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618篇 您的检索式：作者名="Simonin"

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	题名	作者	年代	出处	被引量
1	Characterization of two rat models of cystic fibrosis—KO and F508del CFTR—Generated by Crispr-Cas9显示文摘Background: Genetically engineered animals are essential for gaining a proper understanding of the disease mechanisms of cystic fibrosis(CF). The rat is a relevant laboratory model for CF because of its zootechnical capacity, size, and airway characteristics, including the presence of submucosal glands.Methods: We describe the generation of a CF rat model(F508 del) homozygous for the p.Phe508 del mutation in the transmembrane conductance regulator(Cftr) gene. This model was compared to new Cftr-/-rats(CFTR KO). Target organs in CF were examined by histological staining of tissue sections and tooth enamel was quantified by micro-computed tomography. The activity of CFTR was evaluated by nasal potential difference(NPD) and short-circuit current measurements. The effect of VX-809 and VX-770 was analyzed on nasal epithelial primary cell cultures from F508 del rats.Results: Both newborn F508 del and Knock out(KO) animals developed intestinal obstruction that could be partly compensated by special diet combined with an osmotic laxative. The two rat models exhibited CF phenotypic anomalies such as vas deferens agenesis and tooth enamel defects. Histology of the intestine, pancreas, liver, and lungs was normal. Absence of CFTR function in KO rats was confirmed ex vivo by short-circuit current measurements on colon mucosae and in vivo by NPD, whereas residual CFTR activity was observed in F508 del rats. Exposure of F508 del CFTR nasal primary cultures to a combination of VX-809 and VX-770 improved CFTR-mediated Cl-transport.Conclusions: The F508 del rats reproduce the phenotypes observed in CFTR KO animals and represent a novel resource to advance the development of CF therapeutics.	Elise Dreano Marc Bacchetta Juliette Simonin Louise Galmiche Claire Usal Lotfi Slimani Jérémy Sadoine Laurent Tesson Ignacio Anegon Jean-Paul Concordet Aurélie Hatton Lucile Vignaud Danielle Tondelier Isabelle Sermet-Gaudelus Marc Chanson Charles-Henry Cottart	2019	Animal Models and Experimental Medicine2019，2，4：	3
2	Optimization of pressure-induced germination of Bacillus sporothermodurans spores in water and milk显示文摘	C. Aouadhi H. Simonin H. Prévost M. de Lamballerie A. Maaroufi S. Mejri	2011	Food Microbiology2011，，1：	2
3	Land use change and its effects on the value of ecosystem services along the coast of the Gulf of Mexico显示文摘	G. Mendoza-González M.L. Martínez D. Lithgow O. Pérez-Maqueo P. Simonin	2012	Ecological Economics2012，，：	2
4	Isoprenoid biosynthesis in bacteria: a novel pathway for the early steps leading to isopentenyl diphosphate显示文摘	Knani M Simonin P	1993	Biochem J1993，295，：	1
5	Transfer of marketing know-how in international strategic alliances:an empirical investigation of the role and antecedents of knowledge ambiguity显示文摘	Simonin B L	1999	Journal of International Business Studies1999，30，3：	1
6	The importance of collaborative know-how:an empirical test of the learning organization显示文摘	Simonin BL	1997	Academy of Management Journal1997，40，5：	1
7	Adult biphenotypic acute leukaemia: an entity with poor prognosis which is related to unfavourable cytogenetics and P-glycoprotein over-expression显示文摘	Legrand O Perrot JY Simonin G	1998	BrJ Haematol1998，100，1：	1
8	The importance of collaborative know-how: an empirical test of the learning organization 显示文摘	Simonin B L	1997	Academy of Management Journal1997，40，5：	1
9	Adult biphenotypic acute leukemia; an entity with poor prognosis which is related to unfavourable cytogenetics and pglycoprotein over expression显示文摘	Legrand O Perrot J Y Simonin G	1998	Br J Haematol1998，100，1：	1
10	The importance of developing collabora- tive know-how: An empirical test of the learning orga- nization显示文摘	Simonin B L	1997	Academy of Management Journal1997，40，5：	1
11	Pefloxacin-induced achilles tendon toxicity in rodents: biochemical changes in proteoglycan synthesis and oxidative damage to collagen 显示文摘	Simonin MA Gegout Pottie P Minn A	2000	Antimicrob Agents Chemother2000，44，4：	1
12	Transfer of Marketing Know-how in Inter national Strategic Alliances:An Empirical Investigation of the Role and Antecedents of Knowledge Ambiguity显示文摘	Simonin L B	1999	Journal of International Business Studies1999，30，3：	1
13	Transfer of marketing know-how in international strategic alliances: An empirical investigation of the role and antecedents of knowledge ambiguity 显示文摘	Simonin B L	1999	Journal of International Business Studies1999，33，3：	1
14	Transfer of marketing know--how in international strategic alliances: all empirical investigation of the role and antecedents of knowledge ambiguity显示文摘	SIMONIN B L	1999	Journal of International Business Studies1999，30，3：	1
15	Two- and three-dimensional simulations of a bubble plume using a two41uid model显示文摘	Mudde R F Simonin O	1999	Chen ical Engineering Science1999，54，：	1
16	Adult biphenotypie acute leukemia: an entity with poor prognosis which is related to unfavourable cytogenetics and P-glycoprotein over-expression显示文摘	LEGRAND O PERROT JY SIMONIN G	1998	Br J Haematol1998，100，1：	1
17	Adult biphenotypic acute leukemia:an entity with poor progrosis which is related to un- favourable cytogenetics and P-glycoprotein over-expression显示文摘	Legrand O Perror JY Simonin G	2012	Bri J Haematol2012，100，1：	1
18	Both P-gp and MRP contribute to drug resistance in AML显示文摘	Legrand O Simonin G Zittoun R	1998	Leukemia1998，12，8：	1
19	Ambiguity and the process of knowledge transfer in strategic alliances 显示文摘	Simonin B L	1999	Strategic Management Journal1999，20，7：	1
20	An Empirical Investigation of the Process of Knowledge Transfer in International Strategic Alliances显示文摘	Simonin B L	2004	Journal of International Busi- ness Studies2004，，35：	1

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