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| 1 | Systematic review: Safety of balloon assisted enteroscopy in Crohn's disease显示文摘AIM To determine the overall and comparative risk of procedure related perforation of balloon assisted enteroscopy(BAE) in Crohn's disease(CD). METHODS Systematic review(PROSPERO #CRD42015016381) of studies reporting on CD patients undergoing BAE. Seventy-three studies reporting on 1812 patients undergoing 2340 BAEs were included. Primary outcome of interest was the overall and comparative risk of procedure related perforation of diagnostic BAE in CD. Secondary outcomes of interest were risk of procedure related perforation of diagnostic double balloon enteroscopy(DBE), risk of procedure related perforation of therapeutic BAE, efficacy of stricture dilation, and clinical utility of endoscopically assessing small bowel disease activity.RESULTS Per procedure perforation rate of diagnostic BAE in CD was 0.15%(95%CI: 0.05-0.45), which was similar to diagnostic BAE for all indications(0.11%; IRR = 1.41, 95%CI: 0.28-4.50). Per procedure perforation rate of diagnostic DBE in CD was 0.12%(95%CI: 0.03-0.44), which was similar to diagnostic DBE for all indications(0.22%; IRR = 0.54, 95%CI: 0.06-0.24). Per procedure perforation rate of therapeutic BAE in CD was 1.74%(95%CI: 0.85-3.55). Eighty-six percentof therapeutic perforations were secondary to stricture dilation. Dilation was attempted in 207 patients and 30% required surgery during median follow-up of 18 months. When diagnostic BAE assessed small bowel disease activity, changes in medical therapy resulted in endoscopic improvement in 77% of patients. CONCLUSION Diagnostic BAE in CD has a similar rate of perforation as diagnostic BAE for all indications and can be safely performed in assessment of mucosal healing. | Ahilan Arulanandan Parambir S Dulai Siddharth Singh William J Sandborn Denise Kalmaz | 2016 | World Journal of Gastroenterology2016，22，40： | 2 |
| 2 | The cellular protein p58IPK regulates influenza virus mRNA translation and replication through a PKR-mediated mechanism显示文摘 | Goodman A G Jennifer A S Siddharth B | 2007 | J Virol2007，81，： | 1 |
| 3 | Some Characteristics of Emerging Distribution Systems Considering the Smart Grid Initiative显示文摘 | Hilary E B Siddharth S Gerald T | | 0，，05： | 1 |
| 4 | CO2 sequestration by enzyme immobilized onto bioinspired silica显示文摘 | Forsyth C Yip T W S Siddharth V | 2013 | Chemical Communications2013，49，： | 1 |
| 5 | A game- theoretic approach for calibration of low-cost magneto- meter under uncertainty显示文摘 | Siddharth S Ali A S E1-Sheimy N | 2012 | Measurement Science and Technology2012，23，2： | 1 |
| 6 | Structural characterization of coke on spent hydroprocessing catalysts used for processing of vacuum gas oils 显示文摘 | SANGRAMA K SAHO0 SIDDHARTH S RAY I D SINGH | 2004 | Applied Catalysis A: General2004，278，2： | 1 |
| 7 | Synthesis and bi- ological evaluation of andrographolide analogues as anti-cancer agents显示文摘 | Preet R Chakraborty B Siddharth S etal | 2014 | Eur J Med Chem2014，85，： | 1 |
| 8 | Multidisciplinary perspective of hepatocellular carcinoma: A Pacific Northwest experience显示文摘Hepatocellular carcinoma(HCC) is the most rapidly increasing type of cancer in the United States. HCC is a highly malignant cancer, accounting for at least 14000 deaths in the United States annually, and it ranks third as a cause of cancer mortality in men. One major difficulty is that most patients with HCC are diagnosed when the disease is already at an advanced stage, and the cancer cannot be surgically removed. Furthermore, because almost all patients have cirrhosis, neither chemotherapy nor major resections are well tolerated. Clearly there is need of a multidisciplinary approach for the management of HCC. For example, there is a need for better understanding of the fundamental etiologic mechanisms that are involved in hepatocarcinogenesis, which could lead to the development of successful preventive and therapeutic modalities. It is also essential to define the cellular and molecular bases for malignant transformation of hepatocytes. Such knowledge would:(1) greatly facilitate the identification of patients at risk;(2) prompt efforts to decrease risk factors; and(3) improve surveillance and early diagnosis through diagnostic imaging modalities. Possible benefits extend also to the clinical management of this disease. Because there are many factors involved in pathogenesis of HCC,this paper reviews a multidisciplinary perspective of recent advances in basic and clinical understanding of HCC that include: molecular hepatocarcinogenesis, noninvasive diagnostics modalities, diagnostic pathology, surgical modality, transplantation, local therapy and oncological/target therapeutics. | Matthew M Yeh Raymond S Yeung Smith Apisarnthanarax Renuka Bhattacharya Carlos Cuevas William P Harris Tony Lim Kiat Hon Siddharth A Padia James O Park Kevin M Riggle Sayed S Daoud | 2015 | World Journal of Hepatology2015，7，11： | 1 |
| 9 | N-polar GaN epitaxy and high electron mobility transistors显示文摘 | Man Hoi Wong Stacia Keller Nidhi Sansaptak Dasgupta Daniel J Denninghoff Seshadri Kolluri David F Brown Jing Lu Nicholas A Fichtenbaum Elaheh Ahmadi Uttam Singisetti Alessandro Chini Siddharth Rajan Steven P DenBaars James S Speck Umesh K Mishra | 2013 | Semiconductor Science and Technology2013，，7： | 1 |
| 10 | When do creditor rights work? 显示文摘 | M Sat-avian and Siddharth S | 2007 | Joumal of Comparative Economics2007，35，3： | 1 |
| 11 | Induction of apoptosis by 4-(3-(tert-butylamino) imidazopyridine-2-yl)benzoic acid in breast Cancer cells via upregulation of PTEN显示文摘 | Siddharth S Mohapatra P Preet R | 2013 | Oncol Res2013，21，1： | 1 |
| 12 | Evaluation of antiba-cterial activity of Mangifera indica on anaerobic dental microglora based on in vivo studies显示文摘 | Bairy I Reeja S Siddharth | 2002 | Indian J Pathol Microbiol2002，45，3： | 1 |
| 13 | Evaluation of antibacterial activity of Mangifera indica on anaerobic dental microglora based on in vivo studies 显示文摘 | Bairy I Reeja S Siddharth | 2002 | Indian J Pathol Microbiol2002，45，3： | 1 |
| 14 | The effects of postinjection massage on the sensitivity of lymphatic mapping in breast cancer显示文摘 | Siddharth S Bass MD Charles E Cox | 2001 | J Am Coll Surg2001，192，： | 1 |
| 15 | Stem cells-A window to periodontal regeneration显示文摘 | Siddharth M Varshney S Singla A | | 0，，02： | 1 |
| 16 | CO2sequestration by enzyme immobilized onto bioinspired silica显示文摘 | Forsyth C Yip T W S Siddharth V | 2013 | Chemical Communications2013，49，31： | 1 |
| 17 | Structureal changes of FCC catalyst from fresh to regeneration stages and associated coke in a FCC refining unit: A multinuclear solid state NMR approach显示文摘 | Babita Behera Siddharth S R | 2009 | Catalysis Today2009，141，1： | 1 |
| 18 | Impact of all oral anti-hepatitis C virus therapy:A metaanalysis显示文摘AIM:To investigate the efficacy,safety,and cost of treatment of direct acting antivirals(DAAs) with and without peg interferon alfa2a(P),and/or ribavirin(R) in treating hepatitis C virus(HCV) genotype 1 patients.METHODS:MEDLINE was searched for randomized controlled trials(RCT) using DAAs for HCV treatment.Phase 1 trials and studies with investigational drugs on genotype 2 or 3,and on human immunodeficiency virus patients were excluded.Data were pooled for sustained virologic response(SVR),serious adverse effects,and drug discontinuation rate on various treatment arms in trials:P + R;1st generation DAA(telaprevir or boceprevir) + P + R;2nd generation DAA(sofosbuvir or simeprevir) + P + R;2nd generation DAA + R;two 2nd generation DAA + R;and two 2nd gen DAA.Data were analyzed separately for each arm for treatment naive and non-responders(NR) to previous treatment.The cost of treatment with each regimen for achieving one SVR was also compared.RESULTS:Twenty three RCTs(n = 9354,62% male,11% cirrhosis) were analyzed.All oral(P free) regimens with combination of 2 DAA achieved SVR above 95%.The cost of treatment to achieve an SVR with DAA based regimens was lower for NR compared to P+R regimen.However,the cost per SVR remained higher for treatment naive patients.CONCLUSION:Second generation and emerging DAAs are promising agents in HCV treatment,with a very high level of safety and efficacy.An important drawback is their high cost.However,the present meta-analysis shows that the cost per SVR for non responders(but not for naive patients) was lower compared to P + R.This finding together with the superior safety profile and better compliance makes these drugs highly attractive.It is possible that further reduction in treatment duration may make them even more cost effective. | Siddharth Bansal Ashwani K Singal Brendan M Mc Guire Bhupinder S Anand | 2015 | World Journal of Hepatology2015，7，5： | 1 |
| 19 | Evaluation of antibacterial activity of mangifera indica on anaerobic dental microglora based on in vivo studies显示文摘 | Dairy I Reeja S Siddharth | 2002 | Indian J Pathol Microbiol2002，45，3： | 1 |
| 20 | Retain- ing Brand Loyalty显示文摘 | Anita Agrawal Siddharth S | 2010 | Copper Bridge Media2010，，： | 1 |
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