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| 1 | 3个中国地方黄牛品种遗传结构及其遗传分化的研究显示文摘利用12对微卫星引物对中国3个地方黄牛品种(鲁西黄牛、渤海黑牛及闽南黄牛)及2个对照群体(中国荷斯坦牛和青海牦牛)的群体遗传结构、遗传分化及基因流水平进行研究,结合聚类分析,结果表明:5个牛群体总近交系数(Fit)为58.5%,群体内近交系数(Fis)为43.2%,群体间基因分化系数(Fst)为26.9%,3个指标均达到极显著水平(P<0.001)。5个牛群体内近交系数(Fis)鲁西黄牛最高(0.640),青海牦牛最低(0.231)。鲁西黄牛与荷斯坦牛间每世代群体间有效迁移个体数(Nem)最大(1.149),牦牛与鲁西黄牛间最小(0.509)。5个牛群体每个体属于所属群体的平均概率从91.4%到98.5%不等。结合聚类分析、基因流分析及STRUCTURE分析结果,5个牛群可分为3大类:鲁西黄牛和中国荷斯坦牛为一类,渤海黑牛和闽南黄牛为一类,牦牛自为一类,这说明在鲁西黄牛和渤海黑牛的形成过程中,鲁西黄牛受普通牛影响较大,而渤海黑牛受瘤牛影响较大,同时探讨了以上品种的演化与形成过程。 | 毛永江 常洪 杨章平 张柳 许明 孙伟 常国斌 宋光明 Henner Simianer | 2007 | 畜牧兽医学报2007，38，2： | 9 |
| 2 | 遗传距离与利用微卫星进行系统树构建初探显示文摘以中国牛亚科家畜6个群体12对微卫星数据为基础,采用6种遗传距离(DA、DC、DS、Dsw,(σμ)2和DTL)和2种聚类方法(UPGMA和NJ法),探索它们对系统树构建准确性的影响。结果表明:微卫星位点平均杂合度水平显著影响系统树构建的准确性,用DA和DC遗传距离构建的系统树准确性相对较高,但很难确定NJ法和UPGMA法哪一种更适合于系统树的构建,而DTL遗传距离用于系统树构建有待进一步完善;最后,对微卫星用于家畜系统树构建的有效性和局限性进行了探讨。 | 毛永江 常洪 杨章平 张柳 许明 常国斌 孙伟 宋光明 Henner Simianer | 2008 | 畜牧兽医学报2008，39，2： | 4 |
| 3 | Inflammatory bowel disease: A descriptive study of 716 local Chilean patients显示文摘AIM: To demographically and clinically characterize inflammatory bowel disease(IBD) from the local registry and update data previously published by our group.METHODS: A descriptive study of a cohort based on a registry of patients aged 15 years or older who were diagnosed with IBD and attended the IBD program at Clínica Las Condes in Santiago, Chile. The registry was created in April 2012 and includes patients registered up to October 2015. The information was anonymously downloaded in a monthly report, and the information on patients with more than one visit was updated. The registry includes demographic, clinical and disease characteristics, including the Montreal Classification, medical treatment, surgeries and hospitalizations for crisis. Data regarding infection with Clostridium difficile(C. difficile) were incorporated in the registry in 2014. Data for patients who received consultations as second opinions and continued treatment at this institution were also analyzed. RESULTS: The study included 716 patients with IBD: 508 patients(71%) were diagnosed with ulcerative colitis(UC), 196 patients(27%) were diagnosed with Crohn's disease(CD) and 12 patients(2%) were diagnosed with unclassifiable IBD. The UC/CD ratio was 2.6/1. The median age was 36 years(range 16-88), and 58% of the patients were female, with a median age at diagnosis of 29 years(range 5-76). In the past 15 years, a sustained increase in the number of patients diagnosed with IBD was observed, where 87% of the patients were diagnosed between the years 2001 and 2015. In the cohort examined in the present study, extensive colitis(50%) and colonic involvement(44%) predominated in the patients with UC and CD, respectively. In CD patients, nonstricturing/non-penetrating behavior was more frequent(80%), and perianal disease was observed in 28% of the patients. There were significant differences in treatment between UC and CD, with a higher use of corticosteroids, and immunosuppressive and biological therapies was observed in the patients with CD(P < 0.05 and P < 0.01). Significant surgical differences were also observed: 5% of the UC patients underwent surgery, whereas 38% of the CD patients required at least one surgery(P < 0.01). The patients with CD were hospitalized more often during their disease course than the patients with UC(55% and 35% of the patients, respectively; P < 0.01). C. difficile infection was acquired by 5% of the patients in each group at some point during the disease course. Nearly half of the patients consulted at the institution for a second opinion, and 32% of these individuals continued treatment at the institution. CONCLUSION: IBD has continued to increase in the study cohort, slowly approaching the level reported in developed countries. | Daniela Simian Daniela Fluxá Lilian Flores Jaime Lubascher Patricio Ibánez Carolina Figueroa Udo Kronberg Raúl Acuna Mauricio Moreno Rodrigo Quera | 2016 | World Journal of Gastroenterology2016，22，22： | 2 |
| 4 | Knee osteochondml fractures in skeletally immature patients: French multicenter study 显示文摘 | Chotel F Knorr G Simian E | 2011 | Orthop Traumatol Surg Res2011，97，11： | 1 |
| 5 | Characterization of the pathogenic KU-SHIV model of acquired immunodefieiency syndrome in macaques 显示文摘 | simian/ loss of J Virol Joag SV Li Z Larry Foresman L et 81 | 1997 | AIDS Res Human Betroviruses1997，13，8： | 1 |
| 6 | Interaction of genotype with production system for slaughter weight in rainbow trout (Oncorhynchus mykiss ) 显示文摘 | Sylv6n S Rye M Simianer H | 1991 | Livestock Production Science1991，28，3： | 1 |
| 7 | Mitochondrial DNA D-loop sequences suggest a Southeast Asian and Indian origin of Zimbabwean village chickens显示文摘 | Muchadeyi F C Eding H Simianer H | 2008 | Anim Genet2008，39，6： | 1 |
| 8 | Assessment of ge- netic diversity and conservation priority of Omani local chickens using microsatellite markers显示文摘 | A1-Qamashoui B Simianer H Kadim I et ol | 2014 | Tropical Anita Health Prod2014，46，5： | 1 |
| 9 | Online adaptation to post-edits for phrase-based statistical machine translation显示文摘 | BERTOLDI Nicola SIMIANER Patrick CETTOLO Mauro | 2014 | Machine translation2014，28，34： | 1 |
| 10 | Regulation of cell growth of a progestin-dependent murine mammary carcinoma in vitro:progesterone receptor involvement in serum or growth factor-induced cell proliferation 显示文摘 | Lambc Simian M Molinolo A | 1999 | J Steroid Biochem Mol Biol1999，70，46： | 1 |
| 11 | Identification and synthe- sis of 2-heptanethiol, a new flavor compound found in bell peppers 显示文摘 | Simian H Robert F Blank I | 2004 | J Agric Food Chem2004，52，30： | 1 |
| 12 | Past and Future Activities to Harmonize Farm Animal Biodiversity Studies on a Global scale 显示文摘 | SIMIANER H MEYER J N | 2003 | Archivos de Zootecnia2003，52，： | 1 |
| 13 | Potential of gas chromatography-orthogonal acceleration time-of-flight mass spectrometry (GC-oaTOFMS) in flavor research显示文摘 | FAY L B NEWTON A SIMIAN H | 2003 | Journal of Agricultural and Food Chemistry2003，51，9： | 1 |
| 14 | Role of MMPs in metastatic dissemination: implications for therapeutic advances显示文摘 | Raffo D Pontiggia O Simian M | 2011 | Curr Pharm Biotechno2011，12，11： | 1 |
| 15 | Approaches to the management of inbreeding and relationship in the German Holstein dairy cattle population 显示文摘 | Koenig S Simianer H | 2006 | Livestock Science2006，103，1： | 1 |
| 16 | Genetic diversity studies in farm animals-a survey显示文摘 | Baumung R Simianer H Hoffmann I | 2004 | Journal of Animal Breeding and Genetics2004，121，3： | 1 |
| 17 | The interplay of matrix metalloproteinases,morphogens and growth factors is necessary for branching of mammary epithelial cells显示文摘 | Simian M Hirai Y Navre M | 2001 | Development2001，128，16： | 1 |
| 18 | The hyperplas- tic phenotype in PR A and PR-B transgenic mice: Lessons on the role of estrogen and progesterone re- ceptors in the mouse mammary gland and breast cancer显示文摘 | Sampayo R Recouvreux S Simian M | 2013 | Vitam Horm2013，93，： | 1 |
| 19 | Weitzman' s approach and conservation of breed diversity: an application to afican cattle breeds显示文摘 | Reist-Marti S B Simianer H Gibson J | 2003 | Conserv Biol2003，17，： | 1 |
| 20 | LDSO: a program to simulate pedigrees and molecular information under various evolutionary forces显示文摘 | F. Ytournel S. Teyssèdre D. Roldan M. Erbe H. Simianer D. Boichard H. Gilbert T. Druet A. Legarra | 2012 | Journal of Animal Breeding and Genetics2012，，5： | 1 |
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