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| 1 | Ursodeoxycholic acid improves gastrointestinal motility defects in gallstone patients显示文摘AIM: To simultaneously evaluate the presence of defects in gallbladder and gastric emptying, as well as in intestinal transit in gallstone patients (GS) and the effect of chronic ursodeoxycholic acid (UDCA) administration on these parameters and on serum bile acids and clinical outcome in GS and controls (CTR). METHODS: After a standard liquid test meal, gallbla-dder and gastric emptying (by ultrasound), oroileal transit time (OITT) (by an immunoenzymatic technique) and serum bile acids (by HPLC) were evaluated before and after 3 mo of UDCA (12 mg/kg bw/d) or placebo administration in 10 symptomatic GS and 10 matched healthy CTR. RESULTS: OITT was longer in GS than in CTR (P < 0.0001); UDCA significantly reduced OITT in GS (P < 0.0001), but not in CTR. GS had longer gastric half-emptying time (t1/2) than CTR (P < 0.0044) at baseline; after UDCA, t1/2 significantly decreased (P < 0.006) in GS but not in CTR. Placebo administration had no effect on gastric emptying and intestinal transit in both GS and CTR. CONCLUSION: The gallstone patient has simultaneous multiple impairments of gallbladder and gastric emptying, as well as of intestinal transit. UDCA administration restores these defects in GS, without any effect in CTR. These results confirm the pathogenetic role of gastrointestinal motility in gallstone disease and suggest an additional mechanism of action for UDCA in reducing bile cholesterol supersaturation. | A Colecchia G Mazzella L Sandri F Azzaroli M Magliuolo P Simoni ML Bacchi-Reggiani E Roda D Festi | 2006 | World Journal of Gastroenterology2006，12，33： | 4 |
| 2 | Eosinophilic inflammation in asthma 显示文摘 | Bousquet J Chanez P Lacoste JY Barneon G Ghavanian N Enander I Venge P Ahlstedt S Simony - Lafontaine J Godard P | 1990 | N Engl J Med1990，323，： | 1 |
| 3 | Two distinct mechanisms mediate a differential regulation of protein kinase C isozymes in acute and prolonged myocardial ischemia显示文摘 | STRASSER R H SIMONIS G SCHON S P | 1999 | Circ Res1999，85，1： | 1 |
| 4 | Regulation of protein kinase C isozymes in volume overload cardiac hypertrophy显示文摘 | Braun MU LaRosee P Simonis G | 2004 | Mol Cell Biochem2004，262，： | 1 |
| 5 | Residues of antimicrobial drugs and feed additives in animal products显示文摘 | Simoni P G Revesado P R Cadahia O | 2000 | Livestock Production Science2000，871，： | 1 |
| 6 | Synthesis of 2-(5'-substituted isoxazol-3'-yl)-4-oxo-3-thiazolidinylalkanoic acids显示文摘 | BARAD P G SIMONI D MORODER F | 1982 | J Heterocyclic Chem1982，19，3： | 1 |
| 7 | The inflammatory response in cerebral ischemia:focus on cytokines in stroke patients 显示文摘 | De Simoni M G Milia P Barba M | 2002 | Clin Exp Hypertens2002，24，78： | 1 |
| 8 | Preparation of 3,4- dihydroxy-l-benzeneethanol : a reinvestigation 显示文摘 | Baraldi P G Simoni D Manfredini S | 1983 | Liebigs Ann Chem1983，83，： | 1 |
| 9 | Residues of antimicrobial drugs and feed additives in animal products显示文摘 | Simoni P G Revesado P R Cadahia O | 2000 | Livestock Production Science2000，871，： | 1 |
| 10 | LITHOPROBE seismic reflection structure of the southeastern Canadian Cordillera:initial results显示文摘 | Green A G Simony P S | 1988 | Tectonics1988，7，2： | 1 |
| 11 | 查看详情显示文摘 | M G Tarallo J Miller J Agresti E D'Ambrosio R DeSalvo D Forest B Lagrange J M Mackowsky C Michel J L Montorio N Morgado L Pinard A Pemillcux B Simoni and P Willems | | 0，，26： | 1 |
| 12 | An Improved Preparation of Enaminones from 1,3-diketones and Ammonium Acetate or Amine Acetates 显示文摘 | BARALDI P G SIMONI D MANFREDINI S | 1983 | Synthesis1983，11，： | 1 |
| 13 | Preparation of 3,4-dihydroxy-l-benzeneethanol : A reinvestigation显示文摘 | BARALDI P G SIMONI D MANFREDINI S | 1983 | Liebigs Annalen der Chemic1983，1983，4： | 1 |
| 14 | Pro-inflammatory monocyte-macrophage polarization imbalance in human hypercholesterolemia and atherosclerosis显示文摘 | Fadini G P Simoni F Cappellari R | 2014 | Atherosclerosis2014，237，2： | 1 |
| 15 | An improved preparation of enaminones from 1,3-diketones and ammonium acetate or amine acetates 显示文摘 | BARALDI P G SIMONI D MANFREDINI S | 1983 | Synthesis1983，11，： | 1 |
| 16 | Pro-inflam- matory monocyte- macrophage polarization imbalance in human hypercholesterolemia and atherosclerosis显示文摘 | Fadini G P Simoni F Cappellari R | 2014 | Atherosclerosis2014，237，2： | 1 |
| 17 | Short-term,low-dose triple therapy for eradication of Helicobacter pylori显示文摘 | Bazzoli F Zagari RM Fossi S Pozzato P Alampi G Simoni P Rocla A Roda E | | 0，，： | 1 |
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