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| 1 | Experimental Investigation of Separation and Transition Processes on a High-Lift Low-Pressure Turbine Profile Under Steady and Unsteady Inflow at Low Reynolds Number显示文摘The effects induced by the presence of incoming wakes on the boundary layer developing over a high-lift low-pressure turbine profile have been investigated in a linear cascade at mid-span.The tested Reynolds number is 70000,typical of the cruise operating condition.The results of the investigations performed under steady and unsteady inflow conditions are analyzed.The unsteady investigations have been performed at the reduced frequency of f+=0.62,representative of the real engine operating condition.Profile aerodynamic loadings as well as boundary layer velocity profiles have been measured to survey the separation and transition processes.Spectral analysis has been also performed to better understand the phenomena associated with the transition process under steady inflow.For the unsteady case,a phase-locked ensemble averaging technique has been employed to reconstruct the time-resolved boundary layer velocity distributions from the hot-wire instantaneous signal output.The ensemble-averaging technique allowed a detailed analysis of the effects induced by incoming wakes-boundary layer interaction in separation suppression.Time-resolved results are presented in terms of mean velocity and unresolved unsteadiness time-space plots. | Satta F Simoni D Ubaldi M Zunino P Bertini F | 2010 | Journal of Thermal Science2010，19，1： | 9 |
| 2 | Ursodeoxycholic acid improves gastrointestinal motility defects in gallstone patients显示文摘AIM: To simultaneously evaluate the presence of defects in gallbladder and gastric emptying, as well as in intestinal transit in gallstone patients (GS) and the effect of chronic ursodeoxycholic acid (UDCA) administration on these parameters and on serum bile acids and clinical outcome in GS and controls (CTR). METHODS: After a standard liquid test meal, gallbla-dder and gastric emptying (by ultrasound), oroileal transit time (OITT) (by an immunoenzymatic technique) and serum bile acids (by HPLC) were evaluated before and after 3 mo of UDCA (12 mg/kg bw/d) or placebo administration in 10 symptomatic GS and 10 matched healthy CTR. RESULTS: OITT was longer in GS than in CTR (P < 0.0001); UDCA significantly reduced OITT in GS (P < 0.0001), but not in CTR. GS had longer gastric half-emptying time (t1/2) than CTR (P < 0.0044) at baseline; after UDCA, t1/2 significantly decreased (P < 0.006) in GS but not in CTR. Placebo administration had no effect on gastric emptying and intestinal transit in both GS and CTR. CONCLUSION: The gallstone patient has simultaneous multiple impairments of gallbladder and gastric emptying, as well as of intestinal transit. UDCA administration restores these defects in GS, without any effect in CTR. These results confirm the pathogenetic role of gastrointestinal motility in gallstone disease and suggest an additional mechanism of action for UDCA in reducing bile cholesterol supersaturation. | A Colecchia G Mazzella L Sandri F Azzaroli M Magliuolo P Simoni ML Bacchi-Reggiani E Roda D Festi | 2006 | World Journal of Gastroenterology2006，12，33： | 4 |
| 3 | Novel A- Ring and B-Ring modified combretastatin A-4 (CA-4) analogues endowed with interesting cytotoxic activity 显示文摘 | SIMONI D ROMAGNOLI R BARUCHELLO R | 2008 | J Med Chem2008，51，19： | 1 |
| 4 | De-sign,synthesis and biological evaluation of novel stilbene-based antitumor agents显示文摘 | SIMONI D INVIDIATA F P ELEOPRA M | 2009 | Bioorg Med Chem2009，17，2： | 1 |
| 5 | Stilbene-based anticancer agents: Resveratrol analogues active toward HIf30 leukemic cells with a non-specific phase mecha- nism 显示文摘 | Simoni D Roberti M Invidiata F P | 2006 | Bioorg Med Chem Lett2006，16，12： | 1 |
| 6 | Drug resistance and apoptosis in cancer tceatmant:development of new apoptosis-inducing agents active in drug resistant malignancies 显示文摘 | Tolomeo M Simoni D | 2002 | Curt Med Chem Anticancer Agents2002，2，3： | 1 |
| 7 | Tetramethylguanidine (TMG)-catalyzed addition of dialkyl phosphites to α,β-un- saturated carbonyl compounds, alkenenitriles, aldehydes, ketones and imines 显示文摘 | Simoni D Invidiata F P Manferdini M | 1998 | Tetrahedron Lett1998，39，41： | 1 |
| 8 | Antiretroviral Adherence Interventions:A Review of Current Literature and Ongoing Studies显示文摘 | Simoni J Frick P Pantalone D | 2003 | Tropics in HIV medicine2003，11，6： | 1 |
| 9 | Conjugated Polyene Fatty Acids as Fluorescent Probes:Binding to Bovine Serum Albumin显示文摘 | Sklar L A Hudson B S Simoni R D | 1977 | Biochemistry1977，16，23： | 1 |
| 10 | Drug resistance and apoptosis in cancer treatment: development of new apoptosis-inducing agents active in drug resistant malignancies 显示文摘 | Simoni D | 2002 | Curr Med Chem Anti-Canc Agents2002，2，3： | 1 |
| 11 | Drug resistance and apoptosis in cancer treatment:development of new apoptosis-inducing agents active in drug resistant malignancies显示文摘 | Tolomeo M Simoni D | 2002 | Curr Med Chem Anticancer Agents2002，2，3： | 1 |
| 12 | Conjugated polyene fatty acids as fluorescent probes:synthetic phospholipid membrane studies显示文摘 | Sklar L A Hudson R D Simoni R D | 1977 | Biochemistry1977，16，5： | 1 |
| 13 | Social support and depressive symptomatology among HIV- positive women: the mediating role of self-esteem and mastery 显示文摘 | SIMONI J M MONTOYA H D HUANG B | 2005 | Women Health2005，42，4： | 1 |
| 14 | Application of a synthetic jet to control boundary layer separation under ultra-high-lift turbine pressure distribution显示文摘 | Lengani D Simoni D Ubaldi M | 2011 | Flow Turbulence andCombust2011，87，4： | 1 |
| 15 | Facile synthesis of 2-nitroalkanois by tetramethyl-guanidine (TMG)-catalyzed addition of primary nitroalkanes to aldehydes and alicyclicketones显示文摘 | Simoni D Invidiata F P Manfredini S | | 0，，15： | 1 |
| 16 | Social capital,accultu- ration,mental health,and perceived access to services among Mexican American women显示文摘 | Valencia-Garcia D Simoni JM Alegria M | 2012 | J Cons Clin Psychol2012，80，2： | 1 |
| 17 | Strong Bicyclic Guanidine Base-promoted Wittig and Horner-Wadsworth-Emmons reactions显示文摘 | Simoni D Rossi M Rondanin R | 2000 | Org let2000，2，24： | 1 |
| 18 | Synthesis of 2-(5'-substituted isoxazol-3'-yl)-4-oxo-3-thiazolidinylalkanoic acids显示文摘 | BARAD P G SIMONI D MORODER F | 1982 | J Heterocyclic Chem1982，19，3： | 1 |
| 19 | Preparation of 3,4- dihydroxy-l-benzeneethanol : a reinvestigation 显示文摘 | Baraldi P G Simoni D Manfredini S | 1983 | Liebigs Ann Chem1983，83，： | 1 |
| 20 | Melanoma cell adhesion can be blocked by heparin in vitro:Suggestion of VLA-4 as a novel target for antimetastatic approaches显示文摘 | Fritzsche J Simonis D Bendas G | 2008 | Thromb Haemost2008，100，6： | 1 |
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