Jorg Niehueser-Saran Alan Watson Ling Gao Tetsuro Ishii Patricia de Winter Richard C. M. Siow | 2007 | 生理学报2007，59，2： | 35 |
| 2 | Contents of four active components in different commercial crude drugs and preparations of Danshen (Salvia miltiorrhiza)显示文摘AIM:To detect the contents of four active components of Salvia miltiorrhiza in various commercially available danshen crude drugs and preparations.METHODS:Commercially available danshen crude drugs from different sources,as well as danshen pills and intravenous injection preparations containing danshen alone or in combination with other herbs were collected.The composition of these danshen samples was analyzed using HPLC.Specifically,the amounts of magnesium tanshinoate B(MTB),danshensu,isotanshinone IIA,and cryptotanshinone were determined.In some of these samples,the content of MTB was further confirmed by liquid chromatography-tandem mass spectrometer (LC-MS)/MS method.RESULTS:There were great variations in the amount of the four active ingredients in the commercially available danshen crude drugs and drug preparations in this study.The amount of MTB was the highest among the four components measured in the crude drugs.However,the amounts of MTB in all danshen preparations were much lower than those in crude drugs.The 2 lipophilic components,isotanshinone IIA and cryptotanshinone,were very low or not detectable in both injection and oral preparations.CONCLUSION:MTB can be used to standardize the various forms of danshen crude drugs and drug preparations from different sources.In view of the variation in the amounts of MTB and other components,improvement in the production methods of danshen preparations is essential to ensure consistent amount of its active ingredients and reproducible pharmacological actions. | Susan Wai Sum LEUNG Yaw Loong SIOW Ricky Ying Keung MAN | 2002 | Acta Pharmacologica Sinica2002，23，12： | 6 |
| 3 | 耳郭假性囊肿的手术治疗显示文摘目的评估耳郭假性囊肿手术治疗的临床价值。方法选择合适的患者30例进行治疗。沿对耳轮作皮肤切口,充分暴露囊肿腹侧的软骨膜及其附着的薄层软骨,然后予以切除,并清除囊肿背侧软骨表面可能存在的纤维束或肉芽组织。以常规方式缝合切口后,再作贯穿耳郭的双侧钮扣缝合固定。结果所有病例均一期愈合,无并发症发生,随访未见复发。结论对耳郭假性囊肿,建议采取手术治疗,但须严格按照无菌操作要求,并防止术后继发感染。 | 蔡昌枰 Siow Jin-keat Samuel Yeak | 2007 | 山东大学耳鼻喉眼学报2007，21，5： | 2 |
| 4 | Induction of HO-1 and redox signaling in endothelial cells by advanced glycation end products: A role for Nrf2 in vascular protection in diabetes显示文摘 | M. He R.C.M. Siow D. Sugden L. Gao X. Cheng G.E. Mann | 2010 | Nutrition, Metabolism and Cardiovascular Diseases2010，，4： | 2 |
| 5 | Inhibition by ginkgolides and bilobalide of the production of nitric oxide in macrophages (THP- 1)but not in endothelial cells (HUVEC)显示文摘 | Cheung F Siow YL OK | 2001 | Biochem Pharmacol2001，61，4： | 1 |
| 6 | Inhibitory effect of Ginkgo biloba extract on the expression of inducible mitric oxide synthase in endothelial cells显示文摘 | Cheung F Siow YL Chen WZ | 1999 | Biochem Pharmacol1999，58，10： | 1 |
| 7 | Relationship between serum mullerian-inhibiting substance and other reproductive hormones in untreated women with polycystic ovary syndrome and normal women显示文摘 | Cook C L Siow Y Brenner A G | 2002 | Fertility and Sterility2002，77，1： | 1 |
| 8 | Migration of adventitial myofibroblasts following vascular bal- loon injury: insights from in vivo gene transfer to rat carotid arteries显示文摘 | SIOW R C MALLAWAARACHCHI C M WEISSBERG P L | 2003 | Cardiovascular Research2003，59，1： | 1 |
| 9 | Hyperhomocysteine- mia induces liver injury in rat : protective effect of folic acid supple- mentation 显示文摘 | Woo CW Prathapasinghe GA Siow YL | 2006 | Biochimica et Biophysica Acta2006，1762，7： | 1 |
| 10 | Left bundle branch block without concordant ST changes is rarely associated with acute coronary occlusion显示文摘 | McMahon R Siow W Bhindi R | 2013 | IntJ Cardiol2013，167，4： | 1 |
| 11 | Exposed versus buried wires for fixation of lateral humeral condyle fractures in children : a comparison of safety and efficacy 显示文摘 | Chan LW Siow HM | 2011 | J Child Orthop2011，5，5： | 1 |
| 12 | Expression of stress proteins heme oxygenase-1 and -2 in acute pancreatitis and pancreatic islet betaTC3 and acinar AR42Jcells显示文摘 | Sato H Siow RC Bartlett S | 1997 | FEBS Lett1997，405，2： | 1 |
| 13 | Homocysteine stimulates nuclear factor kappaB activity and monocyte chemoattractant protein-1 expression in vascular smooth-muscle cells:a possible role for protein kinase C显示文摘 | WANG G SIOW Y L | 2000 | Biochem J2000，352，3： | 1 |
| 14 | The corrosion behaviour of copper in neutral tap water Part Ⅱ:Determination of corrosion rates显示文摘 | Feng Y Teo W K Siow K S | | 0，，： | 1 |
| 15 | Homocysteine stimulates monocyte chemoattractant protein- 1 expression in naesangial cells via NF - kappaB activation 显示文摘 | Cheung GT Siow YL | 2008 | Can J Pharmacol2008，86，3： | 1 |
| 16 | Corrosion protection of copper by a self-assembled monolayer of alkanethiol 显示文摘 | FENG Y TEO W K SIOW K S | 1997 | J Electrochem Soc1997，144，： | 1 |
| 17 | ATP acts via P2Y1 receptors to stimulate acetylcholinesterase and acetylcholine receptor expression: transduction and transcription control 显示文摘 | Choi RCY Siow NL Cheng AWM | 2003 | J Neurosci2003，23，11： | 1 |
| 18 | Effect of temperature on moromi fermentation of soy sauce with intermittent aeration显示文摘 | Wu T Y Kan M S Siow L F | | 0，，05： | 1 |
| 19 | Extraction of antioxidative and antihypertensive bioactive peptides from Parkia speciosa seeds显示文摘 | Hwee-Leng Siow Chee-Yuen Gan | 2013 | Food Chemistry2013，，4： | 1 |
| 20 | Culture of human endothelial cells from umbilical veins显示文摘 | Siow R C | 2012 | Methods Mol Biol2012，806，： | 1 |
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