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| 1 | Immunological Effects of Silica and Asbestos显示文摘Silicosis patients(SILs) and patients who have been exposed to asbestos develop not only respiratory diseases but also certain immunological disorders. In particular,SIL sometimes complicates autoimmune diseases such as systemic scleroderma,rheumatoid arthritis(known as Caplan syndrome) ,and systemic lupus erythematoses. In addition,malignant complications such as lung cancer and malignant mesothelioma often occurr in patients exposed to asbestos,and may be involved in the reduction of tumor immunity. Although silica-induced disorders of autoimmunity have been explained as adjuvant-type effects of silica,more precise analyses are needed and should reflect the recent progress in immunomolecular findings. A brief summary of our investigations related to the immunological effects of silica/asbestos is presented. Recent advances in immunomolecular studies led to detailed analyses of the immunological effects of asbestos and silica. Both affect immuno-competent cells and these effects may be associated with the pathophysiological development of complications in silicosis and asbestos-exposed patients such as the occurrence of autoimmune disorders and malignant tumors,respectively. In addition,immunological analyses may lead to the development of new clinical tools for the modification of the pathophysiological aspects of diseases such as the regulation of autoimmunity or tumor immunity using cell-mediated therapies,various cytokines,and molecule-targeting therapies. In particular,as the incidence of asbestos-related malignancies is increasing and such malignancies have been a medical and social problem since the summer of 2005 in Japan,efforts should be focused on developing a cure for these diseases to eliminate nationwide anxiety. | Takemi Otsuki Megumi Maeda Shuko Murakami Hiroaki Hayashi Yoshie Miura Masayasu Kusaka Takashi Nakano Kazuya Fukuoka Takumi Kishimoto Fuminori Hyodoh Ayako Ueki Yasumitsu Nishimura | 2007 | Cellular & Molecular Immunology2007，4，4： | 9 |
| 2 | Incidence and characteristics of HBV reactivation in hematological malignant patients in south Egypt显示文摘AIM:To investigate characteristics of hepatitis B virus(HBV)implicated in HBV reactivation in patients with hematological malignancies receiving immunosuppressive therapy.METHODS:Serum samples were collected from 53 patients with hematological malignancies negative for hepatitis B surface antigen(HBsAg)before the start of and throughout the chemotherapy course.HBV reactivation was diagnosed when the HBsAg status changed from negative to positive after the initiation of chemotherapy and/or when HBV DNA was detected by realtime detection polymerase chain reaction(RTD-PCR).For detecting the serological markers of HBV infection,HBsAg as well as antibodies to the core antigen(antiHBc)and to the surface antigen were measured in the sera by CEIA.Nucleic acids were extracted from sera,and HBV DNA sequences spanning the S gene were amplified by RTD-PCR.The extracted DNA was further subjected to PCR to amplify the complete genome as well as the specific genomic sequences bearing the enhancerⅡ/core promoter/pre-core/core regions(nt1628-2364).Amplicons were sequenced directly.RESULTS:Thirty-five(66%)of the 53 HBsAg-negative patients were found to be negative serologically for antiHBc,and the remaining 18(34%)patients were positive for anti-HBc.Five of the 53(9.4%)patients with hematologic malignancies experienced HBV reactivation.Genotype D1 was detected in all five patients.Four types of mutant strains were detected in the S gene product of HBV strains and were isolated from 3 patients with HBV reactivation:T/S120,L143,and I126.HBV DNA was detected in the pretreatment HBsAg-negative samples in one of the five patients with HBV reactivation.In this patient,sequences encompassing the HBV full genome obtained from sera before the start of chemotherapy and at the time of de novo HBV hepatitis were detected and it showed 100%homology.Furthermore,in the phylogenetic tree,the sequences were clustered together,thereby indicating that this patient developed reactivation from an occult HBV infection.CONCLUSION:Past infection with HBV is a risk factor for HBV reactivation in Egypt.Mandatory anti-HBc screening prior to chemotherapy in patients with hematological malignancies is recommended. | Abeer Elkady Sahar Aboulfotuh Elsayed Mostafa Ali Douaa Sayed Nashwa M Abdel-Aziz Amany M Ali Shuko Murakami Sayuki Iijima Yasuhito Tanaka | 2013 | World Journal of Gastroenterology2013，19，37： | 7 |
| 3 | Clinical implications of doubling time of gastrointestinal submucosal tumors显示文摘AIM To evaluate the efficacy of doubling time(DT) of gastrointestinal submucosal tumors(GIST).METHODS From April 1987 through November 2012, a total of 323 patients were given a final histopathological diagnosis of GISTs on surgical resection or endoscopic ultrasound-guided fine-needle aspiration(EUS-FNA) in Kitasato University East Hospital or Kitasato University Hospital. We studied 53 of these patients(34 with resected tumors and 19 with unresected tumors) whose tumors could be measured on EUS on at least two successive occasions. The histopathological diagnosis was GIST in 34 patients, leiomyoma in 5, schwannoma in 3, ectopic pancreas in 1, hamartoma in 1, cyst in 1, Brunner's adenoma in 1, and spindle-cell tumor in 7. We retrospectively calculated the DT of GISTs on the basis of the time course of EUS findings to estimate the growth rate of such tumors.RESULTS The DT was 17.2 mo for GIST, as compared with 231.2 mo for leiomyoma, 104.7 mo for schwannoma, 274.9mo for ectopic pancreas, 61.2 mo for hamartoma, 49.0 mo for cyst, and 134.7 mo for Brunner's adenoma. The GISTs were divided into risk classes on the basis of tumor diameters and mitotic figures(Fletcher's classification). The classification was extremely low risk or low risk in 28 patients, intermediate risk in 3, and high risk in 3. DT of GIST according to risk was 24.0 mo for extremely low-risk plus low-risk GIST, 17.1 mo for intermediate-risk GIST, and 3.9 mo for high-risk GIST. DT of GIST was significantly shorter than that of leiomyoma plus schwannoma(P < 0.05), and DT of high-risk GIST was significantly shorter than that of extremely low-risk plus low-risk GIST(P < 0.05).CONCLUSION For GIST, a higher risk grade was associated with a significantly shorter DT. Small SMTs should initially be followed up within 6 mo after detection. | Shuko Koizumi Mitsuhiro Kida Hiroshi Yamauchi Kosuke Okuwaki Tomohisa Iwai Shiro Miyazawa Miyoko Takezawa Hiroshi Imaizumi Wasaburo Koizumi | 2016 | World Journal of Gastroenterology2016，22，45： | 3 |
| 4 | Passive-bending,short-type single-balloon enteroscope for endoscopic retrograde cholangiopancreatography in Roux-en-Y anastomosis patients显示文摘AIM:To evaluate short-type-single-balloon enteroscope(SBE) with passive-bending,high-force transmission functions for endoscopic retrograde cholangiopancreatography(ERCP) in patients with Roux-en-Y anastomosis.METHODS:Short-type SBE with this technology(SIF-Y0004-V01; working length,1520 mm; channel diameter,3.2 mm) was used to perform 50 ERCP procedures in 37 patients with Roux-en-Y anastomosis.The rate of reaching the blind end,time required to reach the blind end,diagnostic and therapeutic success rates,and procedure time and complications were studied retrospectively and compared with the results of 34 sessions of ERCP performed using a short-type SBE without this technology(SIF-Y0004; working length,1520 mm; channel diameter,3.2 mm) in 25 patients.RESULTS:The rate of reaching the blind end was 90% with SIF-Y0004-V01 and 91% with SIF-Y0004(P = 0.59).The median time required to reach the papilla was significantly shorter with SIF-Y0004-V01 than with SIF-Y0004(16 min vs 24 min,P = 0.04).The diagnostic success rate was 93% with SIFY0004-V01 and 84% with SIF-Y0004(P = 0.17).The therapeutic success rate was 95% with SIF-Y0004-V01 and 96% with SIF-Y0004(P = 0.68).The median procedure time was 40 min with SIF-Y0004-V01 and 36 min with SIF-Y0004(P = 0.50).The incidence of hyperamylasemia was 6.0% in the SIF-Y0004-V01 group and 14.7% in the SIF-Y0004 group(P = 0.723).The incidence of pancreatitis was 0% in the SIFY0004-V01 group and 5.9% in the SIF-Y0004 group(P > 0.999).The incidence of gastrointestinal perforation was 2.0%(1/50) in the SIF-Y0004-V01 group and 2.9%(1/34) in the SIF-Y0004 group(P > 0.999).CONCLUSION:SIF-Y0004-V01 is useful for ERCP inpatients with Roux-en-Y anastomosis and may reduce the time required to reach the blind end. | Hiroshi Yamauchi Mitsuhiro Kida Kosuke Okuwaki Shiro Miyazawa Tomohisa Iwai Shuko Tokunaga Miyoko Takezawa Hiroshi Imaizumi Wasaburo Koizumi | 2015 | World Journal of Gastroenterology2015，21，5： | 3 |
| 5 | Characteristics of escape mutations from occult hepatitis B virus infected patients with hematological malignancies in South Egypt显示文摘AIM To investigate the prevalence and virological characteristics of occult hepatitis B virus(HBV) infections in patients with hematological malignancies in South Egypt.METHODS Serum samples were collected from 165 patients with hematological malignancies to monitor titers of HBV DNA, hepatitis B surface antigen(HBs Ag), and antibodies to HBV core(anti-HBc) and surface antigens. Serum samples negative for HBs Ag and positive for anti-HBc were subjected to nucleic acid extraction and HBV DNA detection by real-time polymerase chain reaction. DNA sequences spanning the S region were analyzed in cases with occult HBV infection. In vitro comparative study of constructed 1.24-fold wild type and S protein mutant HBV genotype D clones was further performed. RESULTS HBV DNA was detected in 23(42.6%) of 54 patients with hematological malignancies who were HBsA g negative, but anti-HBc positive, suggesting the presence of occult HBV infection. The complete HBV genome was retrieved from 6 occult HBV patients, and P120 T and S143 L were detected in 3 and 2 cases, respectively. Site directed mutagenesis was done to produce 1.24-fold genotype D clones with amino acid mutations T120 and L143. The in vitro analyses revealed that a lower level of extracellular HBsA g was detected by chemiluminescence enzyme immunoassay(CLEIA) with the clone containing T120 mutation, compared with the wild type or the clone with S143 L mutation despite the similar levels of extracellular and intracellular HBs Ag detected by Western blot. Southern blot experiments showed that the levels of intracellular HBV DNA were not different between these clones. CONCLUSION Occult HBV infection is common in patients with hematological malignancies and associated with P120 T and S143 L mutations. 120 T mutation impairs the detection of HBsA g by CLEIA. | Abeer Elkady Sayuki Iijima Sahar Aboulfotuh Elsayed Mostafa Ali Douaa Sayed Nashwa M Abdel-Aziz Amany M Ali Shuko Murakami Masanori Isogawa Yasuhito Tanaka | 2017 | World Journal of Hepatology2017，9，9： | 2 |
| 6 | Usefulness of single and repetitive percutaneous transhepatic gallbladder aspiration for the treatment of acute cholecystitis显示文摘 | Kunihiko Tsutsui Naohito Uchida Shuko Hirabayashi Hideki Kamada Masahiro Ono Mutsumi Ogawa Toru Ezaki Hiroki Fukuma Hideki Kobara Yuichi Aritomo Tsutomu Masaki Toshiaki Nakatsu Shigeki Kuriyama | 2007 | Journal of Gastroenterology2007，，7： | 1 |
| 7 | Knockout of exogenous EGFP gene in porcine somatic cells using zinc-finger nucleases显示文摘 | Masahito Watanabe Kazuhiro Umeyama Hitomi Matsunari Shuko Takayanagi Erika Haruyama Kazuaki Nakano Tsukasa Fujiwara Yuka Ikezawa Hiromitsu Nakauchi Hiroshi Nagashima | 2010 | Biochemical and Biophysical Research Communications2010，，1： | 1 |
| 8 | Narrow-band imaging of the gastrointestinal tract显示文摘 | Manabu Muto Takahiro Horimatsu Yasumasa Ezoe Kimiko Hori Yoshiyuki Yukawa Shuko Morita Shinichi Miyamoto Tsutomu Chiba | 2009 | Journal of Gastroenterology2009，，1： | 1 |
| 9 | Seasonal variations in the cooling effect of urban green areas on surrounding urban areas显示文摘 | Shuko Hamada Takeshi Ohta | 2009 | Urban Forestry & Urban Greening2009，，1： | 1 |
| 10 | Change in sense of coherence (SOC) and causal relationships with social support among upper-grade elementary school children: a one-year longitudinal survey显示文摘 | Hotoge Shuko Takeda Fumi Togari Taisuke Yamazaki Yoshihiko Kida Haruyo | 2012 | Japanese joumM of public health2012，58，11： | 1 |
| 11 | In vitro bioactivity of MOEP grafted ePTFE membranes for eraniofaeial applications 显示文摘 | Suzukl Shuko Grondahl Lisbeth Leavesley David | 2005 | Biomaterials2005，，26： | 1 |
| 12 | Narrow-band imaging of the gastrointestinal tract显示文摘 | Manabu Muto Takahiro Horimatsu Yasumasa Ezoe Kimiko Hori Yoshiyuki Yukawa Shuko Morita Shinichi Miyamoto Tsutomu Chiba | 2009 | Journal of Gastroenterology2009，，1： | 1 |
| 13 | A subnanometre heterodyne interferometric system with improved phase sensitivity using a three longitudinalmode He-Ne laser显示文摘 | Toshiuki Yokoyama Tsutomu Araki Shuko Yokoyama | 2001 | Measurement Science & Technology2001，12，： | 1 |
| 14 | Interfer- on-r block the stimulatory effect of tumor necrosis factor-a on prostaglandin F2a synthesis by bovine en- dometrial stromal eells显示文摘 | KIYOSHI O YUKO K SHUKO M | 2004 | Biol Reprod2004，70，： | 1 |
| 15 | Prevalence of foodborne pathogens in open markets and supermarkets in Thailand显示文摘 | Atsuka Minami Wanpen Chaicumpa Manas Chongsa-Nguan Seksun Samosornsuk Shuko Monden Kouichi Takeshi Sou-ichi Makino Keiko Kawamoto | 2009 | Food Control2009，，3： | 1 |
| 16 | Narrow-band imaging of the gastrointestinal tract显示文摘 | Manabu Muto Takahiro Horimatsu Yasumasa Ezoe Kimiko Hori Yoshiyuki Yukawa Shuko Morita Shinichi Miyamoto Tsutomu Chiba | 2009 | Journal of Gastroenterology2009，，1： | 1 |
| 17 | Dose-Dependent Contribution of CD34-Positive Cell Transplantation to Concurrent Vasculogenesis and Cardiomyogenesis for Functional Regenerative Recovery After Myocardial Infarction显示文摘 | Hiroto Iwasaki Atsuhiko Kawamoto Masakazu Ishikawa Akira Oyamada Shuko Nakamori Hiromi Nishimura Kazuyo Sadamoto Miki Horii Tomoyuki Matsumoto Satoshi Murasawa Toshihiko Shibata Shigefumi Suehiro Takayuki Asahara | 2006 | Circulation2006，，10： | 1 |
| 18 | Seasonal variations in the cooling effect of urban green areas on surrounding urban areas 显示文摘 | Shuko H Takeshi O | 2010 | Urban Forestry & Urban Greening2010，9，1： | 1 |
| 19 | Transoral surgery for laryngo-pharyngeal cancer – The paradigm shift of the head and cancer treatment显示文摘 | Ichiro Tateya Akihiro Shiotani Yasuo Satou Masayuki Tomifuji Shuko Morita Manabu Muto Juichi Ito | 2015 | Auris Nasus Larynx2015，，： | 1 |
| 20 | Validation of Aβ 1-40 administration into mouse eerebroventrieles as an animal model for Alzheimer disease显示文摘 | Shuko Takeda Naoyuki Sato Kazue Niisato | 2009 | Brain Res2009，1280，： | 1 |
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