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| 1 | Zebrafish embryo toxicity of 15 chlorinated, brominated, and iodinated disinfection by-products显示文摘Disinfection to protect human health occurs at drinking water and wastewater facilities through application of non-selective oxidants including chlorine. Oxidants also transform organic material and form disinfection by-products(DBPs), many of which are halogenated and cyto-and genotoxic. Only a handful of assays have been used to compare DBP toxicity,and researchers are unsure which DBP(s) drive the increased cancer risk associated with drinking chlorinated water. The most extensive data set employs an in vitro model cell,Chinese hamster ovary cells. Traditionally, most DBP research focuses on the threat to human health, but the effects on aquatic species exposed to DBPs in wastewater effluents remain ill defined. We present the developmental toxicity for 15 DBPs and a chlorinated wastewater to a model aquatic vertebrate, zebrafish. Mono-halogenated DBPs followed the in vivo toxicity rank order: acetamides > acetic acids > acetonitriles ~ nitrosamines, which agrees well with previously published mammalian in vitro data. Di-and tri-halogenated acetonitriles were more toxic than their mono-halogenated analogues, and bromine-and iodine-substituted DBPs tended to be more toxic than chlorinated analogues. No zebrafish development effects were observed after exposure to undiluted or non-concentrated,chlorinated wastewater. We find zebrafish development to be a viable in vivo alternative or confirmatory assay to mammalian in vitro cell assays. | David Hanigan Lisa Truong Michael Simonich Robert Tanguay Paul Westerhoff | 2017 | Journal of Environmental Sciences2017，29，8： | 5 |
| 2 | Nanofiltra- tion and ultrafiltration of endocrine disrupting compounds, pharma- ceuticals and personal care products 显示文摘 | Yeomin Yoon Paul Westerhoff Shane A Snyder | 2006 | Joumal of Membrane Sci- ence2006，270，12： | 1 |
| 3 | Factors affecting formation of haloacetonitriles, haloketones, chloropicrin and cyanogen halides during chloramination显示文摘 | Yang Xin Shang Chii Westerhoff Paul | 2007 | Water Research2007，41，6： | 1 |
| 4 | Dissolved organic nitrogen in drink- ing water supplies: a review 显示文摘 | Paul Westerhoff Heath Mash | 2002 | J Water SRT-Aqua2002，51，： | 1 |
| 5 | Formation, precursors, control, and occurrence of nitrosamines in drinking water: A review显示文摘 | Stuart W. Krasner William A. Mitch Daniel L. McCurry David Hanigan Paul Westerhoff | 2013 | Water Research2013，，13： | 1 |
| 6 | Photocatalytic reduction of nitrate using titanium dioxide for regeneration of ion exchange brine显示文摘 | Ting Yang Kyle Doudrick Paul Westerhoff | 2012 | Water Research2012，，： | 1 |
| 7 | Dissolved organic nitrogen in drinking water supplies: a review Journal of Water Supply 显示文摘 | Paul Westerhoff Heath Mash | 2002 | Research and Technology-AQUA2002，8，51： | 1 |
| 8 | Occurrenceand removal of titanium at full scale wastewater treatment plants: implications for TiO2 nanomaterials 显示文摘 | Paul Westerhoff Guixue Song KirilHristovski | 2011 | J Environ Monitoring2011，13，： | 1 |
| 9 | Factors affecting formation of haloacetonitriles, haloketones, chloropicrin and cyanogen halides during chloramination显示文摘 | Xin Yang Chii Shang Paul Westerhoff | 2007 | Water Research2007，，6： | 1 |
| 10 | Nitrate removal in zero-valent iron packed columns显示文摘 | Paul Westerhoff Jennifer James | 2003 | Water Research2003，7，8： | 1 |
| 11 | Fluorescence excita- tion-emission matrix regional integration to quantify spectra for dis- solved organic matter 显示文摘 | Chen Wen Paul Westerhoff Jerrya Leenheer | 2003 | Environmental Science Technology2003，37，24： | 1 |
| 12 | Intraparticle diffusion and adsorption of arsenate onto granular ferric hydroxide (GFH)显示文摘 | Mohammad Badruzzaman Paul Westerhoff Detlef R.U. Knappe | 2004 | Water Research2004，，18： | 1 |
| 13 | Dissolved organic nitrogen measurement using dialysis pretreatment 显示文摘 | Lee Wontae Paul Westerhoff | 2005 | Environ Sci Technol2005，39，3： | 1 |
| 14 | Dissolved organic nitrogen removal during water treatment by aluminum sulfate and cationic polymer coagulation 显示文摘 | Lee Wontae Paul Westerhoff | 2006 | Water Res2006，40，20： | 1 |
| 15 | Fate and biological effects of silver, titanium dioxide, and C 60 (fullerene) nanomaterials during simulated wastewater treatment processes显示文摘 | Yifei Wang Paul Westerhoff Kiril D. Hristovski | 2011 | Journal of Hazardous Materials2011，，： | 1 |
| 16 | Nanofiltration and ultrafiltration of endocrine disrupting compounds, pharmaceuticals and personal care products显示文摘 | Yeomin Yoon Paul Westerhoff Shane A. Snyder Eric C. Wert | 2005 | Journal of Membrane Science2005，，1： | 1 |
| 17 | Biosorption of nanoparticles to heterotrophic wastewater biomass显示文摘 | Mehlika A. Kiser Hodon Ryu Hyunyoung Jang Kiril Hristovski Paul Westerhoff | 2010 | Water Research2010，，14： | 1 |
| 18 | Nitrate removal in zero - valent iron packed columns 显示文摘 | Paul Westerhoff Jennifer James | 2003 | Water Research2003，37，： | 1 |
| 19 | Nitrate removal in zerovalent iron packed columns显示文摘 | Paul Westerhoff Jennifer Jamesb | 2003 | Water Research2003，37，： | 1 |
| 20 | Nitrate removal in zero-valent iron packed columns显示文摘 | Paul Westerhoff Jennifer James | 2003 | Water Research2003，，37： | 1 |
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