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| 1 | Nasogastric or nasointestinal feeding in severe acute pancreatitis显示文摘AIM:To assess the rate of spontaneous tube migration and to compare the effects of naso-gastric and nasointestinal(NI)(beyond the ligament of Treitz) feeding in severe acute pancreatitis(SAP).METHODS:After bedside intragastric insertion,tube position was assessed,and enteral nutrition(EN) started at day 4,irrespective of tube localization.Patients were monitored daily and clinical and laboratory parameters evaluated to compare the outcome of patients with nasogastric(NG) or NI tube.RESULTS:Spontaneous tube migration to a NI site occurred in 10/25(40%) prospectively enrolled SAP patients,while in 15(60%) nutrition was started with a NG tube.Groups were similar for demographics and pancreatitis aetiology but computed tomography(CT) severity index was higher in NG tube patients than in NI(mean 6.2 vs 4.7,P=0.04).The CT index seemed a risk factor for failed obtainment of spontaneous distal migration.EN trough NG or NI tube were similar in terms of tolerability,safety,clinical goals,complications and hospital stay.CONCLUSION:Spontaneous distal tube migration is successful in 40% of SAP patients,with higher CT severity index predicting intragastric retention;in such cases EN by NG tubes seems to provide a pragmatic alternative opportunity with similar outcomes. | Matteo Piciucchi Elettra Merola Massimo Marignani Mari-anna Signoretti Roberto Valente Lucia Cocomello Flavia Baccini Francesco Panzuto Gabriele Capurso Gianfranco Delle Fave | 2010 | World Journal of Gastroenterology2010，16，29： | 13 |
| 2 | Endoscopy-guided ablation of pancreatic lesions:Technical possibilities and clinical outlook显示文摘Endoscopic ultrasound(EUS) and endoscopic retrograde cholangiopancreatography(ERCP)-guided ablation procedures are emerging as a minimally invasive therapeutic alternative to radiological and surgical treatments for locally advanced pancreatic cancer(LAPC), pancreatic neuroendocrine tumours(PNETs), and pancreatic cystic lesions(PCLs). The advantages of treatment under endoscopic control are the real-time imaging guidance and the possibility to reach a deep target like the pancreas. Currently, radiofrequency probes specifically designed for ERCP or EUS ablation are available as wel as hybrid cryotherm probe combining radiofrequency with cryotechnology. To date, many reports and case series have confirmed the safety and feasibility of that kind of ablation technique in the pancreatic setting.Moreover, EUS-guided fine-needle injection is emerging as a method to deliver ablative and anti-tumoral agents inside the tumuor. Ethanol injection has been proposed mostly for the treatment of PCLs and for symptomatic functioning PNETs, and the use of gemcitabine and paclitaxel is also interesting in this setting. EUS-guided injection of chemical or biological agents including mixed lymphocyte culture, oncolytic viruses, and immature dendritic cells has been investigated for the treatment of LAPC. Data on the long-term efficacy of these approaches,and large prospective randomized studies are needed to confirm the real clinical benefits of these techniques for the management of pancreatic lesions. | Marianna Signoretti Roberto Valente Alessandro Repici Gianfranco Delle Fave Gabriele Capurso Silvia Carrara | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，2： | 5 |
| 3 | Methods and outcomes of screening for pancreatic adenocarcinoma in high-risk individuals显示文摘Pancreatic ductal adenocarcinoma(PDAC) is a lethal neoplasia, for which secondary prevention(i.e., screening) is advisable for high-risk individuals with 'familiar pancreatic cancer' and with other specific genetic syndromes(Peutz-Jeghers, p16, BRCA2, PALB and mismatch repair gene mutation carriers). There is limited evidence regarding the accuracy of screening tests, their acceptability, costs and availability, and agreement on whom to treat. Successful target of screening are small resectable PDAC, intraductal papillary mucinous neoplasms with high-grade dysplasia and advanced pancreatic intraepithelial neoplasia. Both magnetic resonance imaging(MRI) and endoscopic ultrasound(EUS) are employed for screening, and the overall yield for pre-malignant or malignant pancreatic lesions is of about 20% with EUS and 14% with MRI/magnetic resonance colangiopancreatography. EUS performs better for solid and MRI for cystic lesions. However, only 2% of these detected lesions can be considered a successful target, and there are insufficient data demonstrating that resection of benign or low grade lesions improves survival. Many patients in the published studies therefore seemed to have received an overtreatment by undergoing surgery. It is crucial to better stratify the risk of malignancy individually, and to better define optimal screening intervals and methods either with computerized tools or molecular biomarkers, possibly in large multicentre studies. At the moment, screening should be carefully performed within research protocols at experienced centres, offering involved individuals medical and psychological advice. | Gabriele Capurso Marianna Signoretti Roberto Valente Urban Arnelo Matthias Lohr Jan-Werner Poley Gianfranco Delle Fave Marco Del Chiaro | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，9： | 2 |
| 4 | Oncogenic role of the ubiquitin ligase subunit Skp2in human breast cancer显示文摘 | Signoretti S Di Marcotullio L Richardson A | 2002 | J Clin Invest2002，110，5： | 1 |
| 5 | LDH-A inhibition,a therapeutic strategy for treatment of hereditary leiomyomatosis and renal cel cancer显示文摘 | Xie H Valera VA Merino MJ Amato AM Signoretti S Linehan WM | 2009 | Mol Cancer Ther2009，8，3： | 1 |
| 6 | p63 is a prostatebasal cell marker and is requieed for rostate development 显示文摘 | Signoretti S Waltregny D Dilks J | 2000 | Am J Pathol2000，157，6： | 1 |
| 7 | p63 is a prostate basal cell marker and is required for prostate development显示文摘 | Signoretti S Waltregny D Dilks J | 2000 | Am J Pathol2000，157，： | 1 |
| 8 | Her - 2 - neu expression and progression toward androgen independence in human prostate cancer显示文摘 | Signoretti S Monfironi R Manola J | 2000 | J Nail Cancer Inst2000，92，23： | 1 |
| 9 | Predominance of cellular edema in traumatic brain swelling in patients with severe head injuries显示文摘 | Mrmarou A Signoretti S Fatouros PP | | 0，，05： | 1 |
| 10 | Detection of clonal T-cell receptor gamma gene rearrangements in paraffin-embedded tissue by polymerase chain reaction and nonradioactive single-strand conformational polymorphism analysis显示文摘 | SIGNORETTI S MURPHY M CANGI M G | 1999 | Am J Pathol1999，154，1： | 1 |
| 11 | The Impact of the Sovereign Debt Crisis on the Activity of Italian Banks 显示文摘 | Ugo Albertazzi Tiziano Ropele Gabriele Sene Federico Maria Signoretti | 2014 | Journal of Banking & Finance2014，46，： | 1 |
| 12 | BCR/ABL regulates expression of the cyclin-dependent kinase inhibitor p27Kip1 through the phosphatidylinositol 3-Kinase/AKT pathway 显示文摘 | Gesbert F Sellers W R Signoretti S | 2000 | J Biol Chem2000，275，39： | 1 |
| 13 | Combination of radiofrequency ablation with antiangiogenic therapy for tumor ablation efficacy: study in mice显示文摘 | Hakime A Hines-Peralta A Peddi H Atkins M B Sukhatme V P Signoretti S | 2007 | Radiology2007，244，： | 1 |
| 14 | Transition from in situ to invasire testicular germ cell neoplasia is associated with loss of p21 and gain of mdm-2 expression显示文摘 | Datta M Macri E Signoretti S | 2001 | Mod Pathol2001，14，5： | 1 |
| 15 | BCR/ABL regulates expression of the cyclin - dependent kinase inhibitor p27Kipl through the phosphatidylinositol 3 - Kinase/AKT pathway显示文摘 | Gesbert F Sellers WR Signoretti S | 2000 | J - Biol - Chem2000，275，39： | 1 |
| 16 | Persistent extraradicular infection in root-filled asymptomatic human tooth : scanning electron microscopic analysis and microbial investigation after apical micro- surgery显示文摘 | Signoretti FG Endo MS Gomes BP | 2011 | J Endod2011，37，12： | 1 |
| 17 | p63 is a prostate basal cell marker and is required for prostate development 显示文摘 | Signoretti S Waltregny D Dilks J | 2000 | Am J Pathol2000，157，6： | 1 |
| 18 | BCR/ABL regulates expression of the cyclin-dependent kinase inhibitor p27kipl through the phosphatidylinositol 3-kinase/AKT pathway 显示文摘 | Gesbert F sellers WR Signoretti S | 2000 | J Biol Chem2000，275，39： | 1 |
| 19 | Does the addition of a second antipsychotic drug improve clozap- ine treatment 显示文摘 | Corrado Barbui Alessandra Signoretti Serena Mule | 2009 | Schizophrenia Bulletin2009，35，： | 1 |
| 20 | The isopeptidase USP2a regulates the stability of fatty acid synthase in prostate cancer显示文摘 | Edgard Graner Dan Tang Sabrina Rossi Antonella Baron Toshiro Migita Lisa J Weinstein Mirna Lechpammer Dieter Huesken Johann Zimmermann Sabina Signoretti Massimo Loda | 2004 | Cancer Cell2004，，3： | 1 |
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