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| 1 | Anomalous expression of chloride transporters in the sclerosed hippocampus of mesial temporal lobe epilepsy patients显示文摘The Na+-K+-Cl-cotransporter 1 and K+-Cl-cotransporter 2 regulate the levels of intracellular chloride in hippocampal cells.Impaired chloride transport by these proteins is thought to be involved in the pathophysiological mechanisms of mesial temporal lobe epilepsy.Imbalance in the relative expression of these two proteins can lead to a collapse of Cl-homeostasis,resulting in a loss of gamma-aminobutyric acid-ergic inhibition and even epileptiform discharges.In this study,we investigated the expression of Na+-K+-Cl-cotransporter 1 and K+-Cl-cotransporter 2 in the sclerosed hippocampus of patients with mesial temporal lobe epilepsy,using western blot analysis and immunohistochemistry.Compared with the histologically normal hippocampus,the sclerosed hippocampus showed increased Na+-K+-Cl-cotransporter 1 expression and decreased K+-Cl-cotransporter 2 expression,especially in CA2 and the dentate gyrus.The change was more prominent for the Na+-K+-Cl-cotransporter 1 than for the K+-Cl-cotransporter 2.These experimental findings indicate that the balance between intracellular and extracellular chloride may be disturbed in hippocampal sclerosis,contributing to the hyperexcitability underlying epileptic seizures.Changes in Na+-K+-Cl-cotransporter 1 expression seems to be the main contributor.Our study may shed new light on possible therapies for patients with mesial temporal lobe epilepsy with hippocampal sclerosis. | Xiaodong Cai Libai Yang Jueqian Zhou Dan Zhu Qiang Guo Ziyi Chen Shuda Chen Liemin Zhou | 2013 | Neural Regeneration Research2013，8，6： | 2 |
| 2 | The Surface Impurity Distribution on Synthetic Diamond显示文摘 | Zhang Shuda | 1993 | High- Pressure Science and Technology-- 1993 523-526 AlP Press New York1993，，： | 1 |
| 3 | Enhanced expression of $8, L12, L23a, L27 and L30 ribosomal protein mRNAs in human hepatocellular carcinoma显示文摘 | Kondoh N Shuda M Tanaka K | 2001 | Anticancer Res2001，21，4： | 1 |
| 4 | Aurora kinase B modulates chromosome alignment in mouse oocytes显示文摘 | Shuda K Schindler K Ma J | 2009 | Mol Reprod Dev2009，76，11： | 1 |
| 5 | Aurora kinase B modulates chromosome alignment in mouse oocytes显示文摘 | Shuda K Schindler K Ma J | 2009 | Mol Reprod Dev2009，76，11： | 1 |
| 6 | Activation of theATF6, XBP1 and grp78 genes in human hepatocellularcarcinoma: a possible involvement of the ER stress pathwayin hepatocarcinogenesis显示文摘 | Shuda M Kondoh N Imazeki N | 2003 | J Hepatol2003，38，5： | 1 |
| 7 | RAD51C deficiency in mice results in early prophase I arrest in males and sister chromatid separation at metaphase II in females显示文摘 | Pellegrini M Shuda K | 2007 | J Cell Biol2007，176，5： | 1 |
| 8 | Enhanced expres- sion of translation factor mRNAs in hepatoeellular carei-noma 显示文摘 | Shuda M Kondoh N Tanaka K | 2000 | Anticancer Res2000，20，4： | 1 |
| 9 | Dynamic expression of P-glycoprotein in the CA1,CA3 and dentate gyrus of the rat hippocampus following lithium-pilocarpine-induced status epilepticus显示文摘Epileptic seizures induce overexpression of P-glycoprotein in the blood-brain barrier. However,it is unclear whether hippocampal neurons also overexpress P-glycoprotein following seizure. This study confirmed that the clinical manifestation,pathological characteristics and electroencephalography in the rat model of lithium-pilocarpine-induced mesial temporal lobe epilepsy were consistent with clinical reports of mesial temporal lobe epilepsy in humans. Immunohistochemistry staining demonstrated that P-glycoprotein positive staining was found in neurons in the pyramidal layer of the hippocampus. Western blot assay and real-time polymerase chain reaction revealed that P-glycoprotein overexpression was exhibited in the CA1,CA3,and dentate gyrus of the hippocampus at 24 and 60 days following model induction,but no significant difference was detected in the same region at various time points. These results indicate that seizures led to overexpression of P-glycoprotein in neurons of the hippocampus,but no evidence was found for a positive association between P-glycoprotein expression and seizure frequency. | Shuda Chen Jueqian Zhou Xiuling Liang Ziyi Chen Libai Yang Liemin Zhou | 2010 | Neural Regeneration Research2010，5，24： | 1 |
| 10 | Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesis 显示文摘 | Shuda M Kondoh N Imazeki N | 2003 | J Hepatol2003，38，： | 1 |
| 11 | Activation of the ATF6,XBP1 and grp78 genes in human hepatocellular carcinoma:a possible involvement of the ER stress pathway in hepatocarcinogenesis显示文摘 | Shuda M Kondoh N Imazeki N | 2003 | J Hepatol2003，38，5： | 1 |
| 12 | RAD51C deficiency in mice results in early prophase I arrest in males and sister chromatid sep- aration at metaphase II in females显示文摘 | Kuznetsov S Pellegrini M Shuda K | 2007 | J Cell Biol2007，176，5： | 1 |
| 13 | Clonal integration of a polyomavirus in human Merkel cell carcinoma显示文摘 | Feng H Shuda M Chang Y | 2008 | Sci- ence2008，319，6950： | 1 |
| 14 | Clonal integration of a polyomavirus in human Merkel cell carcinoma显示文摘 | Feng H Shuda M Chang Y | 2008 | Science2008，319，5866： | 1 |
| 15 | Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesis 显示文摘 | Shuda M Kondoh N Imazeki N | 2003 | J Hepatol2003，38，5： | 1 |
| 16 | Enhanced expression of mRNAs of antisecretory factor-1,gp96,DAD1 and CDC34 in human hepatocellular carcinomas显示文摘 | TANAKA K KONDOH N SHUDA M | 2001 | Biochim Biophys Acta2001，，1： | 1 |
| 17 | Clonal integration of a polyonm- virus in human Merkel cell carcinoma 显示文摘 | Feng H Shuda M Chang Y | 2008 | Science2008，319，5866： | 1 |
| 18 | Activation ofthe ATF6 ,XBP1 and grp78 genes in human hepato-cellular carcinoma ? a possible involvement of the ERstress pathway in hepatocarcinogenesis显示文摘 | Shuda M Kondoh N Imazeki N | 2003 | Hepatol-ogy2003，38，5： | 1 |
| 19 | Activation of the A-TF6,XBP1 and grp78 genes in human hepatocellular carcinoma:a possible involvement of the ER stress pathway in hepatocarcinogenesis显示文摘 | SHUDA M KONDOH N IMAZEKI N | 2003 | J Hepatol2003，38，5： | 1 |
| 20 | Enhanced expression of translation factor mRNAs in hepatocellular carcinoma显示文摘 | Shuda M Kondoh N Tanaka K | 2000 | Antieancer Res2000，20，4： | 1 |
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