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| 1 | Critical role of bicarbonate and bicarbonate transporters in cardiac function显示文摘Bicarbonate is one of the major anions in mammalian tissues and extracellular fluids. Along with accompanying H+, HCO3- is generated from CO2 and H2 O, either spontaneously or via the catalytic activity of carbonic anhydrase. It serves as a component of the major buffer system, thereby playing a critical role in pH homeostasis. Bicarbonate can also be utilized by a variety of ion transporters, often working in coupled systems, to transport other ions and organic substrates across cell membranes. The functions of HCO3- and HCO3--transporters in epithelial tissues have been studied extensively, but their functions in heart are less well understood. Here we review studies of the identities and physiological functions of Cl-/HCO3- exchangers and Na+/HCO3-cotransporters of the SLC4 A and SLC26 A families in heart. We also present RNA Seq analysis of their cardiac mRNA expression levels. These studies indicate that slc4a3(AE3) is the major Cl-/HCO3- exchanger and plays a protective role in heart failure, and that Slc4a4(NBCe1) is the major Na+/HCO3- cotransporter and affects action potential duration. In addition, previous studies show that HCO3- has a positive inotropic effect in the perfused heart that is largely independent of effects on intracellular Ca2+. The importance of HCO3- in the regulation of contractility is supported by experiments showing that isolated cardiomyocytes exhibit sharply enhanced contractility, with no change in Ca2+ transients, when switched from Hepes-buffered to HCO3-- buffered solutions. These studies demonstrate that HCO3- and HCO3--handling proteins play important roles in the regulation of cardiac function. | Hong-Sheng Wang Yamei Chen Kanimozhi Vairamani Gary E Shull | 2014 | World Journal of Biological Chemistry2014，5，3： | 2 |
| 2 | A polymerase chain rea- ction (PCR) assay specific for Streptococcus Suis based on the gene encoding the glutamate dehydrogenase显示文摘 | OKWUMABUA O O' CONNOR M SHULL E | 2003 | FEMS Microbiol Lett2003，11，218： | 1 |
| 3 | Eggshell thinning in ring doves exposed to p, p'-dicofol 显示文摘 | SCHWARZBACH S E SHULL L GRAU C R | 1988 | Ar- chive Environmental Contamination Toxicology1988，17，： | 1 |
| 4 | A polymerase chain reaction (PCR) assay specific for Streptococcus suis based on the gene encoding the glutamate dehydrogenase显示文摘 | Okwumabua O O?Connor M Shull E | 2003 | FEMS Microbiol Lett2003，218，1： | 1 |
| 5 | A polymerase chain reaction (PCR) assay specific for Streptococcus suis based on the gene encoding the glutamate dehydrogenase显示文摘 | OKWUMABUA O O'CONNOR M SHULL E | 2003 | FEMS Microbiol Lett2003，218，1： | 1 |
| 6 | A polymerase chain reaction(PCR) assay specific for Streptococcus suis based on the gene encoding the glutamate dehydrogenase显示文摘 | O'Connor M Shull E | 2003 | FEMS Microbiol Lett2003，218，1： | 1 |
| 7 | Plasma membrane Ca^sup 2+^-ATPase isoform 4 antagonizes cardiac hypertrophy in association with calcineurin inhibition in rodents显示文摘 | Wu Xu Chang Baojun Blair N Scott Sargent Michelle York Allen J Robbins Jeffrey Shull Gary E Molkentin Jeffery D | 2009 | Journal of Clinical Investigation2009，，4： | 1 |
| 8 | The cuticle:surface structure and function 显示文摘 | Bukovac M J Rasmussen H P Shull V E | 1981 | Scanning Electron Microscopy1981，3，： | 1 |
| 9 | cDNA Cloning and Tissue Distribution of mRNAs for Two Proteins that are Related to the Band 3Cl-/HCO3-exchanger显示文摘 | KUDRYCKI K E NEWMAN P R SHULL G E | 1990 | J Biol Chem1990，265，： | 1 |
| 10 | Estimation of Hydroxyl, Methyl, and Phenyl in Dimethyldiphenyl Silicone Resins by Infrared Spectrophotometry显示文摘 | Shull E R | 1960 | Anal Chem1960，32，12： | 1 |
| 11 | A polymerase chain re- action (PCR) assay specific for Streptococcus suis based on the gent encoding the glutamate dehydrogenase显示文摘 | Okwumabua O O'Connor M Shull E | 2003 | FEMS Microbiol Lett2003，218，1： | 1 |
| 12 | Functional comparisons between isoforms of the sarcoplasmic or endoplasmic reticulum family of calcium pumps 显示文摘 | Lytton J Westlin M Burk S E Shull G E MacLennan D H | 1992 | J Biol Chem1992，267，14： | 1 |
| 13 | A polymerase ehain reaction (PCR) assay specific for Streptococcus suis based on the gene encoding the glutamate delydrogenase显示文摘 | Okwumabua O O Connor M Shull E | 2003 | FEMS Microbiol Lett2003，218，： | 1 |
| 14 | Neutron diffraction studies of Nail and NaD 显示文摘 | Shull C G Wollan E O Morton G A | 1948 | Phys Rev1948，73，： | 1 |
| 15 | Nanoscale impedance microscopy-a characterization tool for nano-electronic devices and circuits显示文摘 | PINGREE L S C MARTIN E F SHULL K R | 2005 | IEEE Trans Nanotech2005，4，2： | 1 |
| 16 | A polymerase chain reaction(PCR) assay specific for Streptococcus suis based on the gene encoding the glutamate dehydrogenase 显示文摘 | Okwumabua O O'Connor M Shull E | 2003 | FEMS Microbiol Lett2003，218，1： | 1 |
| 17 | A polymerase chain reaction(PCR) assay specific for Streptococcus suis based on the gene encoding the glutamate dehy drogenase 显示文摘 | Okwumabua O O'Connor M Shull E | 2003 | FE1VIS Microbiology Letters2003，218，1： | 1 |
| 18 | Magnetocalorie effect in superpararnagnets 显示文摘 | MCMICHAEL R D SHULL R D SWARTZENDRUBER L J BENNETT L H WATSON R E | 1992 | J Magn Magn Mater1992，111，12： | 1 |
| 19 | Increased metallothionein gene expression,zinc,and zinc-dependent resistance to apoptosis in circulating monocytes during HIV viremia显示文摘 | Raymond A D Gekonge B Giri M S Hancock A Papasavvas E Chehimi J Kossenkov A V Nicols C YousefM Mounzer K Shull J Kostman J Showe L Montaner L J | | 0，，03： | 1 |
| 20 | Bleomycin regulation of transforming growth factor-beta mRNA in rat lung fibroblasts显示文摘 | Breen E Shull S Burne S | 1992 | Am J Respir Cell Mol Biol1992，6，2： | 1 |
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