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| 1 | Androgen synthesis inhibitors in the treatment of castration-resistant prostate cancer显示文摘gonadal 睾丸激素合成的抑制首先代表标准为变形前列腺癌症的治疗的线治疗。在得阉割抵抗的前列腺癌症(CRPC ) 的病人的多数,然而,通过自己在肾上腺或在肿瘤以内生产的雄激素检测雄激素受体(AR ) 的坚持的激活是可能的。Abiraterone 醋酸盐作为 17 α 与活动作为双功能的细胞色素 P450 酶 CYP17 的一个不可逆的禁止者被开发; -hydroxylase 和 17,20-lyase。CYP17 为从胆固醇的 nongonadal 雄激素的生产是必要的。基于与 abiraterone 和泼尼松对泼尼松在全面幸存(OS ) 显示出重要改进的阶段 III 试用,在 2011 的 abiraterone 的规章的赞同代表了指向 AR 为与 CRPC 在人改进结果是必要的原则的证明。 17 α 的抑制;由 abiraterone 的 -hydroxylase 由于垂体的调停皮质醇的抑制的损失导致在上游的 mineralocorticoids 的累积促肾上腺皮质的荷尔蒙( ACTH ),为 17,20-lyase 为 CYP17 禁止者的开发向一个基本原理提供增加的特性( orteronel , galeterone 和 VT-464 )没有外长的 corticosteroids ,那能潜在地被管理。在这篇文章,我们考察 abiraterone 和另外的 CYP17 禁止者的发展;有 abiraterone 的最近的研究在 quality-of-life,反应的潜在的早预言者,并且关于另外的代理人的 abiraterone 的最佳的定序上通知我们的理解象药效果那样的临床的参数;并且提供卓见进抵抗机制给导致临床的试用,药联合设计了延长 abiraterone 利益或恢复 abiraterone 活动的 CYP17 禁止者的翻译研究结果。 | Mark N Stein | 2014 | Asian Journal of Andrology2014，16，3： | 3 |
| 2 | Preshaping command inputs to reduce system vibration 显示文摘 | Singer N C Seering W P | 1990 | Trans ASME: J Dynam Syst Measur Control1990，112，1： | 1 |
| 3 | Chemical and spectroscopic properties of leaf litter and decomposed organic matter in the Carmel Range, Israel显示文摘 | Gressel N Inbar Y Singer A | 1995 | Soil Biology and Biochemistry1995，27，1： | 1 |
| 4 | The ability of clove oil and MS-222 to minimize handling stress in rainbow trout ( Oncorhynchus mykiss Walbaum ) 显示文摘 | WAGNER G N SINGER T D MCKINLEY R S | 2003 | Aquaculture Research2003，34，： | 1 |
| 5 | Pasteurella haemolytica found in the respiratory tract of fowl显示文摘 | MUSHIN R WEISMAN Y SINGER N | 1979 | Avian Dis1979，24，1： | 1 |
| 6 | Preshaping command inputs to reduce system vibration 显示文摘 | Singer N C Seering W P | 1990 | Journal of Dynamic Systems Measurement and Control1990，112，： | 1 |
| 7 | Neutrophil gelatinase- associated lipocalin: pathophysiology and clinical applica- tions显示文摘 | Cardio - re- conference of Eur Heart J Singer E Marko L Paragas N | 2013 | Acta Physiol (Oxf)2013，207，4： | 1 |
| 8 | Preshaping command in- puts to reduce system vibration 显示文摘 | SINGER N C SEERING W P | 1990 | Journal of Dynamic Systems Measurement and Control1990，112，1： | 1 |
| 9 | Is theinflammasome a potential therapeutic target in renal disease?显示文摘 | Turner CM Arulkumaran N Singer M | 2014 | BMC Nephrol2014，15，： | 1 |
| 10 | Pegasos: primal estimated sub-gradient solver for SVM 显示文摘 | Shalev-Shwartz S Singer Y Srebro N | 2011 | Mathematical Programming2011，127，1： | 1 |
| 11 | X-ray diffraction of MoS2 coatings prepared byion-beam-assisted deposition显示文摘 | L E Seitzman R N Bolster I L Singer | 1992 | Surf Coat Technol1992，52，： | 1 |
| 12 | Preshaping command inputs to reduce system vibration显示文摘 | Singer N C Seering W P | 1990 | Journal of Dynamic Systems Measurement and Control1990，112，1： | 1 |
| 13 | Obturator hernia显示文摘 | Singer R Leary P M Hofmeyr N G | 1955 | S Afr Med J1955，29，4： | 1 |
| 14 | Development states associated with the floral transition显示文摘 | McDaniel C N Singer S R Smith S M E | 1992 | Dev Biol1992，153，： | 1 |
| 15 | IBAD MoS2 lubrication of titanium alloys 显示文摘 | Seitzman L E Bolster R N Singer I L | 1996 | Surface and Coatings Technology1996，78，13： | 1 |
| 16 | DNA barcoding:how it complements taxonomy,molecular phylogenetics and population genetics显示文摘 | H AJIBABAEI M SINGER G A C HEBERT P D N | 2007 | Trends in Genetics2007，23，： | 1 |
| 17 | Improving repeatability of coordinate measuring machines With shaped command signals 显示文摘 | SINGHOSE W E SINGER N SEERING W | 1996 | Precision Engineering1996，18，： | 1 |
| 18 | The hierarchical hidden Markov model:Analysis and applications显示文摘 | Fine S Singer Y Tishby N | 1998 | Machine Learning1998，32，： | 1 |
| 19 | Determination of residual stress and thermal history for IM7/977-2 composite laminates显示文摘 | Schulz W A Myers D G Singer T N | 2005 | Composites Science and Technology2005，65，13： | 1 |
| 20 | The power of amnesia: learning probabilistic automata with variable memory length 显示文摘 | RON D SINGER Y TISHBY N | 1996 | Machine Learning1996，25，23： | 1 |
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