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| 1 | Isolation and characterization of gomesin,an 18-residue cysteine-rich defense peptide from the spider acanthoscurrria gomesiana hemocytes with sequence similarities to horseshoe crab antimicrobial peptides of the tachyplesin family显示文摘 | Silva PI Daffre S Bulet P | 2000 | J Biol Chem2000，275，33： | 1 |
| 2 | Acanthoscurrin: a novel glycine- rich antimierobial peptide constitutively expressed in the hemocytes of the spider Acanthoseurria gomeslana显示文摘 | Lorenzini DM da Silva PI Fogaca AC | 2003 | Developmental and Comparative Immunology2003，27，9： | 1 |
| 3 | Efficacy of Bifido- bacterium breve and Lactobacillus casei oral supplementation on necrotizing enterocolitis in very-low-birth-weight preterm infants: a double-blind, randomized, controlled trial显示文摘 | Braga TD da Silva GA de Lira PI | 2011 | Am J Clin Nutr2011，93，1： | 1 |
| 4 | Isolation and characterization of gomesin,an 18-residue cysteine-rich defense peptide from the spider Acanthoscurria gomesiana hemocytes with sequence similarities to horseshoe crab antimicrobial peptides of the tachyplesin family显示文摘 | SILVA PI Jr DAFFRE S BULET P | 2000 | J Biol Chem2000，275，33： | 1 |
| 5 | Correlations of mutations in katG, oxyR-ahpC and inhA genes and in vitro suseeptibility in Mycobacterium tuberculosis clinical strains segregated by spoligotype families from tuberculosis prevalent countries in South America显示文摘 | Dalla Costa ER Ribeiro MO Silva MS Arnold LS Rostirolla DC Cafrune PI Espinoza RC Palaci M Telles MA Ritaeeo V Suffys PN Lopes ML Campelo CL Miranda SS Kremer K da Silva PE Fonseea Lde S Ho JL Kritski AL Rossetti ML | 2009 | BMC Microbiol2009，9，： | 1 |
| 6 | Physiological concentrations of interleukin-6 directly promote insulin secretion, signal transduction, nitric oxide release, and redox stares in a clonal pancreatic 13-cell line and mouse islets显示文摘 | da Silva Krause M Bittencourt A Honaem de Bittencourt PI Jr | 2012 | J Etldocrinol2012，214，3： | 1 |
| 7 | Immunological aspects of phenol oxidase enzymatic system of Schistosoma mansoni显示文摘 | Ribeiro-Paes JT da Costa PI da Silva D | 1994 | Rev Inst Med Trop Sao Paulo1994，36，5： | 1 |
| 8 | Delayed tooth replantation following root canal filling with calcium hydroxide and MTA:Histomorphometric study in rats显示文摘 | Esteves JC Mar珘ao HF Silva PI et al | 2015 | Arch Oral Biol2015，2060，9： | 1 |
| 9 | Antimi- crobial activity of a bovine hemoglobin fragment in the tick Boophilus microplus 显示文摘 | FOGACA AC DA SILVA PI JR MIRANDA MT | 1999 | J Biol Chem1999，274，25： | 1 |
| 10 | Efficacy of Bifidobacterium breve and Lactobacillus casei oral supplementation on necrotizing enterocolitis in very-low-birth-weight preterm infants:a double-blind,randomized,controlled trial显示文摘 | Braga TD da Silva GA de Lira PI | | 0，，01： | 1 |
| 11 | Antimicrobi- al activity of a bovine hemoglobin fragment in the tick Boophilus microplus 显示文摘 | FOGACA A C SILVA PI J MIRANDA M T | 1999 | J Biol chem1999，274，25： | 1 |
| 12 | Lenvatinib as first-line therapy for recurrent hepatocellular carcinoma after liver transplantation:Is the current evidence applicable to these patients?显示文摘Liver transplantation(LT)is one of the leading curative therapies for hepatocellular carcinoma(HCC).Despite recent optimization of transplant selection criteria,including alpha-feto protein,HCC recurrence after LT is still the leading cause of death in these patients.During the last decades,effective systemic treatments for HCC,including tyrosine kinase inhibitors and immunotherapy,have been approved.We describe the clinical scenario of a patient with recurrence of HCC five years after LT,who received lenvatinib as first-line systemic therapy to introduce systemic treatment options in this clinical setting.In this opinion review,we detail first and second-line systemic treatment options,focusing on those feasible for patients with recurrent HCC after LT.Several trials have evaluated new drugs to treat HCC patients in first and secondline therapy,but patients with recurrent HCC after LT have been excluded from these trials.Consequently,most of the evidence comes from observational retrospective studies.Whether tyrosine kinase inhibitors will remain the primary therapeutic approach in these patients,due to a relative contraindication for immunotherapy,may be clarified in the near future. | Federico Piñero Marcos Thompson Juan Ignacio Marín Marcelo Silva | 2020 | World Journal of Transplantation2020，10，11： | 0 |
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