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| 1 | Antimicrobial susceptibility testing for Helicobacter pylori in times of increasing antibiotic resistance显示文摘The gram-negative bacterium Helicobacter pylori(H.pylori)causes chronic gastritis,gastric and duodenal ulcers,gastric cancer and mucosa-associated lymphoid tissue lymphoma.Treatment is recommended in all symptomatic patients.The current treatment options for H.pylori infection are outlined in this review in light of the recent challenges in eradication success,largely due to the rapid emergence of antibiotic resistant strains of H.pylori.Antibiotic resistance is a constantly evolving process and numerous studies have shown that the prevalence of H.pylori antibiotic resistance varies significantly from country to country,and even between regions within the same country.In addition,recent data has shown that previous antibiotic use is associated with harbouring antibiotic resistant H.pylori.Local surveillance of antibiotic resistance is warranted to guide clinicians in their choice of therapy.Antimicrobial resistance is assessed by H.pylori culture and antimicrobial susceptibility testing.Recently developed molecular tests offer an attractive alternative to culture and allow for the rapid molecular genetic identification of H.pylori and resistance-associated mutations directly from biopsy samples or bacterial culture material.Accumulating evidence indicates that surveillance of antimicrobial resistance by susceptibility testing is feasible and necessary to inform clinicians in their choice of therapy for management of H.pylori infection. | Sinéad M Smith Colm O’Morain Deirdre McNamara | 2014 | World Journal of Gastroenterology2014，20，29： | 40 |
| 2 | Role of Toll-like receptors in Helicobacter pylori infection and immunity显示文摘The gram-negative bacterium Helicobacter pylori(H. pylori) infects the stomachs of approximately half of the world's population. Although infection induces an immune response that contributes to chronic gastric inflammation, the response is not sufficient to eliminate the bacterium. H. pylori infection causes peptic ulcers, gastric cancer and mucosa-associated lymphoid tissue lymphoma. Disease outcome is linked to the severity of the host inflammatory response. Gastric epithelial cells represent the first line of innate immune defence against H. pylori, and respond to infection by initiating numerous cell signalling cascades, resulting in cytokine induction and the subsequent recruitment of inflamma-tory cells to the gastric mucosa. Pathogen recognition receptors of the toll-like receptor(TLR) family mediate many of these cell signalling events. This review dis-cusses recent findings on the role of various TLRs in the recognition of H. pylori in distinct cell types, describes the TLRs responsible for the recognition of individual H. pylori components and outlines the influence of innate immune activation on the subsequent development of the adaptive immune response. The mechanistic iden-tification of host mediators of H. pylori-induced patho-genesis has the potential to reveal drug targets and opportunities for therapeutic intervention or prevention of H. pylori-associated disease by means of vaccines or immunomodulatory therapy. | Sinéad M Smith | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，3： | 11 |
| 3 | Molecular detection of Helicobacter pylori antibiotic resistance in stool vs biopsy samples显示文摘AIM To compare(1) demographics in urea breath test(UBT) vs endoscopy patients; and(2) the molecular detection of antibiotic resistance in stool vs biopsy samples.METHODS Six hundred and sixteen adult patients undergoing endoscopy or a UBT were prospectively recruited to the study. The Geno Type Helico DR assay was used to detect Helicobacter pylori(H. pylori) and antibiotic resistance using biopsy and/or stool samples from CLOpositive endoscopy patients and stool samples from UBT-positive patients. RESULTS Infection rates were significantly higher in patients referred for a UBT than endoscopy(overall rates: 33% vs 19%; treatment-na?ve patients: 33% vs 14.7%, respectively). H. pylori-infected UBT patients were younger than H. pylori-infected endoscopy patients(41.4 vs 48.4 years, respectively, P < 0.005), with a higher percentage of H. pylori-infected males in the endoscopy-compared to the UBT-cohort(52.6% vs 33.3%, P = 0.03). The Geno Type Helico DR assay was more accurate at detecting H. pylori infection using biopsy samples than stool samples [98.2%(n = 54/55) vs 80.3%(n =53/66), P < 0.005]. Subset analysis using stool and biopsy samples from CLO-positive endoscopy patients revealed a higher detection rate ofresistance-associated mutations using stool samples compared to biopsies. The concordance rates between stool and biopsy samples for the detection of H. pylori DNA, clarithromycin and fluoroquinolone resistance were just 85%, 53% and 35%, respectively. CONCLUSION Differences between endoscopy and UBT patients provide a rationale for non-invasive detection of H. pylori antibiotic resistance. However, the Geno Type Helico DR assay is an unsuitable approach. | Denise E Brennan Joseph Omorogbe Mary Hussey Donal Tighe Grainne Holleran Colm O'Morain Sinéad M Smith Deirdre McNamara | 2016 | World Journal of Gastroenterology2016，22，41： | 6 |
| 4 | Can bacterial virulence factors predict antibiotic resistant Helicobacter pylori infection?显示文摘AIM To evaluate the association between virulence factor status and antibiotic resistance in Helicobacter pylori(H. pylori)-infected patients in Ireland. METHODS DNA was extracted from antral and corpus biopsies obtained from 165 H. pylori-infected patients. Genotyping for clarithromycin and fluoroquinolone-mediating mutations was performed using the Genotype Helico DR assay. cag A and vac A genotypes were investigated using PCR. RESULTS Primary, secondary and overall resistance rates for clarithromycin were 50.5%(n = 53/105), 78.3%(n = 47/60) and 60.6%(n = 100/165), respectively. Primary, secondary and overall resistance rates for fluoroquinolones were 15.2%(n = 16/105) and 28.3%(n = 17/60) and 20%(n = 33/165), respectively. Resistance to both antibiotics was 12.4%(n = 13/105) in treatment-na?ve patients, 25%(n = 15/60) in those previously treated and 17%(n = 28/165) overall. A cag A-positive genotype was detected in 22.4%(n = 37/165) of patient samples. The dominant vac A genotype was S1/M2 at 44.8%(n = 74/165), followed by S2/M2 at 26.7%(n = 44/165), S1/M1 at 23.6%(n = 39/165) and S2/M1 at 4.8%(n = 8/165). Primary clarithromycin resistance was significantly lower in cag A-positive strains than in cag A-negative strains [32%(n = 8/25) vs 56.3%(n = 45/80); P = 0.03]. Similarly, in patients infected with more virulent H. pylori strains bearing the vac A s1 genotype, primary clarithromycin resistance was significantly lower than in those infected with less virulent strains bearing the vac A s2 genotype, [41%(n = 32/78) vs 77.8%(n = 21/27); P = 0.0001]. No statistically significant association was found between primary fluoroquinolone resistance and virulence factor status.CONCLUSION Genotypic H. pylori clarithromycin resistance is high and cag A-negative strains are dominant in our population. Less virulent(cag A-negative and vac A S2-containing) strains of H. pylori are associated with primary clarithromycin resistance. | Denise E Brennan Colin Dowd Colm O'Morain Deirdre McNamara Sinéad M Smith | 2018 | World Journal of Gastroenterology2018，24，9： | 4 |
| 5 | Use of allopurinol in showing the propression of renal diseased through its ability to lower serum uric acid level显示文摘 | Sin Y Leung K Tong M | 2006 | Am J Kinduey Dis2006，47，1： | 1 |
| 6 | Effects of team inputsand intrateam processes on perceptions of team viabilityand member satisfaction in nascent ventures显示文摘 | FOO M D SIN H P YIONG L P | 2006 | StrategicManagement Journal2006，27，4： | 1 |
| 7 | Electron microscopic observations of a marine fish iridovirus isolated from brown- spotted grouper, Epinephelus tauvina 显示文摘 | Qin Q w Lam T J Sin Y M | 2001 | J Virol Methods2001，98，： | 1 |
| 8 | Celecoxib decreases growth and angiogenesis and promotes apoptosis in a tumor cell line resistant tochemotherapy显示文摘 | Rosas C Sinning M Ferreira A | 2014 | Biol Res2014，47，1： | 1 |
| 9 | Assessment of the air quality in indoor car parks显示文摘 | Wong Y C Sin D W M Yeung L L | 2002 | Indoor and Built Enviment2002，11，3： | 1 |
| 10 | Determination and on-line clean-up of (fluoro)quinolones in bovine milk using column-switching liquidchromatography fluorescence detection显示文摘 | Clare Ho Della W M Sin Hubert P 0 Tang | 2004 | Journal ofChromatography A2004，1061，： | 1 |
| 11 | Two-dimensional structure of light-harvesting complex Ⅱ (LHⅡ) from the purple bactrerium Rhodovulum sulfidophilum and comparison with LHⅡ from Rhodopseudomonas acidophila 显示文摘 | Savage H Cyrklaff M Montoya G Kuhlbrandt W Sinning I | 1996 | Struture1996，4，： | 1 |
| 12 | Quantitative analysis of lincomycin in animal tissues and bovine milk by liquid chromatography electrospray ionization tandem mass spectrometry显示文摘 | SIN D W M WONG Y C IPB A C | | 0，，03： | 1 |
| 13 | Trends of ambient carbonyl compounds in the urban environment of Hong Kong显示文摘 | Sin D W M Wong Y C Louie P K K | 2001 | Atmospheric Environment2001，35，34： | 1 |
| 14 | Lymph node size and metasratic infiltration in non-small cell lung cancer显示文摘 | Prenzel K L Monig S P Sinning J M | 2003 | Chest2003，123，2： | 1 |
| 15 | Passive trader of protective immunity against ichthyophthiriais from vaccinated mother to fry in tilapias,Oreochromis aureus显示文摘 | SIN Y M LING K H LAM T J | 1994 | Aquaculture1994，120，： | 1 |
| 16 | Determination of quinoxaline-2-carboxylic acid, the major metabolite of carbadox, in porcine liver by isotope dilution gas chromatography-electron capture negative ionization mass spectrometry显示文摘 | Sin D W M Chung L P K Lai M M C | 2004 | Anal Chim Acta2004，508，2： | 1 |
| 17 | Determination of quinoxaline-2-carboxylic acid, the major metabolite of carbadox, in porcine liver by isotope dilution gas chromatography - electron capture negative ionization mass spectrometry显示文摘 | SIN D W M S CHUNG L P K LAI M M C | 2004 | Anal Chem Acta2004，508，： | 1 |
| 18 | Expression of proteinase inhibitor Ⅱ proteins during floral development in Solarium americanum显示文摘 | SIN S F CHYE M L | 2004 | Planta2004，219，6： | 1 |
| 19 | Relationship Marketing Orientation:Scale Development and Cross-cuhural Validation显示文摘 | SIN L Y M TSE A C B YAU O H M | 2005 | Journal of Business Research2005，58，2： | 1 |
| 20 | The development of quali- ty indicators for the prevention and management of postpartum haemorrhage in primary midwifery care in the Netherlands显示文摘 | Smit M Sin&am SI Woiski M | 2013 | BMC Pregnancy Childbirth2013，13，： | 1 |
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