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| 1 | Study on Snake Venom Protein-Antibody Interaction by Surface Plasmon Resonance Spectroscopy显示文摘一台便携式计算机和便宜表面电浆子回声(SPR ) 的发展有为蛇毒液蛋白质的察觉的综合生物传感器的测量设备在这份报纸被介绍。为察觉到的元素的构造,胺联合化学习惯于 bio-functionalize 银有象免疫球蛋白(IgG ) 一样的抗体的涂的玻璃幻灯片。抗体的固定被象紫外可见的光谱学一样的分光镜的大小证实(紫外力) 并且 Fourier 转变红外线的光谱学(FTIR ) 。设备在严峻的毒液蛋白质样品前与钠氯化物和乙醇的标准答案被校准。调查简历分子的相互作用,印度眼镜蛇的粗略的恶意(集中范围:0.1 mg/ml1.0 mg/ml ) 在磷酸盐缓冲区,答案(PBS ) 暴露于生物传感器。试验性地测量的数据从它的起始的价值在电浆子回声角度显示移动(52 敢愠汬? 祥獥? | Subhankar N. CHOUDHURY Barlina KONWAR Simran KAUR Robin DOLEY Biplob MONDAL | 2018 | Photonic Sensors2018，8，3： | 1 |
| 2 | Robotic-assisted cholecystectomy: Current status and future application显示文摘Robotic-assisted cholecystectomy(RC)is increasingly common.However,its exact role remains unde-fined,with multiport conventional laparoscopic cholecystectomy(LC)being regarded as the established gold standard.This review aims to provide an overview of the evidence for RC and to define its current and future role.A literature search was performed on the PubMed and Medline databases to identify relevant articles published between 1994 and February 2022.The evidence obtained was summarised in a narrative style.Greater emphasis was placed on recent 10-year articles and studies of higher meth-odological quality.RC is noninferior to LC.The robotic platform facilitates the application of minimally invasive surgery in a way conventional laparoscopy cannot.LC remains appropriate for the majority of patients requiring cholecystectomy.The advantages of RC include inherent technical benefits,facilitating the learning of new surgical technology and its potential to reduce the risk of open conversion and bile leakage in certain populations(Mirizzi syndrome,complicated calculous disease,chronic liver disease and possibly malignancy).It also has increasing applicability to related biliary surgery.The limitations include cost,loss of tactile feedback and the learning curve associated with initial implementation.Future applications of robotic surgical systems include utilisation in difficult cholecystectomy,cases of biliary malignancy,telerobotic surgery and telementoring. | Simran Chandhok Phillip Chao Jonathan Koea Sanket Srinivasa | 2022 | Laparoscopic, Endoscopic and Robotic Surgery2022，5，3： | 1 |
| 3 | Antimutagenicity of hydrolysable tannins from terminalia chebula in Salmonella typhimurium显示文摘 | IS Grover Majar Singh | 1998 | Mutation Res1998，419，： | 1 |
| 4 | A Randomized trial of nebulized 3% hypertonic saline with pinephrine in the treatment of acute bronchiolitis in the emergency department 显示文摘 | Simran Grewal | 2009 | Arch Pediatr Adolesc Med2009，163，11： | 1 |
| 5 | Using NLP techniques for file fragment classification显示文摘 | Simran Fitzgerald George Mathews Colin Morris Oles Zhulyn | 2012 | Digital Investigation2012，，： | 1 |
| 6 | Plasmamonocyte chemoattractant protein-1 as risk marker in type 2 diabetes mellitus and coronary artery disease in North Indians显示文摘 | Har simran K Singh A A Guruvinder S | 2009 | Diabasc Dis Res2009，6，4： | 1 |
| 7 | Diminution in Parietal Cell Number in Experimental Portal Hypertensive Gastropathy显示文摘 | Navneet Agnihotri Simran Kaur Jang Bahadur Dilawari Shivyogi Ramrayya Bhusnurmath Upjeet Kaur | 1997 | Digestive Diseases and Sciences1997，，2： | 1 |
| 8 | Research Highlights显示文摘 | Simran Maggo | 2011 | Pharmacogenomics2011，，6： | 1 |
| 9 | 用数字化连接消费者显示文摘不同以往任何时候,今天,在数字化的世界里,消费者才是真正的国王。 | Ang Swee Hoon Simran Gill | 2013 | 商业价值2013，，2： | 0 |
| 10 | Why Does Sport Play Such an Important Role in Our Lives?显示文摘英文写作从模仿开始。从2022年起,我们开设“读写园地”专栏,每期会选登一两篇与专题相关的短文,以Model Me(范文)和Tweak Me(改作文)形式交替呈现。我们一同细细品读,发现优点和不足,希望对读者朋友们的英文写作有所启发。 | Simran Ketan Rathod | 2022 | 英语沙龙(原版阅读)2022，，2： | 0 |
| 11 | Diabetes among Muslims during Ramadan:A narrative review显示文摘Fasting during the month of Ramadan is one of the five fundamental principles of Islam,and it is obligatory for healthy Muslim adults and adolescents.During the fasting month,Muslims usually have two meals a day,suhur(before dawn)and iftar(after dusk).However,diabetic patients may face difficulties when fasting,so it is important for medical staff to educate them on safe fasting practices.Prolonged strict fasting can increase the risk of hypoglycemia and diabetic ketoacidosis,but with proper knowledge,careful planning,and medication adjustment,diabetic Muslim patients can fast during Ramadan.For this review,a literature search was conducted using PubMed and Google Scholar until May 2023.Articles other than the English language were excluded.Current strategies for managing blood sugar levels during Ramadan include a combination of patient education on nutrition,regular monitoring of blood glucose,medications,and insulin therapy.Insulin therapy can be continued during fasting if properly titrated to the patients’needs,and finger prick blood sugar levels should be assessed regularly.If certain symptoms such as hypoglycemia,hyperglycemia,dehydration,or acute illness occur,or blood glucose levels become too high(>300 mg/dL)or too low(<70 mg/dL),the fast should be broken.New insulin formulations such as pegylated insulin and medications like tirzepatide,a dual agonist of gastric-inhibitory peptideand glucagonlike-peptide 1 receptors,have shown promise in managing blood sugar levels during Ramadan.Non-insulin dependent medications like sodium-glucose-cotransporter-2 inhibitors,including the Food and Drug Administration-approved ertugliflozin,are also being used to provide additional cardiovascular benefits in patients with type 2 diabetes. | Rohan Kumar Ochani Asim Shaikh Simran Batra Gauri Pikale Salim Surani | 2023 | World Journal of Clinical Cases2023，11，26： | 0 |
| 12 | 腐植酸和黄腐酸转化对污泥改性种植小麦土壤镉有效性的影响显示文摘污泥中富含养分和有机质,是提高土壤肥力和作物生产的优质肥料。然而,因污泥的吸附沉淀作用使其含有重金属,尤其是镉(Cd),是污泥生产利用中面临的一个主要问题。为使污泥改性土壤实现安全生产,降低粮食中的Cd含量,特设置盆栽实验,将2个小麦品种(“NARC-11”和“Shafaq-06”)种植于0、15、30g/kg污泥用量的改性土壤中。结果表明,施用污泥增加了小麦籽粒产量,但2个供试品种籽粒中Cd含量均在允许范围内(24.1-58.6pg/kg干重)。 | SImran Rashid Ghulam Murtaza Zahir Ahmad Zahir 邓祎(译) | 2019 | 腐植酸2019，，1： | 0 |
| 13 | Data mining-based algorithm for assortment planning显示文摘With increasing varieties and products,management of limited shelf space becomes quite difficult for retailers.Hence,an efficient product assortment,which in turn helps to plan the organization of various products across limited shelf space,is extremely important for retailers.Products can be distinguished based on quality,price,brand,and other attributes,and decision needs to be made about an assortment of the products based on these attributes.An efficient assortment planning improves the financial performance of the retailer by increasing profits and reducing operational costs.Clustering techniques can be very effective in grouping products,stores,etc.and help managers solve the problem of assortment planning.This paper proposes data mining approaches for assortment planning for profit maximization with space,and cost constraints by mapping it into well-known knapsack problem. | Praveen Ranjan Srivastava Satyendra Sharma Simran Kaur | 2020 | Journal of Management Analytics2020，7，3： | 0 |
| 14 | Stem cell therapy: A paradigm shift in breast cancer treatment显示文摘As per the latest Globocan statistics,the high prevalence rate of breast cancer in low-and middle-income countries has led to it becoming the most common cancer to be diagnosed,hence posing a major public health challenge.As per this data,more than 11.7%of the estimated new cancer cases in 2020 were due to breast cancer.A small but significant subpopulation of cells with self-renewing ability are present in the tumor stroma and have been given the nomenclature of cancer stem cells(CSCs).These cells display a high degree of plasticity owing to their ability to transition from the slowly cycling quiescent phase to the actively proliferating phenotype.This attribute of CSCs allows them to differentiate into various cell types having diverse functions.Breast CSCs have a pivotal role in development,metastasis,treatment resistance and relapse of breast cancers.This review focuses on the pathways regulating breast CSC maintenance and the current strategies that are being explored for directing the development of novel,targeted,therapeutic approaches for limiting and eradicating this aberrant stem cell population. | Sabiha Khan Moushumi Suryavanshi Jasamrit Kaur Debadatta Nayak Anil Khurana Raj Kumar Manchanda Chanderdeep Tandon Simran Tandon | 2021 | World Journal of Stem Cells2021，13，7： | 0 |
| 15 | Prospective,multicentre study of screening,investigation and management of hyponatraemia after subarachnoid haemorrhage in the UK and Ireland显示文摘Background Hyponatraemia often occurs after subarachnoid haemorrhage(SAH).However,its clinical significance and optimal management are uncertain.We audited the screening,investigation and management of hyponatraemia after SAH.Methods We prospectively identified consecutive patients with spontaneous SAH admitted to neurosurgical units in the United Kingdom or Ireland.We reviewed medical records daily from admission to discharge,21 days or death and extracted all measurements of serum sodium to identify hyponatraemia(<135 mmol/L).Main outcomes were death/dependency at discharge or 21 days and admission duration>10 days.Associations of hyponatraemia with outcome were assessed using logistic regression with adjustment for predictors of outcome after SAH and admission duration.We assessed hyponatraemia-free survival using multivariable Cox regression.Results 175/407(43%)patients admitted to 24 neurosurgical units developed hyponatraemia.5976 serum sodium measurements were made.Serum osmolality,urine osmolality and urine sodium were measured in 30/166(18%)hyponatraemic patients with complete data.The most frequently target daily fluid intake was>3 L and this did not differ during hyponatraemic or non-hyponatraemic episodes.26%(n/N=42/164)patients with hyponatraemia received sodium supplementation.133(35%)patients were dead or dependent within the study period and 240(68%)patients had hospital admission for over 10 days.In the multivariable analyses,hyponatraemia was associated with less dependency(adjusted OR(aOR)=0.35(95%CI 0.17 to 0.69))but longer admissions(aOR=3.2(1.8 to 5.7)).World Federation of Neurosurgical Societies grade I-III,modified Fisher 2-4 and posterior circulation aneurysms were associated with greater hazards of hyponatraemia.Conclusions In this comprehensive multicentre prospective-adjusted analysis of patients with SAH,hyponatraemia was investigated inconsistently and,for most patients,was not associated with changes in management or clinical outcome.This work establishes a basis for the development of evidence-based SAH-specific guidance for targeted screening,investigation and management of high-risk patients to minimise the impact of hyponatraemia on admission duration and to improve consistency of patient care. | James J M Loan Steven Tominey Kirun Baweja Julie Woodfield Thomas J G Chambers Mark Haley Simran S Kundu H Y Josephine Tang Anthony N Wiggins Michael T C Poon Paul M Brennan | 2023 | Stroke & Vascular Neurology2023，8，3： | 0 |
| 16 | Soluble alpha-synuclein post-translational modifications:unexpected regulators of pathological alpha-synuclein amplification显示文摘The build-up of misfoldedα-synuclein(α-syn)in the central nervous system is the pathological hallmark of a number of neurodegenerative diseases that are known asα-synucleinopathies.These include Parkinson’s disease(PD),Parkinson’s disease with dementia(PDD),dementia with Lewy body(LB),multiple system atrophy(MSA),and a subset of Alzheimer’s disease.Growing evidence underscores that the intercellular transmission and amplification of pathologicalα-syn are critical processes underlying the progression ofα-synucleinopathies(Peng et al.,2020),and as such,the study of these processes could lead to the identification of promising therapeutics to mitigate disease progression.Most previous studies have focused solely on pathological seeds in relation to disease progression. | Simran Kapila Yuhan Sun Chao Peng Shujing Zhang | 2024 | Neural Regeneration Research2024，19，5： | 0 |
| 17 | A review on re-emerging bacteriophage therapy in the era of XDR显示文摘In the present medicine world antibiotic resistance is one of the key threats to universal health coverage.Researchers continue to work hard to combat this global health concern.Phage therapy,an age-old practice during the early twentieth century,was outshined by the discovery of antibiotics.With the advent of widespread antibiotic resistance,phage therapy has again redeemed itself as a potential alternative owing to its adeptness to target bacteria precisely.Limited side effects,the ability to migrate to different body organs,a distinct mode of action,and proliferation at the infection site,make phages a profitable candidate to replace conventional antibiotics.The progressive outcome of numerous in vitro studies and case reports has validated the clinical efficacy of phage therapy.The bright perspective of using phages to treat bacterial infections has fueled enormous medical research to exploit their potential as therapeutics.The gaps in the information about phages and the lack of consent for clinical trials is major hurdle for consideration of phage therapy.Crafting phage therapy as a reality in medicine requires a coordinated effort from different fraternities.With this review,we aim to emphasize the importance of phage therapy in modern medicine.This review explains their historical journey,basic phage biology,cross-talk with the host immunity,obstacles with phage therapy,and their possible remedies.Comprehensive data on the various significant clinical trials of phage therapy has been presented.We evaluated the efficacy of antibiotics and phage therapy in part and in combination,along with recent progress and future perspectives of phage therapy. | POOJA BHADORIYA RICHA SHARMA REKHA MEHROTRA SIMRAN KAUR ISHA SRIVASTAVA MUKUL JAIN PRASHANT KAUSHIK | 2023 | BIOCELL2023，47，9： | 0 |
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