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| 1 | Giant squamous cell carcinoma of the gallbladder: A case report显示文摘BACKGROUND Gallbladder cancer is the most common malignant tumor of the biliary tract. The majority of cases are adenocarcinoma. Squamous cell carcinoma is the histological type present in 12% of all neoplasias accounting for approximately 12% of gallbladder neoplasms. It can occur in its pure form reaching 1%-3% of the tumors. Many patients are at an advanced stage when diagnosed and have bad therapeutic efficacy. CASE SUMMARY A 45-year-old male patient presented with left flank pain for 1 year and irradiated to the mesogastric region. He denied fever, vomiting, and any other intestinal changes. He reported a weight loss of 10 kg in a period of 7 mo. He denied alcoholism, smoking, drug use, or prior illness. Computed tomography of the abdomen showed in the gallbladder fossa a voluminous mesogastric heterogeneous collection that had a thick and irregular capsule with liquid and gaseous contents. A predominantly hypoattenuating rounded material with partially calcified margins measuring about 2.0 cm related to gallstone was also emphasized. No lymphadenomegalies or free fluid was observed in the abdominal cavity. Patient underwent laparotomy where a huge tumor was observed affecting the transverse colon and gallbladder. This mass was resected en bloc removing gallbladder and transverse colon together with corresponding mesocolon and regional lymphadenectomy. There were no complications in the postoperative period. Although oncological treatment was performed, the patient died 6 mo after surgery. CONCLUSION Squamous cell carcinoma represents a rare disease. Patients often present with large, bulky tumors with involvement of adjacent organs. In spite of progress in surgical techniques and adjuvant chemotherapy, the prognosis remains poor. | Marcelo AF Ribeiro Junior Murillo de Lima Favaro Stephanie Santin Cintia Magalhaes Silva Ana Paula Marconi Iamarino | 2019 | World Journal of Clinical Cases2019，7，18： | 2 |
| 2 | An evaluation of p16^INK4a expression in cervical intraepithelial neoplasia specimens,including women with HIV-I显示文摘 | Nicol AF Golub JE e Silva JR | 2012 | Mem Inst Os- waldo Cruz2012，107，5： | 1 |
| 3 | MIT image reconstruction based on edge preserving regularization显示文摘 | Casanova R da Silva AF Borges AR | 2004 | Physiol Meas2004，25，： | 1 |
| 4 | Temporomandibuiar joint and normal occlusion: is there anything singular about it? a computed tomographic evaluation 显示文摘 | Vitral RW da Silva Campos M J Rodrigues AF | 2011 | Am J Orthod Dentofacila Orthop2011，140，1： | 1 |
| 5 | MIT image reconstruction based on edge preserving regularization显示文摘 | Casanova R da Silva AF Borges AR | 2004 | Physiol Meas2004，25，： | 1 |
| 6 | Phytochemical characterization and antinociceptive effect ofLippia gracilis Schauer显示文摘 | Guimares AG Gomes SV Moraes VR Nogueira PC Ferreira AG Blank AF Santos AD Viana MD Silva GH Quintans Júnior LJ | 2012 | J Nat Med2012，66，3： | 1 |
| 7 | Systolic function of patients with myocardial infarction undergoing autologous bone marrow transplantation显示文摘 | Nogueira FB Silva SA Haddad AF | 2009 | Arq Bras Cardiol2009，93，4： | 1 |
| 8 | MzheimerS disease - like pathology ~nduced by amyloid - 13 oligomers in non- human primates 显示文摘 | Forny - Germano L Lyra e Silva NM Batista AF | 2014 | J Neurosci2014，34，13： | 1 |
| 9 | Medical adjuvant treatment to increase patency of arteriovenous fistulae and grafts显示文摘 | Da Silva AF Escofet X Rutherford PA | 2003 | Cochrane Database Syst Rev2003，，00： | 1 |
| 10 | Co-existing abdominal aortic aneurysm and intra-abdominal malignancy:reflections on the order of treatment显示文摘 | Morris HL da Silva AF | 1998 | Br J Surg1998，85，9： | 1 |
| 11 | Cisplatin versus carboplatin in combination with third-generation drugs for advanced non-small cell lungcancer显示文摘 | de Castria TB da Silva EM Gois AF | 2013 | Cochrane Database Syst Rev2013，8，00： | 1 |
| 12 | Hippocampal neuronalloss, decreased GFAP immunoreactivity and cognitive impairmentfollowing experimental intoxication of rats with aluminum citrate显示文摘 | Silva AF Aguiar MS Carvalho OS | 2013 | Brain Res2013，1491，： | 1 |
| 13 | Delayed leukoen- cephalopathy after acute carbon monoxide intoxication 显示文摘 | Geraldo AF Silva C Neutel D | 2014 | J Radiol Case Rep2014，8，5： | 1 |
| 14 | Clinical evaluation of two desensitizing treatments in southern Brazil:A 3-month follow-up显示文摘 | Lund RG Silva AF Piva E | 2013 | Acta Odontol Scand2013，71，6： | 1 |
| 15 | Oral tolerance induced to house dust mite extract in naive and sensitized mice: evaluation of immunoglohulin G anti-immunoglohulin E autoantibodies and IgG-IgE complexes显示文摘 | Sato MN Carvalho AF Silva AO | 1998 | Immunology1998，95，2： | 1 |
| 16 | Cisplatin versus carboplatin in combination with third-generation drugs for advanced non-small cell lung cancer显示文摘 | de CASTRIA TB da SILVA EM GOIS AF | 2013 | Cochrane Database Syst Rev2013，8，00： | 1 |
| 17 | Evaluation of hu man sperm chromatin status after selection using a modi fled Diff Quik stain indicates embryo quality and pregnan cy outcomes following in vitro fertilization显示文摘 | Tavares RS Silva AF Loureno B | 2013 | Cell2013，1，83： | 1 |
| 18 | Low dose of orally administered antigen down-regulates the T helper type 2-response in a murine model of dust mite hypersensitivity 显示文摘 | Sato MN Carvalho AF Silva AO | 1999 | Immunology1999，98，3： | 1 |
| 19 | Evaluation of antimutagenic activity and mechanisms of action ofβ-glucan from barlely,in CHO-KI and HTC cell lines using the micronucleus test显示文摘 | Oliveira R J Ribeiro LR Silva AF | 2006 | Toxicology Vitro2006，20，1： | 1 |
| 20 | Kikuehi- Fujimoto disease: an unusual association with acute renal failure显示文摘 | Silva AF Focaccia R Oliveira AC | 2010 | Braz J Infect Dis2010，14，6： | 1 |
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