|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Machine perfusion of the liver: Which is the best technique to mitigate ischaemia-reperfusion injury?显示文摘Longstanding research describes the mechanisms whereby the restoration of blood flow and reoxygenation(reperfusion) aggravates the ischaemic injury caused by a period of anoxia to a donor liver. This phenomenon, called ischaemia-reperfusion injury(IRI), leads to parenchymal cell death,microcirculatory failure, and inflammatory immune response. Clinically, IRI is the main factor responsible for the occurrence of posttransplant graft dysfunction and ischaemic-type biliary lesions. While extended criteria donor livers are more vulnerable to IRI, their utilisation is required to address the shortfall in donor organs. Thus, the mitigation of IRI should drive the setting of a new benchmark for marginal organ preservation. Herein, strategies incorporating different modalities of machine perfusion of the liver to alleviate IRI are discussed in conjunction with advantages and disadvantages of individual protocols.Techniques leading to reperfusion of the liver during machine perfusion(in situ normothermic regional perfusion and ex situ normothermic machine perfusion)may mitigate IRI by shortening the ischaemic period of the organs. This benefit potentially escalates from the minimum level, obtained following just partial alleviation of the ischaemic period, to the maximum level, which can be potentially achieved with ischaemia-free organ transplantation. Techniques that do not lead to reperfusion of the liver during machine perfusion(hypothermic,subnormothermic, and controlled-oxygenated rewarming) optimise mitochondrial oxidative function and replenish cellular energy stores, thereby lowering reactive oxygen species production as well as the activation ofdownstream inflammatory pathways during reperfusion. Further mechanistic insights into IRI may guide the development of donor-specific protocols of machine perfusion on the basis of the limitations of individual categories of extended criteria donor organs. | Yuri L Boteon Simon C Afford | 2019 | World Journal of Transplantation2019，9，1： | 5 |
| 2 | Mechanisms of autophagy activation in endothelial cell and their targeting during normothermic machine liver perfusion显示文摘Ischaemia-reperfusion injury(IRI) is the leading cause of injury seen in the liver following transplantation. IRI also causes injury following liver surgery and haemodynamic shock. The first cells within the liver to be injured by IRI are the liver sinusoidal endothelial cells(LSEC). Recent evidence suggests that LSEC coordinate and regulates the livers response to a variety of injuries. It is becoming increasingly apparent that the cyto-protective cellular process of autophagy is a key regulator of IRI. In particular LSEC autophagy may be an essential gatekeeper to the development of IRI. The recent availability of liver perfusion devices has allowed for the therapeutic targeting of autophagy to reduce IRI. In particular normothermic machine liver perfusion(NMP-L) allow the delivery of pharmacological agents to donor livers whilst maintaining physiological temperature and hepatic flow rates. In this review we summarise the current understanding of endothelial autophagy and how this may be manipulated during NMP-L to reduce liver IRI. | Yuri L Boteon Richard Laing Hynek Mergental Gary M Reynolds Darius F Mirza Simon C Afford Ricky H Bhogal | 2017 | World Journal of Gastroenterology2017，23，48： | 4 |
| 3 | Quantitative Gas-Chromatographic Determination of Pentaerythritol and its By-Products by Direct Oximation and then Silyation of Aqueous Solutions显示文摘 | Simon C D Comninos H Cornish L | 1993 | Journal of Chromatographic Science1993，31，6： | 2 |
| 4 | Impact of machine perfusion of the liver on post-transplant biliary complications: A systematic review显示文摘AIM To review the clinical impact of machine perfusion(MP) of the liver on biliary complications post-transplantation, particularly ischaemic-type biliary lesions(ITBL). METHODS This systematic review was performed in accordance with the Preferred Reporting Systematic Reviews and MetaAnalysis(PRISMA) protocol. The following databases were searched: PubMed, MEDLINE and Scopus. The keyword 'liver transplantation' was used in combination with the free term 'machine perfusion'. Clinical studies reporting results of transplantation of donor human livers following ex situ or in situ MP were analysed. Details relating to donor characteristics, recipients, technique of MP performed and post-operative biliary complications(ITBL, bile leak and anastomotic strictures) were critically analysed.RESULTS Fifteen articles were considered to fit the criteria for this review. Ex situ normothermic MP was used in 6 studies, ex situ hypothermic MP in 5 studies and the other 4 studies investigated in situ normothermic regional perfusion(NRP) and controlled oxygenated rewarming. MP techniques which have per se the potential to alleviate ischaemia-reperfusion injury: Such as hypothermic MP and NRP, have also reported lower rates of ITBL. Other biliary complications, such as biliary leak and anastomotic biliary strictures, are reported with similar incidences with all MP techniques. There is currently less clinical evidence available to support normothermic MP as a mitigator of biliary complications following liver transplantation. On the other hand, restoration of organ to full metabolism during normothermic MP allows assessment of hepatobiliary function before transplantation, although universally accepted criteria have yet to be validated.CONCLUSION MP of the liver has the potential to have a positive impact on post-transplant biliary complications, specifically ITBL, and expand extended criteria donor livers utilisation. | Yuri L Boteon Amanda PCS Boteon Joseph Attard Lorraine Wallace Ricky H Bhogal Simon C Afford | 2018 | World Journal of Transplantation2018，8，6： | 2 |
| 5 | Activation and early parthenogenesis of bovine oocytes treated with ethanol and strontium显示文摘 | Simone C M Claudia L V L Joaquim M G | 2004 | Animal Reproduction Science2004，81，： | 1 |
| 6 | Circadian and ultradian variations of leptin in normal man under continuous enteral nutrition: relationship to sleep and body temperature显示文摘 | SIMON C GRONF1ER C SCHLIENGER J L | 1998 | J Clin Endocrinol Metab1998，83，6： | 1 |
| 7 | Edible wheat gluten(WG) protein films 显示文摘 | Mojumdar S C Moresoli C Simon L C | 2011 | J Therm Anal Calorim2011，104，： | 1 |
| 8 | Automotive tribology o- verview of current advances and challenges for the future 显示文摘 | Simon C Tung M L Mc Millan | 2004 | Tribology International2004，1，37： | 1 |
| 9 | Magmatic--hydrothermal origin of Ne- vada~ s Carlin- type gold deposits显示文摘 | Muntean J L J S Cline A C Simon | 2011 | Nature Geoscience2011，4，12： | 1 |
| 10 | Two-phase n-butenes dimerization by nickel complexes in molten salt media显示文摘 | Dupont J de Souza R F | 1998 | Appl Catal A:General1998，775，： | 1 |
| 11 | Association of Enterococcus cecorum with vertebral osteomyelitis and spondylolisthesis in broiler parent chicks显示文摘 | MAKRAI L NENES C SIMON A | 2011 | Acta Vet Hung2011，59，1： | 1 |
| 12 | Outcomed and clinicopa thologic variables associated with late recurrence after nephrectomy fkr localiged Renal cell carcinoma显示文摘 | SIMON P K CHRISTOPHER J M BRADLEY C L | 2011 | Urology2011，78，5： | 1 |
| 13 | Toxicity of oxysterols to human monocyte-macrophages显示文摘 | Katharine C Simon J H Keri L H | 1995 | Atherosclerosis1995，118，： | 1 |
| 14 | Lensed fiber-array assembly with individu- al fiber fine positioning in the submicrometer range 显示文摘 | Johan H C van Zantvoort Simon G L Plukker Erwin C A Dekkers | 2006 | IEEE Selected Topics in Quantum Electronics2006，12，05： | 1 |
| 15 | Secure group communication using key graphs 显示文摘 | Wong C K Gouda M Simon L S | 2000 | IEEE/ACM Transactions on Networking2000，8，1： | 1 |
| 16 | Modification of Al current collector/active material interface for power improvement of electrochemical capacitor electrodes 显示文摘 | PORTET C TABERNA P L SIMON P | 2006 | The Electrochemical Society2006，153，4： | 1 |
| 17 | Telemedieal treatment at home of diabetic显示文摘 | Jane C Simon B L Niels E | 2005 | Journal of Telemedicine and Telecare2005，11，2： | 1 |
| 18 | Polyethylene made with in situ supported ni-diimine/SMAO: replication phenomenon and effect of polymerization conditions on polymer microstructure and morphology 显示文摘 | Simon L C Patel H Soares J B P | 2001 | Macromol Chem Phys2001，202，17： | 1 |
| 19 | Communication skills training in heahhcare: A review of the literature 显示文摘 | Simon C Tim J Jacqueline R l | 2002 | Nurs Edu Today2002，22，3： | 1 |
| 20 | Magmatic–hydrothermal origin of Nevada’s Carlin-type gold deposits显示文摘 | Muntean J L Cline J S Simon A C | 2011 | Nature Geoscience2011，4，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员