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| 1 | Oncogenic miR-19a and miR-19b co-regulate tumor suppressor MTUS1 to promote cell proliferation and migration in lung cancer显示文摘MTUS1 (联系微导管的肿瘤 suppressor 1 ) 被识别了那能在许多恶意的肿瘤作为肿瘤 suppressor 基因工作。然而,位于 MTUS1 的规定下面的功能和机制是不清楚的。在现在的学习,我们报导 miR-19a 和 miR-19b (miR-19a/b ) 由指向 MTUS1 支持肺癌症房间的增长和移植。首先, MTUS1 被证明在肺癌症作为肿瘤 suppressor 工作并且被连接到房间增长和移植提升。第二,在 miR-19a/b 表示之间的反的关联和 MTUS1 mRNA/protein 表示在人的肺癌症纸巾被注意。第三, MTUS1 被生物信息学分析作为 miR-19a/b 的一个直接目标估价。第四,由在肺癌症房间的 miR-19a/b 的直接 MTUS1 规定被房间 transfection 试验性地肯定试金和酶记者试金。最后, miR-19a/b 被显示合作地镇压 MTUS1 表示并且 synergistically 调整 MTUS1 表示支持肺癌症房间增长和移植。在结论,我们的调查结果关于 miR-19a/b 的角色提供了第一线索,它看起来由 downregulating MTUS1 在肺癌症作为 oncomirs 工作。 | Yuanyuan Gu Shuoxin Liu Xiaodan Zhang Guimin Chen Hongwei Liang Mengchao Yu Zhicong Liao Yong Zhou Chen-Yu Zhang Tao Wang Chen Wang Junfeng Zhang Xi Chen | 2017 | Protein & Cell2017，8，6： | 6 |
| 2 | Production, purification and characterization of a ther- mostablelaccase from a tropical white-rot fungus显示文摘 | Guo Liqiong Lin Shuoxin Zheng Xiaobing | 2011 | World Journal of Microbiology and Biotechnology2011，27，3： | 1 |
| 3 | Photosynthesis, growth and yield of soybean and maize in a tree-based agroforestry intercropping system on the Loess Plateau显示文摘 | Xiaobang Peng Yuanying Zhang Jing Cai Zaimin Jiang Shuoxin Zhang | 2009 | Agroforestry Systems2009，，3： | 1 |
| 4 | Gene flow among wild and cultivated common walnut(Juglans regia)trees in the Qinling Mountains revealed by microsatellite markers显示文摘Patterns of gene flow and gene introgres sion can be used to assess the risk of genetic pollution of wild forest trees from widespread cultivated trees.A comprehensive understanding of the genetic relationships and levels of gene flow among wild and cultivated common walnut(Juglans regia)has become an urgent issue.Using twelve microsatellite markers,we investigated the genetic diversity and gene flow between cultivated and wild trees of J.regia in the Qinling Mountains,China.A high level of genetic variation was detected in both cultivated and wild trees.The mean number of alleles per locus was 17.5.Observed heterozygosity(HO)and expected heterozygosity(HE)were 0.777 and 0.800,respectively.Pollination of mother trees was not by nearest neighbors,and a paternity of 60.7%of offspring evaluated could not be assigned to a local,sampled tree.Pollen flow from cultivated trees to wild trees was infrequent(5.4%),and selfing rates ranged from zero to 25.0%.Male parents were located from 0 to 1005 m from their female partners,with an average pollination distance of 285.1 m.These results are discussed in light of the cultivated species’diversity,outlining the frequent spontaneous genetic contributions from the wild to the cultivated compartment.In addition,the pollen flow parameters provide useful information about the dynamics of pollen movement within J.regia populations. | Huijuan Zhou Peng Zhao Keith Woeste Shuoxin Zhang | 2021 | Journal of Forestry Research2021，32，5： | 0 |
| 5 | Pan-genome and transcriptome analyses provide insights into genomic variation and differential gene expression profiles related to disease resistance and fatty acid biosynthesis in eastern black walnut (Juglans nigra)显示文摘Walnut(Juglans)species are used as nut crops worldwide.Eastern black walnut(EBW,Juglans nigra),a diploid,horticultural important woody species is native to much of eastern North America.Although it is highly valued for its wood and nut,there are few resources for understanding EBW genetics.Here,we present a high-quality genome assembly of J.nigra based on Illumina,Pacbio,and HiC technologies.The genome size was 540.8 Mb,with a scaffold N50 size of 35.1 Mb,and 99.0%of the assembly was anchored to 16 chromosomes.Using this genome as a reference,the resequencing of 74 accessions revealed the effective population size of J.nigra declined during the glacial maximum.A single whole-genome duplication event was identified in the J.nigra genome.Large syntenic blocks among J.nigra,Juglans regia,and Juglans microcarpa predominated,but inversions of more than 600 kb were identified.By comparing the EBW genome with those of J.regia and J.microcarpa,we detected InDel sizes of 34.9 Mb in J.regia and 18.3 Mb in J.microcarpa,respectively.Transcriptomic analysis of differentially expressed genes identified five presumed NBS-LRR(NUCLEOTIDE BINDING SITELEUCINE-RICH REPEAT)genes were upregulated during the development of walnut husks and shells compared to developing embryos.We also identified candidate genes with essential roles in seed oil synthesis,including FAD(FATTY ACID DESATURASE)and OLE(OLEOSIN).Our work advances the understanding of fatty acid bioaccumulation and disease resistance in nut crops,and also provides an essential resource for conducting genomics-enabled breeding in walnut. | Huijuan Zhou Feng Yan Fan Hao Hang Ye Ming Yue Keith Woeste Peng Zhao Shuoxin Zhang | 2023 | Horticulture Research2023，10，3： | 0 |
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