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| 1 | Mapping QTL associated with Verticillium dahliae resistance in the cultivated strawberry(Fragaria×ananassa)显示文摘A biparental cross of octoploid strawberry segregating for resistance to Verticillium dahliae,the causative agent of Verticillium wilt,was screened under field conditions for three seasons.Average wilt scores were significantly associated with multiple QTL,which were mostly significant across all years.Markers significantly associated with the traits were used to screen material with known wilt resistance and susceptibility phenotypes.A clear and statistically significant relationship was observed between resistant,tolerant and susceptible material and the total number of markers present in the different resistance classes.In field situations resistance QTL appear to behave in an additive manner.These markers are abundant in the cultivated strawberry germplasm indicating that,despite the large number of markers,clear genetic gain is possible through marker-assisted breeding. | L Antanaviciute NŠurbanovski N Harrison K J McLeary D W Simpson F Wilson D J Sargent R J Harrison | 2015 | Horticulture Research2015，2，1： | 5 |
| 2 | Hepatitis E virus in patients with acute severe liver injury显示文摘AIM: To examine the incidence of hepatitis E(HepE) in individuals with acute liver injury severe enough to warrant treatment at a transplant unit.METHODS: Hepatitis E virus(HEV) is an emerging pathogen in developed countries causing severe illness, particularly in immunocompromised patients or those with underlying chronic liver disease. HepE infection isoften under diagnosed, as clinicians can be reluctant to test patients who have not travelled to regions traditionally considered hyperendemic for HepE. There are few data regarding the significance of HEV in patients with very severe acute liver injury in developed countries. Eighty patients with acute severe liver injury attending the Scottish Liver Transplant unit were tested for HEV and anti-HEV IgG and IgM. Severe acute liver injury was defined as a sudden deterioration in liver function confirmed by abnormal liver function tests and coagulopathy or presence of hepatic encephalopathy. Eighty percent of these patients were diagnosed with paracetomol overdose. No patients had a history of chronic or decompensated chronic liver disease at time of sampling. IgG positive samples were quantified against the World Health Organization anti-HEV IgG standard. Samples were screened for HEV viral RNA by quantitative reverse transcription polymerase chain reaction.RESULTS: Four cases of hepatitis E were identified. Three of the four cases were only diagnosed on retrospective testing and were initially erroneously ascribed to drug-induced liver injury and decompensated chronic liver disease, with the cause of the decompensation uncertain. One case was caused by HEV genotype 1 in a traveller returning from Asia, the other three were autochthonous and diagnosed on retrospective testing. In two of these cases(where RNA was detected) HEV was found to be genotype 3, the most prevalent genotype in developed countries. Three patients survived, two of whom had been misdiagnosed as having drug induced liver injury. The fourth patient died from sepsis and liver failure precipitated as a result of hepatitis E infection and previously undiagnosed cirrhosis. Histopathology data to date is limited to mainly that seen for endemic HepE. All patients, with the exception of patient 1, demonstrated characteristics of HepE infection, as seen in previously described locally acquired cases.CONCLUSION: In patients with acute severe liver injury, HEV testing should be part of the initial diagnostic investigation algorithm irrespective of suspected initial diagnosis, age or travel history. | Claire Louise Crossan Kenneth J Simpson Darren G Craig Christopher Bellamy Janice Davidson Harry R Dalton Linda Scobie | 2014 | World Journal of Hepatology2014，6，6： | 4 |
| 3 | Satellite detection of natural hydrocarbon seepage: Palm Valley gas field, Amadeus Basin, Central Australia显示文摘 | Simpson C J Wilford J R Macials L F | 1989 | The APEA Journal1989，29，： | 1 |
| 4 | Developments in unsteady pipe flow friction modeling 显示文摘 | BERGANT A SIMPSON A R VITKOVSKY J P | 2001 | J Hydraul Res2001，39，3： | 1 |
| 5 | Leak detection and calibration using transients and genetic algorithms显示文摘 | Vitkovsky J P Simpson A R Martin F L | 2000 | Journal Water Resource Planning and Management2000，126，4： | 1 |
| 6 | Product platform design: Method and application 显示文摘 | Simpson T W Maier J R A Mistree F | 2001 | Research in Engineering Design2001，13，1： | 1 |
| 7 | A Procedure for the Detection and Removal of Cloud Shadow from AVHRR Data over Land显示文摘 | Simpson J J Stitt J R | 1998 | IEEE Transaction on Geoscience and Remote Sensing1998，36，3： | 1 |
| 8 | Reynolds stress and TKE production in an estuary with a tidal bore显示文摘 | SIMPSON J H FISHER N R WILES P | 2004 | Estuarine Coastal and Shelf Science2004，60，4： | 1 |
| 9 | A proposed Tropical Rainfall Measuring Mission (TRMM) satellite显示文摘 | SIMPSON J ADLER R F NORTH G R | 1988 | Bull Amer Meteor Soc1988，69，3： | 1 |
| 10 | A micmRNA upregulated in asthma airway T cells promotes TH2 cytokine production显示文摘 | Simpson L J Patel S Bhakta N R | 2014 | Nat Immunol2014，15，12： | 1 |
| 11 | Stratification of sudden death risk in patients receiving long-term amiodarone treatment for sustained ventricular tachycardia or ventricular fibrillation显示文摘 | WOELFEL A SIMPSON R J | 1993 | Am J Cardiol1993，71，10： | 1 |
| 12 | Dermatology quality of life scales-ameasure of the impact of skin diseases显示文摘 | Morgan M Mc Creedy R Simpson J | 2007 | British Jour- nal of Dermatology2007，136，2： | 1 |
| 13 | Quantitative analysis of the expression of ACAT genes in human tissues by real-time PCR 显示文摘 | SMITH J L RANGARAJ K SIMPSON R | 2004 | J Lipid Res2004，45，4： | 1 |
| 14 | Behaviour of plant-derived extracellular phytase upon addition to soil显示文摘 | George T S Richardson A E Simpson R J | 2005 | Soil Biology and Biochemistry2005，37，5： | 1 |
| 15 | Three Dimensional Metrology 显示文摘 | HOCKEN R SIMPSON J A BORCHARDT B | 1977 | Annals of the CIRP1977，26，1： | 1 |
| 16 | Inflammatory subtypes in asthma: assessment and identification using induced sputum显示文摘 | Simpson JL Scott R Michael J | 2006 | Respirology2006，11，1： | 1 |
| 17 | Three dimensional metrology 显示文摘 | Hocken R Simpson A J | 1977 | Annals of the CIRP1977，26，2： | 1 |
| 18 | Es sential role for estrogen receptor beta in stromal-epi thelial regulation of prostatic hyperplasia显示文摘 | McPherson S J Ellem S J Simpson E R et at | 2007 | Endo crinology2007，148，2： | 1 |
| 19 | Analysis of the structureand function of the transcriptional coregulator H0P显示文摘 | Kook H Yung W W Simpson R J | 2006 | Bioche-mistry2006，45，10： | 1 |
| 20 | Anterior approachet and stabilization of the disrupted sacmiliac joint 显示文摘 | Simpson L A Waddell J P Leighton R K | 1987 | J Trauma1987，27，12： | 1 |
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