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| 1 | Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress显示文摘AMPK, a master regulator of metabolic homeostasis, is activated by both AMP-dependent and AMP-independent mechanisms. The conditions under which these different mechanisms operate, and their biological implications are unclear. Here, we show that, depending on the degree of elevation of cellular AMP, distinct compartmentalized pools of AMPK are activated, phosphorylating different sets of targets. Low glucose activates AMPK exclusively through the AMP-independent, AXIN-based pathway in lysosomes to phosphorylate targets such as ACC1 and SREBP1c, exerting early anti-anabolic and pro-catabolic roles. Moderate increases in AMP expand this to activate cytosolic AMPK also in an AXIN-dependent manner. In contrast, high concentrations of AMP, arising from severe nutrient stress, activate all pools of AMPK independently of AXIN. Surprisingly, mitochondrion-localized AMPK is activated to phosphorylate ACC2 and mitochondrial fission factor (MFF) only during severe nutrient stress. Our findings reveal a spatiotemporal basis for hierarchical activation of different pools of AMPK during differing degrees of stress severity. | Yue Zong Chen-Song Zhang Mengqi Li Wen Wang Zhichao Wang Simon A. Hawley Teng Ma Jin-Wei Feng Xiao Tian Qu Qi Yu-Qing Wu Cixiong Zhang Zhiyun Ye Shu-Yong Lin Hai-Long Piao D. Grahame Hardie Sheng-Cai Lin | 2019 | Cell Research2019，29，6： | 8 |
| 2 | Current and future molecular diagnostics in colorectal cancer and colorectal adenoma显示文摘Colorectal cancer(CRC)is one of the most prevalent cancers in developed countries.On the other hand,CRC is also one of the most curable cancers if it is detected in early stages through regular colonoscopy or sigmoidoscopy.Since CRC develops slowly from precancerous lesions,early detection can reduce both the incidence and mortality of the disease.Fecal occult blood test is a widely used non-invasive screening tool for CRC.Although fecal occult blood test is simple and cost-effective in screening CRC,there is room for improvement in terms of the accuracy of the test.Genetic dysregulations have been found to play an important role in CRC development.With better understanding of the molecular basis of CRC,there is a growing expectation on the development of diagnostic tests based on more sensitive and specific molecular markers and those tests may provide a breakthrough to the limitations of current screening tests for CRC.In this review,the molecular basis of CRC development,the characteristics and applications of different non-invasive molecular biomarkers,as well as the technologies available for the detection were discussed.This review intended to provide a summary on the current and future molecular diagnostics in CRC and its pre-malignant state,colorectal adenoma. | Andy Hin-Fung Tsang Ka-Ho Cheng Apple Siu-Ping Wong Simon Siu-Man Ng Brigette Buig-Yue Ma Charles Ming-Lok Chan Nancy Bo-Yin Tsui Lawrence Wing-Chi Chan Benjamin Yat-Ming Yung Sze-Chuen Cesar Wong | 2014 | World Journal of Gastroenterology2014，20，14： | 7 |
| 3 | 863 genomes reveal the origin and domestication of chicken显示文摘Despite the substantial role that chickens have played in human societies across the world,both the geographic and temporal origins of their domestication remain controversial.To address this issue,we analyzed 863 genomes from a worldwide sampling of chickens and representatives of all four species of wild jungle fowl and each of the five subspecies of red jungle fowl(RJF).Our study suggests that domestic chickens were initially derived from the RJF subspecies Gallus gallus spadiceus whose present-day distribution is predominantly in southwestern China,northern Thailand and Myanmar.Following their domestication,chickens were translocated across Southeast and South Asia where they interbred locally with both RJF subspecies and other jungle fowl species.In addition,our results show that the White Leghorn chicken breed possesses a mosaic of divergent ancestries inherited from other subspecies of RJF.Despite the strong episodic gene flow from geographically divergent lineages of jungle fowls,our analyses show that domestic chickens undergo genetic adaptations that underlie their unique behavioral,morphological and reproductive traits.Our study provides novel insights into the evolutionary history of domestic chickens and a valuable resource to facilitate ongoing genetic and functional investigations of the world's most numerous domestic animal. | Ming-Shan Wang Mukesh Thakur Min-Sheng Peng Yu Jiang Laurent Alain Francois Frantz Ming Li Jin-Jin Zhang Sheng Wang Joris Peters Newton Otieno Otecko Chatmongkon Suwannapoom Xing Guo Zhu-Qing Zheng Ali Esmailizadeh Nalini Yasoda Hirimuthugoda Hidayat Ashari Sri Suladari Moch Syamsul Arifin Zein Szilvia Kusza Saeed Sohrabi Hamed Kharrati-Koopaee Quan-Kuan Shen Lin Zeng Min-Min Yang Ya-Jiang Wu Xing-Yan Yang Xue-Mei Lu Xin-Zheng Jia Qing-Hua Nie Susan Joy Lamont Emiliano Lasagna Simone Ceccobelli Humpita Gamaralalage Thilini Nisanka Gunwardana Thilina Madusanka Senasige Shao-Hong Feng Jing-Fang Si Hao Zhang Jie-Qiong Jin Ming-Li Li Yan-Hu Liu Hong-Man Chen Cheng Ma Shan-Shan Dai Abul Kashem Fazlul Haque Bhuiyan Muhammad Sajjad Khan Gamamada Liyanage Lalanie Pradeepa Silva Thi-Thuy Le Okeyo Ally Mwai Mohamed Nawaz Mohamed Ibrahim Megan Supple Beth Shapiro Olivier Hanotte Guojie Zhang Greger Larson Jian-Lin Han Dong-Dong Wu Ya-Ping Zhang | 2020 | Cell Research2020，30，8： | 7 |
| 4 | Predicting the potential geographic distribution of Bactrocera bryoniae and Bactrocera neohumeralis(Diptera: Tephritidae) in China using MaxEnt ecological niche modeling显示文摘Bactrocera bryoniae and Bactrocera neohumeralis are highly destructive and major biosecurity/quarantine pests of fruit and vegetable in the tropical and subtropical regions in the South Pacific and Australia.Although these pests have not established in China,precautions must be taken due to their highly destructive nature.Thus,we predicted the potential geographic distribution of B.bryoniae and B.neohumeralis across the world and in particular China by ecological niche modeling of the Maximum Entropy(Max Ent)model with the occurrence records of these two species.Bactrocera bryoniae and B.neohumeralis exhibit similar potential geographic distribution ranges across the world and in China,and each species was predicted to be able to distribute to over 20%of the globe.Globally,the potential geographic distribution ranges for these two fruit fly species included southern Asia,the central and the southeast coast of Africa,southern North America,northern and central South America,and Australia.While within China,most of the southern Yangtze River area was found suitable for these species.Notably,southern China was considered to have the highest risk of B.bryoniae and B.neohumeralis invasions.Our study identifies the regions at high risk for potential establishment of B.bryoniae and B.neohumeralis in the world and in particular China,and informs the development of inspection and biosecurity/quarantine measures to prevent and control their invasions. | Jing Wan QI Guo-jun MA Jun Yonglin REN WANG Rui Simon MCKIRDY | 2020 | Journal of Integrative Agriculture2020，19，8： | 5 |
| 5 | Accelerated design and characterization of non-uniform cellular materials via a machine-learning based framework显示文摘Cellular materials,widely found in engineered and nature systems,are highly dependent on their geometric arrangement.A nonuniform arrangement could lead to a significant variation of mechanical properties while bringing challenges in material design.Here,this proof-of-concept study demonstrates a machine-learning based framework with the capability of accelerated characterization and pattern generation.Results showed that the proposed framework is capable of predicting the mechanical response curve of any given geometric pattern within the design domain under appropriate neural network architecture and parameters.Additionally,the framework is capable of generating matching geometric patterns for a targeted response through a databank constructed from our machine learning model.The accuracy of the predictions was verified with finite element simulations and the sources of errors were identified.Overall,our machine-learning based framework can boost the design efficiency of cellular materials at unit level,and open new avenues for the programmability of function at system level. | Chunping Ma Zhiwei Zhang Benjamin Luce Simon Pusateri Binglin Xie Mohammad H.Rafiei Nan Hu | 2020 | npj Computational Materials2020，，1： | 3 |
| 6 | Entanglement and discord assisted entropic uncertainty relations under decoherence显示文摘The uncertainty principle is a crucial aspect of quantum mechanics.It has been shown that quantum entanglement as well as more general notions of correlations,such as quantum discord,can relax or tighten the entropic uncertainty relation in the presence of an ancillary system.We explored the behaviour of entropic uncertainty relations for system of two qubits—one of which subjects to several forms of independent quantum noise,in both Markovian and non-Markovian regimes.The uncertainties and their lower bounds,identified by the entropic uncertainty relations,increase under independent local unital Markovian noisy channels,but they may decrease under non-unital channels.The behaviour of the uncertainties(and lower bounds)exhibit periodical oscillations due to correlation dynamics under independent non-Markovian reservoirs.In addition,we compare different entropic uncertainty relations in several special cases and find that discord-tightened entropic uncertainty relations offer in general a better estimate of the uncertainties in play. | YAO ChunMei CHEN ZhiHua MA ZhiHao SEVERINI Simone SERAFINI Alessio | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，9： | 2 |
| 7 | Data-Driven Discovery in Mineralogy: Recent Advances in Data Resources, Analysis, and Visualization显示文摘Large and growing data resources on the diversity, distribution, and properties of minerals are ushering in a new era of data-driven discovery in mineralogy. The most comprehensive international mineral database is the IMA database, which includes information on more than 5400 approved mineral species and their properties, and the mindat.org data source, which contains more than 1 million species/locality data on minerals found at more than 300 000 localities. Analysis and visualization of these data with diverse techniques—including chord diagrams, cluster diagrams, Klee diagrams, skyline diagrams, and varied methods of network analysis—are leading to a greater understanding of the co-evolving geosphere and biosphere. New data-driven approaches include mineral evolution, mineral ecology, and mineral network analysis—methods that collectively consider the distribution and diversity of minerals through space and time. These strategies are fostering a deeper understanding of mineral co-occurrences and, for the first time, facilitating predictions of mineral species that occur on Earth but have yet to be discovered and described. | Robert M. Hazen Robert T. Downs Ahmed Eleish Peter Fox Olivier C. Gagné Joshua J. Golden Edward S. Grew Daniel R. Hummer Grethe Hystad Sergey V. Krivovichev Congrui Li Chao Liu Xiaogang Ma Shaunna M. Morrison Feifei Pan Alexander J. Pires Anirudh Prabhu Jolyon Ralph Simone E. Runyon Hao Zhong | 2019 | Engineering2019，5，3： | 2 |
| 8 | A cervical anterior spinal artery syndrome after diagnostic blockade of the right C6 - nerve root 显示文摘 | Brouwers PJ Kottink EJ Simon MA | 2001 | Pain2001，91，： | 1 |
| 9 | A cervical anterior spinal artery syndrome after diagnostic blockade of the right C6-nerve root 显示文摘 | Brouwers PJ Kottnik EJ Simon MA | 2001 | Pain2001，91，3： | 1 |
| 10 | Limb-salvage treatment versus amputation for osteosarcoma of the distal end of the femur显示文摘 | Simon MA Aschliman MA Thomas N | | 0，，09： | 1 |
| 11 | Phase VII trial of an allogeneic cellular immunotherapy in hormone - na? ve prostate cancer 显示文摘 | Simons JW Carducci MA Mikhak B | 2006 | Clin Cancer Res2006，12，111： | 1 |
| 12 | Fecal microbiota in sensitized wheezy and non-sensitized non-wheezy children: a nested case-control study 显示文摘 | Murray CS Tannock GW Simon MA | 2005 | Clin Exp Allergy2005，35，： | 1 |
| 13 | The integrin family of cell surface receptors显示文摘 | De Simone DW Stepp MA Patel RS | 1987 | Biochem Soc Trans1987，15，5： | 1 |
| 14 | Variations of biogeography-based optimization and Markov analysis 显示文摘 | MA Hat-ping Simon Dan FEI Min-rui | 2013 | Information Sciences2013，220，： | 1 |
| 15 | Limb slavagetreatment versus amputation for osteosarcoma of the distalend of the femur显示文摘 | Simon MA Aschliman M Thomas N | 1986 | J Bone Joint Surg(Am)1986，68，9： | 1 |
| 16 | Accurate on-line support vector regression 显示文摘 | Ma junshui James Theiler Simon Perkins | 2003 | Nenral Computation2003，15，11： | 1 |
| 17 | Radical cystectomy after bacil- lus Calmette-Guerin for high-risk Ta,Tl,and carcinoma in situ: de- fining the risk of initial bladder preservation显示文摘 | Nieder AM Simon MA Kim SS | 2006 | Urology2006，67，： | 1 |
| 18 | Androgen therapy improves insulin sensitivity and decreases leptin level in healthy adult men with low plasma toal testosterone:a 3-months randomized placebo-controlled trial显示文摘 | Simon D Charles MA Lahlou N | 2001 | Diabetes Care2001，24，12： | 1 |
| 19 | Molecular basis of restenosis and drug-eluting stents 显示文摘 | Costa MA Simon DI | 2005 | Circulation2005，111，17： | 1 |
| 20 | Analysis of migration models of biogeography- based optimization using Markov theory 显示文摘 | Ma H P Simon D | 2011 | Engineering Application of Artificial Intelligence2011，24，6： | 1 |
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