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| 1 | Update on pathogenesis and predictors of response of therapeutic strategies used in inflammatory bowel disease显示文摘The search for biomarkers that characterize specific aspects of inflammatory bowel disease(IBD), has received substantial interest in the past years and is moving forward rapidly with the help of modern technologies. Nevertheless, there is a direct demand to identify adequate biomarkers for predicting and evaluating therapeutic response to different therapies. In this subset, pharmacogenetics deserves more attention as part of the endeavor to provide personalized medicine. The ultimate goal in this area is the adjustment of medication for a patient's specific genetic background and thereby to improve drug efficacy and safety rates. The aim of the following review is to utilize the latest knowledge on immunopathogenesis of IBD and update the findings on the field of Immunology and Genetics, to evaluate the response to the different therapies. In the present article, more than 400 publications were reviewed but finally 287 included based on design, reproducibility(or expectancy to be reproducible and translationable into humans) or already measured in humans. A few testshave shown clinical applicability. Other, i.e., genetic associations for the different therapies in IBD have not yet shown consistent or robust results. In the close future it is anticipated that this, cellular and genetic material, as well as the determination of biomarkers will be implemented in an integrated molecular diagnostic and prognostic approach to manage IBD patients. | Emilio G Quetglas Zlatan Mujagic Simone Wigge Daniel Keszthelyi Sebastian Wachten Ad Masclee Walter Reinisch | 2015 | World Journal of Gastroenterology2015，21，44： | 3 |
| 2 | Diathesis Stresses in the cnntext of life stress research: implications for the depressive disorders 显示文摘 | Monrone SC Simon AD | 1991 | Psehological Bulletin1991，110，3： | 1 |
| 3 | Circulating levels of IL- l beta,a prothrombotic cytokine,are elevated in unstable angina versus stable angina显示文摘 | Simon AD Yazdani S Wang W | 2000 | J Thromb Thrombolysis2000，9，3： | 1 |
| 4 | Life events,number of social relationships and twelve-month naturalistic course of major depression in a community sample of women显示文摘 | Wildes JE Harkness KL Simons AD | 2002 | Depress Anxiety2002，16，3： | 1 |
| 5 | Interrelationship and clinical significance of increased resistance in the uterine arteries in patients with hypertension or preeclanpsia or both 显示文摘 | Kafinas AD Perry M Simon NV | 1992 | Am j Obstet Gynecol1992，166，： | 1 |
| 6 | Diathesis-stress theorisis in the context of life stress research:Implications for the depressive disorders显示文摘 | Monroe SM Simons AD | 1991 | Psychological bulletin1991，110，3： | 1 |
| 7 | Roleof catheter-induced mechanical trauma in localization of target sites of radiofrequency ablation in automatic atrial tachycardia显示文摘 | Pappone C Stabile G Simone AD | 1996 | J Am Coll Cardiol1996，27，： | 1 |
| 8 | The multistep process of homotypic neutrophil aggregation : a review of the mole cules and affects of hydrodynamics显示文摘 | Simon SI Neelamegham S Taylor AD | 1998 | Cell Adhes Commun1998，6，23： | 1 |
| 9 | Relapse after cognitive behavior therapy of depression:potential implications for longer courses of treatment 显示文摘 | Thase ME Simons AD MeGeary J | 1992 | Am J Psychiatry1992，149，： | 1 |
| 10 | Antisense strategies to inhibit restenosis显示文摘 | Lee M Simon AD Stein CA | 1999 | Antisense Nuceleic Acid Drug Development1999，9，： | 1 |
| 11 | Non-specific chemical inhibition of the Fanconi anemia pathway sensitizes cancer cells to cisplatin显示文摘 | Jacquemont C Simon JA D'Andrea AD | 2012 | Mol Cancer2012，11，： | 1 |
| 12 | Circulating levels of IL-1beta,a prothrombotic cytokine,and elevated in unstable angina versus stable angina显示文摘 | Simon AD Yazdani S Wang W | 2000 | J Thromb Thrombolysis2000，9，3： | 1 |
| 13 | L-selectin(CD62L) cross-linking signals neutrophil adhesive function via the Mac-1(CD11b/CD18) beta2-integrin显示文摘 | Simon SI Burns AR Taylor AD | 1995 | J Immunol1995，155，： | 1 |
| 14 | Recent advances in synthetic biosafety显示文摘 | Simon AJ Ellington AD | 2016 | FIO00 Res2016，5，3： | 1 |
| 15 | Circulating levels of IL-1beta,a prothrombotic cytokine,are elevated in unstable angina versus stable angina显示文摘 | YAZDANI S WANG W | 2000 | J Thromb Thrombolysis2000，9，3： | 1 |
| 16 | Relapse after cognitive behavior therapy of depression: Potential implications for longer courses of treatment显示文摘 | Thase ME Simons AD McGeary J | 1992 | Am J Psychiatry1992，149，： | 1 |
| 17 | Inhibi- tion of glutathione and thioredoxin metabolism en- hances sensitivity to perifosine in head and neck cancer cells显示文摘 | Simons AL Parsons AD Foster KA | 2009 | J Oncol2009，，51： | 1 |
| 18 | Anal sphincter EMG does not distinguish between muhiple system atrophy and Parkinson' s disease 显示文摘 | Giladi N Simon ES Korczyn AD | 2000 | Muscle Nerve2000，23，5： | 1 |
| 19 | Anal sphincter EMG does not distinguish between multiple system atrophy and Parkinson's disease 显示文摘 | Simon ES Korczyn AD | 2000 | Muscle Nerve2000，23，5： | 1 |
| 20 | Topoisomerase IIα and other drug resistance markers in advanced non-small cell lung cancer显示文摘 | Anne-Marie CD Jannette AD Simone S | 2001 | Lung Cancer2001，32，： | 1 |
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