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| 1 | 伦理学与SARS:多伦多的教训显示文摘SARS的流行说明传染病在世界范围内流行是件多么容易的事,为了更好地应对下一次流行病,我们不仅要解决医学方面的问题,也同样需要解决伦理学方面的问题。 | Peter A Singer Solomon R Benatar Mark Bernstein Abdallah S Daar Bernard M Dickens Susan K MacRae Ross E G Upshur Linda Wright Randi Zlotnik Shaul 肖月 | 2004 | 英国医学杂志中文版2004，7，4： | 3 |
| 2 | Combination drug regimens for metastatic clear cell renal cell carcinoma显示文摘Renal cell carcinomas(RCC)make up about 90%of kidney cancers,of which 80%are of the clear cell subtype.About 20%of patients are already metastatic at the time of diagnosis.Initial treatment is often cytoreductive nephrectomy,but systemic therapy is required for advanced RCC.Single agent targeted therapies are moderately toxic and only somewhat effective,leading to development of immunotherapies and combination therapies.This review identifies limitations of monotherapies for metastatic renal cell carcinoma,discusses recent advances in combination therapies,and highlights therapeutic options under development.The goal behind combining various modalities of systemic therapy is to potentiate a synergistic antitumor effect.However,combining targeted therapies may cause increased toxicity.The initial attempts to create therapeutic combinations based on inhibition of the vascular endothelial growth factor or mammalian target of rapamycin pathways were largely unsuccessful in achieving a profile of increased synergy without increased toxicity.To date,five combination therapies have been approved by the U.S.Food and Drug Administration,with the most recently approved therapies being a combination of checkpoint inhibition plus targeted therapy.Several other combination therapies are under development,including some in the phase 3 stage.The new wave of combination therapies for metastatic RCC has the potential to increase response rates and improve survival outcomes while maintaining tolerable side effect profiles. | Viraj V Khetani Daniella E Portal Mansi R Shah Tina Mayer Eric A Singer | 2020 | World Journal of Clinical Oncology2020，11，8： | 2 |
| 3 | The transtheoretical model and primary care:“The Times They Are A Changin”显示文摘 | Singer E A | 2007 | J Am Acad Nurse Pract2007，19，1： | 1 |
| 4 | Recent developments in the spray forming of metals显示文摘 | SINGER A R E | 1985 | Inter J of Powder Metall and Powder Tech1985，21，3： | 1 |
| 5 | Life sustaining treatment preferences of hemodialysis patients:implications for advance direc- tives显示文摘 | Singer P A Thiel E C Naylor C D | 1995 | J AmSoc Nephrol1995，6，5： | 1 |
| 6 | Secondary plant metabolitiesin phytoremdiation and biotransformation显示文摘 | Singer A C Drowley D E Thompson I P | 2003 | Trends in Biotechnology2003，21，： | 1 |
| 7 | 显示文摘 | Singer A R E | 1970 | Metals and Materials1970，4，2： | 1 |
| 8 | Treatment guidelines for patients with hyperthyroidism and hypothyroidism 显示文摘 | Singer P A Cooper D S Levy E G | 1995 | JAMA1995，273，10： | 1 |
| 9 | Successful removal of an entire lung for carcinoma of the bronchus显示文摘 | Graham E A Singer J J | 1933 | JAMA1933，101，： | 1 |
| 10 | 显示文摘 | Singer A R E | 1991 | Materials Science and Engineering A1991，135，： | 1 |
| 11 | Processing deficits in primary visual cortex of amblyopic cats显示文摘 | Schmidt K E Singer W Galuske R A | 2004 | J Neurophysiol2004，91，4： | 1 |
| 12 | Laparoscopic live donor nephrectomy with vaginal extraction: initial re-port显示文摘 | Allaf M E Singer A Shen W | 2010 | AmJ Transplant2010，10，： | 1 |
| 13 | The challenge of spray forming 显示文摘 | Singer A R E | 1991 | Powder Metallurgy1991，25，4： | 1 |
| 14 | The cyanoacrylate topical skin adhesives显示文摘 | Singer A J Quinn J V Hollander J E | 2008 | The American Journal of Emergency Medicine2008，26，4： | 1 |
| 15 | Spray deposition of metal met显示文摘 | SINGER A R E | 1970 | Mater1970，，4： | 1 |
| 16 | Secondary plant metabolites in phytoremediation and biotransformation 显示文摘 | Singer A C Crowley D E Thompson I P | 2003 | Trends in Biotechnology2003，21，3： | 1 |
| 17 | Observer judgments about moral agents' ethical decisions: the role of scope of justice and moral intensity显示文摘 | Singer M S Singer A E | 1997 | Journal of Business Ethics1997，16，5： | 1 |
| 18 | Antithrombotic therapy for atrial fibrillation: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guide- lines显示文摘 | You J J Singer D E Howard P A | 2012 | Chest2012，141，2： | 1 |
| 19 | Contribution of earthworms to PCB bioremediation显示文摘 | SINGER A C JURY W LEUPROMCHAI E | 2001 | Soil Biol Biochem2001，33，： | 1 |
| 20 | Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model显示文摘 | Singer O Marr R A Rockenstein E | 2005 | Nat Neurosci2005，8，10： | 1 |
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