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| 1 | Spectral analysis of bowel sounds in intestinal obstruction using an electronic stethoscope显示文摘AIM: To determine the value of bowel sounds analysis using an electronic stethoscope to support a clinical diagnosis of intestinal obstruction. METHODS: Subjects were patients who presented with a diagnosis of possible intestinal obstruction based on symptoms, signs, and radiological findings. A 3MTH Littmann Model 4100 electronic stethoscope was used in this study. With the patients lying supine, six 8-second recordings of bowel sounds were taken from each patient from the lower abdomen. The recordings were analysed for sound duration, soundto-sound interval, dominant frequency, and peak frequency. Clinical and radiological data were reviewed and the patients were classified as having either acute, subacute, or no bowel obstruction. Comparison of bowel sound characteristics was made between these subgroups of patients. In the presence of an obstruction, the site of obstruction was identified and bowel calibre was also measured to correlate with bowel sounds. RESULTS: A total of 71 patients were studied during the period July 2009 to January 2011. Forty patientshad acute bowel obstruction (27 small bowel obstruction and 13 large bowel obstruction), 11 had subacute bowel obstruction (eight in the small bowel and three in large bowel) and 20 had no bowel obstruction (diagnoses of other conditions were made). Twenty-five patients received surgical intervention (35.2%) during the same admission for acute abdominal conditions. A total of 426 recordings were made and 420 recordings were used for analysis. There was no significant difference in sound-to-sound interval, dominant frequency, and peak frequency among patients with acute bowel obstruction, subacute bowel obstruction, and no bowel obstruction. In acute large bowel obstruction, the sound duration was significantly longer (median 0.81 s vs 0.55 s, P = 0.021) and the dominant frequency was significantly higher (median 440 Hz vs 288 Hz, P = 0.003) when compared to acute small bowel obstruction. No significant difference was seen between acute large bowel obstruction and large bowel pseudoobstruction. For patients with small bowel obstruction, the sound-to-sound interval was significantly longer in those who subsequently underwent surgery compared with those treated non-operatively (median 1.29 s vs 0.63 s, P < 0.001). There was no correlation between bowel calibre and bowel sound characteristics in both acute small bowel obstruction and acute large bowel obstruction. CONCLUSION: Auscultation of bowel sounds is nonspecific for diagnosing bowel obstruction. Differences in sound characteristics between large bowel and small bowel obstruction may help determine the likely site of obstruction. | Siok Siong Ching Yih Kai Tan | 2012 | World Journal of Gastroenterology2012，18，33： | 14 |
| 2 | Structural basis for blocking PD-l-mediated immune suppression by therapeutic antibody pembrolizumab显示文摘 | Zhenkun Na Siok Ping Yeo Sakshibeedu R Bharath Matthew W Bowler Esra Ballkci Cheng-I Wang Haiwei Song | 2017 | Cell Research2017，27，1： | 10 |
| 3 | Chemical constituents and pharmacological effects of durian shells in ASEAN countries:A review显示文摘Durio zibethnus is mainly distributed in Southeast Asia.Traditional Chinese medicine believes that durian shells have the effects of clearing heat and purging fire,nourishing yin and moisturizing dryness.Therefore,it is often used as a pharmaceutic food in the Chinese folk to assist treating diseases.At present,the chemical constituents isolated from durian shell include phenolic acids,phenolic glycosides,flavonoids,coumarins,triterpenes,simple glycosides and other compounds.Modern pharmacological studies show that durian shell has many pharmacological activities,such as antioxidant,antiinflammatory,regulation of glucose and lipid metabolism.The chemical composition and pharmacological effects of durian shells are summarized in order to provide references for the further research and application of durian shell. | Yuan-fei Zhan Xiao-tao Hou Li-li Fan Zheng-cai Du Soo Ee Ch'ng Siok Meng Ng Khamphanh Thepkaysone Er-wei Hao Jia-gang Deng | 2021 | Chinese Herbal Medicines2021，13，4： | 2 |
| 4 | Phoenixin: a novel brain-gut-skin peptide with multiple bioactivity显示文摘在这简短评论,我们相对小肽 ligand 的发现总结当前的 fndings, phoenixin (PNX ) 。用一条生物信息的途径,分别地,包含 14 和 20 氨基酸的二新奇的肽 PNX-14 和 PNX-20 包括大脑,心,肺和胃从多样的纸巾被孤立。集体 spectrometry 分析识别了相应于 PNX-14 和 PNX-20 的一座主要、次要的山峰,在针的绳索提取的老鼠或老鼠。与兔子 polyclonal 抗血清的使用, phoenixin immunoreactivity (irPNX ) 包括几 hypothalamic subnuclei 和迷走神经的背面的马达原子核在啮齿类动物大脑的分离区域被检测。另外, irPNX 包括背面的根中心,有节的中心和三叉的中心在感觉中心房间的一张人口,并且在浓密地散布到背面的角,独居的道的原子核和针的三叉的道的表面的层的房间过程被检测。irPNX 房间过程也在皮肤和 myenteric 丛被检测,建议一个大脑勇气或大脑皮连接。PNX-14 皮下地注射了到老鼠的颈的项的药理学研究表演挑起了重复的抓一回与 hindpaws 指导了到颈的背的剂量依赖者。我们的结果建议肽 PNX-14 或 PNX-20,可以用作内长的信号分子 transducing 痒感觉之一。另外,从另外的实验室的结果证明外长的 PNX 可以影响象记忆形成,消沉,复制,食物吸入和象 anxiolytic 一样行为那样的很多多样的行为。 | Rong-Ming LYU Alan COWAN Ying ZHANG Yi-Hung CHEN Siok L DUN Jaw-Kang CHANG Nae J DUN Jin Jun LUO | 2018 | Acta Pharmacologica Sinica2018，39，5： | 2 |
| 5 | Treatment of Helicobacter pylori in surgical practice:A randomised trial of triple versus quadruple therapy in a rural district general hospital显示文摘AIM: To compare a lansoprazole-based triple versus quadruple therapy for Helicobacter pylori (H pylori) eradication with emphasis on side effect prof ile,patient compliance and eradication rate at a rural district general hospital in Wales,United Kingdom. METHODS: One hundred one patients with H pylori infection were included in the study. Patients were randomised to receive triple therapy comprising of lansoprazole 30 mg,amoxycillin 1 g,clarithromycin 500 mg,all b.d. (LAC),or quadruple therapy comprising of lansoprazole 30 mg b.d.,metronidazole 500 mg t.d.s.,bismuth subcitrate 240 mg b.d.,and tetracycline chloride 500 mg q.d.s. (LMBT). Cure was defi ned as a negative 13C urea breath test 2 mo after treatment. RESULTS: Seven patients were withdrawn after randomisation. Fifty patients were assigned to LAC group and 44 to LMBT group. The intention-to-treat cure rates were 92% and 91%,whereas the per-protocol cure rates were 92% and 97%,respectively. Side effects were common,with 56% experiencingmoderate to severe symptoms in the LAC group and 59% in the LMBT group. Symptoms of vomiting,diarrhoea and black stools were significantly more common in the LMBT group. Patient compliance was 100% for triple therapy and 86% for quadruple therapy (P < 0.01). One-third of patients in both groups were still taking acid-reducing medications at six-month follow-up. CONCLUSION: One-week triple and quadruple therapies have similar intention-to-treat eradication rates. Certain side effects are more common with quadruple therapy,which can compromise patient compliance. Patient education or modifi cations to the regimen are alternative options to improve compliance of the quadruple regimen. | Siok Siong Ching Sivakumaran Sabanathan Lloyd R Jenkinson | 2008 | World Journal of Gastroenterology2008，14，24： | 2 |
| 6 | Biological abnormality of impaired reading is constrained by culture显示文摘 | Wai Ting Siok Charles A. Perfetti Zhen Jin Li Hai Tan | 2006 | 中国生物学文摘2006，20，3： | 2 |
| 7 | Distinct brain regions associated with syllable and phoneme显示文摘 | Jin Z Fletcher P | 2003 | Human Brain Mapping2003，18，3： | 1 |
| 8 | Epidemiology of diabetic foot problems and predictive factors for limb loss 显示文摘 | Natheremail A Siok BC Huak CY | 2008 | J Diabetes Complications2008，22，2： | 1 |
| 9 | Biological abnormality of impaired reading is constrained by culture显示文摘 | Perfetti CA Jin Z | 2004 | Nature2004，431，7004： | 1 |
| 10 | Smad4/DPC4 and Smad3 mediate TGF-β1 signaling through direct binding to a novel TGF-responsive element in the human plasminogen activator inhibitor-1 promoter显示文摘 | Song C Siok TE Gelehrter TD | 1998 | J Biol Chem1998，273，29： | 1 |
| 11 | Biologicalabnormality of im- pairedreading is eonstrainedby culture 显示文摘 | Siok WT Perfetti CA Jin Z | 2004 | Nature2004，431，： | 1 |
| 12 | Direct Cost Analysis of Intensive Care Unit Stay in Four European Countries: Applying a Standardized Costing Methodology显示文摘 | Siok Swan Tan PhD | 2012 | Value in health2012，15，： | 1 |
| 13 | From Receptive to Productive: Improving ESL Learners' Use of Vocabulary in a Postreading Composition Task 显示文摘 | Siok H L James M | 2005 | Tesol Quarterly2005，，3： | 1 |
| 14 | A structural-functional basis for dyslexia in the cortex of Chinese readers 显示文摘 | Siok WT Niu Z Jin Z | 2008 | Proc Natl Acad Sci U S A2008，105，14： | 1 |
| 15 | Biological abnormality of impaired reading is constrained by culture显示文摘 | Siok Wai Ting Charles A.Perfetti Zhenjin Li Hai Tan | | 0，，： | 1 |
| 16 | A structural-func- tional basis for dyslexia in the cortex oi Chinese readers 显示文摘 | Siok W T Niu Z D Jin Z | 2008 | Proceedings of the National Academy of Sciences2008，105，14： | 1 |
| 17 | Children’s Reading Performance is Correlated with White Matter Structure Measured by Diffusion Tensor Imaging显示文摘 | Gayle K. Deutsch Robert F. Dougherty Roland Bammer Wai Ting Siok John D.E. Gabrieli Brian Wandell | 2005 | Cortex2005，，3： | 1 |
| 18 | Biological abnormality of impaired reading is constrained by culture显示文摘 | Siok WT Perfetti CA Jin Z | 2004 | Nature2004，431，： | 1 |
| 19 | Epidemiology of diabetic foot problems and predictive factors for limb loss 显示文摘 | Natheremail A Siok BC Huak CY | 2008 | J Diabetes Complications2008，22，2： | 1 |
| 20 | The role of phonological awareness and visual-orthographic skills in Chinese reading显示文摘 | Siok W.T Fletcher P | | 0，，06： | 1 |
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