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| 1 | Large-scale evaluation of pea(Pisum sativum L.)germplasm for cold tolerance in the field during winter in Qingdao显示文摘As a cool-season crop, pea(Pisum sativum L.) can tolerate frost at the vegetative stage but experiences yield loss when freezing stress occurs at the reproductive stage. Cold-tolerance improvement of pea varieties is important for stable yield and expansion of the winter pea planting area. Under natural low-temperature conditions during winter in Qingdao,Shandong, China, we evaluated the cold tolerance of 3672 pea germplasm accessions in the field and categorized them as displaying high resistance(214), moderate resistance(835), or susceptibility(2623). The highly and moderately resistant genotypes were validated in the following year. We found that genotypes from the winter production region showed higher cold tolerance than genotypes from the spring production region. The accessions identified as having high levels of cold tolerance are recommended as potential genetic resources in cold-tolerance breeding of pea. | Xiaoyan Zhang Shuwei Wan Junjie Hao Jinguo Hu Tao Yang Xuxiao Zong | 2016 | The Crop Journal2016，4，5： | 2 |
| 2 | miR-7/TGF-β2 axis sustains acidic tumor microenvironment-induced lung cancer metastasis显示文摘Acidosis,regardless of hypoxia involvement,is recognized as a chronic and harsh tumor microenvironment(TME)that educates malignant cells to thrive and metastasize.Although overwhelming evidence supports an acidic environment as a driver or ubiquitous hallmark of cancer progression,the unrevealed core mechanisms underlying the direct effect of acidification on tumorigenesis have hindered the discovery of novel therapeutic targets and clinical therapy.Here,chemical-induced and transgenic mouse models for colon,liver and lung cancer were established,respectively.miR-7 and TGF-β2 expressions were examined in clinical tissues(n=184).RNA-seq,miRNA-seq,proteomics,biosynthesis analyses and functional studies were performed to validate the mechanisms involved in the acidic TME-induced lung cancer metastasis.Our data show that lung cancer is sensitive to the increased acidification of TME,and acidic TME-induced lung cancer metastasis via inhibition of miR-7-5 p.TGF-β2 is a direct target of miR-7-5 p.The reduced expression of miR-7-5 p subsequently increases the expression of TGF-β2 which enhances the metastatic potential of the lung cancer.Indeed,overexpression of miR-7-5 p reduces the acidic p H-enhanced lung cancer metastasis.Furthermore,the human lung tumor samples also show a reduced miR-7-5 p expression but an elevated level of activated TGF-β2;the expressions of both miR-7-5 p and TGF-β2 are correlated with patients’survival.We are the first to identify the role of the miR-7/TGF-β2 axis in acidic p H-enhanced lung cancer metastasis.Our study not only delineates how acidification directly affects tumorigenesis,but also suggests miR-7 is a novel reliable biomarker for acidic TME and a novel therapeutic target for non-small cell lung cancer(NSCLC)treatment.Our study opens an avenue to explore the p H-sensitive subcellular components as novel therapeutic targets for cancer treatment. | Tao Su Suchao Huang Yanmin Zhang Yajuan Guo Shuwei Zhang Jiaji Guan Mingjing Meng Linxin Liu Caiyan Wang Dihua Yu Hiu-Yee Kwan Zhiying Huang Qiuju Huang Elaine Lai-Han Leung Ming Hu Ying Wang Zhongqiu Liu Linlin Lu | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 2 |
| 3 | Optimisation Method for Determination of Crack Tip Position Based on Gauss-Newton Iterative Technique显示文摘In the digital image correlation research of fatigue crack growth rate,the accuracy of the crack tip position determines the accuracy of the calculation of the stress intensity factor,thereby affecting the life prediction.This paper proposes a Gauss-Newton iteration method for solving the crack tip position.The conventional linear fitting method provides an iterative initial solution for this method,and the preconditioned conjugate gradient method is used to solve the ill-conditioned matrix.A noise-added artificial displacement field is used to verify the feasibility of the method,which shows that all parameters can be solved with satisfactory results.The actual stress intensity factor solution case shows that the stress intensity factor value obtained by the method in this paper is very close to the finite element result,and the relative error between the two is only−0.621%;The Williams coefficient obtained by this method can also better define the contour of the plastic zone at the crack tip,and the maximum relative error with the test plastic zone area is−11.29%.The relative error between the contour of the plastic zone defined by the conventional method and the area of the experimental plastic zone reached a maximum of 26.05%.The crack tip coordinates,stress intensity factors,and plastic zone contour changes in the loading and unloading phases are explored.The results show that the crack tip change during the loading process is faster than the change during the unloading process;the stress intensity factor during the unloading process under the same load condition is larger than that during the loading process;under the same load,the theoretical plastic zone during the unloading process is higher than that during the loading process. | Bing Yang Zhanjiang Wei Zhen Liao Shuwei Zhou Shoune Xiao Tao Zhu Guangwu Yang Mingmeng Wang | 2021 | Chinese Journal of Mechanical Engineering2021，34，4： | 1 |
| 4 | Controllable speckle compression in atomic vapor by frequency modulation and its application in ghost imaging显示文摘An image undergoes a paraxial diffraction spreading when propagating in free space.The reduction of diffraction is critical for many potential applications[1-3].Recently,it has been recognized that optical diffraction can be greatly suppressed or even eliminated by using atomic coherence effects[4-9].Several experimental attempts to extent the | JinWen Wang Xin Yang ShuWei Qiu Ming Tao Cao Dong Wei Hong Gao FuLi Li | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，9： | 0 |
| 5 | Development of solid base catalyst X/Y/MgO/-Al_(2)O_(3) for optimization of preparation of biodiesel from Jatropha curcas L.seed oil显示文摘The preparation and regeneration conditions of the identified catalyst X/Y/MgO/?-Al2O3 with high catalytic activity were studied and optimized. The biodiesel was prepared by transesterification of Jatropha curcas seed oil produced in Guizhou with methanol at its reflux temoerature in the presence of X/Y/MgO/?-Al2O3 . The pilot plant tests were carried out in a 100 L reaction vessel. Both average yield and fatty acid methyl esters (FAME) content reached more than 96.50% under the optimum reaction conditions of the pilot plant tests designed with an oil/methanol molar ratio of 1 : 10, catalyst concentration of 1.00%, and reaction time of 3 h at reflux temperature. In addition, analysis shows that the quality of biodiesel meets the standard EN 14214. | Rui WANG Song YANG Shitao YIN Baoan SONG Pinaki SBHADURY Wei XUE Shuwei TAO Zhaohui JIA Da LIU Liang GAO | 2008 | Frontiers of Chemical Science and Engineering2008，2，4： | 0 |
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