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| 1 | Gastro-duodenal disease in Africa: Literature review and clinical data from Accra, Ghana显示文摘Gastroduodenal disease(GDD)was initially thought to be uncommon in Africa.Amongst others,lack of access to optimal health infrastructure and suspicion of conventional medicine resulted in the reported prevalence of GDD being significantly lower than that in other areas of the world.Following the increasing availability of flexible upper gastro-intestinal endoscopy,it has now become apparent that GDD,especially peptic ulcer disease(PUD),is prevalent across the continent of Africa.Recognised risk factors for gastric cancer(GCA)include Helicobater pylori(H.pylori),diet,Epstein-Barr virus infection and industrial chemical exposure,while those for PUD are H.pylori,non-steroidal antiinflammatory drug(NSAID)-use,smoking and alcohol consumption.Of these,H.pylori is generally accepted to be causally related to the development of atrophic gastritis(AG),intestinal metaplasia(IM),PUD and distal GCA.Here,we perform a systematic review of the patterns of GDD across Africa obtained with endoscopy,and complement the analysis with new data obtained on premalignant gastric his-topathological lesions in Accra,Ghana which was compared with previous data from Maputo,Mozambique.As there is a general lack of structured cohort studies in Africa,we also considered endoscopy-based hospital or tertiary centre studies of symptomatic individuals.In Africa,there is considerable heterogeneity in the prevalence of PUD with no clear geographical patterns.Furthermore,there are differences in PUD within-country despite universally endemic H.pylori infection.PUD is not uncommon in Africa.Most of the African tertiary-centre studies had higher prevalence of PUD when compared with similar studies in western countries.An additional intriguing observation is a recent,ongoing decline in PUD in some African countries where H.pylori infection is still high.One possible reason for the high,sustained prevalence of PUD may be the significant use of NSAIDs in local or over-the-counter preparations.The prevalence of AG and IM,were similar or modestly higher over rates in western countries but lower than those seen in Asia..In our new data,sampling of 136 patients in Accra detected evidence of pre-malignant lesions(AG and/or IM)in 20 individuals(14.7%).Likewise,the prevalence of pre-malignant lesions,in a sample of 109 patients from Maputo,were 8.3%AG and 8.3%IM.While H.pylori is endemic in Africa,the observed prevalence for GCA is rather low.However,cancer data is drawn from country cancer registries that are not comprehensive due to considerable variation in the availability of efficient local cancer reporting systems,diagnostic health facilities and expertise.Validation of cases and their source as well as specificity of outcome definitions are not explicit in most studies further contributing to uncertainty about the precise incidence rates of GCA on the continent.We conclude that evidence is still lacking to support(or not)the African enigma theory due to inconsistencies in the data that indicate a particularly low incidence of GDD in African countries. | Timothy N Archampong Richard H Asmah Cathy J Richards Vicki J Martin Christopher D Bayliss Edília Botao Leonor David Sandra Beleza Carla Carrilho | 2019 | World Journal of Gastroenterology2019，25，26： | 3 |
| 2 | Cognitive performance in patients with COPD显示文摘 | Jeroen J.W Liesker Dirkje S Postma Rypko J Beukema Nick H.T ten Hacken Thys van der Molen Roland A Riemersma Ed H van Zomeren Huib A.M Kerstjens | 2003 | Respiratory Medicine2003，，4： | 3 |
| 3 | Global research trends in the microbiome related to irritable bowel syndrome: A bibliometric and visualized study显示文摘BACKGROUND Irritable bowel syndrome(IBS) is a common functional gastrointestinal disorder. Dysregulation of the gut–brain axis plays a central role in the pathophysiology of IBS. It is increasingly clear that the microbiome plays a key role in the development and normal functioning of the gut–brain axis.AIM To facilitate the identification of specific areas of focus that may be of relevance to future research. This study represents a bibliometric analysis of the literature pertaining to the microbiome in IBS to understand the development of this field.METHODS The data used in our bibliometric analysis were retrieved from the Scopus database. The terms related to IBS and microbiome were searched in titles or abstracts within the period of 2000–2019. VOSviewer software was used for data visualization.RESULTS A total of 13055 documents related to IBS were retrieved at the global level. There were 1872 scientific publications focused on the microbiome in IBS. There was a strong positive correlation between publication productivity related to IBS in all fields and productivity related to the microbiome in IBS(r = 0.951, P < 0.001). The United States was the most prolific country with 449(24%) publications, followed by the United Kingdom(n = 176, 9.4%), China(n = 154, 8.2%), and Italy(n = 151, 8.1%). The h-index for all retrieved publications related to the microbiome in IBS was 138. The hot topics were stratified into four clusters:(1) The gut–brain axis related to IBS;(2) Clinical trials related to IBS and the microbiome;(3) Drugmediated manipulation of the gut microbiome;and(4) The role of the altered composition of intestinal microbiota in IBS prevention.CONCLUSION This is the first study to evaluate and quantify global research productivity pertaining to the microbiome in IBS. The number of publications regarding the gut microbiota in IBS has continuously grown since 2013. This finding suggests that the future outlook for interventions targeting the gut microbiota in IBS remains promising. | Sa'ed H Zyoud Simon Smale W Stephen Waring Waleed Sweileh Samah W Al-Jabi | 2021 | World Journal of Gastroenterology2021，27，13： | 2 |
| 4 | Global research on Clostridium difficile-associated diarrhoea:A visualized study显示文摘BACKGROUND Clostridioides(Clostridium)difficile(C.difficile)is still the most common cause of healthcare-associated diarrhoea and is increasing in prevalence as a communityacquired infection.In addition,the emergence of antibiotic resistance in C.difficile can increase the likelihood of the disease developing and/or spreading.AIM To provide an up-to-date picture of the trends in publications related to C.difficile infection,together with specific insights into hot-button issues in this field.METHODS Publications on C.difficile infections in the field of microbiology between 2001 and 2020 were identified from the Scopus database and Reference Citation Analysis.Bibliometric indicators were determined,including the number and type of publications,countries,affiliations,funding agencies,journals and citation patterns.VOSviewer was used to determine research areas and hot-button issues by identifying recurring terms with a high relative occurrence in the title and abstract.RESULTS A total of 8127 documents on‘C.difficile-associated diarrhoea’published between 2001 and 2020 were retrieved from the Scopus database.In the last decade,there has been a significant almost fourfold increase in the number of published papers on this topic.The United States was among the countries(44.11%)with the most publications,and the most involved institution was the University of Leeds in the United Kingdom(2.50%).Three clusters of research were identified and included‘illness spectrum and severity,as well as the signs,symptoms and clinical pathogenesis of C.difficile’;‘laboratory diagnosis and characterization of C.difficile’and‘risk factors for C.difficile infection’.CONCLUSION This study contains the most up-to-date and comprehensive data ever compiled in this field.More international research and cross-institutional collaborations are needed to address more global C.difficile concerns and to benefit from greater sharing of expertise,which will result in higher quality or more effective studies in the future.Promising research avenues in the near future may draw the attention of relevant scientists and funding organizations and open up novel C.difficile infection–based diagnosis and treatment approaches. | Sa'ed H Zyoud | 2022 | World Journal of Gastroenterology2022，28，28： | 2 |
| 5 | Cognitive performance in patients with COPD显示文摘 | Jeroen J.W Liesker Dirkje S Postma Rypko J Beukema Nick H.T ten Hacken Thys van der Molen Roland A Riemersma Ed H van Zomeren Huib A.M Kerstjens | 2003 | Respiratory Medicine2003，，4： | 2 |
| 6 | Relationship between dental caries experience and surface enamel fluoride concentration in young men from three optimally fluoridated cities显示文摘 | Keene H J Mellberg JR Pederson ED | 1980 | J Dent Res1980，59，11： | 1 |
| 7 | Is simultaneous surgical management of advanced craniofaeial steoradioneerosiseost-effective? 显示文摘 | Kelishadi SS St-Hilaire H Rodriguez ED | 2009 | Plast Reconstr Surg2009，123，3： | 1 |
| 8 | Laminin-binding integrins in rat lens morpho- genesis and their regulation during fibre differentiation显示文摘 | WedereU ED Brown H O' Connor M Chamberlain CG McAvoy JW de Iongh RU | 2005 | Exp Eye Res2005，81，3： | 1 |
| 9 | The radiologic diagno- sis of quadriceps twndon rupture显示文摘 | Spector ED DiMm'cangelo MT Jacoby J H | 1995 | N J Med1995，92，： | 1 |
| 10 | Approximation for periodic functions via weighted statistical convergence显示文摘 | EDELY OSAMA H H MURSALEER M KHAN A | 2013 | Applied Mathematics and Computation2013，219，15： | 1 |
| 11 | Regulatory element detection using correlation with expression显示文摘 | Bussemaker H J Li H Siggia ED | 2001 | Nat Genet2001，27，2： | 1 |
| 12 | Recurrent mutations at codon 625 of the splicing factor SF3B1 in uveal melanoma显示文摘 | Harbour JW Roberson ED Anbunathan H | 2013 | Nat Genet2013，45，2： | 1 |
| 13 | Implications of B7-H1 expression in clear cell of the kidney for prognostication and therapy 显示文摘 | Thompson RH Dong H Kwon ED | 2007 | Clin Cancer Res2007，13，2： | 1 |
| 14 | New antihypertensive peptides isolated from rapeseed显示文摘 | Marczak ED Usui H Fujita H | 2003 | Peptides2003，24，： | 1 |
| 15 | Relaxin reverses cardiac and renal fibrosis in spontaneously hypertensive rats 显示文摘 | Lekgabe ED Kiriazis H Zhao C | 2005 | Hypertension2005，46，2： | 1 |
| 16 | New developments in recirculating aquaculture systems in Europe:A perspective on environmental sustainability显示文摘 | MARTINS C I M EDING E H VERDEGEM M C J | | 0，，： | 1 |
| 17 | DNA damage response induced by exposure of human lung adenocarcinoma cells to smoke from tobacco-and nicotine-free cigarettes显示文摘 | Jorgensen ED Zhao H Traganos F | 2010 | Cell Cycle2010，9，11： | 1 |
| 18 | First reported cases of intravascular large cell lymphoma of the NK cell type:clinical,histologic,immunophenotypic,and molecular features显示文摘 | Wu H Said JW Ames ED | 2005 | Am J Clin Pathol2005，123，4： | 1 |
| 19 | Human monoclonal antibodies against anthrax lethal factor and protective antigen act independently to protect against Bacillus anthracis infection and enhance endogenous immunity to anthrax显示文摘 | Albrecht MT Li H Williamson ED | 2007 | Infect Immun2007，75，11： | 1 |
| 20 | A quantitative framework to analyze cooperation between rural house holds显示文摘 | GERICHHAUSEN M BERKHOUT ED HAMERS H J M | 2009 | Agricuhural Systems2009，，101： | 1 |
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