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| 1 | 术中应用荧光素钠有利于胶质母细胞瘤浸润边缘的手术切除(英文)显示文摘Objective Extent of resection is an important prognostic factor in patients undergoing surgery for glioblastoma( GBM).Recent evidence suggests that intravenously administered fluorescein sodium associates with tumor tissue,facilitating safe maximal resection of GBM. In this study,the authors evaluate the safety and utility of intraoperative fluorescein guidance for the prediction of histopathological alteration both in the contrast-enhancing( CE) regions,where this relationship has been established,and into the nonCE( NCE),diffusely infiltrated margins. Methods Thirty-two patients received fluorescein sodium( 3 mg/kg) intravenously prior to resection. Fluorescence was intraoperatively visualized using a Zeiss Pentero surgical microscope equipped with a YELLOW 560 filter.Stereotactically localized biopsy specimens were acquired from CE and NCE regions based on preoperative MRI in conjunction with neuronavigation. The fluorescence intensity of these specimens was subjectively classified in real time with subsequent quantitative image analysis,histopathological evaluation of localized biopsy specimens,and radiological volumetric assessment of the extent of resection.Results Bright fluorescence was observed in all GBMs and localized to the CE regions and portions of the NCE margins of the tumors,thus serving as a visual guide during resection. Gross-total resection( GTR) was achieved in 84% of the patients with an average resected volume of 95%,and this rate was higher among patients for whom GTR was the surgical goal( GTR achieved in 93. 1% of patients,average resected volume of 99. 7%). Intraoperative fluorescein staining correlated with histopathological alteration in both CE and NCE regions,with positive predictive values by subjective fluorescence evaluation greater than 96% in NCE regions. Conclusions Intraoperative administration of fluorescein provides an easily visualized marker for glioma pathology in both CE and NCE regions of GBM. These findingssupport the use of fluorescein as a microsurgical adjunct for guiding GBM resection to facilitate safe maximal removal. | Neira JA Ung TH Sims J Malone HR Chow DS Samanamud JL Zanazzi GJ Guo X Bowden SG Zhao B Sheth SA McKhann GM 2nd Sisti MB Canoll P D'Amico RS Bruce JN | 2016 | 中华神经外科疾病研究杂志2016，15，5： | 2 |
| 2 | Modal analysis of structures with uncertain-but-bounded parameters via interval analysis 显示文摘 | Sim J Qiu Z Wang X | 2007 | Journal of Sound and Vibration2007，303，12： | 1 |
| 3 | Stepwise differentiation of CD4 memory T cells defined by expression of CCR7and CD27显示文摘 | Fritsch RD Shen X Sims GP | 2005 | J Immunol2005，175，10： | 1 |
| 4 | Risk aversion in inventory management显示文摘 | Chen X Sim M Levi D | 2007 | Operations Research2007，55，5： | 1 |
| 5 | Mutations of the same conserved glutamate residue in NBD2 of the sulfonylurea receptor 1 subunit of the KATP channel can result in either hyperinsulinism or neonatal diabetes显示文摘 | M(a)nnikk(o) R Flanagan SE Sim X | | 0，，06： | 1 |
| 6 | The Knaster-Kuratowski and Mazurkiewicz theory in hyperconvex metric spaces and some of its applications显示文摘 | Kirk W A Sims B Yuan X Z | 2000 | Nonlinear Anal2000，39，： | 1 |
| 7 | Replication of 13 obesity loci among Singaporean Chinese, Malay and Asian-Indian populations显示文摘 | Dorajoo R Blakemore AI Sim X | 2012 | Int J Obes (Lond)2012，36，1： | 1 |
| 8 | Mechanical properties of adult vertebral cancellous bone: correlation with collagen intermo- lecular cross-links显示文摘 | Banse X Sims T J Bailey AJ | 2002 | J Bone Miner Res2002，17，9： | 1 |
| 9 | The estimation of magnetotel- luric impedance tensor elements from measured data 显示文摘 | Sims W E Bostick F X Smith H W | 1971 | Geophys- ics1971，36，5： | 1 |
| 10 | Versatile transfer of a- ligned carbon nanotubes with polydimethylsiloxane as the inter- mediate显示文摘 | Zhu Y W Lim X D Sim M C | 2008 | Nanotechnology2008，19，32： | 1 |
| 11 | SIGIRR, a negative reg-ulator of Toll-like receptor-interleukin 1 receptor signaling显示文摘 | Wald D Qin J Zhao Z Qian Y Naramura M Tian L Towne J Sims JE Stark GR Li X | 2003 | Nat Immunol2003，4，9： | 1 |
| 12 | Cholesterol oxidation in egg yolk powder during storage and heating as affected by dietary oil and tocopherol显示文摘 | LI S X CHERIAN G SIM J S | 1996 | Journal of Food Science1996，61，4： | 1 |
| 13 | Risk aversion in inventory management 显示文摘 | CHEN X SIM M SIMCHI-LEVI D | 2007 | Operations Research2007，55，5： | 1 |
| 14 | Electrostatic effects on first pass transfer efficiency in the application of powder coatings显示文摘 | Sims R A Mazumder M K Liu X | 2001 | IEEE Trans Ind Appl2001，，37： | 1 |
| 15 | In vitro vasodilator mechanisms of the indole alkaloids rhynchophylline and isorhynchophylline,isolated from the hook of Uncaria rhynchophylla (Miquel)显示文摘 | Zhang W B Chen C X Sim S M | | 0，，02： | 1 |
| 16 | Replication of 13 obesity loci among Singaporean Chinese,Malay and Asian-Indian populations显示文摘 | Dorajoo R Blakemore AI Sim X | | 0，，01： | 1 |
| 17 | Risk aversion in inventory management显示文摘 | Chen X Sim M Simchi-Lev D | 2007 | Operations Research2007，55，5： | 1 |
| 18 | Induction of neutralizing antibodies against dengue virus type 2 upon mucosal administration of a recombinant Lactococcus lactis strain expressing envelope domain Ⅲ antigen显示文摘 | Sim A C N Lin W W Tan G K X | 2008 | Vaccine2008，26，9： | 1 |
| 19 | L-arginine regulates asymmetric dimethylarginine metabolism by inhibiting dimethylarginine dimethylaminohydrolase activity in hepatic (HepG2) cells显示文摘 | WANG J SIM A S WANG X L | 2006 | Cell Mol Life Sci2006，63，： | 1 |
| 20 | Styryl-lactone derivatives and alkaloids from Goniothalamus borneensis (Annonaceae) 显示文摘 | Cao S G Wu X H Sim K Y | 1998 | Tetrahedron1998，54，10： | 1 |
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