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| 1 | Euphorbia factor L2 induces apoptosis in A549 cells through the mitochondrial pathway显示文摘Euphorbia factor L2, a lathyrane diterpenoid isolated from caper euphorbia seed(the seeds of Euphorbia lathyris L.), has been traditionally applied to treat cancer. This article focuses on the cytotoxic activity of Euphorbia factor L2 against lung carcinoma A549 cells and the mechanism by which apoptosis is induced. We analyzed the cytotoxicity and related mechanism of Euphorbia factor L2 with an MTT assay, an annexin V-FITC/PI test, a colorimetric assay, and immunoblotting. Euphorbia factor L2 showed potent cytotoxicity to A549 cells. Euphorbia factor L2 led to an increase in reactive oxygen species(ROS) generation,a loss of mitochondrial electrochemical potential, release of cytochrome c, activation of caspase-9 and caspase-3, and cleavage of poly(ADP-ribose) polymerase, suggesting that Euphorbia factor L2 induced apoptosis through a mitochondrial pathway. The cytotoxic activity of Euphorbia factor L2 in A549 cells and the related mechanisms of apoptotic induction provide support for the further investigation of caper euphorbia seeds. | Minting Lin Sili Tang Chao Zhang Hubiao Chen Wenjing Huang Yun Liu Jianye Zhang | 2017 | Acta Pharmaceutica Sinica B2017，7，1： | 14 |
| 2 | Field Simulation of Aerosol Transmission of SARS-CoV-2 in a Special Building Layout—Guangdong Province,China,2021显示文摘What is already known on this topic?Aerosol transmission was one route for the spread of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and usually occurred in confined spaces.What is added by this report?Aerosol transmission was found to exist between handshake buildings,i.e.,buildings with extremely close proximity that formed relatively enclosed spaces.Transmission was mainly affected by the airflow layout caused by switching air conditioners on and off as well as opening and closing doors and windows.What are the implications for public health practice?Centralized isolation and home isolation in handshake buildings creates a risk of SARS-CoV-2 aerosol transmission under certain conditions.Attention should be paid to the influence of air distribution layout on aerosol diffusion in isolation wards,and disinfection of isolation venues should be strengthened. | Zhuona Zhang Xia Li Qin Wang Jin Xu Qinqin Jiang Sili Jiang Jiayun Lyu Shiqiang Liu Ling Ye Jun Yuan Wenru Feng Dongqun Xu | 2021 | China CDC weekly2021，3，34： | 8 |
| 3 | Novel way to research nonlinear feedback shift register显示文摘In this paper,we regard the nonlinear feedback shift register(NLFSR)as a special Boolean network,and use semi-tensor product of matrices and matrix expression of logic to convert the dynamic equations of NLFSR into an equivalent algebraic equation.Based on them,we propose some novel and generalized techniques to study NLFSR.First,a general method is presented to solve an open problem of how to obtain the properties(the number of fixed points and the cycles with different lengths)of the state sequences produced by a given NLFSR,i.e.,the analysis of a given NLFSR.We then show how to construct all 22n-(l-n)/22n-lshortest n-stage feedback shift registers(nFSR)and at least 22n-(l-n)-1/22n-l-1shortest n-stage nonlinear feedback shift registers(nNLFSR)which can output a given nonperiodic/periodic sequence with length l.Besides,we propose two novel cycles joining algorithms for the construction of full-length nNLFSR.Finally,two algorithms are presented to construct 22n-2-1different full-length nNLFSRs,respectively. | ZHAO DaWei PENG HaiPeng LI LiXiang HUI SiLi YANG YiXian | 2014 | Science China(Information Sciences)2014，57，9： | 7 |
| 4 | Remineralization of enamel caries by an amelogenin-derived peptide and fluoride in vitro显示文摘Dental caries is one of the most common oral diseases in the world.This study was tantamount to investigate the combinatory effects of an amelogenin-derived peptide(called QP5)and fluoride on the remineralization of artificial enamel caries.The peptide QP5 was synthesized and characterized,and the binding capability of the peptide on hydroxyapatite(HA)and demineralized tooth enamel surface was analysed.Then,the mineralization function of the peptide and fluoride was studied through the spontaneous mineralization testing and remineralization on enamel caries in vitro.First,the novel peptide QP5 could bind on the hydroxyapatite and demineralized tooth enamel surfaces.Second,QP5 can transitorily stabilize the formation of amorphous calcium phosphate and direct the transformation into hydroxyapatite crystals alone and in combination with fluoride.In addition,compared to blocks treated by peptide QP5 alone or fluoride,the sample blocks showed significantly higher surface microhardness,lower mineral loss and shallower lesion depth after treatment with a combination of QP5 and fluoride at high or low concentrations.The peptide QP5 could control the crystallization of hydroxyapatite,and combinatory application of peptide QP5 and fluoride had a potential synergistic effect on the remineralization of enamel caries. | Longjiang Ding Sili Han Kun Wang Sainan Zheng Wenyue Zheng Xiu Peng Yumei Niu Wei Li Linglin Zhang | 2020 | Regenerative Biomaterials2020，7，3： | 6 |
| 5 | Design and syntheses of functionalized copper-based MOFs and its adsorption behavior for Pb(Ⅱ)显示文摘A novel copper-based MOFs adsorbent(Cu-BTC-Th) was prepared using an one-step method by introducing a new organic ligand of 4-thioureidobenzoicacid(Th) with active groups for selectively adsorbing Pb(Ⅱ) from aqueous solutions. The chemical composition and structure of the prepared MOFs materials were characterized by scanning electron microscope(SEM), X-ray diffraction(XRD), fourier transform infrared spectroscopy(FTIR), X-ray photoelectron spectroscopy(XPS), Brunner-Emmet-Teller(BET) analysis, and zeta potential measurements. The adsorption capability of the prepared Cu-MOFs was significantly enhanced by introducing the new organic ligand of Th in the materials. The maximum adsorption capacity of the Cu-BTC-Th for Pb(Ⅱ) attains 732.86 mg/g under the optimal conditions. In addition,the adsorption kinetics and adsorption isotherm analysis showed that the adsorption process followed the pseudo-second-order kinetic model and Langmuir adsorption model, indicating that the adsorption of Pb(Ⅱ) by Cu-BTC-Th was a monolayer chemisorption. The adsorption mechanism of Cu-BTC-Th for Pb(Ⅱ)was discussed and revealed. On one hand, the adsorption of Pb(Ⅱ) is mainly through ion exchange with the Cu(Ⅱ). On the other hand, the-NH2 and-C=S functional groups introduced in the Cu-BTC-Th materials have stronger coordination ability with the Pb(Ⅱ) ions to enhance the adsorption capability. | Jingping Zhong Jian Zhou Minsi Xiao Jun Liu Jili Shen Juan Liu Sili Ren | 2022 | Chinese Chemical Letters2022，33，2： | 3 |
| 6 | CLT OF WAVELET ESTIMATOR IN SEMIPARAMETRIC MODEL WITH CORRELATED ERRORS显示文摘这篇论文认为 semiparametric 回归模型 y i = x i 是 +g (t i )+V i (1 i n )(x i, t i ) 被知道设计点,是一个未知斜坡参数, g ( | Sili NIU Yamei LIU | 2012 | Journal of Systems Science & Complexity2012，25，3： | 3 |
| 7 | Endothelial METRNL determines circulating METRNL level and maintains endothelial function against atherosclerosis显示文摘METRNL is a recently identified secreted protein with emerging functions.This study is to find major cellular source of circulating METRNL and to determine METRNL novel function.Here,we show METRNL is abundant in human and mouse vascular endothelium and released by endothelial cells using endoplasmic reticulum-Golgi apparatus pathway.By creating endothelial cell-specific Metrnl knockout mice,combined with bone marrow transplantation to produce bone marrow-specific deletion of Metrnl,we demonstrate that most of circulating METRNL(approximately 75%)originates from the endothelial cells.Both endothelial and circulating METRNL decrease in atherosclerosis mice and patients.By generating endothelial cell-specific Metrnl knockout in apolipoprotein E-deficient mice,combined with bone marrow-specific deletion of Metrnl in apolipoprotein E-deficient mice,we further demonstrate that endothelial METRNL deficiency accelerates atherosclerosis.Mechanically,endothelial METRNL deficiency causes vascular endothelial dysfunction including vasodilation impairment via reducing eNOS phosphorylation at Ser1177 and inflammation activation via enhancing NFκB pathway,which promotes the susceptibility of atherosclerosis.Exogenous METRNL rescues METRNL deficiency induced endothelial dysfunction.These findings reveal that METRNL is a new endothelial substance not only determining the circulating METRNL level but also regulating endothelial function for vascular health and disease.METRNL is a therapeutic target against endothelial dysfunction and atherosclerosis. | Sili Zheng Zhiyong Li Jie Song Pin Wang Jian Xu Wenjun Hu Yi Shi Qi Qi Zhuwei Miao Yunfeng Guan Chaoyu Miao | 2023 | Acta Pharmaceutica Sinica B2023，13，4： | 2 |
| 8 | Methane Direct Conversion on Mo/ZSM-5 Catalysts Modified by Pd and Ru显示文摘到在甲烷的 dehydroaromatization 使用的 Mo/HZSM-5 催化剂的 Ru 和 Pd 的增加的效果被调查。催化测试和规划温度的氧化结果证明基于 Pd 的催化剂对萘更选择并且承受了强壮的释放。因为 Mo2C 表面的保护的机制, Ru 的存在可能改进了这项活动和稳定性,与在碳质沉积的减少。给词调音:甲烷;Pd;Ru;瞬间;ZSM-5; | Priscila Dias Sily Fabio Bellot Noronha Fabio Barboza Passos | 2006 | Journal of Natural Gas Chemistry2006，15，2： | 2 |
| 9 | An enhanced method for nucleic acid detection with CRISPR-Cas12a using phosphorothioate modified primers and optimized gold-nanopaticle strip显示文摘CRISPR-Cas12a system has been shown promising for nucleic acid diagnostics due to its rapid,portable and accurate features.However,cleavage of the amplicons and primers by the cis-and trans-activity of Cas12a hinders the attempts to integrate the amplification and detection into a single reaction.Through phosphorothioate modification of primers,we realized onepot detection with high sensitivity using plasmids of SARS-CoV-2,HPV16 and HPV18.We also identified the activated Cas12a has a much higher affinity to C nucleotide-rich reporter than others.By applying such reporters,the reaction time required for a lateral-flow readout was significantly reduced.Furthermore,to improve the specificity of the strip-based assay,we created a novel reporter and,when combined with a customized gold-nanopaticle strip,the readout was greatly enhanced owing to the elimination of the nonspecific signal.This established system,termed Targeting DNA by Cas12a-based Eye Sight Testing in an Onepot Reaction(TESTOR),was validated using clinical cervical scrape samples for human papillomaviruses(HPVs)detection.Our system represents a general approach to integrating the nucleic acid amplification and detection into a single reaction in CRISPR-Cas systems,highlighting its potential as a rapid,portable and accurate detection platform of nucleic acids. | Jiaojiao Gong Lijuan Kan Xiuming Zhang Ying He Jiaqiang Pan Liping Zhao Qianyun Li Menghao Liu Jie Tian Sili Lin Zhouyu Lu Liang Xue Chaojun Wang Guanghui Tang | 2021 | Bioactive Materials2021，6，12： | 1 |
| 10 | The effects of leptin receptor(LEPR)and melanocortin-4 receptor(MC4R)polymorphisms on fat content,fat distribution and fat composition in a Duroc×Landrace/Large White cross显示文摘 | Galve A Burgos C Silió L | 2012 | Livestock Science2012，145，3： | 1 |
| 11 | Large-scale expansion of dendritic cell-primed polyclonal human cytotoxic T-lymphocyte lines using lymphoblastoid cell lines for adoptive immunotherapy 显示文摘 | Huls MH Davis AR | 2003 | J Immunother2003，26，3： | 1 |
| 12 | Mean strain throughout the heart cycle by longitudinal two-dimensional speckle-tracking echocar- diograpby enables early prediction of infarct size 显示文摘 | Grenne B Eek C Sili B | 2011 | J Am Soc Echocardiogra2011，24，10： | 1 |
| 13 | Characterization of spatial plasma distribution in a divergence-type ECR-PECVD system显示文摘 | Chen Junfang Fu Silie | 2006 | Vacuum2006，81，1： | 1 |
| 14 | Exopolysaccharide-producing cyanobacteria and their possible exploitation:A review显示文摘 | De Philippis R Sili C Paperi R | 2001 | J Appl Phycol2001，13，： | 1 |
| 15 | Exopolysaeeharide- producing cyanobacteria and their possible exploitation: a review 显示文摘 | DE PHILIPPIS R SILI C PAPERI R | 2001 | Journal of Applied Phycology2001，13，： | 1 |
| 16 | A Nonlinear lnverse Scale Space Method for a Convex Multiplicative Noise Model 显示文摘 | SilI J ~1 OSiiER S | 2008 | SIAM Journal on Imaging Sciences2008，1，3： | 1 |
| 17 | Effects of water chemistry on microcracking and compressive strength of granite显示文摘 | FENG XIA TING CHEN SILI LI SHAO JUN | 2001 | International Journal of Rock Mechanics and Mining Sciences2001，38，4： | 1 |
| 18 | High prevalence of anti-cardiolipin and other autoantibodies in a healthy elderly population显示文摘 | Tzioufas AG Silis MP | 1987 | Clin Exp Immunol1987，69，： | 1 |
| 19 | Generating CTLs against the subdominant Epstein-Barr virus LMP1 antigen for the adoptive immunotherapy of EBV-assoeiated malignancies 显示文摘 | Gottschalk S Edwards OL Sili U | 2003 | Blood2003，101，5： | 1 |
| 20 | Exopolysaecharide-producing cyanobacteria and their possible exploitation: a review显示文摘 | De Philippis R Sili C Paperi R | 2001 | J Appl Phycol2001，13，： | 1 |
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