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| 1 | High-intensity focused ultrasound ablation:An effective bridging therapy for hepatocellular carcinoma patients显示文摘AIM:To analyze whether high-intensity focused ultrasound(HIFU) ablation is an effective bridging therapy for patients with hepatocellular carcinoma(HCC).METHODS:From January 2007 to December 2010,49 consecutive HCC patients were listed for liver transplantation(UCSF criteria).The median waiting time for transplantation was 9.5 mo.Twenty-nine patients received transarterial chemoembolization(TACE) as a bringing therapy and 16 patients received no treatment before transplantation.Five patients received HIFU ablation as a bridging therapy.Another five patients with the same tumor staging(within the UCSF criteria) who received HIFU ablation but not on the transplant list were included for comparison.Patients were comparable in terms of Child-Pugh and model for end-stage liver disease scores,tumor size and number,and cause of cirrhosis.RESULTS:The HIFU group and TACE group showed no difference in terms of tumor size and tumor number.One patient in the HIFU group and no patient in the TACE group had gross ascites.The median hospital stay was 1 d(range,1-21 d) in the TACE group and two days(range,1-9 d) in the HIFU group(P < 0.000).No HIFU-related complication occurred.In the HIFU group,nine patients(90%) had complete response and one patient(10%) had partial response to the treatment.In the TACE group,only one patient(3%) had response to the treatment while 14 patients(48%) had stable disease and 14 patients(48%) had progressive disease(P = 0.00).Seven patients in the TACE group and no patient in the HIFU group dropped out from the transplant waiting list(P = 0.559).CONCLUSION:HIFU ablation is safe and effective in the treatment of HCC for patients with advanced cirrhosis.It may reduce the drop-out rate of liver transplant candidate. | Tan To Cheung Sheung Tat Fan See Ching Chan Kenneth SH Chok Ferdinand SK Chu Caroline R Jenkins Regina CL Lo James YY Fung Albert CY Chan William W Sharr Simon HY Tsang Wing Chiu Dai Ronnie TP Poon Chung Mau Lo | 2013 | World Journal of Gastroenterology2013，19，20： | 23 |
| 2 | Pancreaticoduodenectomy with vascular reconstruction for adenocarcinoma of the pancreas with borderline resectability显示文摘AIM:To analyze whether pancreaticoduodenectomy with simultaneous resection of tumor-involved vessels is a safe approach with acceptable patient survival.METHODS:Between January 2001 and March 2012,136 patients received pancreaticoduodenectomy for adenocarcinoma at our hospital.Seventy-eight patients diagnosed with pancreatic head carcinoma were included in this study.Among them,46 patients received standard pancreaticoduodenectomy(group 1)and32 patients received pancreaticoduodenectomy with simultaneous resection of the portal vein or the superior mesenteric vein or artery(group 2)followed by reconstruction.The immediate surgical outcomes and survivals were compared between the groups.Fifty-five patients with unresectable adenocarcinoma of the pancreas without liver metastasis who received only bypassoperations(group 3)were selected for additional survival comparison.RESULTS:The median ages of patients were 67 years(range:37-82 years)in group 1,and 63 years(range:35-86 years)in group 2.All group 2 patients had resection of the portal vein or the superior mesenteric vein and three patients had resection of the superior mesenteric artery.The pancreatic fistula formation rate was21.7%(10/46)in group 1 and 15.6%(5/32)in group2(P=0.662).Two hospital deaths(4.3%)occurred in group 1 and one hospital death(3.1%)occurred in group 2(P=0.641).The one-year,three-year and five-year overall survival rates in group 1 were 71.1%,23.6%and 13.5%,respectively.The corresponding rates in group 2 were 70.6%,33.3%and 22.2%(P=0.815).The one-year survival rate in group 3 was13.8%.Pancreaticoduodenectomy with simultaneous vascular resection was safe for pancreatic head adenocarcinoma.CONCLUSION:The short-term and survival outcomes with simultaneous resection were not compromised when compared with that of standard pancreaticoduodenectomy. | Tan To Cheung Ronnie TP Poon Kenneth SH Chok Albert CY Chan Simon HY Tsang Wing Chiu Dai See Ching Chan Sheung Tat Fan Chung Mau Lo | 2014 | World Journal of Gastroenterology2014，20，46： | 8 |
| 3 | 面向并行文件系统的性能评估及相对预测模型显示文摘基于Lustre文件系统,对并行文件系统的性能评估和性能建模进行了研究.通过对性能因子的调研,进行了一系列性能评估实验,并提出性能相关性模~(PRModel).在实验评估和PRModel分析中发现,在不同的性能因子之间存在着紧密的性能相关性,为了挖掘并利用这种相关性信息,提出了一种相对性能预测模(RPPModel)来预测不同性能因子条件下的性能.为了验证RPPModel的有效性,设计了大量实验用例.结果表明,预测结果的平均相对误差能够控制在170/o---28%的范围内,易于使用且具有较好的预测准确度. | 赵铁柱 董守斌 Verdi MARCH Simon SEE | 2011 | 软件学报2011，22，9： | 7 |
| 4 | Modulation of graft vascular inflow guided by flowmetry and manometry in liver transplantation显示文摘BACKGROUND:Survival of the partial graft after living donor liver transplantation owes much to its tremendous regenerative ability.With excellent venous outflow capacity,a graft within a wide range of graft-to-standard-liver-volume ratios can cope with portal hypertension that is common in liver transplant recipients.However,when the ratio range is exceeded,modulation of graft vascular inflow becomes necessary for graft survival.The interplay between graft-to-standard-liver-volume ratio and portal pressure,in the presence of portosystemic shunt or otherwise,requires individualized modulation of graft portal and arterial inflows.Boosting of portal inflow by shunt ligation can be guided by transonic flowmetry,whereas muting of portal inflow by splenic artery ligation can be monitored by portal electronic manometry.METHOD:We describe four cases to illustrate the above.RESULTS:One patient had hepatic artery thrombosis resulting from splenic artery steal syndrome which was the sequela of small-for-size syndrome.Emergency splenic artery ligation and re-anastomosis of the hepatic artery successfully muted the portal inflow and boosted the hepatic arterial inflow.Another patient with portal vein thrombosis underwent thrombendvenectomy.Portal inflow was boosted with ligation of portosystemic shunt,which is often present in these patients with portal hypertension.The coexistence of splenic aneurysm and splenorenal shunt required ligation of both in the third patient.The fourth patient,with portal pressure and flow monitoring,avoided ligation of a coronary vein which became a main portal inflow after portal thrombendvenectomy.CONCLUSION:Management of graft inflow modulation guided selectively by transonic flowmetry or portal manometry was described. | See Ching Chan Chung Mau Lo Kenneth SH Chok William W Sharr Tan To Cheung Simon HY Tsang Albert CY Chan Sheung Tat Fan | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，6： | 5 |
| 5 | 基于机器学习的并行文件系统性能预测显示文摘并行文件系统能有效解决高性能计算系统的海量数据存储和I/O瓶颈问题.由于影响系统性能的因素十分复杂,如何有效地评估系统性能并对性能进行预测成为一个潜在的挑战和热点.以并行文件系统的性能评估和预测作为研究目标,在研究文件系统的架构和性能因子后,设计了一个基于机器学习的并行文件系统预测模型,运用特征选择算法对性能因子数量进行约简,挖掘出系统性能和影响因子之间的特定的关系进行性能预测.通过设计大量实验用例,对特定的Lustre文件系统进行性能评估和预测.评估和实验结果表明:threads/OST、对象存储器(OSS)的数量、磁盘数目和RAID的组织方式是4个调整系统性能最重要因子,预测结果的平均相对误差能控制在25.1%~32.1%之间,具有较好预准确度. | 赵铁柱 董守斌 董守斌 Verdi March Simon See | 2011 | 计算机研究与发展2011，48，7： | 5 |
| 6 | Entecavir Monotherapy Is Effective in Suppressing Hepatitis B Virus After Liver Transplantation显示文摘 | James Fung Cindy Cheung See–Ching Chan Man–Fung Yuen Kenneth S.H. Chok William Sharr Wing–Chiu Dai Albert C.Y. Chan Tan–To Cheung Simon Tsang Banny Lam Ching–Lung Lai Chung–Mau Lo | 2011 | Gastroenterology2011，，4： | 3 |
| 7 | 星系分组算法的并行设计与优化:SGI系统与分布式集群对比显示文摘Halo-based Galaxy Group Finder(HGGF)是一种有效的星系分组算法,它根据星系的空间位置、红移、质量等多种属性将星系分组,从而为星系组的形成与演化研究提供重要依据。但是,算法当前的OpenMP实现版本仅能利用单节点提供的资源,在大规模星系分组问题上的应用受到限制。一种优化思路是采用多机并行,使其可以利用更多资源来解决更大规模的星系分组问题,并缩短执行时间。因此,有必要对算法重新进行设计与实现。实现此目标的一大挑战是程序中存在大量半随机性远端内存访问,其在多机并行环境下会对性能造成重大影响。为克服这一难题,设计中提出了邻接星系链表思想,并采用Unified Parallel C(UPC)进行程序实现。对于核代码部分,使用4,8,16节点时,可分别取得2.25,2.78,5.07倍的加速比;同时,对单个节点的内存需求也显著减少。OpenMP版本在SGI UV2000上的实验结果显示,受限于程序的访存特性与机器体系架构的特点,类似HGGF算法这种具有随机数据访问特征的程序,很难有效利用NUMA结构的共享内存系统中提供的大规模线程与内存资源来直接取得高加速比。在分布式内存集群上采用两级并行设计,以更好地利用局部性原理,可能是更好的解决方案。 | 司雨濛 韦建文 Simon SEE 林新华 | 2017 | 计算机科学2017，44，10： | 2 |
| 8 | Retrohepatic vena cava deroofing in living donor liver transplantation for caudate hepatocellular carcinoma显示文摘The removal of tumor together with the native liver in living donor liver transplantation for hepatocellular carcinoma is challenged by a very close resection margin if the tumor abuts the inferior vena cava.This is in contrast to typical deceased donor liver transplantation where the entire retrohepatic inferior vena cava is included in total hepatectomy.Here we report a case of deroofing the retrohepatic vena cava in living donor liver transplantation for caudate hepatocellular carcinoma.In order to ensure clear resection margins,the anterior portion of the inferior vena cava was included.The right liver graft was inset into a Dacron vascular graft on the back table and the composite graft was then implanted to the recipient inferior vena cava.Using this technique,we observed the no-touch technique in tumor removal,hence minimizing the chance of positive resection margin as well as the chance of shedding of tumor cells during manipulation in operation. | See Ching Chan William W Sharr Tan To Cheung Albert CY Chan Simon HY Tsang Kenneth SH Chok Kin Chung Leung Chung Mau Lo | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，5： | 2 |
| 9 | Inflammatory Myofibroblastic Tumors of the Urinary Bladder: A Systematic Review显示文摘 | Jeremy Yuen Chun Teoh Ning-Hong Chan Ho-Yuen Cheung Simon See Ming Hou Chi-Fai Ng | 2014 | Urology2014，，3： | 1 |
| 10 | Entecavir Monotherapy Is Effective in Suppressing Hepatitis B Virus After Liver Transplantation显示文摘 | James Fung Cindy Cheung See–Ching Chan Man–Fung Yuen Kenneth S.H. Chok William Sharr Wing–Chiu Dai Albert C.Y. Chan Tan–To Cheung Simon Tsang Banny Lam Ching–Lung Lai Chung–Mau Lo | 2011 | Gastroenterology2011，，4： | 1 |
| 11 | Entecavir Monotherapy Is Effective in Suppressing Hepatitis B Virus After Liver Transplantation显示文摘 | James Fung Cindy Cheung See–Ching Chan Man–Fung Yuen Kenneth S.H. Chok William Sharr Wing–Chiu Dai Albert C.Y. Chan Tan–To Cheung Simon Tsang Banny Lam Ching–Lung Lai Chung–Mau Lo | 2011 | Gastroenterology2011，，4： | 1 |
| 12 | 基于NVIDIA Kepler的PIC方法并行显示文摘PIC方法是计算等离子体物理中广泛使用的一种计算方法。通常情况下需要使用大量的计算粒子以达到高的计算精度,这导致非常庞大的计算量。因而PIC方法的加速研究对于减少其时间成本非常有意义。设计了一个基于NVIDIA Kepler GPU的PIC算法,并使用CUDA在GPU上实现了该算法。在PIC方法中最耗时间的两个函数collision和mover被移植到GPU上。在实验中使用了NVIDIA新发布的Kepler K20GPU进行这两个函数的性能测试,相比于Intel Sandy Bridge E5-2650,最高获得了30倍的加速。 | 文敏华 林新华 Simon Chong Wee See | 2013 | 计算机工程与科学2013，35，11： | 1 |
| 13 | Outcome of laparoscopic versus open hepatectomy for colorectal liver metastases显示文摘 | Tan To Cheung Ronnie T. P. Poon Wai Key Yuen Kenneth S. H. Chok Simon H. Y. Tsang Thomas Yau See Ching Chan Chung Mau Lo | 2013 | ANZ J Surg2013，，11： | 1 |
| 14 | Samaritan donor interchange in living donor liver transplantation显示文摘BACKGROUND: In order to overcome ABO blood group incompatibility, paired donor interchange has been practised in living donor liver transplantation. Liver transplantations using grafts donated by Samaritan living donors have been performed in Europe, North America, South Korea, and Hong Kong. Such practice is clearly on strong biological grounds although social and psychological implications could be far-reaching. Local experience has been satisfactory but is still limited. As few centers have this arrangement, its safety and viability are still being assessed under a clinical trial setting. METHODS: Here we report a donor interchange involving an ABO-compatible pair with a universal donor and an ABOincompatible pair with a universal recipient. This matching was not only a variation but also an extension of the donor interchange scheme. RESULTS: The four operations(two donor hepatectomies and two recipient operations) were successful. All the two donors and the two recipients recovered well. Such donor interchange further supports the altruistic principle of organ donation in contrast to exchange for a gain. CONCLUSIONS: Samaritan donor interchange certainly taxes further the ethical challenge of donor interchange. Although this practice has obvious biological advantages, such advantages have to be weighed against the potential increase in potential psychological risks to the subjects in the interchange. Further ethical and clinical evaluations of local and overseas experiences of donor interchange should guide future clinical practice in utilizing this potential organ source for transplantation. | See Ching Chan Kenneth SH Chok William W Sharr Albert CY Chan Simon HY Tsang Wing Chiu Dai Chung Mau Lo | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，1： | 0 |
| 15 | 异构集群上的宏基因组聚类优化显示文摘宏基因组基因聚类是筛选致病基因的新型方法,其依赖于海量的测序数据、有效的聚类算法以及高效的计算机来实现。相关系数矩阵的计算是进行聚类前必须完成的操作,占总计算量的比重较大。以某基因库为例,包含1300个样本、每样本百万基因的数据,单线程运行需要27年。充分发挥多核CPU的潜力,利用GPU加速卡强大的计算能力,将程序扩展到多节点集群上运行,是重要而迫切的工作。在仔细分析算法的基础上,首先针对单CPU节点和单GPU卡做了高效实现,获得了接近理想的加速比;然后利用缓存优化进一步提升性能;最后使用负载均衡方法在MPI线程间分发计算任务,实现了良好的扩展。相比未优化的单线程程序,16节点CPU获得了238.8倍的加速,6块GPU卡获得了263.8倍的加速。 | 韦建文 许志耿 王丙强 Simon SEE 林新华 | 2017 | 计算机科学2017，44，3： | 0 |
| 16 | 动态网格的DSMC方法在GPU上的并行显示文摘直接模拟蒙特卡罗方法(direct simulation Monte Carlo,DSMC)是稀薄气体动力学领域的重要工具。然而,DSMC方法有两个比较主要的缺点:一是复杂的网格处理;另一个是庞大的计算量。使用动态网格的DSMC方法可以根据流场信息,动态生成自适应的碰撞网格,能有效解决前一个缺点;针对后一个缺点,使用统一计算架构(compute unified device architecture,CUDA)编写并行程序,将基于动态网格的DSMC方法移植到图形处理器(graphic processing unit,GPU)上以减少计算时间。在并行实现中,GPU负责绝大部分的计算,而CPU只负责初始化、结果输出等少量工作。使用一个二维超音速横掠平板问题作为算例,验证了并行程序的正确性。对于不同规模的算例,在NVIDIA Fermi C2050之上均获得了10倍以上的加速比;对于相同算例,NVIDIA最新发布的Kepler K20上的速度约为FermiC2050上的1.3~1.6倍。 | 文敏华 林新华 Simon Chong Wee See | 2013 | 计算机科学与探索2013，7，5： | 0 |
| 17 | 激光等离子体相互作用模拟的并行和加速研究显示文摘随着生成超短激光脉冲技术的不断发展,对这种激光脉冲和等离子体相互作用进行动力学描述也变得越来越重要。PIC(particle-in-cell)是一种在等离子体物理中,研究充能粒子在电磁场中运动轨迹的广泛采用的方法。尽管现在已经有一些在GPU上的PIC方法的实现,但是基于激光等离子体相互作用模拟的特点,仍然有很多重要问题可以尝试其他解决思路。提出了一种把初始的基于CPU的LPI模拟代码完整移植到GPU上的可行方法。提出了一系列加速初始的GPU版本的方法:动态冗余算法、混合精度算法、粒子排序算法。利用并且评估了GPUDirect RDMA(remote direct memory access)技术,其可以提高MPI的通信性能。实验结果证明,与初始的GPU版本相比,'Scatter'阶段加速比为6.1倍,当MPI传输数据大于3 KB时,通信过程提速了2.8倍。这些研究证明了针对模拟应用和GPU集群的特点进行特殊的优化能对性能带来显著的提升。 | 武海鹏 文敏华 SEE Simon 林新华 | 2018 | 计算机科学与探索2018，12，4： | 0 |
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