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| 1 | Complete mesocolic excision and central vascular ligation in colorectal cancer in the era of minimally invasive surgery显示文摘Since the 19th century,appropriate lymphadenectomy has been considered a cornerstone of oncologic surgery and one of the most important prognostic factors.This approach can be applied to any surgery for gastrointestinal cancer.During surgery for colon and rectal cancer,an adequate portion of the mesentery is removed together with the segment of bowel affected by the disease.The adequate number of lymph nodes to be removed is standardized and reported by several guidelines.It is mandatory to determine the appropriate extent of lymphadenectomy and to balance its oncological benefits with the increased morbidity associated with its execution in cancer patients.Our review focuses on the concept of“complete mesenteric excision(CME)with central vascular ligation(CVL),”a radical lymphadenectomy for colorectal cancer that has gained increasing interest in recent years.The aim of this study was to evaluate the evolution of this approach over the years,its potential oncologic benefits and potential risks,and the improvements offered by laparoscopic techniques.Theoretical advantages of CME are improved local-relapse rates due to complete removal of the intact mesocolic fascia and improved distance recurrence rates due to ligation of vessels at their origin(CVL)which guarantees removal of a larger number of lymph nodes.The development and worldwide diffusion of laparoscopic techniques minimized postoperative trauma in oncologic surgery,providing the same oncologic results as open surgery.This has been widely applied to colorectal cancer surgery;however,CME entails a technical complexity that can limit its wide minimally-invasive application. This review analyzesresults of these procedures in terms of oncological outcomes, technical feasibilityand complexity, especially within the context of minimally invasive surgery. | Marzia Franceschilli Sara Di Carlo Danilo Vinci Bruno Sensi Leandro Siragusa Vittoria Bellato Roberto Caronna Piero Rossi Giuseppe Cavallaro Andrea Guida Simone Sibio | 2021 | World Journal of Clinical Cases2021，9，25： | 2 |
| 2 | Triiodothyronine and breast cancer显示文摘The thyroid hormones(THs), triiodothyronine(T3) and thyroxine(T4), are essential for survival; they are involved in the processes of development, growth, and metabolism. In addition to hyperthyroidism or hypothyroidism, THs are involved in other diseases. The role of THs in the development and differentiation of mammary epithelium is well established; however, their specific role in the pathogenesis of breast cancer(BC) is controversial. Steroid hormones affect many human cancers and the abnormal responsiveness of the mammary epithelial cells to estradiol(E2) in particular is known to be an important cause for the development and progression of BC. The proliferative effect of T3 has been demonstrated in various types of cancer. In BC cell lines, T3 may foster the conditions for tumor proliferation and increase the effect of cell proliferation by E2; thus, T3 may play a role in the developmentand progression of BC. Studies show that T3 has effects similar to E2 in BC cell lines. Despite controversy regarding the relationship between thyroid disturbances and the incidence of BC, studies show that thyroid status may influence the development of tumor, proliferation and metastasis. | Maria Teresa De Sibio Miriane de Oliveira Fernanda Cristina Fontes Moretto Regiane Marques Castro Olimpio Sandro José Conde Aline Carbonera Luvizon Célia Regina Nogueira | 2014 | World Journal of Clinical Oncology2014，5，3： | 2 |
| 3 | Prevention of Peritoneal Metastases from Colon Cancer in High-Risk Patients: Preliminary Results of Surgery plus Prophylactic HIPEC显示文摘 | Paolo Sammartino Simone Sibio Daniele Biacchi Maurizio Cardi Fabio Accarpio Pietro Mingazzini Maria Sofia Rosati Tommaso Cornali Angelo Di Giorgio Paul H. Sugarbaker | 2012 | Gastroenterology Research and Practice2012，，： | 2 |
| 4 | Detection methods and clinical significance of free peritoneal tumor cells found during colorectal cancer surgery显示文摘Peritoneal washing is now part of the standard clinical practice in several abdominal and pelvic neoplasias. However, in colorectal cancer surgery, intra-peritoneal free cancer cells(IFCC) presence is not routinely investigated and their prognostic meaning is still unclear. When peritoneal washing results are positive for the presence of IFCC a worse outcome is usually expected in these colorectal cancer operated patients, but it what is not clear is whether it is associated with an increased risk of local recurrence. It is authors' belief that one of the main reasons why IFCC are not researched as integral part of the routine staging system for colon cancer is that there still isn't a diagnostic or detection method with enough sensibility and specificity. However, the potential clinical implications of a routine research for the presence IFCC in colon neoplasias are enormous: not only to obtain a more accurate clinical staging but also to offer different therapy protocols, based on the presence of IFCC. Based on this, adjuvant chemotherapy could be offered to those patients found to be positive for IFCC; also, protocols of proactive intraperitoneal chemotherapy could be applied. Although presence of IFCC appears to have a valid prognostic significance, further studies are needed to standardize detection and examination procedures, to determine if there are and which are the stages more likely to benefit from routine search for IFCC. | Simone Sibio Cristina Fiorani Carmine Stolfi Andrea Divizia Roberto Pezzuto Fabrizio Montagnese Giulia Bagaglini Paolo Sammartino Giuseppe Sigismondo Sica | 2015 | World Journal of Gastrointestinal Surgery2015，7，9： | 1 |
| 5 | Abdominal rectopexy for complete rectal prolapse:preliminary results of a new technique显示文摘 | Di Giorgio A Biacchi D Sibio S | 2005 | Int J Colorectal Dis2005，20，2： | 1 |
| 6 | Axillary lymph node metastasis as first presentation of peritoneal carcinomatosis from serous papillary ovarian cancer: case report and review of the literature显示文摘 | Sibio S Sammartino P Accarpio F | 2014 | Eur J Gynaecol Oncol2014，35，2： | 1 |
| 7 | Image quality and radi- ation dose of single heartbeat 640-slice coronary CT angiography : A comparison between patients with chronic Atrial Fibrillation and sub- jects in normal sinus rhythm by propensity analysis显示文摘 | Di Cesare E Gennarelli A Di Sibio A | 2015 | Eur J Radi- ol2015，84，： | 1 |
| 8 | Image quality and radiation dose of single heartbeat 640-slice coronary CT angiography: A comparison between patients with chronic Atrial Fibrillation and subjects in normal sinus rhythm by propensity analysis 显示文摘 | Di Cesare E Gennarelli A Di Sibio A | 2015 | Eur J Radiol2015，84，4： | 1 |
| 9 | Current highlights on solid pseudopapillary neoplasm of the pancreas显示文摘Solid pseudopapillary neoplasm of the pancreas is a low-grade malignant tumor that predominantly affects young women in their third and fourth decade.Etiology and risk factors are unknown.Clinical symptoms are aspecific and most commonly due to mass effect.Diagnosis is made by computed tomography scan or magnetic resonance imaging and histological characterization is obtained by endoscopic ultrasound-guided fine needle biopsy.Microscopically,these lesions are composed by both solid and pseudopapillary structures with necrotic and hemorrhagic areas.Occasionally,the biological behavior is aggressive with tumor recurrence and distant metastasis.Usually,curative R0 surgical resection is the best option able to provide long term survival even in advanced disease.Unresectable disease is the main predictor of poor prognosis.Chemotherapy and radiotherapy regimens are not well standardized.However,they could be effective in reducing tumor size as neoadjuvant treatment or disease control in palliative setting.Although complete surgical resection provides a cure rate of>95%,considering young age of the patients and morbidity associated to pancreatic surgery,further studies are needed to better investigate risk factors and responsiveness to hormones in order to allow early diagnosis and follow up strategies that could avoid unnecessary surgery in less aggressive disease. | Simone Sibio Sara Di Carlo | 2022 | World Journal of Hepatology2022，14，1： | 1 |
| 10 | Notch receptor activation in- hibits oligodendrocyte differentiation 显示文摘 | Wang S Sdrulla AD Sibio G | 1998 | Neuron1998，21，1： | 1 |
| 11 | Image quality and radiation dose of single heartbeat 640-slice coro- nary CT angiography: A comparison between patients with chronic Atrial Fibrillation and subjects in normal sinus rhythm by propensity analysis 显示文摘 | Emesto Di Cesare Antonio Gennarelli Alessandra Di Sibio | 2015 | European Journal of Radiology2015，84，： | 1 |
| 12 | Notch receptor activation inhibits oligodendrocyte differentiation 显示文摘 | Wang S Sdrulla AD di Sibio G | 1998 | Neuron1998，21，1： | 1 |
| 13 | Long-term results after proactive management for locoregional control in patients with colonic cancer at high risk of peritoneal metastases显示文摘 | P. Sammartino S. Sibio D. Biacchi M. Cardi P. Mingazzini M. S. Rosati T. Cornali B. Sollazzo J. Maherfouad Atta A. Giorgio | 2014 | International Journal of Colorectal Disease2014，，9： | 1 |
| 14 | Benefits of minimally invasive surgery in the treatment of gastric cancer显示文摘We read with great interest the article that retrospectively analyzed 814 patients with primary gastric cancer,who underwent minimally invasive R0 gastrectomy between 2009 and 2014 by grouping them in laparoscopic vs robotic procedures.The results of the study highlighted that age,American Society of Anesthesiologists status,gastrectomy type and pathological T and N status were the main prognostic factors of minimally invasive gastrectomy and showed how the robotic approach may improve long-term outcomes of advanced gastric cancer.According to most of the current literature,robotic surgery is associated with a statistically longer operating time when compared to open and laparoscopic surgery;however,looking at the adequacy of resection,defined by negative surgical margins and number of lymph nodes removed,it seems that robotic surgery gives better results in terms of the 5-year overall survival and recurrencefree survival.The robotic approach to gastric cancer surgery aims to overcome the difficulties and technical limitations of laparoscopy in major surgery.The threedimensional vision,articulation of the instruments and good ergonomics for the surgeon allow for accurate and precise movements which facilitate the complex steps of surgery such as lymph node dissection,esophagus-jejunal anastomosis packaging and reproducing the technical accuracy of open surgery.If the literature,as well as the analyzed study,offers us countless data regarding the short-term oncological results of robotic surgery in the treatment of gastric cancer,satisfactory data on long-term follow-up are lacking,so future studies are necessary. | Simone Sibio Francesca La Rovere Sara Di Carlo | 2022 | World Journal of Gastroenterology2022，28，30： | 0 |
| 15 | Final results of the first phase of the PROTO-SPHERA experiment: obtainment of the full current stable screw pinch and first evidences of the jet + torus combined plasma configuration显示文摘In astrophysics, the boundary conditions for plasma phenomena are provided by nature and the astronomer faces the problem of understanding them from a variety of observations [Hester J J et al 1996 Astrophys. J. 456 225], on the other hand, in laboratory plasma experiments the electromagnetic boundary conditions become a major problem in the set-up of the machine that produces the plasma, an issue that has to be investigated step by step and to be modified and adapted with great patience, in particular in the case of an innovative plasma confinement experiment. The PROTO-SPHERA machine [Alladio F et al 2006 Nucl. Fusion 46 S613] is a magnetic confinement experiment, that emulates in the laboratory the jet + torus plasma configurations often observed in astrophysics: an inner magnetized jet of plasma centered on the(approximate) axis of symmetry and surrounded by a magnetized plasma torus orthogonal to this jet. The PROTO-SPHERA plasma is simply connected, i.e., no metal current conducting rod is linked to the plasma torus, while instead it is the inner magnetized plasma jet(in the following always called the plasma centerpost) that is linked to the torus. It is mandatory that no spurious plasma current path modifies the optimal shape of the plasma centerpost. Moreover, as the plasma torus is produced and sustained, in absence of any applied inductive electric field, by the inner plasma centerpost through magnetic reconnections [Taylor J B and Turner M F 1989 Nucl.Fusion 29 219], it is required as well that spurious current paths do not surround the torus on its outboard, in order not to lower the efficiency of the magnetic reconnections that maintain the plasma torus at the expense of the plasma centerpost. Boundary conditions have been corrected,up to the point that the first sustainment in steady state has been achieved for the combined plasma. | Paolo MICOZZI Franco ALLADIO Alessandro MANCUSO Vincenzo ZANZA Gerarda APRUZZESE Francesca BOMBARDA Luca BONCAGNI Paolo BURATTI Francesco FILIPPI Giuseppe GALATOLA TEKA Francesco GIAMMANCO Edmondo GIOVANNOZZI Andrea GROSSO Matteo IAFRATI Alessandro LAMPASI Violeta LAZIC Simone MAGAGNINO Simone MANNORI Paolo MARSILI Valerio PIERGOTTI Giuliano ROCCHI Alessandro SIBIO Benedetto TILIA Onofrio TUDISCO | 2024 | Plasma Science and Technology2024，26，2： | 0 |
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