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| 1 | Coinfection with influenza A virus enhances SARS-CoV-2 infectivity显示文摘The upcoming flu season in the Northern Hemisphere merging with the current COVID-19 pandemic raises a potentially severe threat to public health.Through experimental coinfection with influenza A virus(IAV)and either pseudotyped or live SARS-CoV-2 virus,we found that IAV preinfection significantly promoted the infectivity of SARS-CoV-2 in a broad range of cell types.Remarkably,in vivo,increased SARS-CoV-2 viral load and more severe lung damage were observed in mice coinfected with IAV.Moreover,such enhancement of SARS-CoV-2 infectivity was not observed with several other respiratory viruses,likely due to a unique feature of IAV to elevate ACE2 expression.This study illustrates that IAV has a unique ability to aggravate SARS-CoV-2 infection,and thus,prevention of IAV infection is of great significance during the COVID-19 pandemic. | Lei Bai Yongliang Zhao Jiazhen Dong Simeng Liang Ming Guo Xinjin Liu Xin Wang Zhixiang Huang Xiaoyi Sun Zhen Zhang Lianghui Dong Qianyun Liu Yucheng Zheng Danping Niu Min Xiang Kun Song Jiajie Ye Wenchao Zheng Zhidong Tang Mingliang Tang Yu Zhou Chao Shen Li Zhou Yu Chen Huan Yan Ke Lan Ke Xu | 2021 | Cell Research2021，31，4： | 16 |
| 2 | System architecture for high-performance permissioned blockchains显示文摘Blockchain(BC),as an emerging distributed database technology with advanced security and reliability,has attracted much attention from experts who devoted to efinance,intellectual property protection,the internet of things(IoT)and so forth.However,the inefficient transaction processing speed,which hinders the BC’s widespread,has not been well tackled yet.In this paper,we propose a novel architecture,called Dual-Channel Parallel Broadcast model(DCPB),which could address such a problem to a greater extent by using three methods which are dual communication channels,parallel pipeline processing and block broadcast strategy.In the dual-channel model,one channel processes transactions,and the other engages in the execution of BFT.The parallel pipeline processing allows the system to operate asynchronously.The block generation strategy improves the efficiency and speed of processing.Extensive experiments have been applied to BeihangChain,a simplified prototype for BC system,illustrates that its transaction processing speed could be improved to 16K transaction per second which could well support many real-world scenarios such as BC-based energy trading system and Micro-film copyright trading system in CCTV. | Libo FENG Hui ZHANG Wei-Tek TSAI Simeng SUN | 2019 | Frontiers of Computer Science2019，13，6： | 2 |
| 3 | Formation and evolution of petroliferous basins in African continent and their hydrocarbon distribution显示文摘There are eighty sedimentary basins in five different types in African continent,i.e.craton sag basin,foreland basin,intermountain basin,passive margin basin and rift basin,which underwent the stress environment of stable depression-compression-extension.The first three types of basins had been intensely influenced by Hercynian and Alpine tectonic movement,while the later two types of basins always exist in a stable extension environment.Different basin evolution caused the obviously hydrocarbon distribution difference.In North Africa,marginal craton sag and rift basins show great expedition potential of hydrocarbon,marginal craton sag basins had good formation and preservation of Lower Silurian hot shale,tectonic-strata traps and migration pathway formed by Hercynian unconformity,and rift basins had excellent Upper Cretaceous marine source rocks and good hydrocarbon preservation with little tectonic activity.Meanwhile,in the salt-containing passive margin basins and delta basins of West Africa,thick strata containing high quality source rocks and plastic strata were well developed.Source rocks of high maturity,good hydrocarbon preservation,growth faults and deformational structure traps were formed by abundant overlying sediments and sources supplied from Tertiary large water system. | SUN Haitao ZHONG Dakang ZHANG Simeng WANG Xingming | 2010 | Global Geology2010，13，1： | 1 |
| 4 | Rapid inactivation of human respiratory RNA viruses by deep ultraviolet irradiation from light-emitting diodes on a high-temperatureannealed AlN/Sapphire template显示文摘Efficient and eco-friendly disinfection of air-borne human respiratory RNA viruses is pursued in both public environment and portable usage.The AlGaN-based deep ultraviolet(DUV)light-emission diode(LED)has high practical potentials because of its advantages of variable wavelength,rapid sterilization,environmental protection,and miniaturization.Therefore,whether the emission wavelength has effects on the disinfection as well as whether the device is feasible to sterilize various respiratory RNA viruses under portable conditions is crucial.Here,we fabricate AlGaN-based DUV LEDs with different wavelength on high-temperature-annealed(HTA)AlN/Sapphire templates and investigate the inactivation effects for several respiratory RNA viruses.The AlN/AlGaN superlattices are employed between the template and upper n-AlGaN to release the strong compressive stress(SCS),improving the crystal quality and interface roughness.DUV LEDs with the wavelength of 256,265,and 278 nm,corresponding to the light output power of 6.8,9.6,and 12.5 mW,are realized,among which the 256 nm-LED shows the most potent inactivation effect in human respiratory RNA viruses,including SARS-CoV-2,influenza A virus(IAV),and human parainfluenza virus(HPIV),at a similar light power density(LPD)of~0.8 mW/cm2 for 10 s.These results will contribute to the advanced DUV LED application of disinfecting viruses with high potency and broad spectrum in a portable and eco-friendly use. | Ke Jiang Simeng Liang Xiaojuan Sun Jianwei Ben Liang Qu Shanli Zhang Yang Chen Yucheng Zheng Ke Lan Dabing Li Ke Xu | 2023 | Opto-Electronic Advances2023，6，9： | 0 |
| 5 | Effects of hydrological and climatic variables on cyanobacterial blooms in four large shallow lakes fed by the Yangtze River显示文摘Shallow lakes,one of the most widespread water bodies in the world,are easily shifted to a new trophic state due to external interferences.Shifting hydrologic conditions and climate change can cause cyanobacterial harmful algal blooms(CyanoHABs)in shallow lakes,which pose serious threats to ecological integrity and human health.This study analyzed the effects of hydrologic and meteorological variables on cyanobacterial blooms in Yangtze-connected lakes(Lake Dongting and Poyang)and isolated lakes(Lake Chao and Tai).The results show that(i)chlorophyll-a(Chl-a)concentration tends to decrease exponentially with increasing relative lake level fluctuations(RLLF)and precipitation,but to increase linearly with increasing wind speed and air temperature;(ii)Chl-a concentrations in lakes were significantly higher when RLLF<100,precipitation<2.6 mm,wind speed>2.6 ms^(-1),or air temperature>17.8℃;(iii)the Chl-a concentration of Yangtze-isolated lakes was more significantly affected by water level amplitude,precipitation,wind speed and air temperature than the Yangtze-connected lakes;(iv)the RLLF and the ratio of wind speed to mean water depth could be innovative coupling factors to examine variation characteristics of Chl-a in shallow lakes with greater correlation than single factors. | Jian Huang Qiujin Xu Xixi Wang Hao Ji Edward J.Quigley Mohamadali Sharbatmaleki Simeng Li Beidou Xi Biao Sun Caole Li | 2021 | Environmental Science and Ecotechnology2021，，1： | 0 |
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