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| 1 | 世界生物精神病学会联合会(WFSBP)关于焦虑障碍、强迫症和创伤后应激障碍的药物治疗指南显示文摘这篇文章根据现有的随机、安慰剂或参照药物对照临床研究 ,向大家推荐焦虑障碍、强迫症的药物治疗。 5-HT再摄取抑制剂 (SSRI)是治疗惊恐障碍的一线药物。三环类抗抑郁药 (TCA)与SSRI疗效相当 ,但耐受性差。难治性患者 ,如没有药物依赖和耐受史 ,则可使用苯二氮 艹卓 类药物如阿普唑仑。由于单胺氧化酶抑制剂 (MAOI)苯乙肼会产生严重的不良反应 ,且会与其他药物和食物成分相互作用 ,因此只有当一线药物无效时才使用。广泛性焦虑者可用万拉法新和SSRI,也可选用丁螺环酮和丙咪嗪。SSRI可作为社交恐怖症的一线药物 ,MAOI、吗氯贝胺和苯二氮 艹卓 类药物作为二线药物。强迫症最好用SSRI或氯丙咪嗪治疗。 | Borwin Bandelow Josef Zohar Eric Hollander Siegfried Kasper Hans-J¨urgen M¨oller WFSBP Task 项志清 何燕玲 | 2003 | 中国心理卫生杂志2003，17，7： | 30 |
| 2 | Plants as concept generators for biomimetic light-weight structures with variable stiffness and self-repair mechanisms显示文摘Plants possess many structural and functional properties that have a high potential to serve as concept generators for the production of biomimetic technical materials and structures. We present data on two features of plants (variable stiffness due to pressure changes in cellular structures and rapid self-repair functions) that may be used as models for biomimetic projects. | Thomas Speck Tom Masselter Bettina Prüm Olga Speck Rolf Luchsinger Siegfried Fink | 2004 | Journal of Bionic Engineering2004，1，4： | 10 |
| 3 | Parvovirus B19 induced hepatic failure in an adult requiring liver transplantation显示文摘Parvovirus B19 induced acute hepatitis and hepatic failure have been previously reported, mainly in children. Very few cases of parvovirus induced hepatic failure have been reported in adults and fewer still have required liver transplantation. We report the case of a 55-year-old immunocompetent woman who developed fulminant hepatic failure after acute infection with Parvovirus B19 who subsequently underwent orthotopic liver transplantation. This is believed to be the first reported case in the literature in which an adult patient with fulminant hepatic failure associated with acute parvovirus B19 infection and without hematologic abnormalities has been identified prior to undergoing liver transplantation. This case suggests that Parvovirus B19 induced liver disease can affect adults, can occur in the absence of hematologic abnormalities and can be severe enough to require liver transplantation. | Darin S Krygier Urs P Steinbrecher Martin Petric Siegfried R Erb Stephen W Chung Charles H Scudamore Andrzej K Buczkowski Eric M Yoshida | 2009 | World Journal of Gastroenterology2009，15，32： | 3 |
| 4 | 系统性药物治疗儿童银屑病的安全性显示文摘银屑病是一种常见的慢性炎症性皮肤病。成年人的发病率为2%~3%,其中大约有三分之一的患者在18岁之前发病。在儿童期,该病的发病率呈线性增长。从1970年至2000年,儿童银屑病的发病率增加了一倍多。尽管对许多轻度银屑病患儿而言,局部治疗已足够,但对更多可能影响生活质量的重度或顽固性的银屑病患儿,则往往需要系统性治疗。 | bronckers imgj seyger mmb west dp lara-corrales i tollefson m tom wl hogeling m belazarian l zachariae c mahé e siegfried e philipp s szalai z vleugels ra holland k murphy r baselga e cordoro k lambert j alexopoulos a mrowietz u kievit w paller as 邓婕(编译) 张锡宝(审校) 无 | 2017 | 皮肤性病诊疗学杂志2017，24，5： | 3 |
| 5 | Anti-EDRF effect of tumor necrosis factor in isolated perfused cat carotid arteries显示文摘 | Aoky N Siegfried M Lefer AM | 1989 | Am J Physiol1989，256，： | 1 |
| 6 | Monarch larvae sensitivity to Bacillus thuringiensis purified proteins and pollen 显示文摘 | Hellmich R L Siegfried B D Sears M K | 2001 | ProcNatlAcadSci USA2001，98，1： | 1 |
| 7 | Comparison of mutations in the p53 and K-ras genes in lung carcinomas from smoking and nonsmoking women 显示文摘 | Gealy R Zhang L Siegfried J M | 1999 | Cancer Epidemiol Bimnarkers Prev1999，8，41： | 1 |
| 8 | A conceptual model of arid rangeland degradation 显示文摘 | Dean W R J du Plessis M A Siegfried W R | 1994 | Bioscience1994，44，： | 1 |
| 9 | Opposing function of the proprotein convertases furin and PACEA on breast cancer cells malignant phenotypes: role of tissue inhibitors of metalloprotein- ase-1 显示文摘 | Lapierre M Siegfried G Scamuffa N | 2007 | Cancer Res2007，67，19： | 1 |
| 10 | Regulation of endogenous gene expression in human non-small cell lung cancer cells by estrogen receptor ligands 显示文摘 | Hershberger PA Vasquez AC Siegfried M | 2005 | Cancer Res2005，65，4： | 1 |
| 11 | A flexible synthesis of azasugars and homoazasugars via olefin metathesis 显示文摘 | Christoph M H Siegfried B | 1997 | Synthesis1997，，1： | 1 |
| 12 | Biomarkers for hepatocellular cancer显示文摘Hepatocellular carcinoma(HCC)is the third leading cause of cancer-related deaths worldwide.If diagnosed early,curative treatment options such as surgical resection,loco-regional therapies,and liver transplantation are available to patients,increasing their chances of survival and improving their quality of life.Unfortunately,most patients are diagnosed with late stage HCC where only palliative treatment is available.Therefore,biomarkers which could detect HCC early with a high degree of sensitivity and specificity,may play a crucial role in the diagnosis and management of the disease.This review will aim to provide an overview of the different biomarkers of HCC comprising those used in the diagnosis of HCC in at risk populations,as well as others with potential for prognosis,risk predisposition and prediction of response to therapeutic intervention. | Gurjot Singh Eric M Yoshida Sahaj Rathi Vladimir Marquez Peter Kim Siegfried R Erb Baljinder S Salh | 2020 | World Journal of Hepatology2020，12，9： | 1 |
| 13 | Redulation of the vascular ext racellular superoxide dismutase by metric oxide and exercise training显示文摘 | Fukai T Siegfried MR Ushio-Fukai M | 2000 | J Cli n Invest2000，105，： | 1 |
| 14 | Temporal relationshipof conduction system disease and ventricular dysfunction in LMNAcardiomyopathy显示文摘 | Brodt C Siegfried JD Hofmeyer M | 2013 | J Card Fail2013，19，： | 1 |
| 15 | Regulation of endogenous gene expression in human non-small cell lung cancer cells by estrogen receptor ligands显示文摘 | Hershberger PA Vasquez AC Kanterewicz B Land S Siegfried JM Nichols M | 2005 | Cancer Res2005，65，4： | 1 |
| 16 | Studies of the retrogradation process for various starch gels using Ra- man spectroscopy显示文摘 | Fechner P M Siegfried W Peter K | 2005 | Carbohydrate Research2005，340，： | 1 |
| 17 | Women and lung cancer:does oestrogen play a role?显示文摘 | Siegfried J M | 2001 | Lancet Oncol2001，2，8： | 1 |
| 18 | Immune parameters in multiple myeloma patients: influence of treatment and correlation with opportunistic infections显示文摘 | Philipp Schütt Dieter Brandhorst Werner Stellberg Miriam Poser Peter Ebeling Siemke Müller Ulrike Buttkereit Bertram Opalka Monika Lindemann Hans Grosse-Wilde Siegfried Seeber Thomas Moritz Mohammad R. Nowrousian | 2006 | Leukemia & Lymphoma2006，，8： | 1 |
| 19 | Elucidation of an overpotential- limited branching phenomenon observed during the electrocrystallization of cuprous oxide 显示文摘 | Siegfried M J Choi K S | 2008 | Angewandte Chemie2008，120，2： | 1 |
| 20 | Directing the architecture of cuprous oxide crystals during electrochemical growth显示文摘 | Siegfried M J Choi K S | 2005 | Angew Chem Int Ed2005，44，： | 1 |
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